Development of a microreactor for radiosynthesis of ^<18>F-probes

• Project/Area Number: 19390311
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: IWATA Ren Tohoku University, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
• Co-Investigator(Kenkyū-buntansha): YANAI Kazuhiko 東北大学, 大学院・医学系研究科, 教授 (50192787) ; 中西 博昭 島津製作所, 基盤技術研究所, 部長 (90379595)
• Co-Investigator(Renkei-kenkyūsha): NAKANISHI Hiroaki 島津製作所, 基盤技術研究所, 部長 (90379595)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: マイクロリアクター / 標識合成 / フッ素-18 / 電気化学的濃縮 / PET / 分子イメージング / 放射性薬剤 / 電気化学 / F-18 / フッ素イオン

Research Abstract

An automated system was developed for concentration of aqueous ^<18>F-fluoride produced in ^<18>O-water with a cyclotron. It was electrochemically trapped in a disposable microflow cell chip and then released as a complex with K+-K.222 in a small portion of an aprotic solvent (<60μL) such as acetonitrile and DMSO. Thus, the concentrated solution was mixed with a precursor solution followed by passing through a heated microchannel to synthesize ^<18>F-FDG, FLT and FMISO. Reaction time, temperature and solvent were examined for optimizing ^<18>F-substitution reactions. It was observed that microreactor radiosynthesis was very rapid and efficient as reported.

Research Products

• [Journal Article] Electrochemical concentration of no-carrier-added [^<18>F]fluoride from [^<18>O]water in a disposable microfluidic cell for radiosynthesis of ^<18>F-labeled radiopharmaceuticals (2010)
  • Author(s): H. Saiki, R. Iwata, H. Nakanishi, R. Wong, Y. Ishikawa, S. Furumoto, R. Yamahara, K. Sakamoto, E. Ozeki
  • Journal Title: Appl.Radiat.Isot. (印刷中)
  • Peer Reviewed
• [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET (2010)
  • Author(s): N. Okamura, Y. Shiga, S. Furumoto, M. Tashiro, Y. Tsuboi, K. Furukawa, K. Yanai, R. Iwata, H. Arai, Y. Kudo, Y. Itoyama, K. Doh-Ura
  • Journal Title: Eur.J.Nucl.Med.Mol.Imag. (印刷中)
  • Peer Reviewed
• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : Comparison to FDG-PET (2010)
  • Author(s): K. Furukawa, N. Okamura, M. Tashiro, M. Waragai, S. Furumoto, R. Iwata, K. Yanai; Y. Kudo, H. Arai
  • Journal Title: J.Neurosurgery (印刷中)
  • Peer Reviewed
• [Journal Article] Imaging of hypoxic lesion in glioma patients by PET with [^<18>F]FRP-170, a new ^<18>F-labeled 2-nitroimidazole analog (2010)
  • Author(s): I. Shibahara, T. Kumabe, M. Kanamori, R. Saito, Y. Sonoda, M. Watanabe, R. Iwata, S. Higano, K. Takanami, Y. Takai, T. Tominaga
  • Journal Title: J.Neurosurgery (印刷中)
  • Peer Reviewed
• [Journal Article] Imaging of hypoxic lesion in glioma patients by PET with [^<18>F] FRP-170, a new ^<18>F-labeled 2-nitroimidazole analog (2010)
  • Author(s): I.Shibahara, T.Kumabe, M.Kanamori, R.Saito, Y.Sonoda, M.Watanabe, R.Iwata, S.Higano, K.Takanami, Y.Takai, T.Tominaga
  • Journal Title: J.Neurosurgery (In press)
  • Peer Reviewed
• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : Comparison to FDG-PET (2010)
  • Author(s): K.i Furukawa, N.Okamura, M.Tashiro, M.Waragai, S.Furumoto, R.Iwata, K.Yanai, Y.Kudo, H.Arai
  • Journal Title: J.Neurosurgery (In press)
  • Peer Reviewed
• [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET (2010)
  • Author(s): N.Okamura, Y.Shiga, S.Furumoto, M.Tashiro, Y.Tsuboi, K.Furukawa, K.Yanai, R.Iwata, H.Arai, Y.Kudo, Y.Itoyama, K.Doh-Ura
  • Journal Title: Eur.J.Nucl.Med.Mol.Imag (In press)
  • Peer Reviewed
• [Journal Article] Electrochemical Concentration of No-carrier-added [^<18>F]Fluoride from [^<18>O]Water in a Disposable Microfluidic Cell for Radiosynthesis of ^<18>F-labeled Radiopharmaceuticals (2010)
  • Author(s): H.Saiki, R.Iwata, H.Nakanishi, R.Wong, Y.Ishikawa, S.Furumoto, R.Yamahara, K.Sakamoto, E.Ozeki
  • Journal Title: Appl.Radiat.Isot. (In press)
  • Peer Reviewed
• [Journal Article] PET診断に用いる^<18>F-イオン捕捉・回収セルへのパイロポリマー電極の応用に関する研究 (2009)
  • Author(s): 岡本貫志, 守法篤, 岩田錬, 斎木秀和, 中西博昭, 小西聡
  • Journal Title: 電気学会論文誌 (センサ・マイクロマシン部門誌) 129巻 Pages: 393-398
  • NAID: 10025533545
  • Peer Reviewed
• [Journal Article] ^<18>F-イオン濃縮を目的としたPETプローブ合成装置用電気化学的マイクロフローセルの開発 (2009)
  • Author(s): 小関英一, 斎木秀和, 山原亮, 石川洋一, 中西博昭, 岩田錬
  • Journal Title: 島津評論 66巻 Pages: 13-19
• [Journal Article] Dose dependency of brain histamine H_1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [^<11>C]doxepin (2009)
  • Author(s): M. Tashiro, M. Kato, M. Miyake, S. Watanuki, Y. Funaki, Y. Ishikawa, R. Iwata, K. Yanai
  • Journal Title: Human Psychopharmacol 24巻 Pages: 540-548
  • Peer Reviewed
• [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease (2009)
  • Author(s): M. Waragai, N. Okamura, K. Furukawa, M. Tashiro, S. Furumoto, Y. Funaki, M. Kato, R. Iwata, K. Yanai, Y. Kudo, H. Arai
  • Journal Title: J.Nuerol.Sci. 285巻 Pages: 100-108
  • Peer Reviewed
• [Journal Article] ^<11>C-Methionine PET imaging of acute myocardial infarction (2009)
  • Author(s): M. Murooka, K. Kubota, H. Kadowaki, K. Ito, O. Okazaki, M. Kashida, T. Mitsumoto, R. Iwata, K. Ohtomo, M. Hiroe
  • Journal Title: J.Nucl.Med. 50巻 Pages: 1283-1287
  • Peer Reviewed
• [Journal Article] ^<11>C-Methionine PET imaging of acute myocardial infarction (2009)
  • Author(s): M.Murooka, K.Kubota, H.Kadowaki, K.Ito, O.Okazaki, M.Kashida, T.Mitsumoto, R.Iwata, K.Ohtomo, M.Hiroe
  • Journal Title: J.Nucl.Med. 50 Pages: 1283-1287
  • Peer Reviewed
• [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease (2009)
  • Author(s): M.Waragai, N.Okamura, K.Furukawa, M.Tashiro, S.Furumoto, Y.Funaki, M.Kato, R.Iwata, K.Yanai, Y.Kudo, H.Arai
  • Journal Title: J.Nuerol.Sci. 285 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Dose dependency of brain histamine H_1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [^<11>C] doxepin (2009)
  • Author(s): M.Tashiro, M.Kato, M.Miyake, S.Watanuki, Y.Funaki, Y.Ishikawa, R.Iwata, K.Yanai
  • Journal Title: Human Psychopharmacol. 24 Pages: 540-548
  • Peer Reviewed
• [Journal Article] PET診断に用いる^<18>F-イオン捕捉・回収セルへのパイロポリマー電極の応用に関する研究 (2009)
  • Author(s): 岡本貫志、守法篤、岩田錬、斎木秀和、中西博昭、小西聡
  • Journal Title: 電気学会論文誌(センサ・マイクロマシン部門誌) 129 Pages: 393-398
  • NAID: 10025533545
  • Peer Reviewed
• [Journal Article] ^<18>F-イオン濃縮を目的としたPETプローブ合成装置用電気化学的マイクロフローセルの開発 (2009)
  • Author(s): 小関英一、斎木秀和、山原亮、石川洋一、中西博昭、岩田錬
  • Journal Title: 島津評論 66 Pages: 13-19
• [Journal Article] Whole-body tumor imaging : O-[^<11>C]methyl-L-tyrosine/positron emission tomography (2008)
  • Author(s): K. Ishiwata, K. Kubota, T. Nariai, R. Iwata
  • Journal Title: Cancer Imaging 2巻 Pages: 175-179
• [Journal Article] Brain histamine H_1 receptor occupancy of orally administrated antihistamines, bepotastine and diphendydramine, measured by PET with ^<11>C-doxepin (2008)
  • Author(s): M. Tashiro, X. Duan, M. Kato, M. Miyake, S. Watanuki, Y. Ishikawa, Y. Funaki, R. Iwata, M. Itoh, K. Yanai
  • Journal Title: Brit.J.Clin.Pharmacol. 65巻 Pages: 811-821
  • Peer Reviewed
• [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease (2008)
  • Author(s): N. Okamura, Y. Funaki, M. Tashiro, M. Kato, Y. Ishikawa, M. Maruyama, H. Ishikawa, K. Meguro, R. Iwata, K. Yanai
  • Journal Title: Brit.J.Clin.Pharmacol. 65巻 Pages: 472-479
  • Peer Reviewed
• [Journal Article] がん分子イメージングの新展開 : 腫瘍分子イメージングプローブの開発 (2008)
  • Author(s): 岩田錬
  • Journal Title: 癌と化学療法 35巻 Pages: 1286-1290
• [Journal Article] ますます広がる分子イメージング技術-第1章 技術編1. PET・SPECTによる分子イメージング 2) PET用分子プローブの自動合成 (2008)
  • Author(s): 岩田錬
  • Journal Title: 遺伝子医学MOOK(佐治英郎, 田端泰彦・編) 9巻 Pages: 59-66
  • Peer Reviewed
• [Journal Article] Brain histamine H_1 receptor occupancy of orally administrated antihistamines, bepotastine and diphendydramine, measured by PET with ^<11>C-doxepin (2008)
  • Author(s): M. Tashiro, X. Duan, M. Kato, M. Miyake, S. Watanuki, Y. Ishikawa, Y. Funaki, R. Iwata, M. Itoh, K. Yanai
  • Journal Title: Brit. J. Clin. Pharmacol. 65 Pages: 811-821
  • Peer Reviewed
• [Journal Article] 非侵襲的・可視化技術ハンドブック-第5章PETによる生体機能の画像化と疾患診断第2節放射性薬剤合成1.PET核種の製造と標識診断プローブの合成・品質管理 (2008)
  • Author(s): 岩田錬
  • Journal Title: 遺伝子医学MOOK 9 Pages: 59-66
• [Journal Article] がん分子イメージングの新展開 : 腫瘍分子イメージングプローブの開発 (2008)
  • Author(s): 岩田錬
  • Journal Title: Jpn. J. Cancer Chemother. 35 Pages: 1286-1290
• [Journal Article] Evaluation of the binding characteristics of [^<18>F]fluoro-proxyfan in the rat brain for in vivo visualization of histamine H_3 receptor (2007)
  • Author(s): Y. Funaki, K. Sato, M. Kato, Y. Ishikawa, R. Iwata, K. Yanai
  • Journal Title: Nucl.Med.Biol. 34巻 Pages: 981-987
  • Peer Reviewed
• [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner (2007)
  • Author(s): K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi
  • Journal Title: Nucl.Instr.Meth.Phys.Res. A576巻 Pages: 435-440
  • Peer Reviewed
• [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]-ethyl)-6-(2-[fluoro]ethoxy]benzoxazole : a novel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients (2007)
  • Author(s): Y. Kudo, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, M. Maruyama, M. Itoh, R. Iwata, K. Yanai, H. Arai
  • Journal Title: J.Nucl.Med. 48巻 Pages: 553-561
  • Peer Reviewed
• [Journal Article] Initial evaluation of dynamic human imaging using ^<18>F-FRP170 as a new PET tracer for imaging hypoxia (2007)
  • Author(s): K. Kaneta, Y. Takai, R. Iwata, T. Hakamatsuka, H. Yasuda, K. Nakayama, Y. Ishikawa, S. Watanuki, S. Furumoto, Y. Funaki, E. Nakata, K. Jingu, M. Tsujitani, M. Itoh, H. Fukuda, S. Takahashi, S. Yamada
  • Journal Title: Ann.Nucl.Med. 21巻 Pages: 101-107
  • NAID: 10018874948
  • Peer Reviewed
• [Journal Article] Recent advances in the development of amyloid imaging agents (2007)
  • Author(s): S. Furumoto, N. Okamura, R. Iwata, K. Yanai, Hi. Arai, Y. Kudo
  • Journal Title: Current Topics in Medicinal Chemistry 7巻 Pages: 1773-1789
  • Peer Reviewed
• [Journal Article] Initial evaluation of dynamic human imaging using 18F-FRP 170 as a new PET tracer for imaging hypoxia (2007)
  • Author(s): K. Kaneta, Y. Takai, R. Iwata, et. al.(14人)
  • Journal Title: Ann. Nucl. Med. 21 Pages: 101-107
  • NAID: 10018874948
  • Peer Reviewed
• [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethyl)-6-(2-[fluoro]ethoxy]benzoxazole: anovel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients (2007)
  • Author(s): Y. Kudo, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, M. Maruyama, M. Itoh, R. Iwata, K. Yanai and H. Arai.
  • Journal Title: J. Nucl. Med. 48 Pages: 553-561
  • Peer Reviewed
• [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner (2007)
  • Author(s): K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi.
  • Journal Title: Nucl. Instr. Meth. Phys. Res. A576 Pages: 435-440
  • Peer Reviewed
• [Journal Article] Evaluation of the binding characteristics of[18F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H_3 receptor (2007)
  • Author(s): Y. Funaki, K. Sato, M. Kato, Y. Ishikawa, R. Iwata, and K. Yanai.
  • Journal Title: Nucl. Med. Biol. 34 Pages: 981-987
  • Peer Reviewed
• [Presentation] 求核置換反応を利用したフルオロデオキシマンノース合成法の確立と腫瘍集積性の評価 (2010)
  • Author(s): 新保亮, 古本祥三, 吉岡孝志, 仲田栄子, 青野嘉隆, 石川洋一, 岩田錬, 福田寛
  • Organizer: 日本薬学会第130回年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] シンポジウム「がんの分子イメージング」PET診断用腫瘍イメージングプローブの開発 (2009)
  • Author(s): 岩田錬
  • Organizer: 第61回日本気管食道科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] I-125標識ヒト化二重特異性低分子抗体Ex3の動態評価 (2009)
  • Author(s): 古本祥三, 浅野竜太郎, 窪田和雄, 谷内一彦, 岩田錬, 熊谷泉
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-02
• [Presentation] アルツハイマー病診断における[^<18>F]FACT-PETの有用性の検討 (2009)
  • Author(s): 岡村信行, 古本祥三, 田代学, 古川勝敏, 杉健太郎, 船木善仁, 岩田錬, 荒井啓行, 工藤幸司, 谷内一彦
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-02
• [Presentation] マイクロリアクターに適した^<18>F濃縮システムの開発 (2009)
  • Author(s): 斎木秀和, 小関英一, 中西博昭, 岩田錬, 石川洋一
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] Microfluidic radiosynthesis of several routine ^<18>F-PET compounds using electrochemically concentrated [^<18>F]fluoride (2009)
  • Author(s): R. Wong, H. Saiki, R. Iwata, S. Furumoto, Y. Ishikawa
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] マイクロリアクターを用いた[^<18>F]SFBのOne-flow合成法の開発 (2009)
  • Author(s): 木村寛之, 戸松賢治, 河嶋秀和, 中西博昭, 小関英一, 斎木秀和, 藤山陽一, 岩田錬, 久下祐司, 小野正博, 佐治英郎
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] 臨床応用を目指した^<11>C-ガランタミンの実用的標識合成法 (2009)
  • Author(s): 佐藤眞梨, 古本祥三, 石川洋一, 森雅憲, 青野嘉隆, 谷内一彦, 岩田錬
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] ループ法を用いた[^<11>C]PK11195の迅速・効率的な合成法の検討 (2009)
  • Author(s): 寺崎一典, 石川洋一, 小豆島正典, 世良耕一郎, 岩田錬
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] 2-フロロピリジン誘導体化による代謝安定性の向上を目指した^<18>F標識MMP-2画像化プローブの開発 (2009)
  • Author(s): 古本祥三, 酒井英太, 石川洋一, 谷内一彦, 福田寛, 岩田錬
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] 新規前駆体による[^<18>F]FDM合成とその生物学的評価 (2009)
  • Author(s): 新保亮, 古本祥三, 吉岡孝志, 仲田栄子, 青野嘉隆, 石川洋一, 岩田錬, 福田寛
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] Development of one-flow synthesis method for N-succinimidyl 4-[^<18>F]fluorobenzoate ([F-18]SFB) using microreactor for 3-step-reaction (2009)
  • Author(s): H.Kimura, K.Tomatsu, H.Kawashima, H.Nakanishi, E.Ozeki, H.Saiki, R.Iwata, Y.kuge, M.Ono, H.Saji
  • Organizer: 18^<th> Int.Symp.Radiopharm.Sci.
  • Place of Presentation: Edmonton, Canada
  • Year and Date: 2009-07-12
• [Presentation] [^<18>F]FACT PET is Useful for Noninvasive Detection of Amyloid Plaques in Alzheimer's Disease (2009)
  • Author(s): K. Sugi, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, Y. Funaki, H. Arai, Y. Kudo, R. Iwata, K. Yanai
  • Organizer: 欧州核医学会
  • Place of Presentation: バルセロナ
• [Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases (2009)
  • Author(s): N. Okamura, S. Furumoto, M. Tashiro, Y. Funaki, A. Kikuchi, Y Shiga, K. Furukawa, H. Arai, K. Doh-Ura, R. Iwata, K. Yanai, Y. Kudo
  • Organizer: 欧州核医学会
  • Place of Presentation: バルセロナ
• [Presentation] Measurement of brain histamine H_1 receptor occupancy following treatment with various antihistamines using PET with ^<11>C-doxepin : dose dependency of cetirizine hydrochloride (2009)
  • Author(s): M. Tashiro, M. Miyake, S. Watanuki, Y. Funaki, Y. Ishikawa, R. Iwata, K. Yanai
  • Organizer: 2009年世界分子イメージング学会
  • Place of Presentation: モントリオール
• [Presentation] Electrochemical concentrateion of aqueous [^<18>F]fluoride into an aprotic solvent in a disposable microfluidic cell (2009)
  • Author(s): H. Saiki, R. Iwata, R. Wong, S. Furumoto, Y. Ishikawa, H. Nakanishi, E. Ozeki
  • Organizer: 第18回国際放射性医薬品科学シンポジウム
  • Place of Presentation: エドモントン
• [Presentation] Development of one-flow synthesis method for N-succinimidyl 4-[^<18>F]fluorobenzoate ([F-18]SFB) using microreactor for 3-step-reaction (2009)
  • Author(s): H. Kimura, K. Tomatsu, H. Kawashima, H. Nakanishi, E. Ozeki, H. Saiki, R. Iwata, Y. kuge, M. Ono, H. Saji
  • Organizer: 第18回国際放射性医薬品科学シンポジウム
  • Place of Presentation: エドモントン
• [Presentation] Synthesis and preliminary evaluation of [^<18>F]FDM for tumor imaging (2009)
  • Author(s): S. Furumoto, R. Shinbo, T. Yoshioka, Y. Ishikawa, R. Iwata, H. Fukuda
  • Organizer: 第18回国際放射性医薬品科学シンポジウム
  • Place of Presentation: エドモントン
• [Presentation] Electrochemical concentration of aqueous [^<18>F]fluoride into an aprotic solvent in a disposable microfluidic cell (2009)
  • Author(s): H.Saiki, R.Iwata, R.Wong, S.Furumoto, Y.Ishikawa, H.Nakanishi, E.Ozeki
  • Organizer: 18^<th> Int.Symp.Radiopharm.Sci.
  • Place of Presentation: Edmonton, Canada
• [Presentation] Synthesis and preliminary evaluation of [^<18>F]FDM for tumor imaging (2009)
  • Author(s): S.Furumoto, R.Shinbo, T.Yoshioka, Y.Ishikawa, R.Iwata, H.Fukuda
  • Organizer: 18^<th> Int.Symp.Radiopharm.Sci.
  • Place of Presentation: Edmonton, Canada
• [Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases (2009)
  • Author(s): N.Okamura, S.Furumoto, M.Tashiro, Y.Funaki, A.Kikuchi, Y Shiga, K.Furukawa, H.Arai, K.Doh-Ura, R.Iwata, K.Yanai, Y.Kudo
  • Organizer: Ann.Congress Eur.Assoc.Nucl.Med.
  • Place of Presentation: Barcelona, Spain
• [Presentation] [^<18>F]FACT PET is Useful for Noninvasive Detection of Amyloid Plaques in Alzheimer's Disease (2009)
  • Author(s): K.Sugi, N.Okamura, S.Furumoto, M.Tashiro, K.Furukawa, Y.Funaki, H.Arai, Y.Kudo, R.Iwata, K.Yanai
  • Organizer: Ann.Congress Eur.Assoc.Nucl.Med.
  • Place of Presentation: Barcelona (Spain)
• [Presentation] シンポジウム「優れたPET薬剤を創出するために」PET自動合成システム (2008)
  • Author(s): 岩田錬
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 幕張
  • Year and Date: 2008-10-26
• [Presentation] 高速な18Fイオン濃縮を目的とした電気化学的マイクロフローセルの開発 (2008)
  • Author(s): 斎木秀和, 石川洋一, 中西博昭, 岩田錬
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2008-10-25
• [Presentation] 新規アミロイドイメージング剤, [^<18>F]FACT小型自動合成装置の開発 (2008)
  • Author(s): 石川洋一, 渡辺利光, 岩田錬, 古本祥三
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2008-10-25
• [Presentation] フッ素18標識アミロイドイメージング剤の開発 (2008)
  • Author(s): 古本祥三, 岡村信行, 加藤元久, 石川洋一, 丸山将浩, 岩田錬, 谷内一彦, 樋口真人, 須原哲也, 工藤幸司
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2008-10-25
• [Presentation] 臨床利用のための[^<18>F]フッ化ナトリウムの製剤化と品質 (2008)
  • Author(s): 寺崎一典, 世良耕一郎, 小豆島正典, 岩田錬
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張
  • Year and Date: 2008-10-25
• [Presentation] 新規アミロイドイメージング剤、[^<18>F]FACT小型自動合成装置の開発 (2008)
  • Author(s): 石川洋一、渡辺利光、岩田錬、古本祥三
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 千葉市幕張
  • Year and Date: 2008-10-25
• [Presentation] フッ素18標識アミロイドイメージング剤の開発 (2008)
  • Author(s): 古本祥三、岡村信行、加藤元久、石川洋一、丸山将浩、岩田錬、谷内一彦、樋口真人、須原哲也、工藤幸司
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 千葉市幕張
  • Year and Date: 2008-10-25
• [Presentation] A Fluorine-18 Labeled 2-(2-(Thiazol-5-y1)viny1)-benzoxazole Derivative for In Vivo Imaging of Amyloid Deposits (2008)
  • Author(s): S. Furumoto, N. Okamura, M. Kato, Y. Ishikawa, M. Maruyama, R. Iwata, K. Yanai, M. Higuchi, T. Suhara, Y. Kudo
  • Organizer: World Molecular Imaging Congress 2008
  • Place of Presentation: ニース(フランス)
  • Year and Date: 2008-09-12
• [Presentation] 新しいトレーサーと保険適応拡大-基調講演 (2008)
  • Author(s): 岩田錬
  • Organizer: PETサマーセミナー
  • Place of Presentation: 裏磐梯
  • Year and Date: 2008-08-23
• [Presentation] 半導体検出器を用いた新規動物用PET装置の性能評価 (2008)
  • Author(s): 船木善仁, 山崎浩道, 金井泰和, 菊池洋平, 酒巻学, 岩田錬, 石井慶造
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] マトリックスメタロプロテアーゼ-2のイメージングを目的としたPET用標識薬剤の開発 (2007)
  • Author(s): 古本祥三, 澁間裕太郎, 金田朋洋, 石川洋一, 工藤幸司, 岩田錬
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-05
• [Presentation] 血管標的薬AVE8062により誘発される腫瘍低酸素状態の評価 (2007)
  • Author(s): 古本祥三, 本田芳雄, 堀勝義, 石川洋一, 工藤幸司, 岩田錬
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-05
• [Presentation] [^<11>C]BF-227を用いた脳内アミロイド蓄積に関する定量的検討 (2007)
  • Author(s): 田代学, 岡村信行, 熊谷和明, 古本祥三, 船木善仁, 木村雄一, 石渡喜一, 岩田錬, 工藤幸司, 荒井啓行, 谷内一彦
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-05
• [Presentation] 腫瘍イメージング剤O-[^<18>F]fluoromethyl-L-tyroshine (FMT) 前臨床評価 (2007)
  • Author(s): 石渡喜一, 塚田秀夫, 窪田和雄, 岩田錬
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-04
• [Presentation] Loop-SPE法を用いた[^<11>C]PE2Iの標識合成 (2007)
  • Author(s): 金井泰和, 石川洋一, 畑沢順, 岩田錬
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-04
• [Presentation] Electrochemical micro-flow-cell for rapid and efficient concentration of [^<18>F]fluoride to aprotic solvent from [^<18>O]water (2007)
  • Author(s): R. Yamahara, H. Nakanaishi, K. sakamoto, H. saiki, E Ozeki, R. Iwata
  • Organizer: μTAS2007
  • Place of Presentation: パリ