| Project/Area Number |
19390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
HASEGAWA Masatoshi Nara Medical University, 医学部, 教授 (50251111)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Tatsuya 群馬大学, 重粒子線医学研究センター, 准教授 (10344061)
OIKAWA Masakazu 日本原子力研究開発機構, 放射線高度利用施設部, 研究員 (10391301)
ASAKAWA Isao 奈良県立医科大学, 医学部, 助教 (20382319)
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| Research Collaborator |
加藤 真吾 放射線医学総合研究所
村上 健 放射線医学総合研究所
新 雅子 群馬大学, 大学院
中野 隆史 群馬大学, 大学院
藤村 浩子 奈良県立医科大学
崎山 まゆみ 奈良県立医科大学
榎本 喜久子 奈良県立医科大学
玉本 哲郎 奈良県立医科大学
大西 武雄 奈良県立医科大学
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 放射線感受性 / 腫瘍内不均一性 / 分子生物学 / アポトーシス / p53 / 遺伝子発現 / 分化 |
|---|
| Research Abstract |
Tumors of human origin with wild-type (wt) p53 or mutant-type (mt) p53 were transplanted to nude mice and irradiated with carbon ion beams or X-rays to analyze intratumoral inhomogeneous radiosensitivity. In wt-p53 tumors, apoptosis increased after low dose irradiation and significant changes in gene expression were found. Little difference between the profiles induced by carbon ion and those by X-rays was shown, but the two types of tumor cells in a tumor showed different profiles. In mt-p53 tumors, significant changes in gene expression were shown after high dose irradiation, but the profiles induced by carbon ion and those by X-rays were different.
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