| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Intraoperative contrast-enhanced ultrasonography revealed the relationship between the dynamic pattern of angiogenesis in hepatocellular carcinoma (HCC) and the cancer cell differentiation. According to the cDNA microarray, the pattern of angiogenesis was closely associated with the expression of Angiopoietin-2, one of the therapeutic targets evaluated in clinical trials for cancers. Along with the angiogenesis, vascular invasion of cancer cells is started and progressed to metastatic steps. Further transcriptional network analysis revealed the closed relationship between the Aurora B pathways and the vascular-invasion phenotype of HCC. Our preclinical studies using the Aurora-targeted agents indicated novel adjuvant therapy for aggressive HCC.
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