| Project/Area Number |
19390317
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
KINUYA Seigo Kanazawa University, 医学系, 教授 (20281024)
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| Co-Investigator(Kenkyū-buntansha) |
川井 恵一 金沢大学, 医学系研究科, 教授 (30204663)
吉本 光喜 金沢大学, 医学系研究科, 助教 (00345638)
鷲山 幸信 金沢大学, 医学系研究科, 助教 (80313675)
小川 数馬 金沢大学, 学際科学実験センター, 助教 (30347471)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
YOSHIMOTO Mitsuyoshi 国立がん研究センター, 研究員 (00345638)
WASHIYAMA Koshin 金沢大学, 保健学系, 助教 (80313675)
OGAWA Kazuma 金沢大学, 薬学系, 准教授 (30347471)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線治療学 / 放射性医薬品 / 内用療法 / 神経内分泌腫瘍 / 血管新生阻害 / 悪性神経内分泌腫瘍 / アイソトープ / I131-MIBG / 骨髄線量 / フュージョン画像 / 線量計算 / 内照射療法 / 神経芽腫 / 腹腔内播種 / 腹腔内投与 |
|---|
| Research Abstract |
This study aimed to enhance therapeutic efficacy of targeted radionuclide therapy with ^<131>I-MIRG for malignant refractory neuroendcrine tumors. Locoregi onal administration of ^<131>I-MTRG was found to better prolong survival of mice with disseminated tumors than systemic administration. Feasibility of high-dose therapy based on dosimetric analysis was determined firstly in Japan. Fusion images of single photon emission computed tomography (SPFCT) and x-ray CT enabled precise detection of lesions and provided information for accurate dosimetry.
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