Molecular biological analysis of intratumoral inhomogeneous radiosensitivity
| Project/Area Number |
19390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
HASEGAWA Masatoshi Nara Medical University, 医学部, 教授 (50251111)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Tatsuya 群馬大学, 重粒子線医学研究センター, 准教授 (10344061)
OIKAWA Masakazu 日本原子力研究開発機構, 放射線高度利用施設部, 研究員 (10391301)
ASAKAWA Isao 奈良県立医科大学, 医学部, 助教 (20382319)
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| Research Collaborator |
加藤 真吾 放射線医学総合研究所
村上 健 放射線医学総合研究所
新 雅子 群馬大学, 大学院
中野 隆史 群馬大学, 大学院
藤村 浩子 奈良県立医科大学
崎山 まゆみ 奈良県立医科大学
榎本 喜久子 奈良県立医科大学
玉本 哲郎 奈良県立医科大学
大西 武雄 奈良県立医科大学
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 放射線感受性 / 腫瘍内不均一性 / 分子生物学 / アポトーシス / p53 / 遺伝子発現 / 分化 |
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| Research Abstract |
Tumors of human origin with wild-type (wt) p53 or mutant-type (mt) p53 were transplanted to nude mice and irradiated with carbon ion beams or X-rays to analyze intratumoral inhomogeneous radiosensitivity. In wt-p53 tumors, apoptosis increased after low dose irradiation and significant changes in gene expression were found. Little difference between the profiles induced by carbon ion and those by X-rays was shown, but the two types of tumor cells in a tumor showed different profiles. In mt-p53 tumors, significant changes in gene expression were shown after high dose irradiation, but the profiles induced by carbon ion and those by X-rays were different.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Nuclear survivin expression predicts poorer prognosis in glioblastoma.2009
Author(s)
Shirai K, Suzuki Y, Oka K, Noda SE, Katoh H, Suzuki Y, Itoh J, Itoh H, Ishiuchi S, Sakurai H, Hasegawa M, Nakano T.
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Journal Title
J Neurooncol 91巻
Pages: 353-358
Related Report
Peer Reviewed
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