Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells

• Project/Area Number: 19390295
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: TAMAI Katsuto Osaka University, 医学系研究科, 准教授 (20236730)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 骨髄間葉系幹細胞 / 先天性表皮水疱症 / 骨髄移植 / 骨髄由来表皮細胞 / 表皮幹細胞 / 先天性表表皮水疱 / Green fluorescent protein(GFP) / VII型コラーゲン / 表皮水疱症 / PDGFRα / CD44 / Green fluorescent protein (GFP)

Research Abstract

We demonstrated that detached RDEB epithelia recruit platelet-derived growth factor receptor alpha (PDGFRα)-positive bone marrow cells (PDGFRα+ BMCs) via circulation, and that the PDGFRα+ BMCs contain particular population to provide epithelial cells expressing keratin 5 in the RDEB skin by differentiation of those bone marrow-derived PDGFRα-positive cells. Furthermore, the PDGFRα-positive BMCs were shown to be undifferentiated non-hematopoietic cell populations, and to reside particularly on and around surface of the bone and trabeculae in bone marrow by intravital two-photon imaging.

Research Products

• [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue. (2009)
  • Author(s): Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamai K, Kaneda Y, Tabata Y
  • Journal Title: Tissue Eng Part A
  • Peer Reviewed
• [Journal Article] The compound heterozygote for new/recurrent COL7A1 mutations in a Japanese patient with bullous dermolysis of the newborn. (2009)
  • Author(s): Hashikawa K, Hamada T, Ishii N, Fukuda S, Kuroki R, Nakama T, Yasumoto S, Tamai K, Nakano H, Sawamura D, Hashimoto T
  • Journal Title: J Dermatol Sci 56 Pages: 66-8
  • NAID: 10029372278
  • Peer Reviewed
• [Journal Article] Molecular therapies for heritable blistering diseases (2009)
  • Author(s): Tamai K, Kaneda Y, Uitto J
  • Journal Title: Trends Mol Med 15(7) Pages: 285-92
  • Peer Reviewed
• [Journal Article] FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1. (2009)
  • Author(s): Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y
  • Journal Title: Arterioscler Thromb Vasc Biol 29 Pages: 909-14
  • Peer Reviewed
• [Journal Article] Development of a novel antimicrobial peptide, AG-30, with angiogenic properties. (2009)
  • Author(s): Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K, Tomono K, Kaneda Y
  • Journal Title: J Cell Mol Med 13 Pages: 535-46
  • Peer Reviewed
• [Journal Article] 1. FHL-2 Suppresses VEGF-Induced Phosphatidylinositol s-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1. (2009)
  • Author(s): Hayashi H, Nakagami H, Takami Y, Koriyama H, Mort M, Tamai K, Sun J, Nagao K, Morishits R, Kaneda Y.
  • Journal Title: Arterioscler Thromb Vase Biol 29 Pages: 909-914
  • Peer Reviewed
• [Journal Article] Molecular therapies for heritable blistering diseases. (2009)
  • Author(s): Tamar K, Kaneda Y, Uitto J.
  • Journal Title: Trends Mol Med 15 Pages: 285-292
  • Peer Reviewed
• [Journal Article] The compound heterozygote for new/recurrent COL7Al mutations in a Japanese patient with bullous dermolysis of the newborn. (2009)
  • Author(s): Hashikawa K, Hamada T, Ishii N, Fukuda S, Kuroki R, Nakama T, Yasumoto S, Tamar K, Nakano H, Sawamura D, Hashimoto T.
  • Journal Title: J Dermatol Sci 56 Pages: 66-68
  • Peer Reviewed
• [Journal Article] Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue. (2009)
  • Author(s): Kimura Y, Miyazaki N, Hayashi N, Otsuru S, Tamar K, Kaneda Y, Tabata Y.
  • Journal Title: Tissue Eng Part A. 電子版(電子版)
  • Peer Reviewed
• [Journal Article] Development of a novel antimicrobial peptide, AG-30, with angiogenic properties. (2009)
  • Author(s): Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K. Tomono K. Kaneda Y
  • Journal Title: J Cell Mol Med (In press)
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa. (2008)
  • Author(s): Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D
  • Journal Title: J Dermatol 35 Pages: 336-40
  • NAID: 10024297026
  • Peer Reviewed
• [Journal Article] Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance. (2008)
  • Author(s): Chino T, Tamai K, Yamazaki T, Otsuru S, Kikuchi Y, Nimura K, Endo M, Nagai M, Uitto J, Kitajima Y, Kaneda Y
  • Journal Title: Am J Pathol 173 Pages: 803-14
  • Peer Reviewed
• [Journal Article] Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal kerationocytes. (2008)
  • Author(s): Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D
  • Journal Title: J Dermatol Sci 51 Pages: 45-51
  • Peer Reviewed
• [Journal Article] Vitamin D(3) inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis. (2008)
  • Author(s): Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D
  • Journal Title: J Dermatol Sci 50(2) Pages: 155-8
  • Peer Reviewed
• [Journal Article] Functional modification of Sendai virus by siRNA. (2008)
  • Author(s): Saga K, Tamai K, Kawachi M, Shimbo T, Fujita H, Yamazaki T, Kaneda Y
  • Journal Title: J Biotech 133 Pages: 386-94
  • Peer Reviewed
• [Journal Article] Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element. (2008)
  • Author(s): Saito Y, Nakagami H, Kurooka M, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Morishita R, Azuma N, Sasajima T, Kaneda Y
  • Journal Title: Oncogene 27 Pages: 1821-33
  • Peer Reviewed
• [Journal Article] Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. (2008)
  • Author(s): Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y
  • Journal Title: Stem Cells 26 Pages: 223-34
  • Peer Reviewed
• [Journal Article] Cutaneous gene delivery. (2008)
  • Author(s): Kikuchi Y, Tamai K, Kaneda Y
  • Journal Title: J Dermatol Sci 50 Pages: 87-98
  • NAID: 10024118754
  • Peer Reviewed
• [Journal Article] Identification of Skn-1n, a Splice Variant Induced by High Calcium Concentration and Specifically Expressed in Normal Human Keratinocytes. (2008)
  • Author(s): Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D
  • Journal Title: J Invest Dermatol 128(5) Pages: 1336-9
  • Peer Reviewed
• [Journal Article] Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-lpathway (2008)
  • Author(s): Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y.
  • Journal Title: Stem Cells 26 Pages: 223-234
  • Peer Reviewed
• [Journal Article] Functional modification of Sendai virus by siRNA (2008)
  • Author(s): Saga K, Tamai K, Kawachi M, Shimbo T, Fujita H, Yamazaki T, Kaneda Y.
  • Journal Title: J Biotech 133 Pages: 386-394
  • Peer Reviewed
• [Journal Article] Identification of Skn-ln, a Splice Variant Induced by High Calcium Concentration and Specifically Expressed in Normal Human Keratinocytes. (2008)
  • Author(s): Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D
  • Journal Title: J Invest Dermatol 128 Pages: 1336-1339
  • Peer Reviewed
• [Journal Article] Vitamin D(3)inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis. (2008)
  • Author(s): Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D
  • Journal Title: J Dermatol Sci 50 Pages: 1558-1559
  • Peer Reviewed
• [Journal Article] Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen(BPAGl)gene expression in normal humanepidermal kerationocytes. (2008)
  • Author(s): Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D
  • Journal Title: J Dermatol Sci 51 Pages: 45-51
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of Squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa. (2008)
  • Author(s): Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D
  • Journal Title: J Dermatol 35 Pages: 336-340
  • NAID: 10024297026
  • Peer Reviewed
• [Journal Article] Development of a transferrin receptor-targeting HVJ-E vector. (2007)
  • Author(s): Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y
  • Journal Title: Biochem Biophys Res Commun 364 Pages: 423-8
  • Peer Reviewed
• [Journal Article] Oral steroid improves bullous pempygoid-like clinical manifestations in non-Herlizt junctional epidermolysis bullosa with COL17A1 mutation. (2007)
  • Author(s): Mabuchi E, Umegaki N, Murota H, Nakamura T, Tamai K, Katayama I
  • Journal Title: Br J Dermatol 157 Pages: 596-8
  • Peer Reviewed
• [Journal Article] Novel COL7A1 mutations in a Japanese family with transient bullous dermolysis of the newborn associated with pseudosyndactyly. (2007)
  • Author(s): Nakano H, Toyomaki Y, Ohashi S, Nakano A, Jin H, Munakata T, Akita N, Tamai K, Mitsuhashi Y
  • Journal Title: Br J Dermatol 157 Pages: 179-82
  • Peer Reviewed
• [Journal Article] Involvement of gamma-secretase in postnatal angiogenesis. (2007)
  • Author(s): Hayashi H, Nakagami H, Takami Y, Sato N, Saito Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y
  • Journal Title: Biochem Biophys Res Commun 23;363 Pages: 584-90
  • Peer Reviewed
• [Journal Article] Comparative Roles of Twist-1 and Id-1 in Transcriptional Regulation by BMP Signaling. (2007)
  • Author(s): Hayashi M, Nimura K, Kashiwagi K, Harada T, Takaoka K, Kato H, Tamai K, Kaneda Y.
  • Journal Title: J Cell Sci 15;120 Pages: 1350-7
  • Peer Reviewed
• [Journal Article] Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. (2007)
  • Author(s): Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y
  • Journal Title: Biochem Biophys Res Commun 9;354 Pages: 453-8
  • Peer Reviewed
• [Journal Article] Rapid transport of plasmid DNA into the nucleolus via actin depolymerization using HVJ envelope vector. (2007)
  • Author(s): Suvanasuthi S, Tamai K, Kaneda Y
  • Journal Title: J Gene Med 9 Pages: 55-62
  • Peer Reviewed
• [Journal Article] ifferential regulation of karyopherin alpha 2 expression by TGF-β1 and IFN-γin normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1. (2007)
  • Author(s): Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I, Kaneda Y
  • Journal Title: J Invest Dermatol 25;127 Pages: 1456-1465
  • Peer Reviewed
• [Journal Article] Differential regulation of karyopherin alpha 2 expression by TGF-β_l and IFN-γ in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1 (2007)
  • Author(s): Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I and Kaneda Y
  • Journal Title: J Invest Dermatol 127 Pages: 1456-1465
  • Peer Reviewed
• [Journal Article] Rapid transport of plasmid DNA into the nucleolus via actin depolymerization using HVJ envelope vector (2007)
  • Author(s): Suvanasuthi S, Tamai K and Kaneda Y
  • Journal Title: J Gene Med 9(1) Pages: 55-62
  • Peer Reviewed
• [Journal Article] Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. (2007)
  • Author(s): Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y.
  • Journal Title: Biochem Biophys Res Commun 354(2) Pages: 453-458
  • Peer Reviewed
• [Journal Article] Comparative Roles of Twist-1 and Id-1 in Transcriptional Regulation by BMP Signaling (2007)
  • Author(s): Hayashi M, Nimura K, Kashiwagi K, Harada T, Takaoka K, Kato H, Tamai K, and Kaneda Y
  • Journal Title: J Cell Sci 120 Pages: 1350-1357
  • Peer Reviewed
• [Journal Article] Development of Tissue-Targeting Hemagglutinating Virus of Japan Envelope Vector for Successful Delivery of Therapeutic Gene to Mouse Skin. (2007)
  • Author(s): Kawachi M, Tamai K, Saga K, Yamazaki T, Fujita H, Shimbo T, Kikuchi Y, Nimura K, Nishifuji K, Amagai M, Uitto J, Kaneda Y.
  • Journal Title: Hum Gene Ther 18(10) Pages: 881-894
  • Peer Reviewed
• [Journal Article] Involvement of gamma-secretase in postnatal angiogenesis. (2007)
  • Author(s): Hayashi H, Nakagami H, Takami Y, Sato N, Saito Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y.
  • Journal Title: Biochem Biophys Res Commun 363(3) Pages: 584-590
  • Peer Reviewed
• [Journal Article] Novel COL7Al mutations in a Japanese family with transient bullous dermolysis of the newborn associated with pseudosyndactyly (2007)
  • Author(s): Nakano H, Toyomaki Y, Ohashi S, Nakano A, Jin H, Munakata T, Akita N, Tamai K, Mitsuhashi Y
  • Journal Title: Br J Dermatol 157(1) Pages: 179-182
  • Peer Reviewed
• [Journal Article] Oral steroid improves bullous pempygoid-like clinical manifestations in non-Herlizt junctional epidermolysis bullosa with COL17Al mutation (2007)
  • Author(s): Mabuchi E, Umegaki N, Murota H, Nakamura T, Tamai K and Katayama I
  • Journal Title: Br J Dermatol 157(3) Pages: 596-598
  • Peer Reviewed
• [Journal Article] Development of a transferrin receptor-targeting HVJ-E vector (2007)
  • Author(s): Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y
  • Journal Title: Biochem Biophys Res Commun 364(3) Pages: 423-428
  • Peer Reviewed
• [Journal Article] Development of Tissue-Targeting Hemagglutinating Virus of Japan Envelope Vector for Successful Delivery of Therapeutic Gene to Mouse Skin.
  • Author(s): Kawachi M, Tamai K, Saga K, Yamazaki T, Fujita H, Shimbo T, Kikuchi Y, Nimura K, Nishifuji K, Amagai M, Uitto J, Kaneda Y
  • Journal Title: Hum Gene Ther 18 Pages: 881-94
  • Peer Reviewed
• [Presentation] シンポジウム:骨髄由来幹細胞による皮膚再生メカニズム (2009)
  • Author(s): 玉井克人
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 山梨市
  • Year and Date: 2009-09-26
• [Presentation] 骨髄由来幹細胞による皮膚再生メカニズム (2009)
  • Author(s): 玉井克人
  • Organizer: 第73回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 山梨市
  • Year and Date: 2009-09-26
• [Presentation] 骨髄由来多能性幹細胞動員因子を利用した非瘢痕性機能的皮膚組織再生誘導医療の開発 (2009)
  • Author(s): 玉井克人
  • Organizer: 第61回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 別府市
  • Year and Date: 2009-09-26
• [Presentation] 動き出した遺伝性皮膚難病の根治的治療法開発 (2009)
  • Author(s): 玉井克人
  • Organizer: 神奈川県皮膚科医会第130回例会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-06-25
• [Presentation] 表皮水庖症の患者さんから学んだこと (2009)
  • Author(s): 玉井克人
  • Organizer: 第25回日本臨床皮膚科医会総会
  • Place of Presentation: 高知市
  • Year and Date: 2009-05-08
• [Presentation] 表皮水庖症の病態・診断・治療 (2009)
  • Author(s): 玉井克人
  • Organizer: 第108回日本皮膚科学会総会・学術大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-04-24
• [Presentation] シンポジウム:間葉系幹細胞を利用した遺伝性疾患治療法開発のストラテジー (2009)
  • Author(s): 玉井克人
  • Organizer: 第7回遺伝子治療シンポジウム「幹細胞の機能制御と難病治療への応用」
  • Place of Presentation: 吹田市
  • Year and Date: 2009-01-30
• [Presentation] Evening seminar, Maintenance of epidermal homeostasis by bone marrow mesenchymal cells in epidermolysis bullosa (2009)
  • Author(s): Tamai K
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Fukukoka
• [Presentation] 棘融解性水庖を生じた非ベルリッツ接合部型表皮水庖症の一例 (2008)
  • Author(s): 玉井克人, 他
  • Organizer: 第30回水庖症研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-26
• [Presentation] Bone marrow transplants from mouse to human, bone marrow can bean essential source of mesenchymal and epithelial progenitor cells in EB skin (2008)
  • Author(s): Katsuto Tamai
  • Organizer: Workshop for molecular and cellular therapy for EB
  • Place of Presentation: スペイン マドリッド
  • Year and Date: 2008-10-03
• [Presentation] ミニレクチャー:遺伝性皮膚疾患の根治的治療法開発 (2008)
  • Author(s): 玉井克人
  • Organizer: 第23回角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-02
• [Presentation] 遺伝性皮膚疾患の根治的治療法開発 (2008)
  • Author(s): 玉井克人
  • Organizer: 第23回角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-02
• [Presentation] シンポジウム: Novel strategy to collect bone marrow-derived multi-lineage progenitor cells as a potential target of gene and cell therapy for non-hematopoietic genetic diseases. (2008)
  • Author(s): 玉井克人
  • Organizer: 第14回日本遺伝子治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-06-14
• [Presentation] Development of NF-kB decoy ointment and clinical trial for atopic dermatitis (2008)
  • Author(s): Katsuto Tamai
  • Organizer: International Symposium of Atopic Dermatitis
  • Place of Presentation: 京都
  • Year and Date: 2008-05-12
• [Presentation] 創傷治療のニューウエーブ (2008)
  • Author(s): 玉井克人
  • Organizer: 第107回日本皮膚科参会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-04-20
• [Presentation] シンポジウム:骨髄由来ケラチノサイト幹細胞による皮膚再生 (2008)
  • Author(s): 玉井克人
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] 特別講演:見えてきた表皮水疱症の治療:皮膚への骨髄間葉系幹細胞移植療法開発 (2008)
  • Author(s): 玉井克人
  • Organizer: 第51回日本皮膚科学会高知地方会例会
  • Place of Presentation: 高知市
  • Year and Date: 2008-02-22
• [Presentation] Bone marrow replenishes de novo keratinocytes in the regenerating hair follicles via circulating blood. (2008)
  • Author(s): Katsuti Tamai, Takehiko Yamazaki, et al
  • Organizer: International Investigative Dermatology Meeting
  • Place of Presentation: Kyoto
• [Presentation] 骨髄幹細胞動員因子を利用した新しい皮膚再生誘導医療の開発 (2008)
  • Author(s): 玉井克人, 他
  • Organizer: 第15回分子皮膚科学フォーラム
  • Place of Presentation: 京都
• [Presentation] Bone marrow stem cell therapy for epidermolysis bullosa (2007)
  • Author(s): Katsuto Tamai
  • Organizer: IV International Symposium of Epidermolysis Bullosa
  • Place of Presentation: チリ・サンチアゴ
  • Year and Date: 2007-07-27
• [Presentation] Basal keratinocytetargeting gene delivery system for in vivo EB gene therapy. (2007)
  • Author(s): Katsuto Tamai
  • Organizer: IVth International Symposium of EB
  • Place of Presentation: チリ・サンチアゴ
  • Year and Date: 2007-07-27
• [Presentation] Basal keratinocyte-targeting gene delivery system for in vivo EB gene therapy (2007)
  • Author(s): Katsuto Tamai
  • Organizer: IV International Symposium of Epidermolysis Bullosa
  • Place of Presentation: チリ・サンチアゴ
  • Year and Date: 2007-07-27
• [Presentation] Bone marrow-derived keratinocytes can ameliorate abnormality of the genetic skin disease. (2007)
  • Author(s): Katsuto Tamai
  • Organizer: Japanese Society of Gene Therapy, 13th Annual Meeting
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-28
• [Presentation] Bone marrow-derived keratinocytes can ameliorate abnormality of the genetic skin disease (2007)
  • Author(s): Katsuto Tamai
  • Organizer: Japanese Society of Gene Therapy, 13th Annual Meeting
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-28
• [Presentation] Bone marrow is an essential source of keratinocytes in the grafted skin. (2007)
  • Author(s): Katsuto Tamai
  • Organizer: American Society of Gene Therapy, 10th Annual Meeting
  • Place of Presentation: 米国・シアトル
  • Year and Date: 2007-06-03
• [Presentation] Bone marrow is an essential source of keratinocytes in the grafted skin (2007)
  • Author(s): Katsuto Tamai
  • Organizer: American Society of Gene Therapy, 10th Annual Meeting
  • Place of Presentation: 米国・シアトル
  • Year and Date: 2007-06-03
• [Patent(Industrial Property Rights)] 損傷組織の機能的再生促進医薬 (2008)
  • Inventor(s): 玉井克人, 山崎尊彦, 知野剛直, 金田安史
  • Industrial Property Rights Holder: 大阪大学, (株)ジェノミツクス
  • Industrial Property Number: 2008-119324
  • Filing Date: 2008-04-30
  • Overseas
• [Patent(Industrial Property Rights)] 末梢循環への骨髄由来多能性幹細胞動員薬 (2008)
  • Inventor(s): 玉井克人, 山崎尊彦, 知野剛直, 金田安史
  • Industrial Property Rights Holder: 大阪大学, (株)ジェノミツクス
  • Industrial Property Number: 2008-119348
  • Filing Date: 2008-04-30
  • Overseas
• [Patent(Industrial Property Rights)] 生体内機能的細胞の高効率採取法 (2008)
  • Inventor(s): 玉井克人, 山崎尊彦, 知野剛直, 金田安史
  • Industrial Property Rights Holder: 大阪大学, (株)ジェノミツクス
  • Industrial Property Number: 2008-119355
  • Filing Date: 2008-04-30
  • Overseas