The Role of orally administered TGF-β in the prevention of allergic diseases.

• Project/Area Number: 19390273
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAO Atsuhito University of Yamanashi, 大学院・医学工学総合研究部, 教授 (80317445)
• Co-Investigator(Kenkyū-buntansha): YAMAGATA Zentaro 山梨大学, 大学院・医学工学総合研究部, 教授 (10210337)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: アレルギー・ぜんそく / シグナル伝達 / 社会医学 / TGF-β / アレルギー / 予防 / 牛乳 / TGF-beta / 炎症

Research Abstract

本研究で我々は、経口TGF-β作用の生体内における主たる標的臓器は小腸であること、経口免疫寛容を増強する作用があること、マウスアトピー性皮膚炎モデルにおいて病変局所のアレルギー関連サイトカインの発現量を減少させることを明らかにした。また現在、山梨県内の健康な母親の母乳サンプルを用いて母乳中TGF-β濃度と環境因子との相関関係について解析中である。

Research Products

• [Journal Article] The role and potential use of oral TGF-βin the prevention of infant allergy. (2010)
  • Author(s): Nakao A
  • Journal Title: [Review] Clinical & Experimental Allergy 40 Pages: 725-730
  • Peer Reviewed
• [Journal Article] TGF-β signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis. (2010)
  • Author(s): Ouyang Y, Miyata M, Hatsushika K, Ohnuma O, Katoh R, Ogawa H, Okumura K, Masuyama K, Nakao A
  • Journal Title: Allergology International (in press)
  • NAID: 10029670889
  • Peer Reviewed
• [Journal Article] Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. (2009)
  • Author(s): Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A
  • Journal Title: Eur J Immunol 39(11) Pages: 3078-3083
  • Peer Reviewed
• [Journal Article] The latent form of transforming growth factor-βadministered orally is activated by gastric acid in mice. (2009)
  • Author(s): Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A
  • Journal Title: J Nutr 139(8) Pages: 463-1468
  • Peer Reviewed
• [Journal Article] Transforming growth factor-βactivity in commercially available pasteurized cow milk provides protection against inflammation in mice. (2009)
  • Author(s): Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A
  • Journal Title: J Nutr 139(1) Pages: 69-75
  • Peer Reviewed
• [Journal Article] The latent form of transforming growth factor-β administered orally is activated by gastric acid in mice. (2009)
  • Author(s): Nakamura Yuki
  • Journal Title: The Journal of Nutrition 139 Pages: 1463-1468
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice. (2009)
  • Author(s): Ozawa Tetsuro
  • Journal Title: The Journal of Nutrition 139 Pages: 69-75
  • Peer Reviewed
• [Journal Article] Transforming growth factor-βactivity in commercially available pasteurized cow milk provides protection against inflammation in mice. (2009)
  • Author(s): Ozawa T, et al
  • Journal Title: The Journal of Nutrition 139 Pages: 69-75
  • Peer Reviewed
• [Journal Article] Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation. (2008)
  • Author(s): Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A
  • Journal Title: J Allergy Clin Immun 122(6) Pages: 1208-1214
  • Peer Reviewed
• [Journal Article] Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. (2008)
  • Author(s): Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A
  • Journal Title: Eur J Immunol 38(6) Pages: 1487-1492
  • Peer Reviewed
• [Journal Article] A possible link between resveratrol and TGF-β: resveratrol induction of TGF-βexpression and signaling. (2008)
  • Author(s): Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A
  • Journal Title: FEBS Letters 582(5) Pages: 586-590
  • Peer Reviewed
• [Journal Article] Orally administered TGF-βis biologically active in the intestinal mucosa and enhances oral tolerance. (2007)
  • Author(s): Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A
  • Journal Title: J Allergy Clin Immun 120(4) Pages: 916-923
  • Peer Reviewed
• [Journal Article] Transforming Growth Factor-β2 polymorphisms are associated with childhood atopic asthma. (2007)
  • Author(s): Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A
  • Journal Title: Clin Exp Allergy 37(8) Pages: 1165-74
  • Peer Reviewed
• [Journal Article] Human eosinophils have an intact Smad signaling pathway leading to a major TGF-βtarget gene expression. (2007)
  • Author(s): Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A
  • Journal Title: Int Arch Allergy Immunol 142(4) Pages: 309-317
  • Peer Reviewed
• [Journal Article] Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance. (2007)
  • Author(s): Ando Takashi, et. al.
  • Journal Title: J Allergy Clin Immunol 120(4) Pages: 916-23
  • Peer Reviewed
• [Presentation] Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance. (2007)
  • Author(s): Nakao Atsuhito, et. al.
  • Organizer: 13th International Congress of Mucosal Immunology
  • Place of Presentation: Tokyo