Investigation of linkage between histone modification and DNA damage after irradiation
| Project/Area Number |
19390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HAREYAMA Masato Sapporo Medical University, 医学部, 教授 (10173098)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Masaaki 札幌医科大学, 医学部, 研究員 (70240926)
SAKATA Ko-ichi 札幌医科大学, 医学部, 准教授 (10235153)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | ヒストンメチル化 / ヒストンアセチル化 / ヒストンリン酸化 / 放射線感受性 / DNA障害 / アポトーシス / DNA修復 |
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| Research Abstract |
This study clearly demonstrates that histone modulation, especially inhibition of histone methylation at lysine 20 in histone H4 via SUV420H2 knockdown, can increase radiosensitivity. Also, we have investigated how the ability of repair of DNA DSB influences cancer susceptibility and the radiosensitivity of tumors and normal tissues by focusing on the activity of 5-chloro-2, 4-dihydroxypyridine (Gimeracil) and DNA-PK. These may be useful for establishment of a novel radiotherapy.
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Report
(4 results)
Research Products
(43 results)
