Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
| Project/Area Number |
19390342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
FUJIMOTO Jiro Hyogo College of Medicine, 医学部, 教授 (90199373)
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| Co-Investigator(Kenkyū-buntansha) |
IIMURO Yuji 兵庫医科大学, 医学部, 准教授 (30252018)
HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968)
OH Koshi 兵庫医科大学, 医学部, 助教 (80340967)
UYAMA Naoki 兵庫医科大学, 医学部, 助教 (70402873)
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 消化管癒着 / 線維化 / HGF / 腸管星細胞 |
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| Research Abstract |
Abdominal adhesion formation is constituted after abdominal surgery, and it may cause abdominal pain, bowel obstruction and infertile. Since the mechanism has been still unclear, we established a unique experimental model of adhesion, and elucidated the related molecules which are inflammatory cytokine, interferon-γ, and fibrolytic factor, plasminogen activator inhibitor-1. Furthermore, we could reduce the adhesion to inhibit these molecules using recombinant hepatocyte growth factor, providing a new way to prevent postoperative adhesions.
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Report
(4 results)
Research Products
(19 results)
