Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation
| Project/Area Number |
19390306
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
KANBA Shigenobu Kyushu University, 大学院・医学研究院, 教授 (50195187)
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| Co-Investigator(Kenkyū-buntansha) |
NAKABEPPU Yusaku 九州大学, 生体防御医学研究所, 教授 (30180350)
KUROKI Toshihide 九州大学, 大学院・医学研究院, 准教授 (60215093)
KAWASAKI Hiroaki 九州大学, 大学院・医学研究院, 准教授 (50224762)
ONITSUKA Toshiaki 九州大学, 大学病院, 講師 (00398059)
MAEKAWA Toshihiko 九州大学, 大学病院, 助教 (40448436)
MOTOMURA Keisuke 九州大学, 大学病院, 助教 (60432944)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 精神薬理学 / 双極性障害 / 扁桃体 / 分界条床核 / ミクログリア / サイトカイン / 一酸化窒素 / グルタミン酸 / 聴覚ミスマッチ陰性反応 / c-Fos / アデノシン受容体 |
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| Research Abstract |
Auditory evoked potential and mismatch negativity are less impaired in bipolar disorder as compared with schizophrenia. However, impairment was not statistically significant from healthy volunteers. These markers may differential bipolar disorder from schizophrenia. In addition, polymorphism of serotonin transporter genes is associated with bipolar disorder. In animal study, when given stress ; psychological or immunological, particular circuits are stimulated including hypothalamus, frontal cortex, and limbic reward system regardless the kinds of stimuli.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia.2009
Author(s)
Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S.
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Journal Title
Journal of Immunology 183(12)
Pages: 7778-86
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[Journal Article] Genetic structure of the dopamine receptor D4 gene(DRD4)and lack of association with schizophrenia in Japanese patients2007
Author(s)
Mitsuyasu H, Kawasaki H, Ninomiya H, Kinukawa N, Yamanaka T, Tahira T, Stanton VP Jr, Springett GM, Hayashi K, Tashiro N, Kanba S.
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Journal Title
J Psychiatr Research 41
Pages: 763-775
Related Report
Peer Reviewed
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