Comprehensive Molecular Genetics to Elucidate The Mechanism of Action of Mood Stabilizers
| Project/Area Number |
19390300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
TOMITA Hiroaki Tohoku University, 大学院・医学系研究科, 准教授 (90295064)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 精神薬理学 / 気分調整薬 / 気分安定薬 / リチウム / 双極性障害 / 遺伝子発現 / 機能ゲノム / マイクロアレイ / ゲノム創薬 |
|---|
| Research Abstract |
躁うつ病(双極性障害)の治療薬(気分調整薬)が効く機構を解明してより有効な薬剤の開発に繋げるため、主な気分調整薬4剤を脳内細胞に由来する培養細胞3種に投与後、各細胞の数万種の遺伝子の発現量を測定し、薬剤間で共通に発現変化を受ける遺伝子を特定した。更に末梢血の単球に気分調整薬を投与し脳内変化に関連する発現変化の特定を行った。これらの知見により気分調整薬の奏効機序に関わる機構の解明が進むと期待される。
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Methodological considerations for gene expression profiling of human brain2007
Author(s)
Atz M, Walsh D, Cartagena P, Li J, Evans S, Choudary P, Overman K, Stein R, Tomita H, Potkin S, Myers R, Watson SJ, Jones EG, Akil H, Bunney WE Jr, Vawter MP
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Journal Title
J Neurosci Methods 163(2)
Pages: 295-309
Related Report
Peer Reviewed
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[Journal Article] Sample matching by inferred agonal stress in gene expression analyses of the brain2007
Author(s)
Li JZ, Meng F, Tsavaler L, Evans SJ, Choudary PV, Tomita H, Vawter MP, Walsh D,Shokoohi V, Chung T, Bunney WE Jr, Jones EG, Akil H, Watson SJ, Myers RM
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Journal Title
BMC Genomics 8(1)
Pages: 336-336
Related Report
Peer Reviewed
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[Presentation] Microarray gene expression profiles in neuronal and glial cell lines after lithium, valproate, carbamazepine and lamotrigine treatment2008
Author(s)
Yu Z, Tanaka C, Komatsu H, Takahashi S, Kim HB, Kimura K, Sora I, Bunney WE, Tomita H
Organizer
World Federation of Societies of Biological Psychiatry 2nd Asia-Pacific Congress
Place of Presentation
Toyama, Japan
Related Report
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[Presentation] Microarray gene expression profiles in neuronal and glial cell lines after lithium, valproate, carbamazepine and lamotrigine treatment2008
Author(s)
Yu Z, Tanaka C, Komatsu H, Takahashi S, Kim HB, Kimura K, Sora I, Bunney WE, Tomita H.
Organizer
World Federation of Societies of Biological Psychiatry 2nd Asia-Pacific Congress,
Place of Presentation
Toyama, Japan.
Related Report
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[Presentation] Microarray gene expression profiles in neuronal and glial cell lines after lithium, valproate, carbamazepine and lamotrigine treatment2008
Author(s)
Yu Z, Tanaka C, Komatsu H, Takahashi S, Kim HB, Kimura K, Sora I, Bunnev WE, Tomita H.
Organizer
Society for Neuroscience 38th annual meeting
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Microarray gene expression analyses of neurons, astrocytes and, oligod endrocytes, and neurons after mood stabilizer treatment2008
Author(s)
Yu Z, Tanaka C, Komatu H, Takahashi S, Kimura K, Sora I, Tomita H
Organizer
Tohoku University-Fudan University Neuroscience Workshop for Young Scientists
Place of Presentation
Shanghai, China
Related Report
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