| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
The final goal of our research is to conquer brain injuries often found in the premature newborn. As the experimental model, we produced fetal growth retardation (FGR) model rats. The FGR pups exhibited a significant delay in postnatal neurological development, a high density of apoptotic cells in the cortical plate, and a reduced amount of brain chondroitin sulfate proteoglycans that is a major brain niche constituent. Hypoxic treatment of a neural cell mixture which differentiated from neural stem cells in culture revealed that neuronal cells were more sensitive to hypoxia than oligodendrocytes. Addition of fibroblast growth factor-2 or epidermal growth factor to the hypoxic culture reduced cell death, suggesting that these growth factors are promising to prevent cell death found in the cortical plate of the FGR rat newborn.
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