• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of gene therapy for malignant lymphoma using mesenchymal stem cells with tumor-accumulating capacity

Research Project

Project/Area Number 19390267
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

OZAWA Keiya  Jichi Medical University, 医学部, 教授 (30137707)

Co-Investigator(Kenkyū-buntansha) OZAKI Katsutoshi  自治医科大学, 医学部, 講師 (10286453)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords悪性リンパ腫 / 間葉系幹細胞 / 腫瘍集積性 / 遺伝子治療 / 抗腫瘍性サイトカイン / 遺伝子導入 / 細胞治療 / 可溶型TRAIL
Research Abstract

(1)間葉系幹細胞(MSC: mesenchymal stem cell)の腫瘍集積性を応用した悪性リンパ腫に対する新規治療法の開発研究を行った。可溶型TRAIL の腫瘍細胞に対するアポトーシス誘導を利用した治療ストラテジーの有用性を見出した。
(2)MSC の腫瘍集積性を増強するために、腫瘍集積性の分子機構に関する検討を行った。TNF-αによる接着分子の発現誘導、ならびに血管内皮細胞への接着性の亢進がMSC の腫瘍集積性に重要な役割を担っていることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (63 results)

All 2009 2008 2007

All Journal Article (32 results) (of which Peer Reviewed: 24 results) Presentation (30 results) Book (1 results)

  • [Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.2009

    • Author(s)
      Uchibori, R., Okada, T., Ito, T., Urabe, M., Mizukami, H., Kume, A., and Ozawa, K.
    • Journal Title

      J. Gene Med. 11

      Pages: 373-381

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma.2009

    • Author(s)
      Hatano, K., Kikuchi, J., Takatoku, M., Shimizu, R., Wada, T., Ueda, M., Nobuyoshi, M., Oh, I., Sato, K., Suzuki, T., Ozaki, K., Mori, M., Nagai, T., Muroi, K., Kano, Y,. Furukawa, Y., and Ozawa, K.
    • Journal Title

      Oncogene 28(2)

      Pages: 231-242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.2009

    • Author(s)
      Uchibori, R.
    • Journal Title

      J. Gene Med. 11

      Pages: 373-381

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bortezomib overcomes cell adhesion-mediated drug resistance through dovvnregulation of VLA-4 expression in multiple myeloma.2009

    • Author(s)
      Hatano, K.
    • Journal Title

      Oncogene 28

      Pages: 231-242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays.2008

    • Author(s)
      Fujiwara, S., Yamashita, Y., Nakamura, N., Choi, Y.L., Ueno, T., Watanabe, H., Kurashina, K., Soda, M., Enomoto, M., Hatanaka, H., Takada, S., Abe, M., Ozawa, K., and Mano, H.
    • Journal Title

      Leukemia 22(10)

      Pages: 1891-1898

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species.2008

    • Author(s)
      Yoshida, K., Kirito, K., Yongzhen, H., Ozawa, K., Kaushansky, K., and Komatsu, N.
    • Journal Title

      Int J Hematol. 88(1)

      Pages: 43-51

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2. J. Cell.2008

    • Author(s)
      Nagai, T., Kikuchi, S., Ohmine, K., Miyoshi, T., Nakamura, M., Kondo, T., Furuyama, K., Komatsu, N., and Ozawa, K.
    • Journal Title

      Biochem. 104(2)

      Pages: 680-691

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.2008

    • Author(s)
      Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, T., Nomoto, T., Hojo, Y., Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Ikeda, U., Shimada, K., and Ozawa, K.
    • Journal Title

      J Gene Med. 10(4)

      Pages: 368-374

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell and gene therapy using mesenchymal stem cells (MSCs).2008

    • Author(s)
      Ozawa, K., Sato, K., Oh, I., Ozaki, K., Uchibori, R., Obara, Y., Kikuchi, Y., Ito, T., Okada, T., Urabe, M., Mizukami, H., and Kume, A.
    • Journal Title

      J. Autoimmun. 30(3)

      Pages: 121-127

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy. Front.2008

    • Author(s)
      Okada, T. and Ozawa, K.
    • Journal Title

      Biosci. 13

      Pages: 1887-1891

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cell and gene therapy using mesenchymal stem cells (MSCs).2008

    • Author(s)
      Ozawa, K., Sato, K., Oh, I., Ozaki, K,. Uchibori, R., Obara, Y., Kikuchi, Y., Ito, T.,Okada, T., Urabe, M., Mizukami, H., and Kume, A.
    • Journal Title

      J. Autoimmun. 30(3)

      Pages: 121-127

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vectorproducing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy.2008

    • Author(s)
      Okada, T. and Ozawa, K.
    • Journal Title

      Front. Biosci. 13

      Pages: 1887-1891

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays.2008

    • Author(s)
      Fujiwara, S.
    • Journal Title

      Leukemia 22

      Pages: 1891-1898

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombopoietin (TPO)regulates HIF-lalpha levels through generation of mitochondrial reactive oxygen species.2008

    • Author(s)
      Yoshida, K.
    • Journal Title

      Int J Hematol. 88

      Pages: 43-51

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemin reduces cellular sensitivity to itnatinib and anthracyclins via Nrf2.2008

    • Author(s)
      Nagai, T.
    • Journal Title

      J. Cell. Biochem. 104

      Pages: 680-691

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.2008

    • Author(s)
      Nonaka-Sarukavva, M.
    • Journal Title

      J Gene Med. 10

      Pages: 368-374

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell and gene therapy using mesenchymal stem cells (MSCs).2008

    • Author(s)
      Ozawa, K.
    • Journal Title

      J. Autoimmun. 30

      Pages: 121-127

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Vector-producing tumor-tracking multipotent mesenchymal stromal cellsfor suicide cancer gene therapy.2008

    • Author(s)
      Okada, T.
    • Journal Title

      Front. Biosci. 13

      Pages: 1887-1891

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Cell and gene therapy using mesenchymal stem cells(MSCs).2008

    • Author(s)
      Ozawa, K.
    • Journal Title

      J.Autoimmun. 30

      Pages: 121-127

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy.2008

    • Author(s)
      Okada, T.
    • Journal Title

      Front. Biosci. 13

      Pages: 1887-1891

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mechanisms of immunomodulation by mesenchymal stem cells.2007

    • Author(s)
      Ozaki, K., Sato, K., Oh, I., Meguro, A., Tatara, R., Muroi, K., and Ozawa, K.
    • Journal Title

      Int. J. Hematol. 86

      Pages: 5-7

    • NAID

      10018515331

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosisinducing ligand.2007

    • Author(s)
      Kikuchi, S., Nagai, T., Kunitama, M., Kirito, K., Ozawa, K., and Komatsu, N.
    • Journal Title

      Cancer Sci. 98

      Pages: 1949-1958

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and characterization of a human BCR/ABL-positive cell line, K562/RR, resistant to the farnesyltransferase nhibition by tipifarnib.2007

    • Author(s)
      Miyoshi, T., Nagai, T., Kikuchi, S., Ohmine, K., Nakamura, M., Hanafusa, T., Komatsu, N., and Ozawa, K.
    • Journal Title

      Exp. Hematol. 35

      Pages: 1358-1365

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of genes responsible for differentiation of mouse mesenchymal stromal cells by DNA microarray analysis of C3H10T1/2 and C3H10T1/2 -derived cell lines.2007

    • Author(s)
      Oh, I., Ozaki, K., Miyazato, A., Sato, K., Meguro, A., Muroi, K., N agai, T., Mano, H., and Ozawa, K.
    • Journal Title

      Cytotherapy 9

      Pages: 80-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-gamma and NF-kappaB mediate nitric oxide production by mesenchymal stromal cells.2007

    • Author(s)
      Oh, T., Ozaki, K., Sato, K., Meguro, A., Tatara, R., Hatanaka, K., Nagai, T., Muroi, K., Ozawa, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 956-962

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] E2F-6 suppresses growth-associated apoptosis of human hematopoieticprogenitor cells by counteracting proapoptotic activity of E2F-1.2007

    • Author(s)
      Kikuchi, J., Shimizu, R., Wada, T., Ando, H., Nakamura, M., Ozawa, K., and Furukawa, Y.
    • Journal Title

      Stem Cells 25

      Pages: 2439-2447

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of immunomodulation by mesenchymal stem cells.2007

    • Author(s)
      Ozaki, K.
    • Journal Title

      Int. J. Hematol. 86

      Pages: 5-7

    • NAID

      40015594590

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Active FKHRLI overcomes imatinib resistance in chronic myeloaenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand.2007

    • Author(s)
      Kikuchi, S.
    • Journal Title

      Cancer Sci. 98

      Pages: 1949-1958

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloningand characterization of a human BCR/ABL-positivecell line,K562/RR,resistant to the farnesyltransferase inhibition by tipifarnib.2007

    • Author(s)
      Miyoshi, T.
    • Journal Title

      Exp. Hematol. 35

      Pages: 1358-1365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of genes responsible for differentiation ofmouse mesenchymal stromal cells by DNA microarray analysis of C3HIOT 1/2 and C3H10T1/2-derived cell lines.2007

    • Author(s)
      Oh, I.
    • Journal Title

      Cytotherapy 9

      Pages: 80-90

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-gamma and NF-kappaB mediate nitric oxide production by mesenchymal stromal cells.2007

    • Author(s)
      Oh, I.
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 956-962

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E2F-6 suppresses growth-associated apoptosis of human hematopoieticprogenitor cells by counteracting proapoptotic activity of E2F-1.2007

    • Author(s)
      Kikuchi, J.
    • Journal Title

      Stem Cells 25

      Pages: 2439-2447

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Co-transplantation of MSC Improves the Engraftment of HSC after Auto-iBMT in Non-Human Primates.2008

    • Author(s)
      Masuda, S. et al.
    • Organizer
      The American Society of Hematology 50^<th> Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Co-transplantation of MSC Improves the Engraftment of HSC after Auto-iBMT in Non-Human Primates. .2008

    • Author(s)
      Masuda, S.
    • Organizer
      The American Society of Hematology 50^<th> Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bortezomib Overcomes Cell Adhesion-Mediated Drug Resistance Via Down-regulation of VLA-4 Expression in Multiple Myeloma.2008

    • Author(s)
      Hatano, K. et al.
    • Organizer
      The American Society of Hematology 50^<th> Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Blocking of IL-21 Signal Attenuates Graft-Versus-Host disease but Not Graft-Versus-Leukemia Effect in a Mouse model.2008

    • Author(s)
      Megro, A. et al.
    • Organizer
      The American Society of Hematology 50^<th> Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Blocking of IL-21 Signal Attenuates Graft-Versus-Host disease but Not Graft-Versus-Leukemia Effect in a Mouse model.2008

    • Author(s)
      Megro, A.
    • Organizer
      The American Society of Hematology 50^th Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 間葉系幹細胞と造血幹細胞の相互作用の分子メカニズム2008

    • Author(s)
      菊池 裕二、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 多発性骨髄腫と骨髄ストローマ細胞間相互作用が誘導する薬剤耐性における鍵分子の探索2008

    • Author(s)
      畑野 かおる、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 間葉系幹細胞の腫瘍集積メカニズムにおける炎症性サイトカインの役割2008

    • Author(s)
      内堀 亮介、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] GVHDにおけるIL-21の役割2008

    • Author(s)
      目黒 明子、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] AAVを利用した第19番染色体AAVS1領域特異的遺伝子組込み法:遺伝子導入の発現期間に関する検討2008

    • Author(s)
      小原 陽子、他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] AAVを利用した第19番染色体AAVSI領域特異的遺伝子組込み法:遺伝子導入の発現期間に関する検討2008

    • Author(s)
      小原 陽子
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 間葉系幹細胞と造血幹細胞の相互作用の分子メカニズム2008

    • Author(s)
      菊池 裕二、他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 問葉系幹細胞と造血幹細胞の相互作用の分子メカニズム2008

    • Author(s)
      菊池 裕二
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Unexpected silencing of transgene integrated at AAVS1 locus using AAV machinery.2008

    • Author(s)
      Obara, Y. et al.
    • Organizer
      The 14^<th> Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 骨髄間葉系幹細胞を用いた細胞治療/遺伝子治療の開発2008

    • Author(s)
      小澤 敬也
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-14
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Molecular Mechanisms of Immunosuppressive Activity of MSCs (Mesenchymal Stem Cells)2008

    • Author(s)
      Ozawa, K.
    • Organizer
      第30回日本造血細胞移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular Mechanisms of Immunosuppressive Activity of MSCs(Mesenchymal Stem Cells)2008

    • Author(s)
      Ozawa, K.
    • Organizer
      第30回日本造血細胞移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hyaluronidase and IFN-g from Activated T-cells are Key Mediators to Induce Immunosuppressive Activity of Mesenchymal Stem Cells.2007

    • Author(s)
      Sato, K. et al.
    • Organizer
      The American Society of Hematology 49th Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Hyalumnidase and IFN-g ffom Activated T-cells are Key Medlators to Induce Immunosunnressive Actwity ofMesenchvmal Stem Cells.2007

    • Author(s)
      Sato, K.
    • Organizer
      The American Society of Hematology 49^<th> Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Retroviral vector-producing mesenchymal stem cells for tumor tracking and therapeutic gene amplification in suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R. et al.
    • Organizer
      The American Society of Hematology 49th Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Retroviral vector-producing mesenchymal stem cells for tumor tracking and therapeutic gene amplification in suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R.
    • Organizer
      The American Society ofHematology 49^<th> Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 間葉系幹細胞におけるヒアルロン酸の役割2007

    • Author(s)
      佐藤 一也、他
    • Organizer
      日本血液学会日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 間葉系幹細胞におけるピアルロン酸の役割2007

    • Author(s)
      佐藤 一也
    • Organizer
      日本血液学会日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] ベクター産生型間葉系幹細胞の開発と自殺遺伝子療法への応用2007

    • Author(s)
      内堀 亮介、他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Tumor tracking and therapeutic gene amplification by using retroviral vector-producing Mesenchymal stem cells for reinforcement of suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R. et al.
    • Organizer
      The 13th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Tumor tracking and therapeutic gene amplification by using retroviral vector-producing Mesenchymal stem cells for reinforcement of suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R.
    • Organizer
      The 13^<th> Annual Meeting ofJapan Society ofGene Therapy
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] MSC (mesenchymal stem cell)-based cell and gene therapy.2007

    • Author(s)
      Ozawa, K. et al.
    • Organizer
      13th ISCT (International Society for Cellular Therapy) Annual Meeting
    • Place of Presentation
      Sydney
    • Year and Date
      2007-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] MSC(mesenchymal stem cell)-based cell and gene therapy2007

    • Author(s)
      Ozawa, K.
    • Organizer
      13^<th> ISCT(lnternational Society for Cellular Therapy)Annual Meeting
    • Place of Presentation
      Sydney
    • Year and Date
      2007-06-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Retroviral vector-producing mesenchymal stem cells for tumor tracking and therapeutic gene amplification as systemic suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R. et al.
    • Organizer
      The 10th Annual Meeting of American Society of Gene Therapy
    • Place of Presentation
      Seattle
    • Year and Date
      2007-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Retroviral vector-producing mesenchymal stem cells for tumor tracking and therapeutic gene amplification as systemic suicide cancer gene therapy.2007

    • Author(s)
      Uchibori, R.
    • Organizer
      The 10^<th> Annual Meeting of American Society ofGene Therapy
    • Place of Presentation
      Seattle
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Book] Progress in Gene Therapy, Vol. 2, Autologous and Cancer Stem Cell Gene Therapy.2008

    • Author(s)
      Urabe, M. et al.
    • Publisher
      World Scientific Publishing Co.
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi