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Novel hematopoietic stem cell transplantation using cancer-specific T-cell receptor gene transfer

Research Project

Project/Area Number 19390265
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionEhime University

Principal Investigator

YASUKAWA Masaki  Ehime University, 大学院・医学系研究科, 教授 (60127917)

Co-Investigator(Kenkyū-buntansha) 薬師神 芳洋  愛媛大学, 医学部附属病院, 講師 (30294797)
Co-Investigator(Renkei-kenkyūsha) YAKUSHIJIN Yoshihiro  愛媛大学, 医学部・附属病院, 講師 (30294797)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywordsがん免疫療法 / 細胞傷害性T細胞 / T細胞レセプター遺伝子 / 遺伝子治療 / 造血幹細胞移植 / T細胞レセプター / 造血幹細胞 / がん免疫 / 白血病
Research Abstract

革新的造血幹細胞移植療法の開発の目的で、新たな造血器腫瘍関連抗原の同定と腫瘍特異的細胞傷害性T細胞(CTL)由来T細胞レセプター(TCR)遺伝子導入による免疫遺伝子治療の開発をおこなった。その結果、新たな白血病関連抗原として、CML66とAurora-Aを同定した。また、がん特異的CTL由来TCR遺伝子導入によって、HLA拘束性のがん特異性を獲得することが確認された。さらに、がん特異的TCR遺伝子導入造血幹細胞が、マウス体内でがん特異的成熟T細胞に分化増殖できることを確認しえたことから、今後、GVHDに頼らない新たな自己造血幹細胞移植療法の開発が可能であることが示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (67 results)

All 2009 2008 2007 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results) Presentation (24 results) Book (4 results) Remarks (2 results)

  • [Journal Article] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation2009

    • Author(s)
      Matsubara E, Yasukawa M, Yakushijin, Y.,et.al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 3480-3487

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia2009

    • Author(s)
      Ochi, T., Yasukawa, M. Yakushijin, Y., et.al.
    • Journal Title

      Blood 113

      Pages: 66-74

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes2009

    • Author(s)
      Suemori, K., Yasukawa, M., et al.
    • Journal Title

      J Gen Virol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes2009

    • Author(s)
      Suemori, K., Yasukawa, M., et al.
    • Journal Title

      Br J Haematol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrjome2009

    • Author(s)
      Yasukawa, M., et al.
    • Journal Title

      Am J Hematol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of co-expression of CD21 and LFA-1 in non-Hodgkin' s B-celllymphoma2009

    • Author(s)
      Tanimoto, K., Yasukawa, M., et al.
    • Journal Title

      Int J Hematol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation2009

    • Author(s)
      Matsubara, E., Yasukawa, M., et al.
    • Journal Title

      J Biol Chem 284

      Pages: 3480-3487

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aurora-A kinase : A novel target of cellular immunotherapy for leukemia2009

    • Author(s)
      Ochi, T., Yasukawa, M., et al.
    • Journal Title

      Blood 113

      Pages: 66-74

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of accmulaticn of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model2009

    • Author(s)
      Hasegawa, H., Yasukawa, M., et al.
    • Journal Title

      Gene Ther 15

      Pages: 171-182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an epitope derived from CML66, a novel tumor-associated antigen broadly expressed in human leukemia, recognized by HLA-A*2402-restricted cytotoxic T lymphocytes2008

    • Author(s)
      Suemori, K., Yasukawa, M. Yakushijin, Y., et.al.
    • Journal Title

      Cancer Sci. 99

      Pages: 1414-1419

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic stem cell transplantation for refractory adult T-cell leukemia using a non-T-cell-depleted HLAincompatible family donor graft, with reference to the grown-up child donor to parent recipient setting : report of a pilot study2008

    • Author(s)
      Fujiwara, H., Yasukawa, M., et.al.
    • Journal Title

      Int.J.Hematol 87

      Pages: 319-326

    • NAID

      10021256219

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation2008

    • Author(s)
      Hato, T., Yakushijin, Y., Yasukawa, M., et.al.
    • Journal Title

      J.Biol. Chem. 283

      Pages: 5662-5668

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model2008

    • Author(s)
      Hasegawa, H., Yasukawa, M. et.al.
    • Journal Title

      Gene Therapy 15

      Pages: 171-182

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an epitope derived from CML66, a novel tumor-associated antigenbroadly expressed in human leukemia, recognized by HLA-A*2402-restxicted cytotoxicT lymphocytes2008

    • Author(s)
      Suemori, K., Yasukawa, M., et al.
    • Journal Title

      Cancer Sci 99

      Pages: 1414-1419

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic stem cell transplantation for refractory adult T-cell leukemia using anon-T-cell-depleted HLA-incompatible family donor graft, with reference to theg rcwn-up child donor to parent recipient setting : report of a pilot study2008

    • Author(s)
      Fujiwara, H., Yasukawa, M., etal.
    • Journal Title

      Int J Hematol 87

      Pages: 319-326

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative role of the membrane-proximal and distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation2008

    • Author(s)
      Hato, T., Yasukawa, M., et al.
    • Journal Title

      J Biol Chem 283

      Pages: 5662-5668

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an epitope derived from CML66, a novel tumor associated antigen broadly expressed in human leukemia, recognized by HLA-A^*2402-restricted cytotoxic T lymphocytes2008

    • Author(s)
      Suemori K, Yasukawa M, et. al.
    • Journal Title

      Cancer Sci (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative role of the membrane-proximal and distal residues of the integrin beta 3cytoplasmic domain in regulation of talin-・mediated alpha IIbbeta 3 activation2008

    • Author(s)
      Hato T, Yasukawa M, et. al.
    • Journal Title

      J.Biol.Chem (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of accumulation of CXCR3-expressing regulatory T cells on liver and intestinal damages in a murine acute GVHD model2008

    • Author(s)
      Hasegawa H, Yasukawa M, et. al.
    • Journal Title

      Gene Ther 15

      Pages: 171-182

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma2007

    • Author(s)
      Tsuboi, A., Yasukawa, M., et.al.
    • Journal Title

      Int J Hematol 86

      Pages: 414-417

    • NAID

      10019533221

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis2007

    • Author(s)
      Nagafuji, K., Yasukawa, M., et.al.
    • Journal Title

      Haematologica 92

      Pages: 978-981

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of hemophagocytic lymphohistiocytosis in Japan2007

    • Author(s)
      Ishii, E., Yasukawa, M., et.al.
    • Journal Title

      Int.J.Hematol 86

      Pages: 58-65

    • NAID

      10018515633

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of human herpesvirus-6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome2007

    • Author(s)
      Tohyama, M., Yasukawa, M., et.al.
    • Journal Title

      Br.J.Dermatol 157

      Pages: 934-940

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice2007

    • Author(s)
      Hasegawa, H., Yasukawa, M., et.al.
    • Journal Title

      Arthritis Res. Ther. 9(1)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mitotic kinase TOPK enhances cdk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis2007

    • Author(s)
      Abe, Y., Yasukawa, M. et.al.
    • Journal Title

      J.Mol.Biol. 370

      Pages: 231-245

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of chlamydial infection in Japanese patients with ocular adnexal MALT lymphoma2007

    • Author(s)
      Yakushijin, Y., Yasukawa. M. et.al.
    • Journal Title

      Int.J.Hematol 85

      Pages: 223-230

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of Wilms' tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal nocturnal hemoglobinuria clone2007

    • Author(s)
      Ikeda, K., Yasukawa, M., et.al.
    • Journal Title

      Exp.Hematol 35

      Pages: 618-626

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a WT1 (Wilms' tumor gene) proteinderived HLA-DRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes2007

    • Author(s)
      Fujiki, F., Yasukawa, M., et.al.
    • Journal Title

      J.Immunother 30

      Pages: 282-293

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wilms tumor gene WT1 pepide-based immunotherapy induced a minimal response in a patient with advanoed therapy-resistant multiple myeloma2007

    • Author(s)
      Tsuboi A, Yasukawa M, et. al.
    • Journal Title

      Int.J.Hematol 86

      Pages: 414-417

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice2007

    • Author(s)
      Hasegawa H, Yasukawa M, et. al.
    • Journal Title

      Arthritis Res.Ther 9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mitotic kinase TOPK enhanoes odk1/cyclin B1-dependent phosphorylation of PRC1 and promotes cytokinesis2007

    • Author(s)
      Abe Y, Yasukawa M, et. al.
    • Journal Title

      J.Mol.Biol 370

      Pages: 231-245

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of Wilms'tumor gene peptide-specific cytotoxic T lymphocytes in immunologic selection of a paroxysmal hemoglobinuria clone2007

    • Author(s)
      Ikeda K, Yasukawa M, et. al.
    • Journal Title

      Exp.Hematol 35

      Pages: 618-626

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a WT1(Wilms'tumor gene)protein-derived HLA-DRB1^*0405-restricted 16-mer helper peptide that proxnotes the induction and activation of WT1-specific cytotoxic T lymphocytes2007

    • Author(s)
      Fujiki F, Yasukawa M, et. al.
    • Journal Title

      J.Immunother 30

      Pages: 282-293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HBZ is an immunogenic protein but not a target antigen for HTLV-1-specific cytotoxic T lymphocytes

    • Author(s)
      Suemori, K., Yasukawa, M., et.al.
    • Journal Title

      J.Gen. Virol. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel epitope derived from CML66 which is recognized by anti-leukaemia cytotoxic T lymphocytes

    • Author(s)
      Suemori, K., Yasukawa, M., Yakushijin, Y., et.al.
    • Journal Title

      Br.J.Haematol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of WT1 peptide vaccination in patients with acute myelogenous leukemia and myelodysplastic syndrome

    • Author(s)
      Yasukawa, M., Yakushijin, Y., et.al.
    • Journal Title

      Am.J.Hematol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of co-expression of CD21 and LFA-1 in non-Hodgkin's B-cell lymphoma

    • Author(s)
      Tanimoto, K., Yakushijin, Y., Yasukawa, M., et.al.
    • Journal Title

      Int. J.Hematol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Aurora-A kinase : A novel target of cellular immunotherapy for humanleukemia2008

    • Author(s)
      Ochi, T., Yasukawa, M., et al
    • Organizer
      50th American Society of Hermatology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Integrin β3 membrane-proximal and-distal residues cooperatively regulate talin-mediated α〓bβ3 activation2008

    • Author(s)
      Yamanouchi, J., Yasukawa, M., et.al.
    • Organizer
      50th American Society of Hematology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinical significance of CD21 Co-Expression with LFA-1 in Non-Hodgkin's B-cell lymphoma2008

    • Author(s)
      Tanimoto, K., Yasukawa, M., et.al.
    • Organizer
      50th American Society of Hematology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Aurora-A kinase : A novel target of cellular immunotherapy for human leukemia2008

    • Author(s)
      Ochi, T., Yasukawa, M. et.al.
    • Organizer
      50th American Society ofHematology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Integrin β3 membrane-proximal and - distal residues cooperativelyregulate talin-mediated α II bβ3 activation2008

    • Author(s)
      Yamanouchi, J., Yasukawa, M., et al.
    • Organizer
      50th American Society of Hematology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical significance of CD21 Co-Expression with LFA-1 in Non-Hodgkin's B-cell limphoma2008

    • Author(s)
      Tanimoto, K., Yasukawa, M., et al.
    • Organizer
      50th American Society of Hematology Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Zinc finger protein 521/early hematopoietic zinc finger proteinの赤血球分化における役割2008

    • Author(s)
      松原悦子、安川正貴、他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of anti-leukemic immunotherapy targeting Aurora-A kinase2008

    • Author(s)
      Ochi, T., Yasukawa, M., et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Establishment and characterization of a novel CD8+T cell line with cytotoxicity via perforin / granzyme B.2008

    • Author(s)
      Suemori, K., Yasukawa, M., et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Zinc finger protein 521 / early hematopoietic zinc finger proteinの赤血球分化における役割2008

    • Author(s)
      松原悦子, 安川正貴, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Establishment and characterization of a novel CD8+ T cell line with cytotoxicity via perforin / granzyme B2008

    • Author(s)
      Suemori, K., Yasukawa, M. etal.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Zinc finger protein 521 の赤血球分化における制御機構の解析2008

    • Author(s)
      松原悦子, 安川正貴, 他
    • Organizer
      第70回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腫瘍関連抗原CML66の臨床的有用性2008

    • Author(s)
      末盛浩一郎, 安川正貴, 他
    • Organizer
      第70回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aurora-A kinaseを標的とした抗白血病免疫療法の開発2008

    • Author(s)
      越智俊元、安川正貴、他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 腫瘍関連抗原CML66の臨床的有用性2008

    • Author(s)
      末盛浩一郎、安川正貴、他
    • Organizer
      70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Zinc finger protein 521の赤血球分化における制御機構の解析2008

    • Author(s)
      松原悦子、安川正貴、他
    • Organizer
      70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Aurora-A kinaseを標的とした抗白血病免疫療法の開発2008

    • Author(s)
      越智俊元, 安川正貴, 他
    • Organizer
      第70回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cytotoxic T-lymphocytes harnessing CML66 can kill human myeloid leukemia cells in vitro2007

    • Author(s)
      Suemori K, Yasukawa M, et. al.
    • Organizer
      The 49^<th> Anmnual Meeting of American Society of Hematology
    • Place of Presentation
      Atlanta,Georgia,U.S.A.
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Therapeutic effect of CXCR3-expressing regulatory T cells on liver and intestinal dameges in a murine acute GVHD model2007

    • Author(s)
      Yamanouchi J, Yasukawa M, et. al.
    • Organizer
      The 49^<th> Anmnual Meeting of American Society of Hematology
    • Place of Presentation
      Atlanta,Georgia,U.S.A.
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aurora-A kinase: A novel target for the immunotherapy against human leukemias2007

    • Author(s)
      Ochi T, Yasukawa M, et. al.
    • Organizer
      The 49^<th> Anmnual Meeting of American Society of Hematology
    • Place of Presentation
      Atlanta,Georgia,U.S.A.
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト細胞傷害性T細胞が認識するAurora-A由来エピトープの同定2007

    • Author(s)
      越智 俊元、安川 正貴, 他
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会合同総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腫瘍関連抗原CML66特異的細胞傷害性T細胞の誘導と機能解析2007

    • Author(s)
      末盛 浩一郎、安川 正貴、 他
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会合同総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction and functional analysis of CML66-specific cytotoxic T lymphocytes2007

    • Author(s)
      Suemori K, Yasukawa M, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of an epitope derived from Aurora-A kinase which induces leukemia-specific CTL2007

    • Author(s)
      Ochi T, Yasukawa M, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Book] Oncogene proteins : Targets for cancer immuno-cell therapy. Oncogene proteins : Structures, Functions and Analyses2008

    • Author(s)
      Fujiwara, H., Yasukawa, M.
    • Publisher
      Nova Biomedical Books. New York
    • Related Report
      2008 Final Research Report
  • [Book] Oncogene proteins : Structures, Functions and Analyses2008

    • Author(s)
      Fujiwara, H., Yasukawa, M.
    • Total Pages
      31
    • Publisher
      Qncogene proteins : Targets for cancer immuno-cell therapy
    • Related Report
      2008 Annual Research Report
  • [Book] 造血器腫瘍「細胞免疫療法総論」2007

    • Author(s)
      安川 正貴
    • Publisher
      日本臨床社
    • Related Report
      2007 Annual Research Report
  • [Book] 造血器腫瘍「細胞免疫療法各論」2007

    • Author(s)
      安川 正貴
    • Publisher
      日本臨床社
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/int.m

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/int.medl/index.htm

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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