• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion

Research Project

Project/Area Number 19390342
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

FUJIMOTO Jiro  Hyogo College of Medicine, 医学部, 教授 (90199373)

Co-Investigator(Kenkyū-buntansha) IIMURO Yuji  兵庫医科大学, 医学部, 准教授 (30252018)
HIRANO Tadamichi  兵庫医科大学, 医学部, 講師 (90340968)
OH Koshi  兵庫医科大学, 医学部, 助教 (80340967)
UYAMA Naoki  兵庫医科大学, 医学部, 助教 (70402873)
NAKANISHI Kenji  兵庫医科大学, 医学部, 教授 (60172350)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords消化管癒着 / 線維化 / HGF / 腸管星細胞
Research Abstract

Abdominal adhesion formation is constituted after abdominal surgery, and it may cause abdominal pain, bowel obstruction and infertile. Since the mechanism has been still unclear, we established a unique experimental model of adhesion, and elucidated the related molecules which are inflammatory cytokine, interferon-γ, and fibrolytic factor, plasminogen activator inhibitor-1. Furthermore, we could reduce the adhesion to inhibit these molecules using recombinant hepatocyte growth factor, providing a new way to prevent postoperative adhesions.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation Nature Medicine2008

    • Author(s)
      Kosaka H, Fujimoto J, et al.
    • Journal Title

      14

      Pages: 437-441

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-γ is a therapeutic target molecule for prevention of postope rative adhesion formation2008

    • Author(s)
      Kosaka H, Fujimoto J, et al.
    • Journal Title

      Nature Medicine 14

      Pages: 437-441

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腹腔内癒着形成ラットモデルの開発と解析2009

    • Author(s)
      小坂久,藤元治朗
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] HGFを用いた術後癒着予防法の展開2009

    • Author(s)
      小坂久,藤元治朗
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Brand-new prevention method of postoperative adhesion formation used by HGF.2009

    • Author(s)
      Kosaka H, Fujimoto J
    • Organizer
      4^<th> annual academic surgical congress
    • Place of Presentation
      Fort Myers
    • Year and Date
      2009-02-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Brand-new prevention method of postoperative adhesion formation used by HGF2009

    • Author(s)
      Kosaka H, Fujimoto J, et al.
    • Organizer
      4^<th> annual academic surgical congress
    • Place of Presentation
      Fort Myers. USA
    • Year and Date
      2009-02-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of NKT cell-driven IFN-g in postoperative adhesion formation.2008

    • Author(s)
      Kosaka H, Fujimoto J
    • Organizer
      DDW(AGA)
    • Place of Presentation
      San Diego
    • Year and Date
      2008-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of NKT cell-driven IFN-g in postoperative adhesion formation2008

    • Author(s)
      Kosaka H, Fujimoto J, et al.
    • Organizer
      DDW(AGA)
    • Place of Presentation
      San Diego. USA
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 術後癒着形成はIFN-g/STAT1依存性のPAI亢進による2008

    • Author(s)
      小坂久,藤元治朗
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 術後癒着形成はIFN-γ/STAT1依存性の亢進による2008

    • Author(s)
      Kosaka H, Fujimoto J, et al.
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] NKT cell-driven IFN-γ plays an important role in postoperative adhesion formation.2007

    • Author(s)
      Kosaka H, Fujimoto J
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2009 Final Research Report
  • [Presentation] NKT cell-driven IFN-γ plays an important role in postoperative adhesion formation2007

    • Author(s)
      Kosaka, H.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion.2007

    • Author(s)
      Kosaka H, Fujimoto J
    • Organizer
      42nd Congress of the European Society for Surgical Research (ESSR)
    • Place of Presentation
      Rotterdam
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion2007

    • Author(s)
      Kosaka, H.
    • Organizer
      European Society for Surgical Research(ESSR)
    • Place of Presentation
      Rotterdam
    • Year and Date
      2007-05-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新しいマウス腹腔内癒着モデルの確立と癒着形成に関わる免疫学的要因の解析2007

    • Author(s)
      小坂久,藤元治朗
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しいマウス腹腔内癒着モデルの確立と癒着形成に関わる免疫学的要因の解析2007

    • Author(s)
      小坂 久
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-11
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 実験動物の腸管癒着を形成する方法、腸管癒着実験動物の製造方法、腸管癒着抑制剤のスクリーニング方法および腸管癒着抑制剤2008

    • Inventor(s)
      善本知弘,藤元治朗,中西憲司
    • Industrial Property Rights Holder
      JST
    • Filing Date
      2008-02-13
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 実験動物の腸管癒着を形成する方法、腸管癒着実験動物の製造方法、腸管癒着抑制剤のスクリーニング方法および腸管癒着抑制剤2008

    • Inventor(s)
      善本 知弘、藤元 治朗、中西 憲司
    • Industrial Property Rights Holder
      JST
    • Filing Date
      2008-02-13
    • Related Report
      2007 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 実験動物の腸管癒着を形成する方法、腸管癒着実験動物の製造方法、腸管癒着抑制剤のスクリーニング方法および腸管癒着抑制剤2007

    • Inventor(s)
      善本知弘,藤元治朗,中西憲司
    • Industrial Property Rights Holder
      JST
    • Industrial Property Number
      2007-033904
    • Filing Date
      2007-02-14
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi