Radiation Effect on Invasion, Metastatic and Angiogenesis Potential of Cancer
| Project/Area Number |
19390320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
TESHIMA Teruki Osaka University, 大学院・医学系研究科, 教授 (40136049)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Nariaki 大阪大学, 大学院・医学系研究科, 教授 (70190402)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | がん / 転移浸潤 / 血管新生 / X線 / 炭素イオン線 / 腫瘍血管標的薬 / タンパク質遺伝子 / タンパク質 / 遺伝子 / 低酸素 / 照射野辺縁 |
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| Research Abstract |
Carbon ion beams suppressed the potential of invasion and migration of tumor cell lines more significantly than X-ray. Furthermore, the expression of anillin and the activation of RhoA were decreased on these cells. Thus, carbon ion beams irradiation suppressed the invasion and migration of cancer cells via decreasing expression of anillin and inactivation of RhoA. The combination with an antimicrotubule agent TZT-1027 and X-ray irradiation showed synergistic effects of anti-angiogenesis.
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Report
(4 results)
Research Products
(127 results)
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[Journal Article] Radical external beam radiotherapy for prostate cancer in Japan: differences in the patterns of care among Japan, Germany, and the United States2008
Author(s)
Ogawa K., Nakamura K., Sasaki T., Onishi H., Koizumi M., Araya M., Shioyama Y., Okamoto A., Mitsumori M., Teshima T., Japanese PCS Working Subgroup of Prostate Cancer
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Journal Title
Radiation Medicine 26
Pages: 57-62
NAID
Related Report
Peer Reviewed
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[Journal Article] Initial experience with the quality assurance program of radiation therapy on behalf of Japan Radiation Oncology Group (JAROG).2007
Author(s)
Isobe K., Kagami Y., Higuchi K., Kodaira T., Hasegawa M., Shikama N., Nakazawa M., Fukuda I., Nihei K., Ito K., Teshima T., Oguchi M.
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Journal Title
Jpn. J. Clin. Oncol. 37
Pages: 135-139
Related Report
Peer Reviewed
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[Journal Article] A multicenter phase II study of local radiotherapy for stage IEA mucosa associated lymphoid tissue lymphomas: A preliminary report from Japan Radiation Oncology Group (JAROG)2007
Author(s)
Isobe K., Kagami Y., Higuchi K., Kodaira T., Hasegawa M., Shikama N., Nakazawa M., Fukuda I., Nihei K., Ito K., Teshima T., Oguchi M.
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Journal Title
Int. J. Radiat. Oncol. Biol. Phys. 69
Pages: 1181-86
Related Report
Peer Reviewed
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[Journal Article] Patterns of Care Study of breast-conserving therapy in Japan: Comparis on of the treatment process between 1995-1997 and 1999-2001 surveys.2007
Author(s)
Yamauchi C., Mitsumori M., Sai H., Imagunbai T., Negoro Y., Sasaki Y., Hiraoka M., Shikama N., Sasaki S., Takegawa H., Inoue T., Teshima T.
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Journal Title
Jpn. J. Clin. Oncol. 37
Pages: 737-743
Related Report
Peer Reviewed
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[Presentation] 前立腺癌2009
Author(s)
中村和正
Organizer
第22回日本放射線腫瘍学会学術大会
Place of Presentation
国立京都国際会館(京都)
Year and Date
2009-09-18
Related Report
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[Presentation] Current situation in radiotherapy in Japan.2008
Author(s)
Teshima T, JASTRO database committee and Japanese PCS Working Group.
Organizer
Modern Radiation Oncology: Innovative Technologies and Translational Research The 21st International Symposium Foundation forPromotion of Cancer Research
Place of Presentation
Tokyo
Year and Date
2008-02-21
Related Report
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