| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.
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