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Development of small animal imaging system to depict function and morphology

Research Project

Project/Area Number 19390313
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEDA Tohoru  University of Tsukuba, 大学院・人間総合科学研究科, 講師 (10197311)

Co-Investigator(Kenkyū-buntansha) MINAMI Manabu  筑波大学, 大学院・人間総合科学研究科, 教授 (10174096)
YUASA Tetsuya  山形大学, 大学院・理工学研究科, 教授 (30240146)
赤塚 孝雄  山形大学, 大学院・理工学研究科, 名誉教授 (80091875)
Research Collaborator 呉 勁  千葉大学, 社会精神保健教育研究センター, ポスドク研究員
兵藤 一行  高エネルギー加速器研究機構, 物質構造科学研究所, ・講師
深見 忠典  山形大学, 大学院・理工学研究科, 助教
舞草 伯秀  バイオテクノロジー開発技術研究組合, ポスドク研究員
霍 慶凱  山形大学, 大学院・, 博士課程
佐藤 英典  山形大学, 大学院・, 修士課程
堀井 高明  山形大学, 大学院・, 修士課程
那須川 清太  山形大学, 大学院・, 修士課程
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Keywords画像診断学 / 放射線診断学 / 核医学 / 蛍光X線 / CT / 生体画像 / 微量元素 / 機能画像 / 透過X線CT / 形態画像 / 半導体検出器
Research Abstract

生体の機能と形態を画像化できる高速撮像可能な蛍光X線CTの基礎・開発研究を行った。本装置は、シートビームで撮影を行うため、試料を回転するだけで画像が得られる第2世代のCT装置に類似した装置である。ファントム及び脳固定生体試料を撮影し、本法により世界で初めて標識物質に含まれるヨウ素分布画像を得ることに成功した(Optics letter33 : 2494,2008)。本研究で、実用前段階の蛍光X線CT装置を製作するための基礎技術の開発研究ができた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (50 results)

All 2009 2008 2007

All Journal Article (24 results) (of which Peer Reviewed: 22 results) Presentation (24 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice.2009

    • Author(s)
      Takeda T, Wu J, Thet-Thet-Lwin, Huo Q, Yuasa T, Hyodo K, Dilmanian FA, Akatsuka T
    • Journal Title

      J Synchrotron Rad 16

      Pages: 57-62

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of the map of myocardial wall thickness for evaluation of heart function2009

    • Author(s)
      2.Sato H, Fukami T, Wu J, Thet-Thet-Lwin, Yuasa T, Takeda T, Akatsuka T
    • Journal Title

      Information and Communication Engineers MI2008-135 (2009-01)

      Pages: 343-348

    • NAID

      110007122903

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging properties of fluorescent X-ray CT : Comparison study2009

    • Author(s)
      Huo Q, Sato H, Takeda T, Wu J, Thet-Thet-Lwin, Yuasa T, Hyodo K, Akatsuka T
    • Journal Title

      Information and Communication Engineers MI2008-142 (2009-01)

      Pages: 375-379

    • NAID

      110007122890

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray, fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice.2009

    • Author(s)
      Tohoru Takeda
    • Journal Title

      J. Synchrotron Rad 16

      Pages: 57-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging properties of fluorescent X-ray CT: Comparison study2009

    • Author(s)
      Qingkai Huo
    • Journal Title

      Information and Communication Engineers MI2008-142(2009-01)

      Pages: 375-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of the map of myocardial wall thickness for evaluation of heart function.2009

    • Author(s)
      Hidenori Sato
    • Journal Title

      Information and Communication Engineers MI2008-135(2009-01)

      Pages: 343-348

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of age dependent myocardial metabolic impairment in cardiomyopathic model hamster obtained by fluorescent X-ray CT using I-127 BMIPP2008

    • Author(s)
      Thet-Thet-Lwin, Takeda T, Wu J , Huo Q, Yuasa T, Hyodo K, Akatsuka T
    • Journal Title

      J Synchrotron Rad 15

      Pages: 528-531

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sheet-Beam Geometry for In-Vivo Fluorescent X-Ray CT : Proof-of-Concept Experiment in Molecular Imaging2008

    • Author(s)
      Huo Q, Yuasa T, Akatsuka T, Takeda T, Wu J Thet-athet-Lwin, Hyodo K, Dilmanian FA
    • Journal Title

      Optics Letter 33

      Pages: 2494-2496

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyzing cerebral blood-flow SPECT imaging for the diagnosis of dementia : a new approach FUSE2008

    • Author(s)
      Kudo H, Takeda T, Asada T
    • Journal Title

      Medical Imaging Technology 26

      Pages: 169-174

    • NAID

      10025543573

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺領域の悪性腫瘍の治療後の経過観察支援のためのPET/CT画像処理2008

    • Author(s)
      新田修平、本谷秀堅、深見忠典、湯浅哲也、赤塚孝雄、呉 勁、武田 徹、織内 昇、遠藤啓吾、渡邉順久
    • Journal Title

      信学技報MI2007-121 (2008-1)

      Pages: 319-324

    • NAID

      110006623311

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射光蛍光X線CT : 新しい分子イメージング技術をめざして2008

    • Author(s)
      湯浅哲也、武田 徹、赤塚孝雄
    • Journal Title

      映像情報メディカル 40

      Pages: 1220-1224

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of age dependent myocardial metabolic impairment in cardiomyopathic model hamster obtained by fluorescent X-ray CT using 1-127 BMIPP.2008

    • Author(s)
      Thet-Thet-Lwin
    • Journal Title

      J. Synchrotron Rad 15

      Pages: 528-531

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sheet-Beam Geometry for In-Vivo Fluorescent X-Ray CT: Proof-of-Concept Experiment in Molecular Imaging.2008

    • Author(s)
      Qingkai Huo
    • Journal Title

      Optics Letter 33

      Pages: 2494-2496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyzing cerebral blood-flow SPECT imaging for the diagnosis of dementia: a new approach FUSE.2008

    • Author(s)
      Hiroyuki Kudo
    • Journal Title

      Medical Imaging Technology 26

      Pages: 169-174

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射光蛍光X線CT:新しい分子イメージング装循を男ざして2008

    • Author(s)
      湯浅 哲也
    • Journal Title

      映像情報メディカル 40

      Pages: 1220-1224

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Interferometer-based phase-contrast X-ray Computed Tomography of colon cancer specimens : Comparative study with 4.74 tesla MRI and optical microscopy2007

    • Author(s)
      Takeda T, Wu J, Thet-Thet-Lwin, Yoneyama A, Hyodo K, Matsuda Y, Kose K
    • Journal Title

      J Compt Assist Tomogr 31

      Pages: 214-217

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow2007

    • Author(s)
      Fukami T, Sato H, Wu J, Thet-Thet-Lwin, Yuasa T, Kawano S, Iida K, Akatsuka T, Hontani H, TakedaT, Tamura M, Yokota H
    • Journal Title

      Phys Med Biol 52

      Pages: 4311-4330

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchrotron radiation used fluorescent X-ray computed tomography as a novel molecular imaging. Proc2007

    • Author(s)
      Sunaguchi N, Hou Q, Nasukawa S, Maikusa N, Fukami T, Yuasa T, Takeda T, Wu J, Thet-Thet-Lwin, Hyodo K, Dilmanian FA, Akatsuka T
    • Journal Title

      The Seventh IASTED International Conference VISUALIZATION, IMAGING, AND IMAGE PROCESSING

      Pages: 94-99

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomedical application of high sensitive synchrotron X-ray imaging techniques to assess the microstructures and function of hamster heart. Proc.2007

    • Author(s)
      Wu J, Takeda T, Thet-Thet-Lwin, Yuasa T, Minami M, Akatsuka T
    • Journal Title

      NFSI & ICFBI 2007

      Pages: 55-58

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] PET/CT画像に基づいた臓器を単位とする腫瘍候補抽出2007

    • Author(s)
      新田修平、本谷秀堅、深見忠典、湯浅哲也、赤塚孝雄、呉 勁、武田 徹、織内 昇、遠藤啓吾
    • Journal Title

      信学技報 MI2006-83 (2007-1)

      Pages: 1-4

    • NAID

      110006201313

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] リンパ腫抽出における偽陽性削減のための局所構造を保持する判別分析2007

    • Author(s)
      澤田好秀、新田修平、本谷秀堅、深見忠典、湯浅哲也、赤塚孝雄、呉勁、武田徹、織内昇、遠藤啓吾
    • Journal Title

      信学技報 MI2006-83 (2007-1)

      Pages: 5-8

    • NAID

      110006201314

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 蛍光X線CT画像におけるヨウ素濃度の定量的推定2007

    • Author(s)
      那須川清太、霍慶凱、舞草伯秀、呉勁、Thet-Thet-Lwin、武田徹、湯浅哲也、兵藤一行、赤塚孝雄
    • Journal Title

      Medical Imaging Technology 25

      Pages: 251-256

    • NAID

      10019938712

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomedical application of high sensitive synchrotron X-ray imaging techniques to assess the microstructures and function of hamster heart2007

    • Author(s)
      Jin Wu, et al.
    • Journal Title

      Proc. NFSI & ICFBI 2007 2007

      Pages: 55-58

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 走査型蛍光X線CTを用いた生体試料観察2007

    • Author(s)
      武田徹, 他
    • Journal Title

      日本金属学会会報「まてりあ」 46

      Pages: 832-832

    • NAID

      10020007594

    • Related Report
      2007 Annual Research Report
  • [Presentation] Imaging properties of fluorescent X-ray CT: Comparison study.2009

    • Author(s)
      Qingkai Huo
    • Organizer
      International Forum on Medical Imaging in A sia (IFMIA) 2009
    • Place of Presentation
      台湾、台北市
    • Year and Date
      2009-01-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of the map of myocardial wall thickness for evaluation of heart function.2009

    • Author(s)
      Hidenori Sato
    • Organizer
      International Forum on Medical Imaging in A sia (IFMIA) 2009
    • Place of Presentation
      台湾、台北市
    • Year and Date
      2009-01-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of the map of myocardial wall thickness for evaluation of heart function2009

    • Author(s)
      Sato H, Fukami T, Wu J, Thet-Thet-Lwin, Yuasa T, Takeda T, Akatsuka T
    • Organizer
      International Forum on Medical Imaging in Asia (IFMIA) 2009
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging properties of fluorescent X-ray CT : Comparison study2009

    • Author(s)
      Huo Q, Sato H, Takeda T, Wu J, Thet-Thet-Lwin, Yuasa T, Hyodo K, Akatsuka T
    • Organizer
      Imaging properties of fluorescent X-ray CT : Comparison study.
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2008 Final Research Report
  • [Presentation] Interferometer based phase?contrast X-ray imaging.2008

    • Author(s)
      Tohoru Takeda
    • Organizer
      XI Latin American of Analysis by X-ray Techniques-SARX 2008
    • Place of Presentation
      ブラジル、カーボブリオ
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] First experimental result with sheet-beam geometry based fluor escent X-ray CT.2008

    • Author(s)
      Qingkai Huo
    • Organizer
      XI Latin American of Analysis by X-ray Tech ninues-SARX 2008
    • Place of Presentation
      ブラジル、カーボプリオ
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光X線CTシステムの撮像高速化の検討。2008

    • Author(s)
      霍慶凱
    • Organizer
      第27回日本医用画像工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interferometer based phase-contrast X-ray imaging2008

    • Author(s)
      Takeda T, Wu J, Thet-Thet-Lwin, Yoneyama A, Hou Q, Sato H, Hyodo K, Yuasa T, Minami M, Akatsuka T
    • Organizer
      XI Latin American of Analysis by X-ray Techniques-SARX 2008
    • Place of Presentation
      Cabo Frio, Brazil
    • Related Report
      2008 Final Research Report
  • [Presentation] First experimental result with sheet-beam geometry based fluorescent X-ray CT2008

    • Author(s)
      Hou Q, Sato H, Wu J, Thet-Thet-Lwin, Yuasa T, Hyodo K, Akatsuka T, Takeda T
    • Organizer
      XI Latin American of Analysis by X-ray Techniques-SARX 2008
    • Place of Presentation
      Cabo Frio, Brazil
    • Related Report
      2008 Final Research Report
  • [Presentation] 蛍光X線CTシステムの撮像高速化の検討2008

    • Author(s)
      霍慶凱、佐藤英典、呉勁、Thet-Thet-Lwin、武田徹、湯浅哲也、兵藤一行、赤塚孝雄
    • Organizer
      第27回日本医用画像工学会大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 蛍光X線CTを用いた生きたマウスの脳血流画像2007

    • Author(s)
      武田徹, 他
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biomedical application of high sensitive synchrotron X-ray imaging techniques to assess the microstructures and function of hamster heart2007

    • Author(s)
      Jin Wu, et al.
    • Organizer
      NFSI & ICFBI 2007
    • Place of Presentation
      中国、杭州
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] In-vivo and ex-vivo cerebral perfusion imaging of mice by fluorescent X-ray CT2007

    • Author(s)
      Jin Wu, et al.
    • Organizer
      The 3^<rd> Hangzhou International Molecular Imaging Conference
    • Place of Presentation
      中国、杭州
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光X線CTを用いた生きたマウスの脳血流画2007

    • Author(s)
      武田徹、呉勁、ティティルイン、南学
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 心筋症ハムスターにおけるI-127BMIPP蛍光X線CTを用いた心筋脂肪酸代謝の経時的観察2007

    • Author(s)
      呉勁、武田徹、ティティルイン、南学
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] Image processing method for analyzing cerebral blood-flow using SPECT and MRI2007

    • Author(s)
      8.Kudo H, Nomura M, Asada T, Takeda T
    • Organizer
      2007 Nuclear Science Symposium and Medical Image Conference
    • Place of Presentation
      Hololulu, Hawaii
    • Related Report
      2008 Final Research Report
  • [Presentation] In-vivo and ex-vivo cerebral perfusion imaging of mice by fluorescent X-ray CT2007

    • Author(s)
      Wu J, Takeda T
    • Organizer
      The 3^<rd> Hangzhou International Molecular Imaging Conference
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Biomedical application of high sensitive synchrotron X-ray imaging technique to assess the microstructures and function of hamster heart2007

    • Author(s)
      Wu J, Takeda T, Thet-Thet-Lwin, Yuasa T, Akatsuka T
    • Organizer
      IEEE
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Synchrotron radiation used fluorescent X-ray computed tomography as a novel molecular imaging2007

    • Author(s)
      11.Sunaguchi N, Hou Q, Nasukawa S, Maikusa N, Fukami T, Yuasa T, Takeda T, Wu J, Thet-Thet-Lwin, Hyodo K, Dilmanian FA, Akatsuka T
    • Organizer
      The Seventh IASTED International Conference VISUALIZATION, IMAGING, AND IMAGE PROCESSING
    • Place of Presentation
      Spain
    • Related Report
      2008 Final Research Report
  • [Presentation] 多素子Ge半導体検出器を用いた蛍光X線CT実現可能性に関する検討2007

    • Author(s)
      霍慶凱、那須川清太、村上岳史、呉勁、Thet-Thet-Lwin、武田徹、湯浅哲也、赤塚孝雄
    • Organizer
      第26回日本医用画像工学会大会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 蛍光X線CT画像におけるヨウ素濃度の定量的推定2007

    • Author(s)
      那須川清太、霍慶凱、村上岳史、呉勁、Thet-Thet-Lwin、武田徹、湯浅哲也、赤塚孝雄
    • Organizer
      第26回日本医用画像工学会大会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report
  • [Presentation] 放射光単色X線を用いた血管造影システム2007

    • Author(s)
      兵藤一行、安藤正海、大塚定徳、武田徹、呉勁、南学、松下昌之助、佐藤藤夫、榊原謙、山口巖
    • Organizer
      第26回日本医用画像工学会大会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report
  • [Presentation] 全身のPET/CT画像中の腫瘍骨転移抽出2007

    • Author(s)
      鈴木貴士、新田修平、本谷秀堅、深見忠典、湯浅哲也、赤塚孝雄、呉勁、武田徹、織内昇、遠藤啓吾、渡辺順久
    • Organizer
      第26回日本医用画像工学会大会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report
  • [Presentation] 判別器の機械学習によるPET/CT画像中の腫瘍抽出高精度化2007

    • Author(s)
      澤田好秀、新田修平、本谷秀堅、深見忠典、湯浅哲也、赤塚孝雄、呉勁、武田徹、織内昇、遠藤啓吾、渡辺順久
    • Organizer
      第26回日本医用画像工学会大会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 蛍光エックス線検出装置2008

    • Inventor(s)
      武田徹、湯浅哲也、呉勁、赤塚孝雄
    • Industrial Property Rights Holder
      筑波大学、山形大学
    • Industrial Property Number
      2008-186551
    • Filing Date
      2008-07-17
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 蛍光エックス線検出装置2008

    • Inventor(s)
      武田徹他
    • Industrial Property Rights Holder
      武田徹他
    • Industrial Property Number
      2008-186551
    • Filing Date
      2008-07-17
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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