A role of LFA-1 in the development of autoreactive Th17 cells
| Project/Area Number |
19390270
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIBUYA Kazuko University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (00302406)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 臨床免疫学 / 自己免疫疾患 / Th17細胞 / LFA-1 / 自己反応性T細胞 / 臨床免疫 / 自己反応T細胞 |
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| Research Abstract |
In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice2009
Author(s)
Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 11230-11235
Related Report
Peer Reviewed
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[Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo2009
Author(s)
Lakshmikanth T., Burke S., Ali T. H., Kimpfler S., Ursini F., Ruggeri L., Capanni M., Umansky V., Paschen A., Sucker A., Pende D., Groh V., Biassoni R., Hoglund P., Kato M., Shibuya K., Schadendorf D., Anichini A., Ferrone S., Velardi A., Karre K., Shibuya A., Carbone E., Colucci F.
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Journal Title
J.Clin.Invest. 119
Pages: 1151-1163
Related Report
Peer Reviewed
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[Journal Article] LFA-1 decreases the antigen dose for T cell activation in vivo2008
Author(s)
Wang Y., Shibuya K., Yamashita Y., Shirakawa J., Shibata K., Kai H., Yokosuka T., Saito T., Honda S., Tahara-Hanaoka S., Shibuya A.
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Journal Title
Int Immunol. 20
Pages: 1119-27
NAID
Related Report
Peer Reviewed
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[Journal Article] Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRγ chain on peritoneal macrophages2007
Author(s)
Nakahashi C., Tahara-Hanaoka S., Totsuka N., Okoshi Y., Takai T., Ohkochi N., Honda S., Shibuya K., Shibuya A.
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Journal Title
J.Immunol. 178
Pages: 765-770
Related Report
Peer Reviewed
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[Journal Article] Th1 and Type 1 Cytotoxic T Cells Dominate the Responses in Tbet Overexpression Transgenic Mice that Develop Contact Dermatitis2007
Author(s)
Ishizaki K., Yamada A., Yoh K., Nakano T., Shimohata H., Maeda A., Fujioka Y, Morito N., Kawachi Y., Shibuya K., Otsuka F., Shibuya A., Takahashi S.
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Journal Title
J.Immunol. 178
Pages: 605-612
Related Report
Peer Reviewed
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[Presentation] ITIMを持つ免疫受容体MAIR-Vの機能解析2007
Author(s)
Ismail Can, Satoko Tahara-Hanaoka, Shin-ichiro Honda, Kazuko Shibuya, Akira Shibuya.
Organizer
第69回 日本血液学会
Place of Presentation
神奈川
Year and Date
2007-10-12
Related Report
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