Clinical evaluation of amyloid-PET in mild cognitive impairment patients

• Project/Area Number: 19390307
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka City University
• Principal Investigator: MIKI Takami Osaka City University, 医学研究科, 教授 (90174002)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hiroyuki 大阪市立大学, 大学院・医学研究科, 准教授 (90254391) ; WATANABE Yasuyoshi 大阪市立大学, 大学院・医学研究科, 教授 (40144399)
• Co-Investigator(Renkei-kenkyūsha): MORI Hiroshi 大阪市立大学, 大学院・医学研究科, 教授 (10159189) ; NAKANISHI Aki 大阪市立弘済院附属病院, 部長 (30453137)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: 認知症 / 老年精神医学 / アミロイド画像診断 / 臨床 / 老化 / 脳神経疾患 / 内科 / 神経科学

Research Abstract

Clinical significance of amyloid imaging (PIB-PET) was investigated by comparison with psychological tests and biomarkers of CSF. The cut-off value of mean cortical value based on cerebellar cortex was 1.3, and co-efficient of variation was 5.22%. Although the PIB-PET negative patients were not rare in spite of the clinical diagnosis as Alzheimer disease, the cortical value was significantly correlated with biomarkers of CSF and apoE4, and PIB-PET imaging was a powerful tool for evaluation of Alzheimer disease. For the detection of amyloid accumulation increase, longer observation period would be required.

Research Products

• [Journal Article] Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography. (2011)
  • Author(s): Y. Yamakawa, H. Shimada, S. Ataka, A. Tamura, H. Masaki, H. Naka, T. Tsutada, A. Nakanishi, S. Shiomi, Y. Watanabe, T. Miki
  • Journal Title: Neurol Sci. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] PiB-negative dementia-a possibility of misdiagnosis of patients with non-Alzheimer's disease (AD) type dementia as having AD. (2011)
  • Author(s): H. Shimada, S. Ataka, J. Takeuchi, H. Mori, S. Wada, Y. Watanabe, T. Miki
  • Journal Title: J Geriatric Psy Nerulogy in-press
  • Peer Reviewed
• [Journal Article] Establishment of in vivo brain imaging method in mice under conscious condition. (2011)
  • Author(s): Mizuma, H, Shukuri, M, Hayashi, T, Watanabe, Y, Onoe, H.
  • Journal Title: J.Nucl.Med. 51 Pages: 1068-1075
  • Peer Reviewed
• [Journal Article] Cortical activation during color discrimination task in macaques as revealed by positron emission tomography. (2011)
  • Author(s): Katsuyama, N, Imamura, K, Onoe, H,, Onoe, K, Tsukada, H, Watanabe, Y
  • Journal Title: Neurosci.Lett. 484 Pages: 168-173
  • Peer Reviewed
• [Journal Article] PiB-negative dementia -a possibility of misdiagnosis of patients with non-Alzheimer's disease (AD) type dementia as having AD (2011)
  • Author(s): H.Shimada, S.Ataka, J.Takeuchi, H.Mori, S.Wada, Y.Watanabe, T.Miki
  • Journal Title: J Geriatric Psy Nerulogy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography (2011)
  • Author(s): Y.Yamakawa, H.Shimada, S.Ataka, A.Tamura, H.Masaki, H.Naka, T.Tsutada, A.Nakanishi, S.Shiomi. Y.Watanabe, T.Miki
  • Journal Title: Neurol Sci.2011 Feb 5. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Neuropsychological status of elderly patients with diabetes mellitus. (2010)
  • Author(s): H. Shimada, T. Miki, A. Tamura, S. Ataka, M. Emoto, Y. Nishizawa
  • Journal Title: Diabetes Ressearch and Clinical Practice 87 Pages: 224-227
  • Peer Reviewed
• [Journal Article] Neuropsychological status of elderly patients with diabetes mellitus (2010)
  • Author(s): H. Shimada, T.Miki, A.Tamura, S.Ataka, M.Emoto, Y.Nishizawa
  • Journal Title: Diabetes Research and Clinical Practice Volume: 87 Pages: 224-227
  • Peer Reviewed
• [Journal Article] Cortical activation during color discrimination task in macaques as revealed by positron emission tomography. (2010)
  • Author(s): Katsuyama, N, Imamura, K, Onoe, H, Onoe, K, Tsukada, H, Watanabe, Y
  • Journal Title: Neurosci.Lett. Volume: 484 Pages: 168-173
  • Peer Reviewed
• [Journal Article] Establishment of in vivo brain imaging method in mice under conscions condition. (2010)
  • Author(s): Mizuma, H, Shukuri, M, Hayashi, T, Watanabe, Y, Onoe, H.
  • Journal Title: J.Nucl.Med Volume: 51 Pages: 1068-1075
  • Peer Reviewed
• [Journal Article] Dietary fat intake and risk of Parkinson's disease : A case-control study in Japan. (2010)
  • Author(s): Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M.
  • Journal Title: J Neurol Sci 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Neuropsychological status of elderly patients with diabetes mellitus (2010)
  • Author(s): H. Shimada, T. Miki, A. Tamura, S. Ataka, M. Emoto, Y. Nishizawa
  • Journal Title: Diabetes Ressearch and Clinical Practice 87 Pages: 224-227
  • Peer Reviewed
• [Journal Article] Neuropsychological status of elderly patients with diabetes mellitus (2010)
  • Author(s): H.Shimada, T.Miki, A.Tamura, S.Ataka, M.Emoto, Y.Nisizawa
  • Journal Title: Diabetes Ressearch and Clinical Practice 87 Pages: 224-227
  • Peer Reviewed
• [Journal Article] Dietary glycemic index is inversely associated with the risk of Parkinson's disease : A case-control study in Japan (2010)
  • Author(s): Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M
  • Journal Title: Nutrition 26 Pages: 515-521
  • Peer Reviewed
• [Journal Article] High Striatal Amyloid-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types. (2009)
  • Author(s): VL. Villemagne, S. Ataka, T. Mizuno, WS. Brooks, Y. Wada, M. Kondo, J. Gareth, Y. Watanabe, R. Mulligan, M. Nakagawa, T. Miki, H. Shimada, H. Mori, C.C. Rowe
  • Journal Title: Arch Neurol 66 Pages: 1537-1544
  • Peer Reviewed
• [Journal Article] High Striatal Amyloid-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types (2009)
  • Author(s): VL. Villemagne, S. Ataka, T. Mizuno, WS. Brooks, Y. Wada, M. Kondo, J. Gareth, Y. Watanabe, R. Mulligan, M. Nakagawa, T. Miki, H. Shimada, H. Mori, C. C. Rowe
  • Journal Title: Arch Neurol 66 Pages: 1537-1544
  • Peer Reviewed
• [Journal Article] High Striatal Amyloid- Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types. (2009)
  • Author(s): Villemagne, VL., Ataka, S., Mizuno, T., Brooks, WS., Wada, Y., Kondo, M., Jones, G., Watanabe, Y., Mulligan, R., Nakagawa, M., Miki, T., Shimada, H., O' Keefe, GJ., Masters, CL., Mori, H., Rowe, CC
  • Journal Title: Arch Neurol 66 Pages: 1537-1544
  • Peer Reviewed
• [Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia. (2008)
  • Author(s): Tomiyama, T. Nagata, T. shimada, H. Teraoka, R. Fukushima, A. Kanemitu, H. Takuma, H Kuwano, R. Imagawa、M. Ataka, S. Wada, Y. Yoshika, E. Nishizaki, T. Watanabe, Y. Mori, H.
  • Journal Title: Ann of Neurology 63 Pages: 377-387
  • Peer Reviewed
• [Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia. . Ann of Neurology, 63 : 377-387, 2008 (2008)
  • Author(s): Tomiyama, T. Nagata, T. shimada, H. teraoka, R. Fukushima, A. Kanemitu, H. Takuma, H Kuwano, R. Imagawa, M. Ataka, S. Wada, Y. Yoshika, E. Nishizaki, T. Watanabe, Y. Mori, H.
  • Journal Title: Ann of Neurology 63 Pages: 377-387
  • Peer Reviewed
• [Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia (2008)
  • Author(s): T.Tomiyama, T.Nagata, H.Shimada, et. al.
  • Journal Title: Ann of Neurology 63 Pages: 377-387
  • Peer Reviewed
• [Presentation] 臨床症状、髄液所見ではアルツハイマー病でPiB PETが陰性であった症例の検討 (2010)
  • Author(s): 竹内潤, 安宅鈴香, 嶋田裕之, 金本元勝, 武田景敏, 伊藤和博, 中弘志, 中西亜紀, 三木隆己, 渡辺恭良
  • Organizer: 第21回 日本老年医学会近畿地方会
  • Place of Presentation: 大阪(大阪市立大学)
  • Year and Date: 2010-11-20
• [Presentation] 撮影条件の異なる[11C]PiB-PET画像、J‐ADNIと大阪市大プロトコールの比較 (2010)
  • Author(s): 安宅鈴香、嶋田裕之、竹内潤, 三木隆己、和田康弘、渡辺恭良, 河邊譲治、下西祥裕、塩見進
  • Organizer: 第50回日本核医学会学術集会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-12
• [Presentation] 撮影条件の異なる[11C]PiB-PET画像、J-ADNIと大阪市大プロトコールの比較 (2010)
  • Author(s): 安宅鈴香、嶋田裕之、竹内潤, 三木隆己、和田康弘、渡辺恭良, 河邊譲治、下西祥裕、塩見進
  • Organizer: 第50回日本核医学会学術集会総会
  • Place of Presentation: 埼玉(大宮ソニックシティ)
  • Year and Date: 2010-11-12
• [Presentation] 1231-MIBG心筋シンチグラフィーによるPiB陰性認知症の鑑別診断の検討 (2010)
  • Author(s): 竹内潤, 安宅鈴香, 嶋田裕之, 河連譲治勢, 和国康弘, 蔦田強司, 塩見進, 中西亜紀, 三木隆己, 森啓, 渡邊恭良
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-06
• [Presentation] 1231-MIBG心筋シンチグラフィーによるPiB陰性認知症の鑑別診断の検討 (2010)
  • Author(s): 竹内潤, 安宅鈴香, 嶋田裕之, 河連譲治勢, 和国康弘, 蔦田強司, 塩見進, 中西亜紀, 三木隆己, 森啓, 渡遵恭良
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋(ウィンク愛知)
  • Year and Date: 2010-11-06
• [Presentation] Characteristics of Neuropsychological Findings of Clinically Diagnosed Alzheimer's Disease and Mild Cognitive Impairment Patients Who Show Negative Results in Amyloid Imaging. (2010)
  • Author(s): H.Takechi, S.Ataka, M.Nishida,, T.Miki, H.Shimada
  • Organizer: ICAD 2010 (ICAD)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] PiB-PET Images, Compared With MRI, FDG-PET, and IMP-SPECT imagesof a Patient With Alzheimer's Disease With Presenilin-1 Mutation (Met233Leu) Showing a New Phenotype (2010)
  • Author(s): M. Takaya, T. Tanaka, S. Ataka, H. Shimada, T. Morihara, T. Miki, H. Kazui, M. Takeda
  • Organizer: ICAD 2010 (ICAD)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] Both PiB positive and negative MCIs have similar risk of conversion to dementia. (2010)
  • Author(s): S.Ataka, H.Shimada, J.Takeuchil, J.Kawabe, K.Takahashi, Y.Wada, A.Nakanish, T.Tsutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
  • Organizer: ICAD 2010 (ICAD)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] Both PiB positive and negative MCIs have similar risk of conversion to dementia. (2010)
  • Author(s): S.Ataka, H.Shimada, J.Takeuchil, J.Kawabe, K.Takahashi, Y.Wada, A.Nakanish, T.Tsutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
  • Organizer: ICAD 2010(International Conference of Arzheimer's disease)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] PiB-PET Images, Compared With MR, FDG-PET, and IMP-SPELT images of a Patient With Alzheimer's Disease With Presenilin-1 Mutation (Met233Leu) Showing a New Phenotype (2010)
  • Author(s): M.Takaya, T.Tanaka, S.Ataka, H.Shimada, T.Morihara, T.Miki, H.Kazui, M.Takeda
  • Organizer: ICAD 2010(International Conference of Alzheimer'sdisease)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] Characteristics of Neuropsychological Findings of Clinically Diagnosed Alzheimer's Disease and Mild Cognitive Impairment Patients Who Show Negative Results in Amyloid Imaging (2010)
  • Author(s): H.Takechi, S.Ataka, M.Nishida, T.Miki, H.Shimada
  • Organizer: ICAD 2010(International Conference of ALzheimer's disease)
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2010-07-12
• [Presentation] 認知症診療における最近の検査 (2010)
  • Author(s): 三木隆己
  • Organizer: 第18回近畿老年期認知症研究会
  • Place of Presentation: 大阪(リーガロイヤルNCB)(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] 軽度認知障害(MCl)においてPIB-PETは認知症へ移行するリスクをどの程度予測できるか (2010)
  • Author(s): 安宅鈴香、嶋田裕之、竹内潤, 河邊譲治、金本元勝、伊藤和博、山川義宏, 蔦田強司、下西祥裕、渡辺恭良、三木隆己
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-21
• [Presentation] 軽度認知障害(MC1)においてPiB-PETは認知症へ移行するリスクをどの程度予測できるか (2010)
  • Author(s): 安宅鈴香、嶋田裕之、竹内潤, 河邊譲治、金本元勝、伊藤和博、山川義宏, 蔦田強司、下西祥裕、渡辺恭良、三木隆己
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2010-06-21
• [Presentation] 臨床的にはアルツハイマー型認知症の診断であったが (2009)
  • Author(s): 竹内潤, 安宅鈴香, 嶋田裕之, 中弘志, 中西亜紀, 三木隆己, 渡邊恭良
  • Organizer: PIB-PET 陰性で嗜銀顆粒性認知症が疑われた1例 : 第20回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-05
• [Presentation] 臨床的にはアルツハイマー型認知症の診断であったが、PIB-PET陰性で嗜銀顆粒性認知症が疑われた一例 (2009)
  • Author(s): 竹内潤, 安宅鈴香, 嶋田裕之, 中弘志, 中西亜紀, 三木隆己, 渡邊恭良
  • Organizer: 第20回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-05
• [Presentation] Aβ deposition in Familial Alzheimer's disease in independent of mutation type or cognitive status (2009)
  • Author(s): 安宅鈴香, VictorL Villemagne, 水野敏樹, 嶋田裕之, 和田康弘, 重松誠, 三木隆己, 渡邊恭良, Christopher C Rowe, 森啓
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-21
• [Presentation] 11C-PiB-PET Imaging and Cognitive Statement in Alzheimer's Disease, Mind Cognitive Impairment and Healthy Aging : 1 to 1.5-Year Follow-Up Study (2009)
  • Author(s): S.Ataka H.Shimada, J.Tkeuchi, J.Kawabe, M.Shigematu, Y.Wada, A.Nakanishi, T.Tutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
  • Organizer: International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: オーストリア、ウイーン
  • Year and Date: 2009-11-13
• [Presentation] 11C-PIB-PET image and cognitive statement in Alzheimer's disease, mild cognitive impairment and healty aging : 1-1.5 year follow-up study. (2009)
  • Author(s): S.Ataka H.Shimada, J.Tkeuchi, J.Kawabe, M.Shigematu, Y.Wada, A.Nakanishi, T.Tutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
  • Organizer: Neuroscience
  • Place of Presentation: シカゴ
  • Year and Date: 2009-10-20
• [Presentation] 11C-PIB-PET image and cognitive statement in Alzheimer's disease, mild cognitive impairment and healty aging: 1-1.5 year follow-up study. (2009)
  • Author(s): S. Ataka H. Shimada, J. Tkeuchi, J. Kawabe, M. Shigematu, Y. Wada, A. Nakanishi, T. Tutada, S. Shiomi, H. Mori, Y. Watanabe, T. Miki
  • Organizer: Neuroscience
  • Place of Presentation: シカゴ
  • Year and Date: 2009-10-20
• [Presentation] Biochemical analysis of intracellular oligomer (2009)
  • Author(s): YAMAMOTO, H.SHIMADA, H.MORI
  • Organizer: NEUROSCOENCE
  • Place of Presentation: シカゴ アメリカ
  • Year and Date: 2009-10-20
• [Presentation] PIB-PETの再現性評価と脳内アミロイド集積の追跡調査 (2009)
  • Author(s): 竹内潤、安宅鈴香、嶋田裕之、中弘志、正木秀樹、中西亜紀、三木隆己、渡辺恭良
  • Organizer: 第26回日本老年学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-20
• [Presentation] PIB-PETの再現性の評価と脳内アミロイド集積の追跡検査 (2009)
  • Author(s): 竹内潤 安宅鈴香 嶋田裕之 中弘志 正木秀樹 中西亜紀 三木隆己 渡邊恭良
  • Organizer: 第51回日本老年医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-08
• [Presentation] PIB-PET陰性ADとPIB-PET陽性ADの比較 (2009)
  • Author(s): 安宅鈴香, 嶋田裕之, 竹内潤, 河邊譲治, 重松誠, 和田康弘, 山川義宏, 蔦田強司, 下西祥裕, 塩見進, 森啓, 渡邊恭良, 三木隆己
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-21
• [Presentation] Characteristics of the PIB negative patients who were clinically diagnosed as AD. (2008)
  • Author(s): Shimada H., Ataka S., Kawabe J., Wada Y., Shiomi S., Mori H., Miki T., Watanabe.Y.
  • Organizer: Neuroscience
  • Place of Presentation: Washington
  • Year and Date: 2008-11-15
• [Presentation] 運動ニューロン病に認知症を合併した2症例のPIB-PET画像の検討 : (2008)
  • Author(s): 山川義宏, 安宅鈴香, 嶋田裕之, 山川義宏, 蔦田強司, 三木隆己
  • Organizer: 第19回日本老年医学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-15
• [Presentation] Characteristics of the PIB negative patients who were clinica 11y diagnosed as AD. (2008)
  • Author(s): Shimada H. Ataka S., Kawabe, J., Wada, Y., Shiomi, S., Mori, H., Miki, T., Watanabe. Y
  • Organizer: Neuroscience
  • Place of Presentation: ワシントン(アメリカ合衆国)
  • Year and Date: 2008-11-13
• [Presentation] AD、MCI、健常高齢者でのPIB-PETによるアミロイド集積と認知機能の経時的変化 (2008)
  • Author(s): 安宅鈴香、嶋田裕之、山川義宏、蔦田強司、三木隆己、塩見進、森啓、渡辺恭良
  • Organizer: 日本認知症学会
  • Place of Presentation: 群馬
  • Year and Date: 2008-10-11
• [Presentation] AD、MCI、健常高齢者でのPIB-PETによるアミロイド集積と認知機能の経時的変化 (2008)
  • Author(s): 安宅鈴香, 嶋田裕之, 山川義宏, 蔦田強司, 三木隆己, 塩見進, 森啓, 渡辺恭良
  • Organizer: 日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-10
• [Presentation] COMPARISON OF AMYLOID DEPOSITION AND BIOCHEMICAL MARKERS IN ALZHEIMER'S DISEASE,NON AD TYPE DEMENTIA AIND MILD COGNITIVE IMPAIRMENT (2007)
  • Author(s): Hiroyuki Shimada, Suzuka Ataka, Jyoji Kawabe, Hideto Yoshioka, Yasuhiro Wada, Akiko Tamura, Akitoshi Takeda, Aki Nakanishi, Tsuyoshi Tsutada. Hiroshi Mori. Yasuyoshi Watanabe, Takami Miki
  • Organizer: International Conference on Prevention of Dementia
  • Place of Presentation: ワシントン
  • Year and Date: 2007-06-11
• [Book] 歩行障害ハンドブック (2008)
  • Author(s): 編集 : 三木隆己, 嶋田裕之
  • Publisher: 新興貿易(株)医書出版部、編集 :