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Engineering three dimensional hepatic tissue with microvascular networks in vivo

Research Project

Project/Area Number 19390340
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

KOIKE Naoto  Yokohama City University, 医学研究科, 客員研究員 (50301081)

Co-Investigator(Kenkyū-buntansha) 谷口 英樹  横浜市立大学, 医学研究科, 教授 (70292555)
鄭 允文  横浜市立大学, 医学部, 助教 (80404995)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords移植外科学 / 人工微小血管 / 三次元培養 / 人工肝 / 微小人工血管 / クラニアルウィンドウ / 生体顕微鏡 / 血管 / 肝臓 / 組織再構築 / 再生医学
Research Abstract

Creation of the highly functional three dimensional (3-D) tissue with microvascular networks has been eagerly waited for regenerative medicine, however, the technology of such reconstitution is not established enough. The final goal of our study is creation of human highly functional and complicated tissues. To reach this final goal, we first seeded human umbilical-vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSC) in a three-dimensional fibronectin-collagen gel and reconstituted human 3D microvessels in vitro. Next, we reconstituted this human microvessls in vivo by transplanting a small piece of this fibronectin-collagen gel embedded HUVEC and hMSC in mouse cranial windows and aimed at the creation of human 3D hepatic tissue with microvascular network.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007

All Journal Article (38 results) (of which Peer Reviewed: 7 results) Presentation (35 results) Book (2 results)

  • [Journal Article] 【ヒト幹細胞による薬物代謝・トランスポート・副作用予測iPS・ES細胞・間葉系細胞を用いた新たな創薬スクリーニング】膵β細胞の分化誘導系の創薬スクリーニングへの利用.2010

    • Author(s)
      谷口英樹
    • Journal Title

      医学のあゆみ 232

      Pages: 110-116

    • Related Report
      2009 Final Research Report
  • [Journal Article] 【ヒト幹細胞による薬物代謝・トランスポート・副作用予測 iPS・ES細胞・間葉系細胞を用いた新たな創薬スクリーニング】膵β細胞の分化誘導系の創薬スクリーニングへの利用2010

    • Author(s)
      谷口英樹
    • Journal Title

      医学のあゆみ 232

      Pages: 110-116

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ヒト幹細胞を用いたin vivoにおける微小血管網の構築とその応用.2009

    • Author(s)
      小池直人, Dai Fukumura, Rakesh K Jain, 谷口英樹
    • Journal Title

      Organ Biology 16(3)

      Pages: 349-357

    • Related Report
      2009 Final Research Report
  • [Journal Article] Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.2009

    • Author(s)
      Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, Yamamoto M, Kawamura S, Kobayashi M, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Ebihara Y, Koike N, Furukawa T
    • Journal Title

      Am J Surg Pathol. 33(8)

      Pages: 1164-1172

    • Related Report
      2009 Final Research Report
  • [Journal Article] Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions.2009

    • Author(s)
      Koike N, Cho A, Nasu K, Seto K, Nagaya S, Ohshima Y, Ohkohchi N
    • Journal Title

      World J Gastroenterol. 15(46)

      Pages: 5805-5812

    • Related Report
      2009 Final Research Report
  • [Journal Article] 【ヒト細胞の創薬研究への利用】ヒト肝幹細胞の創薬研究への応用.2009

    • Author(s)
      谷口英樹
    • Journal Title

      移植 44

      Pages: 178-182

    • Related Report
      2009 Final Research Report
  • [Journal Article] 【幹細胞研究の最近の進歩多能性幹細胞】幹細胞の臨床応用糖尿病の再生治療へ向けた多角的アプローチ.2009

    • Author(s)
      谷口英樹
    • Journal Title

      最新医学 64

      Pages: 1434-1444

    • Related Report
      2009 Final Research Report
  • [Journal Article] 【ここまできた再生医学・再生医療】最先端の幹細胞研究幹細胞を用いた肝組織構造の再構成に向けて.2009

    • Author(s)
      谷口英樹
    • Journal Title

      Surgery Frontier 16

      Pages: 264-265

    • Related Report
      2009 Final Research Report
  • [Journal Article] iPS細胞iPS細胞から肝細胞を分化誘導する意義.2009

    • Author(s)
      谷口英樹
    • Journal Title

      臨床検査 53

      Pages: 1609-1613

    • Related Report
      2009 Final Research Report
  • [Journal Article] iPS細胞iPS細胞から肝細胞を分化誘導する意義2009

    • Author(s)
      谷口英樹
    • Journal Title

      臨床検査 53

      Pages: 1609-1613

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【ここまできた再生医学・再生医療】最先端の幹細胞研究幹細胞を用いた肝組織構造の再構成に向けて2009

    • Author(s)
      谷口英樹
    • Journal Title

      Surgery Frontier 16

      Pages: 264-265

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【幹細胞研究の最近の進歩多能性幹細胞】幹細胞の臨床応用 糖尿病の再生治療へ向けた多角的アプローチ2009

    • Author(s)
      谷口英樹
    • Journal Title

      最新医学 64

      Pages: 1434-1444

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【ヒト細胞の創薬研究への利用】ヒト肝幹細胞の創薬研究への応用2009

    • Author(s)
      谷口英樹
    • Journal Title

      移植 44

      Pages: 178-182

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ヒト幹細胞を用いた in vivo における微小血管網の構築とその応用2009

    • Author(s)
      小池直人, Dai Fukumura, Rakesh K Jain, 谷口英樹
    • Journal Title

      Organ Biology 16

      Pages: 349-357

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions2009

    • Author(s)
      Koike N, Cho A, Nasu K, Seto K, Nagaya S, Ohshima Y, Ohkohchi N
    • Journal Title

      World J Gastroenterol 15

      Pages: 5805-5812

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms2009

    • Author(s)
      Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, Yamamoto M, Kawamura S, Kobayashi M, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Ebihara Y, Koike N, Furukawa T
    • Journal Title

      Am J Surg Pathol 33

      Pages: 1164-1172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.2008

    • Author(s)
      Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H
    • Journal Title

      Development 135

      Pages: 1589-1595

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hepatic hilar resection for hilar cholangiocarcinoma based on a reclassification.2008

    • Author(s)
      Cho A, Asano T, Yamamoto H, Nagata M, Takiguchi N, Kainuma O, Souda H, Gunji H, Miyazaki A, Nojima H, Ikeda A, Matsumoto I, Ryu M, Koike N
    • Journal Title

      Hepatogastroenterology 55(86-87)

      Pages: 1764-1765

    • Related Report
      2009 Final Research Report
  • [Journal Article] Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.2008

    • Author(s)
      Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H
    • Journal Title

      Hepatology 48(6)

      Pages: 1964-78

    • Related Report
      2009 Final Research Report
  • [Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008

    • Author(s)
      Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A
    • Journal Title

      Cancer Research 68(19)

      Pages: 7742-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] 長期生存が得られた腹膜播種を伴う有茎型肝細胞癌の1切除例.2008

    • Author(s)
      小池直人, 趙明浩, 有田誠司, 大河内信弘
    • Journal Title

      日本臨床外科学会雑誌 69(11)

      Pages: 2956-2959

    • NAID

      10024952802

    • Related Report
      2009 Final Research Report
  • [Journal Article] 肝臓における組織幹細胞.2008

    • Author(s)
      谷口英樹, 上野康晴
    • Journal Title

      日本臨床 66

      Pages: 932-938

    • Related Report
      2009 Final Research Report
  • [Journal Article] Stem cells and cancer in the liver.2008

    • Author(s)
      Taniguchi H, Chiba T
    • Journal Title

      Dis Markers 24

      Pages: 223-229

    • Related Report
      2009 Final Research Report
  • [Journal Article] stem cells and cancer in the liver.2008

    • Author(s)
      Taniguchi H, Chiba T.
    • Journal Title

      Dis Markers. 24

      Pages: 223-229

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 肝臓における組織幹細胞2008

    • Author(s)
      谷口英樹, 上野康晴
    • Journal Title

      日本臨床 66

      Pages: 932-938

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 長期生存が得られた腹膜播種を伴う有茎型肝細胞癌の1切除例2008

    • Author(s)
      小池直人, 趙明浩, 有田誠司, 大河内信弘
    • Journal Title

      日本臨床外科学会雑誌 69

      Pages: 2956-2959

    • NAID

      10024952802

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic hilar resection for hilar cholangiocarcinoma based on a reclassification.2008

    • Author(s)
      Cho A, Asano T, Yamamoto H, Nagata M, Takiguchi N, Kainuma O, Souda H, Gunji H, Miyazaki A, Nojima H, Ikeda A, Matsumoto I, Ryu M, Koike N
    • Journal Title

      Hepatogastroenterology 55

      Pages: 1764-1765

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression2008

    • Author(s)
      Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H
    • Journal Title

      Development 135

      Pages: 1589-1595

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intersegmental arterial communication between the medial and left lateral segments of the liver.2007

    • Author(s)
      Cho A, Gunji H, Koike N, Narumoto S, Asano T, Yamamoto H, Kainuma O, Ryu M, Mori C, Murakami G, Okazumi S, Ochiai T
    • Journal Title

      Dig Surg 24(5)

      Pages: 328-30

    • Related Report
      2009 Final Research Report
  • [Journal Article] Adult rat hepatic bipotent progenitor cels remain doramant even after extensive hepatectomy.2007

    • Author(s)
      Yamamoto Y, Togo S, Zheng YW, Kubota T, Taniguchi H, Shimada S
    • Journal Title

      Sound Repair and Regeneration 15

      Pages: 422-429

    • Related Report
      2009 Final Research Report
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Chiba T, Zhen YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H
    • Journal Title

      Gastroenterology 133

      Pages: 937-950

    • Related Report
      2009 Final Research Report
  • [Journal Article] Renal L-Type Fatty Acid-Binding Protein in Acute Ischemic Injury2007

    • Author(s)
      Yamamoto T, Noiri E, Ono Y, Doi K, Negishi K, Kamijo A, Kimura K, Fujita T, Kinukawa T, Taniguchi H, Nakamura K, Goto M, Shinozaki N, Ohshima S, Sugaya T
    • Journal Title

      Journal of the American Society of Nephology 18

      Pages: 2894-2902

    • Related Report
      2009 Final Research Report
  • [Journal Article] Production of Functional Spermatids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules.2007

    • Author(s)
      Kita K, Watanabe T, Ohsaka K, Hayashi H, Kubota Y, Nagashima Y, Aoki I, Taniguchi H, Noce T, Inoue K, Miki H, Ogonuki N, Tanaka H, Ogura A, Ogawa T
    • Journal Title

      Biol Reprod. 76(2)

      Pages: 211-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting.2007

    • Author(s)
      Oshima Y, Suzuki A, Kawashimo K, Ishikawa M, Ohkohchi N, Taniguchi H
    • Journal Title

      Gastroenterology 132(2)

      Pages: 720-732

    • Related Report
      2009 Final Research Report
  • [Journal Article] In vitro reconstitution of hepatic tissue architectures with neonatal mouse liver cells using three-dimensional culture.2007

    • Author(s)
      Okamura A, Zheng Y W, Hirochika R, Tanaka J, Taniguchi H
    • Journal Title

      Journal of Nanoscience and Nanotechnology 7(2)

      Pages: 721-5

    • Related Report
      2009 Final Research Report
  • [Journal Article] Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages.2007

    • Author(s)
      Zhao W, Hirose T, Ishikawa M, Oshima Y, Hirai S, Ohno S, Taniguchi H
    • Journal Title

      Biochemical and Biophysical Research Communications 352(1)

      Pages: 84-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation2007

    • Author(s)
      Chiba T, Zhen YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H
    • Journal Title

      Gastroenterology 133

      Pages: 937-950

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult rat hepatic bipotent progenitor cels remain doramant even after extensive hepatectomy2007

    • Author(s)
      Yamamoto Y, Togo S, Yun-wen Zheng, Kubota T, Taniguchi H, Shimada S
    • Journal Title

      Sound Repair and Regeneration 15

      Pages: 422-429

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] in vivo における血管ネットワークを有したヒト肝組織再構成系の確立2010

    • Author(s)
      藤原綾二, 小池直人, 千葉豊生, Dai Fukumura, Rakesh K Jain, 関根圭輔, 上野康晴, 鄭允文, 谷口英樹
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] in vivoにおける血管ネットワークを有したヒト肝組織再構成系の確立.2010

    • Author(s)
      藤原綾二, 小池直人, 千葉豊生, Dai Fukumura, Rakesh K Jain, 関根圭輔, 上野康晴, 鄭允文, 谷口英樹
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 当院における自家癌ワクチンの経験.2009

    • Author(s)
      小池直人, 眞崎義隆
    • Organizer
      第6回がんワクチン療法研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-31
    • Related Report
      2009 Final Research Report
  • [Presentation] Extended right hepatectomy with portal vein resection and reconstruction used by renal vein graft prior to hepatic dissection for hilar cholangiocarcinoma2009

    • Author(s)
      小池直人, 趙明浩, 大島祐二, 有田誠司, 武内俊章, 田中元, 河上牧夫, 大河内信弘
    • Organizer
      International Surgical Week 2009
    • Place of Presentation
      Adelaide Australia
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎静脈グラフトを用い門脈再建を先行させた肝門部胆管癌に対する拡大肝右葉切除術2009

    • Author(s)
      小池直人, 趙明浩, 有田誠司, 大島祐二, 武内俊章, 川島太一, 田中元, 河上牧夫, 大河内信弘
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸癌化学療法中進行する脾腫に対し腹腔鏡下脾摘を施行した1例.2009

    • Author(s)
      小池直人, 大島祐二, 田中元, 廣橋健太郎, 武内俊章, 川島太一, 有田誠司, 篠崎英司, 河上牧夫
    • Organizer
      第14回千葉内視鏡外科研究会
    • Place of Presentation
      千葉
    • Year and Date
      2009-01-31
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivoにおける血管ネットワーク構造を有するヒト高次肝像組織の再構築.2009

    • Author(s)
      仲野晶, 藤原綾二, 小池直人, 千葉豊生, 網谷猛, 岡村愛, Dai Fukumura, Rakesh K Jain, 上野康晴, 鄭允文, 谷口英樹
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 腎静脈グラフトを用い門脈再建を先行させた肝門部胆管癌に対する拡大肝右葉切除術.2009

    • Author(s)
      小池直人, 趙明浩, 有田誠司, 大島祐二, 武内俊章, 川島太一, 田中元, 河上牧夫, 大河内信弘
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Extended right hepatectomy with portal vein resection and reconstruction used by renal vein graft prior to hepatic dissection for hilar cholangiocarcinoma.2009

    • Author(s)
      Koike N, Cho A, Ohshima Y, Arita S, Takeuchi T, Tanaka H, Kawakami M, Ohkohchi N
    • Organizer
      International Surgical Week 2009
    • Place of Presentation
      Adelaide Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] 当院におけるPTCDの実際.2009

    • Author(s)
      小池直人, 大島祐二, 佐藤慎二
    • Organizer
      第45回日本胆道学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivoにおける血管ネットワーク構造を有するヒト高次肝像組織の再構築2009

    • Author(s)
      仲野晶, 藤原綾二, 小池直人, 千葉豊生, 網谷猛, 岡村愛, Dai Fukumura, Rakesh K Jain, 上野康晴, 鄭允文, 谷口英樹
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 異時性両側副腎転移巣の繰り返し切除を行った肝細胞癌の1例.2008

    • Author(s)
      小池直人, 有田誠司, 大島祐二, 川島太一, 武内俊章, 廣橋健太郎, 田中元
    • Organizer
      第8回千葉肝胆膵外科フォーラム
    • Place of Presentation
      千葉
    • Year and Date
      2008-09-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞を用いた治療の臨床応用をめざして移植用組織の人為的創出へ向けた細胞操作技術の開発.2008

    • Author(s)
      谷口英樹
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2009 Final Research Report
  • [Presentation] エコーにて無黄疸で発見された早期肝外胆管癌の一切除例.2008

    • Author(s)
      小池直人, 田中元, 有田誠司, 大島祐二, 川島太一, 武内俊章, 大河内信弘
    • Organizer
      第20回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      山形
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝細胞癌におけるMRI拡散強調画像の意義.2008

    • Author(s)
      小池直人, 長屋重幸, 有田誠司, 田中元, 大島祐二, 川島太一, 武内俊章, 山本盛雄, 大河内信弘
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Hepatic stem cellとcancer stem cell肝臓における組織幹細胞と癌幹細胞(cancer stem cell).2008

    • Author(s)
      谷口英樹
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝細胞癌におけるMRI拡散強調画像の意義2008

    • Author(s)
      小池直人, 長屋重幸, 有田誠司, 田中元, 大島祐二, 川島太一, 武内俊章, 山本盛雄, 大河内信弘
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hepatic stem cellとcancer stem cell 肝臓における組織幹細胞と癌幹細胞(cancer stem cell)2008

    • Author(s)
      谷口英樹
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞を用いた治療の臨床応用をめざして移植用組織の人為的創出へ向けた細胞操作技術の開発2008

    • Author(s)
      谷口英樹
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] 当院におけるダブルバルーン内視鏡の経験.2007

    • Author(s)
      小池直人, 関谷武司, 有田誠司, 大島祐二, 川島太一, 武内俊章, 山本盛雄, 田中元
    • Organizer
      第19回千葉消化管フォーラム
    • Place of Presentation
      千葉
    • Year and Date
      2007-11-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Metallic stentとマイクロウェーブ焼灼術(MCT)により長期生存した肝外胆管癌の一例.2007

    • Author(s)
      小池直人, 有田誠司, 田中元, 大島祐二, 川島太一, 武内俊章, 山本盛夫, 大河内信弘
    • Organizer
      第7回千葉肝胆膵外科フォーラム
    • Place of Presentation
      千葉
    • Year and Date
      2007-10-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Excessive self-renewal of hepatic stem cells derives cancer initiation.2007

    • Author(s)
      Taniguchi H
    • Organizer
      2007 Soon Chun hyang Stem Cell Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2007-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Excessive self-renewal of hepatic stem cells derives cancer initiation2007

    • Author(s)
      Taniguchi H
    • Organizer
      2007 Soon Chun hyang Stem Cell Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵疾患におけるMRI拡散強調画像の意義.2007

    • Author(s)
      小池直人, 有田誠司, 柏原英彦, 大河内信弘
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 主膵管を広汎に進展する粘液産生に乏しい膵管内乳頭粘液性腺癌の1切除例.2007

    • Author(s)
      小池直人, 有田誠司, 井坂直秀, 柏原英彦, 伴慎一, 大河内信弘
    • Organizer
      第20回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] A successfully resected case of intraductal papillary-mucinous carcinoma without mucin secretion widely growing through the main pancreatic duct.2007

    • Author(s)
      Koike N, Arita S, Isaka S, Kashiwabara H, Ban S, Ohkohchi N
    • Organizer
      International Surgical Week 2007
    • Place of Presentation
      Montreal Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト研究用モデル細胞としての幹細胞クローン.2007

    • Author(s)
      谷口英樹
    • Organizer
      第25回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 組織幹細胞と"がん幹細胞".2007

    • Author(s)
      谷口英樹
    • Organizer
      第17回日本サイトメトリー学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Excessive self-renewal of hepatic:stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Taniguchi H
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 膵島創出へ向けた細胞操作技術の開発.2007

    • Author(s)
      谷口英樹, 仲野晶, 岡村愛, 田中順三
    • Organizer
      第34回日本臓器保存生物医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 膵島創出へ向けた細胞操作技術の開発2007

    • Author(s)
      谷口英樹、仲野晶、岡村愛、田中順三
    • Organizer
      第34回日本臓器保存生物医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] Excessive self-renewal of hepatic: stem/progenitor cells drives cancer initiation2007

    • Author(s)
      Taniguchi H
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト研究用モデル細胞としての幹細胞クローン2007

    • Author(s)
      谷口英樹
    • Organizer
      第25回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵幹細胞の可視化による非対称分裂の解析2007

    • Author(s)
      谷口英樹
    • Organizer
      第17回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織幹細胞と"がん幹細胞"2007

    • Author(s)
      谷口英樹
    • Organizer
      第19回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Book] 再生医療工学の技術2007

    • Author(s)
      谷口英樹
    • Total Pages
      251
    • Publisher
      シーエムシー出版
    • Related Report
      2009 Final Research Report
  • [Book] 再生医療工学の技術2007

    • Author(s)
      谷口英樹(分担執筆)
    • Total Pages
      251
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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