| Project/Area Number |
19390329
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIDA Takanori (2008-2009) Tohoku University, 大学院・医学系研究科, 准教授 (00292318)
石田 孝宣 (2007) Tohoku University, 病院, 講師 (70323011)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808)
OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
小林 芳男 茨城大学, 工学部, 教授 (40250849)
小林 正樹 東北工業大学, 工学部, 教授 (90332981)
大原 智 東北大学, 多元物資科学研究所, 助教 (00396532)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 乳がん / 多機能ナノ粒子 / 蛍光ナノビーズ / センチネルリンパ節 / 複合ナノ粒子 / センシングナノビーズ / シリカコーティング / ナノテクノロジー / 乳癌 / ナノ粒子 |
|---|
| Research Abstract |
Nanoparticles in appropriate size can be passively transported in malignant tissue. We performed in vivo imaging of the dynamics of nanoparticles in various sizes. Nanoparticles of 200nm did not leak in cancer tissue. In contrast, nanoparticles of 20, 40 and 100nm could be transported in cancer tissue. We also performed fluorescence nanoimaging of gastric sentinel lymph node of pigs. And we specified the first area for lymph node metastasis in a sentinel lymph node. These techniques are also utilized for ultrafine cancer operation.
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