Pathogenesis of antiphospholipid syndrome and new therapeutic target

• Project/Area Number: 19390269
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Hokkaido University
• Principal Investigator: KOIKE Takao Hokkaido University, 大学院・医学研究科, 教授 (80146795)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 抗リン脂質抗体症候群 / β_2GPI / 血栓形成 / プロテオーム解析 / シグナル伝達 / p38MAPK / ゲルゾリン / インテグリン / 免疫学 / プロテオーム / バイオテクノロジー

Research Abstract

代表的な抗リン脂質抗体である抗β2グリコプロテインI抗体(抗β2GPI抗体)の血栓原性を明らかにする目的で、単球やマクロファージ細胞株に抗β2GPI抗体を作用させ、抗β2GPI抗体と結合ないし相互作用する細胞表面分子について、免疫沈降法により共沈させ、ウエスタンブロット法あるいは質量分析法などを用いて同定を試みた。質量分析法で同定された複数の候補細胞質蛋白の中でゲルゾリンがβ2GPIと結合していることがウエスタンブロット法で確認された。ゲルゾリンはインテグリンα5β1と共役し、抗β2GPI抗体による細胞刺激に関与する可能性が示唆された。細胞表面分子のみならず抗β2GPI抗体と結合ないし相互作用する流血中の可溶型分子についても検策した。

Research Products

• [Journal Article] FCGR3A-158V/F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2008)
  • Author(s): Nishio M, Endo T, Fujimoto K, Yamamoto S, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T.
  • Journal Title: Eur J Haematol 82(2) Pages: 143-7
  • Peer Reviewed
• [Journal Article] Antiprothrombin antibody testing: detection and clinical utility. Semin (2008)
  • Author(s): Oku K, Atsumi T, Amengual O, Koike T.
  • Journal Title: Thromb Hemost 34(4) Pages: 335-339
  • Peer Reviewed
• [Journal Article] Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases : analysis of 30 cases (2008)
  • Author(s): Fukaya S, Yasuda S, Hashimoto T, Oku K, Kataoka H, Horita T, Atsumi T, Koike T.
  • Journal Title: Rheumatology 47(11) Pages: 1686-1691
  • Peer Reviewed
• [Journal Article] between disease activity and levels of vascular endothelial growth Discrepancy factor in a patient with POEMS syndrome successfully treated with autologous stem-cell transplantation (2008)
  • Author(s): Goto H, Nishio M, Kumano K, Fujimoto K, Yamaguchi K, Koike T.
  • Journal Title: Bone Marrow Transplant 42(9) Pages: 627-629
  • Peer Reviewed
• [Journal Article] A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma(ATL) : clinical impact of graft-versus-leukemia/lymphoma effect (2008)
  • Author(s): Shiratori S, Yasumoto A, Tanaka J, Shigematsu A, Yamamoto S, Nishio M, Hashino S, Morita R, Takahata M, Onozawa M, Kahata K, Kondo T, Ota S, Wakasa K, Sugita J, Koike T, Asaka M, Kasai M, Imamura M.
  • Journal Title: Biol Blood Marrow Transplant 14 Pages: 817-823
  • NAID: 120005906874
  • Peer Reviewed
• [Journal Article] Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain (2008)
  • Author(s): Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, Hatakeyama S.
  • Journal Title: Biochim Biophys Acta 1783(5) Pages: 826-837
  • Peer Reviewed
• [Journal Article] Etiopathology of the Antiphosphospholipid syndrome, In : Tanaka K, Davie EW, editor (2008)
  • Author(s): Atsumi T, Amengual O, Koike T.
  • Journal Title: Recent Advances in Thrombosis and Haemostasis 2008 Pages: 521-535
  • Peer Reviewed
• [Journal Article] Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia (2008)
  • Author(s): Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Obara M, Wakasa K, Takahata M, Takeda Y, Tanaka J, Hashino S, Nishio M, Koike T, Asaka M, Imamura M.
  • Journal Title: Biol Blood Marrow Transplant 14(5) Pages: 568-575
  • NAID: 120005906865
  • Peer Reviewed
• [Journal Article] Exchange of information in Rheumatology between East and West : From Man'yo-shu to the Future (2008)
  • Author(s): Atsumi T, Horita T, Minori T, Koike T
  • Journal Title: Arthritis Rheum 58(2) Pages: 140-142
  • Peer Reviewed
• [Journal Article] Thrombotic microangiopathy in patients withphosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome (2008)
  • Author(s): Kon Y, Atsumi T, Hagiwara H, Furusaki A, Kataoka H, Horita T, Yasuda S, Amengual O, Koike T.
  • Journal Title: Clin Exp Rheumatol 26(1) Pages: 129-132
  • Peer Reviewed
• [Journal Article] The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells (2008)
  • Author(s): Okamoto T, Atsumi T, Shimizu C, Yoshioka N, Koike T.
  • Journal Title: J Atheroscler Thromb 15(1) Pages: 13-19
  • NAID: 10022607656
  • Peer Reviewed
• [Journal Article] Autoimmune disease after autologous hematopoietic stem cell transplantation (2008)
  • Author(s): Bohgaki T, Atsumi T, Koike T.
  • Journal Title: Autoimmun Rev 7(3) Pages: 198-203
  • Peer Reviewed
• [Journal Article] Polymyalgia rheumatica as the manifestation of unclassified aortitis (2008)
  • Author(s): Kataoka H, Atsumi T, Hashimoto T, Horita T, Yasuda S, Koike T.
  • Journal Title: Mod Rheumatol 18(1) Pages: 105-108
  • NAID: 10024149993
  • Peer Reviewed
• [Journal Article] Reversible cardiomyopathy due to secondary hemochromatosis with multitransfusions for severe aplastic anemia after successful non-myeloablative stem cell transplantation (2008)
  • Author(s): Nishio M, Endo T, Nakao S, Sato N, Koike T.
  • Journal Title: Int J Cardiol 127 Pages: 400-401
  • Peer Reviewed
• [Journal Article] Autoimmune disease after autologous hematopoietic stem cell transplantation (2008)
  • Author(s): Bohgaki T, Atsumi T, Koike T
  • Journal Title: Autoimmun Rev 7(3) Pages: 198-203
  • Peer Reviewed
• [Journal Article] Thrombotic microangiopathy in patients with phosphatidylserine dependent antiprothrombin antibodies and antiphospholipid syndrome (2008)
  • Author(s): Kon Y, Atsumi T, Hagiwara H, Furusaki A, Kataoka H, Horita T, Yasuda S, Amengua I O, Koike T
  • Journal Title: Clin Exp Rheumatol 26(1) Pages: 129-132
  • Peer Reviewed
• [Journal Article] Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases : analysis of 30 cases (2008)
  • Author(s): Fukaya S, Yasuda S, Hashimoto T, Oku K, Kataoka H, Horita T, Atsumi T, Koike T
  • Journal Title: Rheumatology. 47(11) Pages: 1686-1691
  • Peer Reviewed
• [Journal Article] Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain (2008)
  • Author(s): Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, Hatakevama S.
  • Journal Title: Biochim Biophys Acta. 1783(5) Pages: 826-837
  • Peer Reviewed
• [Journal Article] Antiprothrombin antibody testing : detection and clinical utility (2008)
  • Author(s): Oku K, Atsumi T, Amengual O. Koike T
  • Journal Title: Semin Thromb Hemost. 34(4) Pages: 335-339
  • Peer Reviewed
• [Journal Article] FCGR3A-158V / F polymorphism may correlate with the levels of immunoglobulin in patients with non-Hodgkin's lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2008)
  • Author(s): Nishio M, Endo T, Fujimoto K, Yamamoto S, Obara M, Yamaguchi K, Takeda Y, Goto H, Kasahara I, Sato N, Koike T
  • Journal Title: Eur J Haematol 82(2) Pages: 143-147
  • Peer Reviewed
• [Journal Article] Discrepancy between disease activity and levels of vascular endothelial growth factor in a patient with POEMS syndrome successfully treated with autoloaous stem-cell transplantation (2008)
  • Author(s): Goto H, Nishio M, Kumano K, Fujimoto K, Yamaguchi K, Koike T.
  • Journal Title: Bone Marrow Transplant 42(9) Pages: 627-629
  • Peer Reviewed
• [Journal Article] A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia / lymphoma (ATL) : clinical impact of graft-versus-leukemia / lymphoma effect (2008)
  • Author(s): Shiratori S, Yasumoto A, Tanaka J, Shigematsu A, Yamamoto S, Nishio M, Hashino S, Morita R, Takahata M, Onozawa M, Kahata K, Kondo T, Ota S, Wakasa K, Sugita J, Koike T, Asaka M, Kasai M, Imamura M.
  • Journal Title: Biol Blood Marrow Transplant. 14 Pages: 817-823
  • NAID: 120005906874
  • Peer Reviewed
• [Journal Article] Excellent outcome of allogeneic hematopoietic stem cell transplantation using a conditioning regimen with medium-dose VP-16, cyclophosphamide and total-body irradiation for adult patients with acute lymphoblastic leukemia (2008)
  • Author(s): Shigematsu A, Kondo T, Yamamoto S, Sugita J, Onozawa M, Kahata K, Endo T, Shiratori S, Ota S, Obara M, Wakasa K, Takahata M, Takeda Y, Tanaka J, Hashino S, Nishio M, Koike T, Asaka M, Imamura M.
  • Journal Title: Biol Blood Marrow Transplant 14(5) Pages: 568-575
  • NAID: 120005906865
  • Peer Reviewed
• [Journal Article] The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells (2008)
  • Author(s): Okamoto T, Atsumi T, Shimizu C, Yoshioka N, Koike T
  • Journal Title: J Atheroscler Thromb 15(1) Pages: 13-19
  • NAID: 10022607656
  • Peer Reviewed
• [Journal Article] Reversible cardiomyopathy due to secondary hemochromatosis with multitransfusions for severe aplastic anemia after successful non-myeloablative stem cell transplantation. (2008)
  • Author(s): Nishio M, Endo T, Nakao S, Sato N, Koike T.
  • Journal Title: Int J Cardiol (in press)
  • Peer Reviewed
• [Journal Article] Multiple autoimmune diseases after autologous stem-cell transplantation (2007)
  • Author(s): Bohgaki T, Atsumi T, Koike T.
  • Journal Title: New Engl J Med 357(26) Pages: 2734-2736
  • NAID: 120005906870
  • Peer Reviewed
• [Journal Article] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis (2007)
  • Author(s): Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y.
  • Journal Title: PNAS 104(46) Pages: 18205-18210
  • Peer Reviewed
• [Journal Article] Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26.CID (2007)
  • Author(s): Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shirasaka T, Kimura S, Oka S.
  • Journal Title: 45(9) Pages: 1230-1237
  • Peer Reviewed
• [Journal Article] Soluble fibrin monomer degradation products as a potentially useful marker for hypercoagulable states with accelerated fibrinolysis (2007)
  • Author(s): Ieko M, Nakabayashi T, Tarumi T, Naito S, Yoshida M, Kanazawa K, Mizukami K, Koike T.
  • Journal Title: Clin Chim Acta 386(1-2) Pages: 38-45
  • Peer Reviewed
• [Journal Article] Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus (2007)
  • Author(s): Yasuda S, Stevens RL, Terada T, Takeda M, Hashimoto T, Fukae J, Horita T, Kataoka H, Atsumi T, Koike T.
  • Journal Title: J. Immunol 179(7) Pages: 4890-4900
  • Peer Reviewed
• [Journal Article] The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation (2007)
  • Author(s): Atsumi T, Cho YR, Leng L, McDonald C, Yu T, Danton C, Hong EG, Mitchell RA, Metz C, Niwa H, Takeuchi J, Onodera S, Umino T, Yoshioka N, Koike T, Kim JK, Bucala R.
  • Journal Title: Immunol 179(8) Pages: 5399-5406
  • Peer Reviewed
• [Journal Article] Increased fructose 2, 6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes (2007)
  • Author(s): Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T.
  • Journal Title: Endocr J 57(4) Pages: 517-520
  • NAID: 10019809194
  • Peer Reviewed
• [Journal Article] Amicrobial pustulosis associated with IgA nephropathy and Sjogren's syndrome (2007)
  • Author(s): Natsuga K, Sawamura D, Homma E, Nomura T, Abe M, Muramatsu R, Mochizuki T, Koike T, Shimizu H.
  • Journal Title: J Am Acad Dermatol 57 Pages: 523-526
  • Peer Reviewed
• [Journal Article] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies (2007)
  • Author(s): Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • Journal Title: Lupus 16(7) Pages: 509-516
  • Peer Reviewed
• [Journal Article] A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus (2007)
  • Author(s): Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, Koike T.
  • Journal Title: Arthritis Rheum. 56(8) Pages: 2803-2809
  • Peer Reviewed
• [Journal Article] Acute onset of type 1 diabetes accompanied by acute hepatitis C : the potential role of proinflammatory cytokine in the pathogenesis of autoimmune diabetes (2007)
  • Author(s): Masuda H, Atsumi T, Fujisaku A, Shimizu C, Yoshioka N, Koike T.
  • Journal Title: Diabetes Res Clin Pract 75(3) Pages: 357-361
  • Peer Reviewed
• [Journal Article] Delayed redistribution of CD27, CD40 and CD80 positive B cells and the impaired in vitro immunoglobulin production in patients with non-Hodgkin lymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation (2007)
  • Author(s): Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koizumi K, Mukai M, Koike T.
  • Journal Title: Br J Haematol 137(4) Pages: 349-354
  • Peer Reviewed
• [Journal Article] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease (2007)
  • Author(s): Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T.
  • Journal Title: Ann Hematol 86(2) Pages: 155-157
  • NAID: 120000973066
  • Peer Reviewed
• [Journal Article] Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome (2007)
  • Author(s): Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H, Koike T.
  • Journal Title: J Endocrinol Invest 30 Pages: 65-69
  • Peer Reviewed
• [Journal Article] "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome (2007)
  • Author(s): Koike T, Atsumi T.
  • Journal Title: Arthritis Rheum 56(2) Pages: 393-394
  • Peer Reviewed
• [Journal Article] Polymyalgia rheumatica as the manifestation of unclassified aortits. (2007)
  • Author(s): Kataoka H, Atsumi T, Hashimoto T, Horita T, Yasuda S, Koike T.
  • Journal Title: Mod Rheumatol 18(1) Pages: 105-108
  • Peer Reviewed
• [Journal Article] Multiple autoimmune diseases after autologous stem-cell transplantation. (2007)
  • Author(s): Bohgaki T, Atsumi T, Koike T.
  • Journal Title: New Engl J Med. 357(26) Pages: 2734-2736
  • NAID: 120005906870
  • Peer Reviewed
• [Journal Article] Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. (2007)
  • Author(s): Chida D, Nakagawa S, Nagai S, Sagara H, Katsumata H, Imaki T, Suzuki H, Mitani F, Ogishima T, Shimizu C, Kotaki H, Kakuta S, Sudo K, Koike T, Kubo M, Iwakura Y.
  • Journal Title: PNAS. 104(46) Pages: 18205-18210
  • Peer Reviewed
• [Journal Article] Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. (2007)
  • Author(s): Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shrasaka T, Kimura S, Oka S.
  • Journal Title: CID 45(9) Pages: 1230-1237
  • Peer Reviewed
• [Journal Article] Soluble fibrin monomer degradation products as a potentially useful markerfor hypercoagulable states with accelerated fibrinolysis. (2007)
  • Author(s): eko M, Nakabayashi T, Tarumi T, Naito S, Yoshida M, Kanazawa K, Mizukami K, Koike T.
  • Journal Title: Clin Chim Acta. 386(1-2) Pages: 38-45
  • Peer Reviewed
• [Journal Article] Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. (2007)
  • Author(s): Yasuda S, Stevens RL, Terada T, Takeda M, Hashimoto T, Fukae J, Horita T, Kataoka H, Atsumi T, Koike T.
  • Journal Title: J. Immunol 179(7) Pages: 4890-4900
  • Peer Reviewed
• [Journal Article] The Proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. (2007)
  • Author(s): Atsumi T, Cho YR, Leng L, McDonald C, Yu T, Danton C, Hong EG, Mitchell RA, Metz C, Niwa H, Takeuchi J, Onodera S, Umino T, Yoshioka N, Koike T, Kim JK, Bucala R.
  • Journal Title: J. Immunol 179(8)
  • Peer Reviewed
• [Journal Article] Increased fructose 2, 6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes. (2007)
  • Author(s): Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T.
  • Journal Title: Endocr J. 57(4) Pages: 517-520
  • NAID: 10019809194
  • Peer Reviewed
• [Journal Article] Amicrobial pustulosis associated with IgA nephropathy and Sjogren's syndrome. (2007)
  • Author(s): Natsuga K, Sawamura D, Homma E, Nomura T, Abe M, Muramatsu R, Mochizuki T, Koike T, Shimizu H.
  • Journal Title: J Am Acad Dermatol 57 Pages: 523-526
  • Peer Reviewed
• [Journal Article] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies. (2007)
  • Author(s): Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • Journal Title: Lupus. 16(7) Pages: 509-516
  • Peer Reviewed
• [Journal Article] A polymorphism in human platelet antigen 6b and risk of thrombocytopenia in patients with systemic lupus erythematosus. (2007)
  • Author(s): Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, KoikeT.
  • Journal Title: Arthritis Rheum. 56(8) Pages: 2803-2809
  • Peer Reviewed
• [Journal Article] Acute onset of type 1 diabetes accompanied by acute hepatitis C: the potential role of proinflammatory cytokine in the pathogenesis of autoimmune diabetes. (2007)
  • Author(s): Masuda H, Atsumi T, Fujisaku A, Shimizu C, Yoshioka N, Koike T.
  • Journal Title: Diabetes Res Clin Pract 75(3) Pages: 357-361
  • Peer Reviewed
• [Journal Article] Delayed redistribution of CD27, CD40 and CD80 positive B cells and the impaired in vitro immunoglobulin production in patients with non-Hodgkinlymphoma after rituximab treatment as an adjuvant to autologous stem cell transplantation. (2007)
  • Author(s): Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Yamaguchi K, Takeda Y, Goto H, Sato N, Koizumi K, Mukai M, Koike T.
  • Journal Title: Br J Haematol 137(4) Pages: 349-354
  • Peer Reviewed
• [Journal Article] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease. (2007)
  • Author(s): Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T.
  • Journal Title: Ann Hematol. 86(2) Pages: 155-157
  • NAID: 120000973066
  • Peer Reviewed
• [Journal Article] Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. (2007)
  • Author(s): Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano H, Koike T.
  • Journal Title: J Endocrinol Invest 30 Pages: 65-69
  • Peer Reviewed
• [Journal Article] "Resurrection of thrombin" in the pathophysiology of the antiphospholipid syndrome. (2007)
  • Author(s): Koike T, Atsumi T.
  • Journal Title: Arthritis Rheum 56(2) Pages: 393-394
  • Peer Reviewed
• [Journal Article] STAT4single nucleotide polymorphism,rs7574865 G/T,as a risk for antiphospholipid syndrome
  • Author(s): Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S, Koike T.
  • Journal Title: Ann Rheum Dis (in press)
  • Peer Reviewed
• [Journal Article] Complement activation in patients with primary antiphospholipid syndrome
  • Author(s): Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, Yasuda S, Koike T.
  • Journal Title: Ann Rheum Dis (in press)
  • Peer Reviewed
• [Journal Article] Complement activation in patients with primary antiphospholipid syndrome
  • Author(s): Oku K, Atsumi T, Bohgaki M, Kataoka H, Horita T, Yasuda S, Koike T.
  • Journal Title: Ann Rheum Dis (In press)
  • Peer Reviewed
• [Journal Article] STAT4 single nucleotide polymorphism, rs7574865 G /T, as a risk for antiphospholipid syndrome
  • Author(s): Horita T, Atsumi T, Yoshida N, Nakagawa H, Kataoka H, Yasuda S. Koike T.
  • Journal Title: Ann Rheum Dis (In press)
  • Peer Reviewed
• [Journal Article] Immunological reconstitution after autologous hematopoietic stem cell transplantation in patients with systemic sclerosis : relationship between clinical benefits and intensity of immunosuppression
  • Author(s): Bohgaki T, Atsumi T, Bohgaki M, Furusaki A, Kondo M, Sato-MatsumuraK, Abe R, Kataoka H, Horita T, Yasuda S, Amasaki Y, Nishio M, Sawada K, Shimizu H, Koike T.
  • Journal Title: J Rheumatol (In press)
  • Peer Reviewed
• [Presentation] Development of Autoimmune Diseases : A Lesson from Stem Cell Transplantation (2008)
  • Author(s): Koike, T
  • Organizer: 6^<th> International Congress on Autoimmunity, Porto, Portugal
  • Place of Presentation: Porto, Portugal
  • Year and Date: 2008-09-13
• [Presentation] Development of Autoimmune Diseases : A Lesson from Stem Cell Transplantation (2008)
  • Author(s): Koike, T
  • Organizer: 6^<th> International Congress on Autoimmunity
  • Place of Presentation: コングレスセンター, Porto, Portugal
  • Year and Date: 2008-09-13
• [Presentation] Multiple autoimmune diseases after CD34+- selected autologous hematopoietic stem cell transplantation in a patient with systemic sclerosis (2008)
  • Author(s): Koike, T
  • Organizer: The Mosaic of Autoimmunity
  • Place of Presentation: Kfar Maccabiah, Israel
  • Year and Date: 2008-02-11
• [Presentation] Multiple autoimmune diseases after CD34+ selected autologous hematopoietic stem cell transplantation in a patient with systemic sclerosis (2008)
  • Author(s): Koike, T. :
  • Organizer: The Mosaic of Autoimmunity
  • Place of Presentation: Kfar Maccabiah Olympic Village, Israel,
  • Year and Date: 2008-02-11
• [Presentation] Antiphospholipid antibodies and cell acyivation (2007)
  • Author(s): Koike,T
  • Organizer: 12^<th> International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Florence, Italy
  • Year and Date: 2007-04-18
• [Presentation] Antiphospholipid antibodies and cell acyivation (2007)
  • Author(s): Koike, T.
  • Organizer: 12th International Congress on Antiphospholipid Antibodies
  • Place of Presentation: Palazzo dei Congressi, Florence, Italy
  • Year and Date: 2007-04-18
• [Presentation] Recent Progress in Systemic Autommune Diseases (2007)
  • Author(s): Koike,T
  • Organizer: 第8回国際SLE学会
  • Place of Presentation: 上海
• [Presentation] Recent Progress in Systemic Autommune Diseases (2007)
  • Author(s): Koike, T
  • Organizer: 第8回国際SLE学会
  • Place of Presentation: Shanghai international Convention Center, 上海
• [Book] Recent Advances in Thrombosis and Haemostasis 2008 (2008)
  • Author(s): Atsumi T, Amengual O, Koike T
  • Total Pages: 643
  • Publisher: Springer