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Functional imaging studies of small rodents by ESR・MRI combined system

Research Project

Project/Area Number 19390322
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

FUJII Hirotada  Sapporo Medical University, 医療人育成センター, 教授 (70209013)

Co-Investigator(Kenkyū-buntansha) 黄田 育宏  北海道大学, 歯学研究科, 助教 (60374716)
Co-Investigator(Renkei-kenkyūsha) ITOH Kouichi  徳島文理大学, 薬学部, 教授 (30291149)
HIRATA Hiroshi  北海道大学, 大学院・情報科学研究科, 教授 (60250958)
KIDA Ikuhiro  (財)東京都医学研究機構, 東京都精神医学総合研究所, 研究員 (60374716)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
KeywordsESR / MRI / フリーラジカル / 活性酸素 / 酸化ストレス / 分子イメージング / プローベ / イメージング
Research Abstract

Electron Spin Resonance Imaging is a versatile imaging method of visualizing free radicals that are so called reactive oxygen species generated in biological systems. In this project, we have developed the ESR・MRI combined system which is capable of visualizing both ESR image and MR image. With this newly developed system, we plan to do the diagnostic study to screen the metabolic syndrome.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] Half-life mapping of nitroxide radicals with three-dimensional Electron Paramagnetic Resonance imaging2010

    • Author(s)
      Sato-Akaba H., et al.
    • Journal Title

      Analytical Chemistry 81

      Pages: 7501-7506

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Half-life mapping of nitroxyl radicals with three-dimensional electron paramagnetic resonance imaging at an interval of 3. 6 seconds.2009

    • Author(s)
      Sato-Akaba H, Kuwahara Y, Fujii H, Hirata H
    • Journal Title

      Anal Chem 81

      Pages: 7501-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resolution-recovery for EPR imaging of free radical molecules in mice.2009

    • Author(s)
      Ikebata Y, Sato-Akaba H, Aoyama T, Fujii H, Itoh K, Hirata H
    • Journal Title

      Magn Reson Med 62

      Pages: 788-95

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging.2008

    • Author(s)
      Sato-Akaba H, Abe H, Fujii H, Hirata H
    • Journal Title

      Magn. Reson. Med. 59

      Pages: 885-890

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy.2008

    • Author(s)
      Fujii H, Sakata K, Katsumata Y, Sato R, Kinouchi M, Someya M, Masunaga S, Hareyama M, Swartz HM, Hirata H
    • Journal Title

      Radiother Oncol 86

      Pages: 354-360

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The entry of manganese ions into the brain is accelerated by the activation of N-methyl-D-aspartate receptors.2008

    • Author(s)
      Itoh K, Sakata M, Watanabe M, Aikawa Y, Fujii H
    • Journal Title

      Neuroscience 154

      Pages: 732-740

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and testing of a CW-EPR apparatus for imaging of short-lifetime nitroxyl radicals in mouse head.2008

    • Author(s)
      Sato-Akaba H., Fujii H., Hirata H.
    • Journal Title

      J. Magn. Reson. 193

      Pages: 191-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of temporal resolution for three-dimensional continuous-wave electron paramagnetic resonance imaging.2008

    • Author(s)
      Sato-Akaba H, Fujii H, Hirata H
    • Journal Title

      Rev Sci Instrum 79

      Pages: 123701-123701

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and testing of a CW-EPR apparatus for Imaging of short-lifetime nitroxyl radicals in mouse head2008

    • Author(s)
      Sato-Akaba H, et al.
    • Journal Title

      Journal of Magnetic Resonance 193

      Pages: 191-198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging2008

    • Author(s)
      Akaba H
    • Journal Title

      Magnetic Resonance in Medicine 59

      Pages: 885-890

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mapping of redox status in mouse brain by EPR imaging and MRI2009

    • Author(s)
      Hirotada Fujii
    • Organizer
      SFRBM2009
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 高速電子常磁性共鳴イメージング法の進展2009

    • Author(s)
      平田拓
    • Organizer
      SEST2009
    • Place of Presentation
      神戸市
    • Year and Date
      2009-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] EPRを用いた2分子同時イメージング法の基礎的実験-15N-TEMPOLとTAMを用いた実験-2009

    • Author(s)
      伊藤良平
    • Organizer
      SEST2009
    • Place of Presentation
      神戸市
    • Year and Date
      2009-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 高速EPRイメージング装置による脳疾患モデル動物での抗酸化マッピング2009

    • Author(s)
      藤井博匡
    • Organizer
      SEST2009
    • Place of Presentation
      神戸市
    • Year and Date
      2009-11-11
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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