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Development of newly immuno-viral therapy incorporated in tumor microenvironment theory for gastrointestinal cancer

Research Project

Project/Area Number 19390341
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionWakayama Medical University

Principal Investigator

YAMAUE Hiroki  Wakayama Medical University, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) NAKAMORI Mikihito  和歌山県立医科大学, 医学部, 講師 (10322372)
IWAHASHI Makoto  和歌山県立医科大学, 医学部, 講師 (70244738)
NAKAMURA Masaki  和歌山県立医科大学, 医学部, 助教 (80364090)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords消化器癌 / 免疫療法 / 腫瘍抗原ペプチド / ウイルス療法 / 実験外科学 / 臨床研究
Research Abstract

Vascular endothelial growth factor receptor 2 (VEGFR2) is an essential factor in tumor angiogenesis and in the growth of pancreatic cancer. Immunotherapy using epitope peptide for VEGFR2 (VEGFR2-169) that we identified previously is expected to improve the clinical outcome. Therefore, a phase I clinical trial combining of VEGFR2-169 with gemcitabine was conducted for patients with advanced pancreatic cancer. Patients with metastatic and unresectable pancreatic cancer were eligible for the trial. In addition, we developed newly oncolytic herpes simplex viruses (HSV). This virus can produce human thrombospondin-1 (TSP-1) and induce apoptosis for human gastric cancer cell lines. In vivo experiments, our virus could suppress tumor angiogenesis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Book (1 results) Remarks (4 results)

  • [Journal Article] I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer.2010

    • Author(s)
      Miyazawa M, Ohsawa R, Tsunoda T, Hirono S, Kawai M, Tani M, Nakamura Y, Yamaue H. Phase
    • Journal Title

      Cancer Sci. 101

      Pages: 433-439

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor2 in combination with gemcitabine for patients with advanced pancreatic cancer2010

    • Author(s)
      Miyazawa M, et al.
    • Journal Title

      Cancer Science 101

      Pages: 433-439

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling2010

    • Author(s)
      Hirono S, et al.
    • Journal Title

      Cancer Science 101

      Pages: 259-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍溶解ウイルスの癌治療への応用2009

    • Author(s)
      中森幹人, 山上裕機
    • Journal Title

      Biotherapy 23

      Pages: 409-415

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] 次世代バイオセラピィの分子標的2008

    • Author(s)
      山上裕機
    • Journal Title

      Biotherapy 22

      Pages: 215-219

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Journal Article] Taxaneの作用機序を標的としたarming oncolytic herpes virusの改良2008

    • Author(s)
      中森幹人
    • Journal Title

      Biotherapy 22

      Pages: 227-232

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tumor vaccine therapy against recrudescent tumor using dendritic cells simulta neously transfected with tumor RNA and granulocyte macrophage colony-stimu latins factor RNA.2008

    • Author(s)
      Nata T, et al.
    • Journal Title

      Cancer Science 99

      Pages: 407-412

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Taxaneの作用機序を標的としたarming oncolytic herpes virus の改良2008

    • Author(s)
      中森幹人
    • Journal Title

      Biotherapy 22

      Pages: 227-232

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Successful cancer vaccine therapy for carcinoembryonic antigen(CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-type 1 cytokines in CEA transgenic mice.2007

    • Author(s)
      Ojima T, et. al.
    • Journal Title

      Int J Cancer 120

      Pages: 585-593

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Adenoviral vector expressing hepatocyte growth factor promotes liver regeneration by preoperative injection:the advantages of performing selective injection to the remnant lobe.2007

    • Author(s)
      Ueno M, et. al.
    • Journal Title

      Surgery 141

      Pages: 511-519

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benefits of gene transduction of granulocyte macrophage colony-stimulating factor in cancer vaccine using genetically modified dendritic cells.2007

    • Author(s)
      Ojima T, et. al.
    • Journal Title

      Int J Oncol 31

      Pages: 931-939

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 膵臓治療戦略-RCT結果に基づいた手術術式の開発と集学的治療2010

    • Author(s)
      山上裕機
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08
    • Related Report
      2009 Final Research Report
  • [Presentation] 膵臓治療戦略-RCT結果に基づいた手術術式の開発と集学的治療2010

    • Author(s)
      山上裕機
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-04-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵臓外科のArtとScience2008

    • Author(s)
      山上裕機
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 譚臓外科のArtとScience2008

    • Author(s)
      山上裕機
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-17
    • Related Report
      2008 Annual Research Report
  • [Book] 飯田橋パピルス分子細胞治療フロンティア2010(分担執筆)2010

    • Author(s)
      山上裕機,宮澤基樹,中森幹人
    • Total Pages
      232
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/2nd-surgery/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/2nd-surgery/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/2nd-surgery/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/2nd-surgery/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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