An epidemiological study of mental health in children and neuroimaging investigation : in view of social and emotional developments

• Project/Area Number: 19390303
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: TAKEI Noriyoshi Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 教授 (80206937)
• Co-Investigator(Kenkyū-buntansha): TSUCHIYA Kenji 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (20362189) ; NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911) ; MIYACHI Taishi 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60444345) ; IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025) ; YOSHIHARA Yujirou 浜松医科大学, 医学部附属病院, 助教 (00529464) ; 杉原 玄一 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (70402261)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 子ども / メンタルヘルス / 社会性 / 疫学 / 脳発達 / 自閉症 / 脳画像

Research Abstract

小学5年から高校3年生(1,412人)を対象に、共感性と情動の安定性を評価した。社会性・情動は成長に伴って向上することが確認された。また、共感性・社会性が低いほど、攻撃性が高く、抑うつ傾向が高いことが分かった。一方、社会性に障害をみる自閉症者に対する脳画像研究(PET画像)を実施した。その結果、自閉症者では、広汎な脳部位でマイクログリアの活性が亢進していることが認められ、脳の神経炎症が障害の形成に関与していることが示唆された。

Research Products

• [Journal Article] Brain Serotonin and Dopamine Transporter Bindings in Adults with High-Functioning Autism. (2010)
  • Author(s): Nakamura K., Sekine Y., Ouchi Y., Tsujii M., Yoshikawa E., Futatsubashi M., Tsuchiya K.J., Sugihara G., Iwata Y., Suzuki K., Matsuzaki H., Suda S., Sugiyama T., Takei N., Mori N.
  • Journal Title: Arch Gen Psychiatry 67(1) Pages: 59-68
  • Peer Reviewed
• [Journal Article] Decreased serum levels of adiponectin in subjects with autism. (2010)
  • Author(s): Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 13
  • Peer Reviewed
• [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34(1) Pages: 154-8
  • Peer Reviewed
• [Journal Article] Brain Serotonin and Dopamine Transporter Bindings in Adults with High-Functioning Autism (2010)
  • Author(s): Nakamura K., Sekine Y., Ouchi Y., Tsujii M., Yoshikawa E., Futatsubashi M., Tsuchiya K.J., Sugihara G., Iwata Y., Suzuki K., Matsuzaki H., Suda S., Sugiyama T., Takei N., Mori N.
  • Journal Title: Arch Gen Psychiatry 67(1) Pages: 59-68
  • Peer Reviewed
• [Journal Article] Decreased serum levels of adiponectin in subjects with autism (2010)
  • Author(s): Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34(3) Pages: 455-8
  • Peer Reviewed
• [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are in creased in male children with autism (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34(1) Pages: 154-8
  • Peer Reviewed
• [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism (2010)
  • Author(s): Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
  • Journal Title: Int J Neuropsychopharmacol 13(4) Pages: 529-34
  • NAID: 120005305395
  • Peer Reviewed
• [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. (2009)
  • Author(s): Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
  • Journal Title: Am J Med Genet B Neuropsychiatr Gene 150B(7) Pages: 967-76
  • Peer Reviewed
• [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population. (2009)
  • Author(s): Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishik
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet
  • Peer Reviewed
• [Journal Article] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis. (2009)
  • Author(s): Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • Journal Title: Neurosci Lett 455(2) Pages: 120-3
  • Peer Reviewed
• [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism. (2009)
  • Author(s): Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiya KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
  • Journal Title: Int J Neuropsychopharmacol 9 Pages: 1-6
  • NAID: 120005305395
  • Peer Reviewed
• [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder (2009)
  • Author(s): Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
  • Journal Title: Am J Med Genet B Neuropsychiatr Gene 150B(7) Pages: 967-76
  • Peer Reviewed
• [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population (2009)
  • Author(s): Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 150B(8) Pages: 1110-7
  • Peer Reviewed
• [Journal Article] An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis (2009)
  • Author(s): Nakamura K, Sekine Y, Takei N, Iwata Y, Suzuki K, Anitha A, Inada T, Harano M, Komiyama T, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Ujike H, Mori N.
  • Journal Title: Neurosci Lett 455(2) Pages: 120-3
  • Peer Reviewed
• [Journal Article] Gene and Expression Analyses Reveal Enhanced Expression of Pericentrin 2 (PCNT2) in Bipolar Disorder. (2008)
  • Author(s): Anitha A., Nakamura K., Yamada K., Iwayama Y., Toyota T., Takei N., Iwata Y., Suzuki K., Sekine Y., Matsuzaki H., Kawai M., Miyoshi K., Katayama T., Matsuzaki S., Baba K., Honda A., Hattori T., Shimizu S., Kumamoto N., Tohyama M., Yoshikawa T., Mori N.
  • Journal Title: Biol Psychiatr 63(7) Pages: 678-85
  • Peer Reviewed
• [Journal Article] Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. (2008)
  • Author(s): Suzuki K., Nakamura K., Iwata Y., Sekine Y., Kawai M., Sugihara G., Tsuchiya K.J., Suda S., Matsuzaki H., Takei N., Hashimoto K., Mori N.
  • Journal Title: Schizophr Res 98(1-3) Pages: 148-56
  • Peer Reviewed
• [Journal Article] Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism. (2008)
  • Author(s): Anitha A., Nakamura K., Yamada K., Suda S., Thanseem I., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G.I., Ouchi Y., Sugiyama T., Koizumi K., Higashida H., Takei Anitha A., Nakamura K.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 147B(7) Pages: 1019-27
  • Peer Reviewed
• [Journal Article] Irradiation in Adulthood as a New Model of Schizophrenia. (2008)
  • Author(s): Iwata Y., Suzuki K., Wakuda T. 1, Seki N., Thanseem I., Matsuzaki H., Mamiya T., Ueki T., Mikawa S., Sasaki T., Suda S., Yamamoto S., Tsuchiya K.J., Sugihara G., Nakamura1 K., Sato K., Takei N., Hashimoto K., Mori N.
  • Journal Title: PLoSone 3(5)
  • NAID: 120005313164
  • Peer Reviewed
• [Journal Article] Methamphetamine causes microglial activation in the brains of human abusers. (2008)
  • Author(s): Sekine Y., Ouchi Y., Sugihara G., Takei N., Yoshikawa E., Nakamura K., Iwata Y., Tsuchiya K.J., Suda S., Suzuki K., Kawai M., Takebayashi K., Yamamoto S., Matsuzaki H., Ueki T., Mori N., Gold M.S., Cadet J.L.
  • Journal Title: J Neurosci 28(22) Pages: 5756-61
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism. (2008)
  • Author(s): Nakamura K., Anitha A., Yamada K., Tsujii M., Iwayama Y., Hattori E., Toyota T., Suda S., Takei N., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K.J., Sugihara G.I., Ouchi Y., Sugiyama T., Yoshikawa T., Mori N.
  • Journal Title: Int J Neuropsychopharmacol 11(8) Pages: 1073-84
  • Peer Reviewed
• [Journal Article] Paternal age at birth and high-functioning autism spectrum disorder in the offspring. (2008)
  • Author(s): Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
  • Journal Title: Bri J Psychiar 193(4) Pages: 316-21
  • Peer Reviewed
• [Journal Article] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • Author(s): Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Bri J Psychiar 193(4) Pages: 338-9
  • Peer Reviewed
• [Journal Article] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • Author(s): Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N.
  • Journal Title: PLoS ONE 3(11)
  • Peer Reviewed
• [Journal Article] Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. (2008)
  • Author(s): Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, Kawai M, Takebayashi K, Suzuki K, Takei N, Iyo M, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N.
  • Journal Title: Ann N Y Acad Sci 1139 Pages: 49-56
  • Peer Reviewed
• [Journal Article] Voxel-based structural magnetic resonance imaging (MRI) study of patients with early onset schizophrenia. (2008)
  • Author(s): Yoshihara Y, Sugihara G, Matsumoto H, Suckling J, Nishimura K, Toyoda T, Isoda H, Tsuchiya KJ, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N.
  • Journal Title: Ann Gen Psychiatry 7 Pages: 25-25
  • NAID: 120005314220
  • Peer Reviewed
• [Journal Article] Voxel-based structural magnetic resonance imaging (MRI)study of patients with early onset schizophrenia. (2008)
  • Author(s): Yoshihara Y, Sugihara G, Mats umoto H, Suckling J, Nishimura K, Toyoda T, Isoda H, Tsuchiya KJ, Takebayashi K, Suzuki K, Sakahara H, Nakamura K, Mori N, Takei N
  • Journal Title: Ann Gen Psychiatry 22 ; 7:25 Pages: 1-11
  • NAID: 120005314220
  • Peer Reviewed
• [Journal Article] Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. (2008)
  • Author(s): Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto s, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takci N, Mori N.
  • Journal Title: PLoS ONE. 3(11) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Serum levels of P-selectin in men with high-functioning autism. (2008)
  • Author(s): Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Br J Psychiatry. 193(4) Pages: 338-9
  • Peer Reviewed
• [Journal Article] Paternal age at birth and high-functioning autistic-spectrum disorder in offspring. (2008)
  • Author(s): Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
  • Journal Title: Br J Psychiatry. 193(4) Pages: 316-21
  • Peer Reviewed
• [Journal Article] Electroconvulsive therapy for burning mouth syndrome. (2008)
  • Author(s): Suda S, Takagai S, Inoshima-Takahashi K, Sugihara G, Mori N, Takei N.
  • Journal Title: Acta Psychiatr Scand. 118 (6) Pages: 503-4
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. (2008)
  • Author(s): Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E. Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • Journal Title: Int J Neuropsychopharmacol. 11(8) : 1073-84 11 (8) Pages: 1073-84
  • Peer Reviewed
• [Journal Article] Irradiation in adulthood as a new model of schizophrenia. (2008)
  • Author(s): Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto S, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N. Hashimoto K. Mori N.
  • Journal Title: PLoS ONE. 3 (5) Pages: 1-8
  • NAID: 120005313164
  • Peer Reviewed
• [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism (2008)
  • Author(s): Anithia A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N. Yoshikawa T. Mori N.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet 147B (7) Pages: 1019-27
  • Peer Reviewed
• [Journal Article] Increased serum soluble L-selectin levels in unmedicated schizophrenia. (2007)
  • Author(s): Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, Sugihara G, Kawai M, Minabe Y, Takei N, Mori N
  • Journal Title: Schizophr Res 89(1-3) Pages: 154-60
  • Peer Reviewed
• [Journal Article] Decreased serum levels of transforming growth factor-beta1 in patients with autism. (2007)
  • Author(s): Okada K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 31 Pages: 187-190
  • Peer Reviewed
• [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism. (2007)
  • Author(s): Sugihara G., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Suda S., Matsuzaki H., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatr 31(2) Pages: 412-415
  • Peer Reviewed
• [Journal Article] Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. (2007)
  • Author(s): Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya KJ, Sugihara G, Matsuzaki H, Suda S, Suzuki K, Takei N, Mori N, Iwayama Y, Takao H, Yoshikawa T, Riley B, Makoff A, Sham P, Chen R, Collier D.
  • Journal Title: Neurosci Res 57(2) Pages: 194-202
  • NAID: 10021188681
  • Peer Reviewed
• [Journal Article] Decreased serum levels of PECAM-1 in subjects with high-functioning autism: a negative correlation with head circumference at birth. (2007)
  • Author(s): Tsuchiya K.J., Hashimoto K., Iwata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N.
  • Journal Title: Biol Psychiatr Nov 1 62(9) Pages: 1056-8
  • Peer Reviewed
• [Journal Article] Disruption of Reelin signaling attenuates methamphetamine-induced hyperlocomotion. (2007)
  • Author(s): Matsuzaki H., Minabe Y., Nakamura K., Suzuki K., Iwata Y., Sekine Y., Tsuchiya K.J., Sugihara G., Suda S., Takei N., Nakahara D., Hashimoto K., Nairn A.C., Mori N., Sato K.
  • Journal Title: Eur J Neurosci 25(11) Pages: 3376-84
  • Peer Reviewed
• [Journal Article] SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism. (2007)
  • Author(s): Toyoda T., Nakamura K., Yamada K., Thanseem I., Anitha A., Suda S., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Ouchi Y., Sugiyama T., Takei N., Yoshikawa T., Toyoda
  • Journal Title: Biochem Biophys Res Commun 360(4) Pages: 715-20
  • Peer Reviewed
• [Journal Article] Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism. (2007)
  • Author(s): Nishimura K., Nakamura K., Anitha A., Yamada K., Tsujii M., Iwayama Y., Hattori E., Toyota T., Takei N., Miyachi T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Suda S., Ouchi Y., Sugiyama T., Yoshikawa T., Mori N.
  • Journal Title: Biochem Biophys Res Commun 356(1) Pages: 200-206
  • Peer Reviewed
• [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. (2007)
  • Author(s): Suzuki K., Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suda S., Sugihara G., Matsuzaki H., Sugiyama T., Kawai M., Minabe Y., Takei N., Mori N.
  • Journal Title: Biol Psychiatr 62(3) Pages: 267-269
  • Peer Reviewed
• [Journal Article] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia. (2007)
  • Author(s): Iwata Y., Suzuki K., Nakamura K., Matsuzaki H., Sekine Y., Tsuchiya K.J., Sugihara G., Kawai M., Minabe Y., Takei N., Mori N.
  • Journal Title: Schizophr Res 89(1-3) Pages: 154-160
  • Peer Reviewed
• [Journal Article] Poor mental health associated with job dissatisfaction among school teachers in Japan. (2007)
  • Author(s): Nagai M., Tsuchiya K.J., Toulopoulou T., Takei N.
  • Journal Title: J Occup Health Nov 49(6) Pages: 515-22
  • Peer Reviewed
• [Journal Article] Increased serum soluble L-selectin levels in unmedicated schizophrenia (2007)
  • Author(s): Iwata Y., Suzuki K., Nakamura K., Minabe Y., Takei N., Mori N.
  • Journal Title: Schizophr Res 89(1-3) Pages: 154-60
  • Peer Reviewed
• [Journal Article] Decreased serum levels of transforming growth factor-betal in patients with autism (2007)
  • Author(s): Okada K, Haslumoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 31 Pages: 187-190
  • Peer Reviewed
• [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioIling autism (2007)
  • Author(s): Sugihara G., Hashimoto K., Iwata Y., Nakamura k., Tsujii M., Tsuchiya K.J., Sekine Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • Journal Title: Prog Neuropsycchopharmacol Biol Psychiatr 31(2) Pages: 412-415
  • Peer Reviewed
• [Journal Article] Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia (2007)
  • Author(s): Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya KJ, Sugihara G, Matsuzaki H, Suda S, Suzuki K, Takei N, Mori N, Iwayama Y, Takao H, Yoshikawa T, Riley B, Makoff A, Sham P, Chen R, Collier D.
  • Journal Title: Neurosci Res 31(2) Pages: 412-415
  • NAID: 10021188681
  • Peer Reviewed
• [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism (2007)
  • Author(s): Sugihara G, Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Such S., MatsuzakiH., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatr 57(2) Pages: 194-202
  • Peer Reviewed
• [Journal Article] Decreased serum levels of PECAM-1 in subjects with high-functioning autism:a negative correlation with head circumference at birth (2007)
  • Author(s): Tsuchiya K.J., Hashimoto K., I wata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N.
  • Journal Title: Biol Psychiatry 62(9) Pages: 1056-8
  • Peer Reviewed
• [Journal Article] Disruption of Reelin signaling attenuates methamphetamine-induced hy perlocomotion (2007)
  • Author(s): Matsuzaki H., Minabe Y., NakamuraK., Suzuki K., Iwata Y., Sekine Y., Tsuchiya K.J., Sugihara G, Suda S., Takei IV., Nakahara D., Haslumoto K., NairnA.C., Mori N., Sato K.
  • Journal Title: Eur J Neurosci 25(11) Pages: 3376-84
  • Peer Reviewed
• [Journal Article] SNP analyses of growth factor genes EGF,TGFbeta-1,and HGF reve al haplotypic association of EGF with autism (2007)
  • Author(s): Toyoda T., Nakamura K., Yamada K., Thanseem I, Anitha A., Suds. S., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyaclu T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Ouchi Y., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • Journal Title: Biochenm Biophys Res Commun 360(4) Pages: 715-20
  • Peer Reviewed
• [Journal Article] Genetic analyses of the brain-derived neurotrophic factor(BDNF)gene in autism (2007)
  • Author(s): Nishimura K, Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota. T, Takei N, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Suds. S, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
  • Journal Title: Biochem Biophys Res Commun 356(1) Pages: 200-206
  • Peer Reviewed
• [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism (2007)
  • Author(s): Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suds. S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
  • Journal Title: Biol Psychiatry 62(3) Pages: 267-269
  • Peer Reviewed
• [Journal Article] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia (2007)
  • Author(s): Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, Sugihara G, Kawai M, Minabe Y, Takei N, Mori N.
  • Journal Title: Schizophr Res 89(1-3) Pages: 154-160
  • Peer Reviewed
• [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism (2007)
  • Author(s): Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
  • Journal Title: Biol Psychiatry 62(3) Pages: 267-269
  • Peer Reviewed
• [Journal Article] Poor mental hea1th associated with job dissatisfaction among school teachers in Japan (2007)
  • Author(s): Nagai M, Tsuchiya KJ, Toulopoulou T, Takei N.
  • Journal Title: J Occup Health. 49(6) Pages: 515-22
  • Peer Reviewed
• [Presentation] Genetic and expression analysis of serotonergic factors in autism. (2009)
  • Author(s): Nakamura K., Miyachi T., Ayyappan A., Tsujii M., Suda S., Thanseem I., Tsuchiya K., Matsuzaki H., Yamada K., Iwayama Y., Toyota T., Hattori E., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • Organizer: The 8th Annual International Meeting for Autism Research
  • Place of Presentation: Chicago, May
• [Presentation] Searching for causes and effects of an increase in LBW children in Japan: The Hamamatsu Birth Cohort for Mothers and Children (HBC) (2009)
  • Author(s): Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Itoh H, Kanayama N, Hirano K, Ohzeki T, Takei N.
  • Organizer: The 6th World Congress on Developmental Origins of Health and Disease
  • Place of Presentation: Santiago, Chile
• [Presentation] Unwanted pregnancy and its detrimental effect on early language development in the offspring: the HBC Study. (2009)
  • Author(s): Matsumoto K, Tsuchiya KJ, Miyachi T, Itoh H, Kanayama N, Takei N.
  • Organizer: The 6th World Congress on Developmental Origins of Health and Disease
  • Place of Presentation: Santiago, Chile
• [Presentation] Machanisms underlying methamphatamine psychoses (2009)
  • Author(s): 武井教使
  • Organizer: Collegium Internationale Neuro -Psychopharamacologicum (CINP)
  • Place of Presentation: Edinburgh, Scotland, UK.
• [Presentation] Wide-spread decreases of serum growth factors levels in male with high-functioning autism. (2008)
  • Author(s): Matsuzaki H., Iwata Y., Tsuchiya J.K., Sugihara G., Suda S., Suzuki K., Nakamura K., Tsujii M., Takei N. Hashimoto K., Mori N.
  • Organizer: The 38th annual meting of the Societry for Neuroscience
  • Place of Presentation: Washington
• [Presentation] Serotonin transporter and serotonin related gene expression in autism. (2008)
  • Author(s): Suda S., Iwata K., Anitha A., Thanseem I., Nakamura K., Matsuzaki H., Iwata Y., Yamamoto S., Suzuki K., Takei N., Koizumi K., Mori N.
  • Organizer: The 38th annual meting of the Societry for Neuroscience
  • Place of Presentation: Washington
• [Presentation] Genetic analysis of serotonergic factors in autism. (2008)
  • Author(s): Nakamura K., Matsuzaki H., Tsujii M., Ayyappan A., Yamada K., Suda S., Iwayama Y., Miyachi T., Tsuchiya K., Sugiyama T., Takei N., Yoshikawa T., Mori N.
  • Organizer: The 7th Annual International Meeting for Autism Research
  • Place of Presentation: London
• [Presentation] Voxel-based structural MRI study of patients with early-onset schizophrenia. (2008)
  • Author(s): Yoshihara Y., Sugihara G., Takei N.
  • Organizer: 1st Schizophrenia Intrernational Research Society Conference
  • Place of Presentation: Venice, Italy
• [Presentation] Decreased serum levels of MMPs in ault subjects with high-functioning autism. (2007)
  • Author(s): Suda S., Matsuzaki H., Iwata Y., Sugihara G., Tsuchiya J.K., Nakamura K., Takei N., Mori N.
  • Organizer: The 37th annual meting of the Societry for Neuroscience
  • Place of Presentation: Washington
• [Book] Recent epidemiological studies of psychiatric disorders in Japan.
  • Author(s): Kawai M., Tsuchiya K. J.., Takei N.
  • Publisher: In: Textbook in Psychiatric Epidemiology. Eds P Jones, M Tsuang. Wiley, London(In press)
• [Book] Disturbed growth in early life and later neurocognitive development related especially to psychiatric disorders.
  • Author(s): Suda S., Takei N.
  • Publisher: In: International Handbook of Behavior, Diet and Nutrition. Eds Victor R Preedy, Colin Martin and Ronald Ross Watson. Springer, London(In press)
• [Remarks]
  • URL: http://rccmd.org/modules/staff/index.php?content_id=3