• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of linkage between histone modification and DNA damage after irradiation

Research Project

Project/Area Number 19390323
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

HAREYAMA Masato  Sapporo Medical University, 医学部, 教授 (10173098)

Co-Investigator(Kenkyū-buntansha) ADACHI Masaaki  札幌医科大学, 医学部, 研究員 (70240926)
SAKATA Ko-ichi  札幌医科大学, 医学部, 准教授 (10235153)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsヒストンメチル化 / ヒストンアセチル化 / ヒストンリン酸化 / 放射線感受性 / DNA障害 / アポトーシス / DNA修復
Research Abstract

This study clearly demonstrates that histone modulation, especially inhibition of histone methylation at lysine 20 in histone H4 via SUV420H2 knockdown, can increase radiosensitivity. Also, we have investigated how the ability of repair of DNA DSB influences cancer susceptibility and the radiosensitivity of tumors and normal tissues by focusing on the activity of 5-chloro-2, 4-dihydroxypyridine (Gimeracil) and DNA-PK. These may be useful for establishment of a novel radiotherapy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (43 results)

All 2010 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (22 results) Book (3 results)

  • [Journal Article] Gimeracil sensitizes cells to radiation via inhibition of homologous recombination.2010

    • Author(s)
      Takagi M, Sakata K, Someya M, Tauchi H, Iijima K, Matsumoto Y, Torigoe T, Takahashi A, Hareyama M
    • Journal Title

      Radiother Oncol (in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress impairs the heat stress response and delays unfolded protein recovery.2009

    • Author(s)
      Adachi M, Liu Y, Fujii K, Calderwood SK, Nakai A, Imai K, Shinomura Y
    • Journal Title

      PLoS One 4

      Pages: 1-11

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventing oxidative stress: A new role for XBP1.2009

    • Author(s)
      Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y
    • Journal Title

      Cell Death Diff 16

      Pages: 847-857

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel combination therapy of arsenic trioxide with parthenolide against pancreatic cancer Cells.2009

    • Author(s)
      Wang W, Adachi M, Zhou J, Zhu D
    • Journal Title

      Pancreas 38

      Pages: 114-123

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress impairs the heat stress response and delays unfolded protein recovery2009

    • Author(s)
      Adachi M
    • Journal Title

      PLoS One. 4

      Pages: 1-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventing oxidative stress : a new role for XBP12009

    • Author(s)
      Liu Y
    • Journal Title

      Cell Death Differ. 16

      Pages: 847-857

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventing oxidative stress : a new role for XBP12009

    • Author(s)
      Y. Liu
    • Journal Title

      Cell Death Differ (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel combination therapy of arsenic trioxide with parthenolide against pancreatic cancer cells.2009

    • Author(s)
      W. Wang
    • Journal Title

      Pancreas (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brachytherapy for oral tongue cancer: An analysis of treatment results with various biological markers.2008

    • Author(s)
      Sakata K, Someya M, Nagakura H, Nakata K, Oouchi A, Takagi M, Hareyama M
    • Journal Title

      Jpn J Clin Oncol 38(6)

      Pages: 402-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis2008

    • Author(s)
      Isomura M
    • Journal Title

      Clin Cancer Res 14

      Pages: 6683-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation asdetermined by EPR spectroscopy2008

    • Author(s)
      Fujii H.
    • Journal Title

      Radiother Oncol. 86

      Pages: 354-360

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells.2007

    • Author(s)
      Adachi M, Sakamoto H, Kawamura R, Wang W, Imai K, Shinomura Y
    • Journal Title

      Histol Histopathol 22

      Pages: 437-442

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.2007

    • Author(s)
      Sakata K, Someya M, Matsumoto Y, Hareyama M
    • Journal Title

      Radiat Med 25(9)

      Pages: 433-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.2007

    • Author(s)
      Sakata K, Yamamoto H, Matsumoto Y, Someya M, Hareyama M
    • Journal Title

      Int J Oncol 30(2)

      Pages: 413-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.2007

    • Author(s)
      Someya M, Sakata K, Matsumoto Y, Tauchi H, Narimatsu H, Hareyama M
    • Journal Title

      Oncol Rep 18(4)

      Pages: 873-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] cDNA analysis of gene expression associated with DNAdependent protein kinase activity.2007

    • Author(s)
      Sakata K, Yamamoto H, Matsumoto Y, Someya M, Hareyama M
    • Journal Title

      Int J Oncol 30(2)

      Pages: 413-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells.2007

    • Author(s)
      Adachi M.
    • Journal Title

      Histol Histopathol. 22

      Pages: 437-442

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] cDNA analysis of gene expression associated with DNA-dependent protein kinase activity2007

    • Author(s)
      Sakata K.
    • Journal Title

      Int J Oncol. 30

      Pages: 413-420

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低酸素及び再酸素状態でのDNA-PK活性について2010

    • Author(s)
      坂田耕一、染谷正則、高木克、晴山雅人
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-04-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 酸化ストレスは、熱ショック後の蛋白質リフォールディング活性を抑制する2009

    • Author(s)
      Adachi M
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酸化ストレスは、熱ショック後の蛋白質リフォールディング活性を抑制する2009

    • Author(s)
      安達正晃劉輝華中井章今井浩三篠村恭久
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Examination of radiosensitization efficacy of Gimeracil.2009

    • Author(s)
      Takagi M, Sakata K, Someya M, Tauch H, Matsumoto Y, Torigoe T, Takahashi A, Hareyama M, Fukushima M
    • Organizer
      Annual Meetingof The American Society of Radiation Oncology
    • Place of Presentation
      Chicago
    • Year and Date
      2009-11-03
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルの放射線増感効果の分子生物学的検討2009

    • Author(s)
      高木克、坂田耕一、染谷正則、三浦勝利、小島一男、中田健生、晴山雅人、松本義久、田内広、福島正和
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルの放射線増感効果の分子メカニズムの検討2009

    • Author(s)
      坂田耕一、染谷正則、高木克、中田健生、小島一男、晴山雅人、田内広、松本義久、福島正和
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルによる放射線増感効果の分子メカニズムの解析2009

    • Author(s)
      染谷正則、坂田耕一、高木克、晴山雅人、松本義久、田内広、福島正和
    • Organizer
      第48回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      富山
    • Year and Date
      2009-07-10
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルの放射線増感効果の検討2009

    • Author(s)
      高木克、坂田耕一、染谷正則、林潤一、小島一男、中田健生、晴山雅人、松本義久、田内広、福島正和
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-11
    • Related Report
      2009 Final Research Report
  • [Presentation] x bp1の新しい機能:酸化ストレス応答への関与2008

    • Author(s)
      安達正晃、劉耀華、趙世光、Koong Albert, Rando Thomas, Dan Ruo, 今井浩三, 篠村泰久
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Preventing oxidative stress: A new role for XBP1 and its candidate as a molecular target for cancer.2008

    • Author(s)
      Adachi M, Liu Y, Zhao S, Hareyama M, Koong A, Imai K, Shinomura Y
    • Organizer
      he 6th International Symposium on cancer research and therapy
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-22
    • Related Report
      2009 Final Research Report
  • [Presentation] XBP1の新しい機能2008

    • Author(s)
      安達正晃、劉耀華、Koong Albert, 今井浩三、篠村泰久
    • Organizer
      第17回日本癌病態治療研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルによる放射線増感効果の検討2008

    • Author(s)
      染谷正則、高木克、坂田耕一、晴山雅人、松本義久、田内広、福島正和
    • Organizer
      第47回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      高知
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルの放射線増感効果の分子メカニズム2008

    • Author(s)
      坂田耕一、染谷正則、高木克、中田健生、小島一男、晴山雅人、田内広、松本義久、福島正和
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 分割照射や抗癌剤併用におけるギメラシルの放射線増感作用の検討2008

    • Author(s)
      高木克、坂田耕一、染谷正則、林潤一、小島一男、中田健生、晴山雅人、松本義久、田内広、福島正和
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-05
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルの放射線増感作用の放射線誘発H2AXフォーカスによる解析2008

    • Author(s)
      染谷正則、高木克、小島一男、中田健生、坂田耕一、晴山雅人、田内広、松本義久、福島正和
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-05
    • Related Report
      2009 Final Research Report
  • [Presentation] IL-2シグナルと小胞体ストレスシグナル2007

    • Author(s)
      安達正晃, 劉耀華、今井浩三、篠村泰久
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] scneoレポーター法によるギメラシル放射線増感効果の検討2007

    • Author(s)
      坂田耕一、染谷正則、高木克、中田健生、小島一男、晴山雅人、田内広、松本義久、福島正和
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] ギメラシルによる放射線誘発rH2AXフォーカスの変化の検討2007

    • Author(s)
      染谷正則、高木克、小島一男、中田健生、坂田耕一、晴山雅人、田内広、松本義久、福島正和
    • Organizer
      日本放射線腫瘍学会第20回学術大
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 頭頸部癌化学放射線療法でのTS1使用経験2007

    • Author(s)
      中田健生、高木克、染谷正則、坂田耕一、晴山雅人、池田光、堀正和、大内敦
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA-PK活性欠損細胞を用いたギメラシルの放射線増感作用の検討2007

    • Author(s)
      高木克、小島一男、中田健生、染谷正則、坂田耕一、晴山雅人、松本義久、福島正和
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 内在性ホルモンを利用した新たな放射線感受性亢進療法の開発2007

    • Author(s)
      安達正晃、今井浩三、晴山雅人、篠村恭久
    • Organizer
      日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 乳癌患者におけるリンパ球DNA-PK活性、放射線誘発NBS1フォーカスと臨床的悪性度の関係2007

    • Author(s)
      染谷正則、坂田耕一、松本義久、晴山雅人
    • Organizer
      第66回日本医学放射線学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-14
    • Related Report
      2009 Final Research Report
  • [Book] 基質依存性増殖/アノイキス(Anoikis)改訂培養細胞実験ハンドブック2008

    • Author(s)
      安達正晃
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] 遺伝子治療看護のための最新医学講座第2版24巻(腫瘍の臨床)2008

    • Author(s)
      安達正晃
    • Publisher
      中山書店
    • Related Report
      2009 Final Research Report
  • [Book] エビデンス放射線治療, 急性期の有害事象2007

    • Author(s)
      染谷正則、晴山雅人.渋谷、晴山、平岡編
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi