Study on the pathophysiological role of the Th2-type chemokine receptor CCR4
| Project/Area Number |
19390277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kinki University |
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Principal Investigator |
YOSHIE Osamu Kinki University, 医学部, 教授 (10166910)
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| Co-Investigator(Kenkyū-buntansha) |
HIESHIMA Kunio 近畿大学, 医学部, 准教授 (10322570)
NAKAYAMA Takashi 近畿大学, 医学部, 講師 (60319663)
NAGAKUDO Daisuke 近畿大学, 医学部, 助教 (10368293)
SHIRAKAWA Aiko 近畿大学, 医学部, 助教 (30260285)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | CCR4 / CCL17 / CCL22 / Th2 / Treg / アレルギー / 喘息 / アトピー / TARC / MDC / 制御性T細胞 / ブレオマイシン誘導肺線維症 / ケモカイン / ケモカイン受容体 / 胸腺 / T細胞分化 |
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| Research Abstract |
CCR4 is a chemokine receptor selectively expressed by Th2 cells, regulatory T cells, and skin-homing T cells. We have shown a potent ther apeutic effect of a small molecule CCR4 inhibitor on Th2-induced airway inflammation in mice. We have also shown that CCR4 and its ligand MDC/CCL22 mediate immunosuppressive interactions of dendritic cells and regulatory T cells in mesenteric lymphonodes. Furthermore, human oncogenic viruses such as EBV and HTLV-1 commonly induce expression of MDC/CCL22 in infected host cells to attract Th2 cells and regulatory T cells for immunoevasion and virus propagation.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with ortal squamous cell carcinoma.2010
Author(s)
Watanebe Y, Katou F, Ohtani H, Nakayma T, Yoshie O, Hashimoto K
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Journal Title
Oral Surgary, Oral Medicine, Oral Pathology, Oral Radiology, and Endocrionology
Related Report
Peer Reviewed
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[Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: Functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.2009
Author(s)
Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
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Journal Title
J. Immunol 183
Pages: 5608-5614
Related Report
Peer Reviewed
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[Journal Article] Differential regulatory function of resting and preactivated allergen-specific CD4+CD25+ regulatory T cells in Th2-type airway inflammation.2008
Author(s)
Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, Nagakubo D, Nitta N, Kanegasaki S, Hieshima K, Yoshie O, Gabazza EC, Katayama N, Shiku H, Kuribayashi K, Kato T
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Journal Title
J. Immunol 181
Pages: 6889-6897
Related Report
Peer Reviewed
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[Presentation] O. Role of Fra-2/JunD heterodimer in CCR4 expression and cell proliferation in adult T-cell leukemia.2007
Author(s)
Nakayama, T., Hieshima, K., Jin, Z., Nagakubo, D., Shirakawa, A., Yoshie, O
Organizer
第37回日本免疫学会総会・学術集会
Place of Presentation
東京
Related Report
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