| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
An automated system was developed for concentration of aqueous ^<18>F-fluoride produced in ^<18>O-water with a cyclotron. It was electrochemically trapped in a disposable microflow cell chip and then released as a complex with K+-K.222 in a small portion of an aprotic solvent (<60μL) such as acetonitrile and DMSO. Thus, the concentrated solution was mixed with a precursor solution followed by passing through a heated microchannel to synthesize ^<18>F-FDG, FLT and FMISO. Reaction time, temperature and solvent were examined for optimizing ^<18>F-substitution reactions. It was observed that microreactor radiosynthesis was very rapid and efficient as reported.
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