Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients

• Project/Area Number: 19390355
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: KAWAKAMI Yutaka Keio University, 医学部, 教授 (50161287)
• Co-Investigator(Kenkyū-buntansha): KITAGAWA Yuukou 慶應義塾大学, 医学部, 教授 (20204878) ; FUJITA Tomonobu 慶應義塾大学, 医学部, 助教 (20199334) ; SAKURAI Toshiharu 慶應義塾大学, 医学部, 助教 (20101933) ; TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117) ; KUDO Chie 慶應義塾大学, 医学部, 助教 (90424126) ; SUMIMOTO Hidetoshi 慶應義塾大学, 医学部, 助教 (00306838)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2007: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 大腸癌 / 免疫療法 / 免疫抑制 / 樹状細胞 / シグナル伝達阻害 / 上皮間葉転換 / 消化器癌 / 膵癌 / 腫瘍抗原 / 癌遺伝子 / RNA干渉

Research Abstract

本研究では、効果的な免疫療法の開発のために、消化器癌による免疫抑制の分子機構の解明と克服法の開発、および免疫療法の標的となるヒト消化器癌抗原の同定を試みた。その結果、発現と良好な予後との相関がみられ、免疫原性の高い腫瘍抗原が同定され、さらに、大腸癌シグナル異常による免疫抑制機構が明らかになり、in vitroおよび大腸癌マウスモデルで、シグナル阻害による免疫抑制の解除と免疫療法の効果増強の可能性が示された。

Research Products

• [Journal Article] Cancer metastasis is accelerated through immunosuppression during EMT of cancer cell (2009)
  • Author(s): Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y.
  • Journal Title: Cancer Cell 16 Pages: 195-206
  • Peer Reviewed
• [Journal Article] Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope. (2009)
  • Author(s): Li Zheyu., Et al.
  • Journal Title: Microbiology and Immunology. (In press)
  • Peer Reviewed
• [Journal Article] Cancer metastasisi is accelerated through immunosuppression during EMT of cancer cell. (2009)
  • Author(s): Kudo-Saito C., et al.
  • Journal Title: Cancer Cell. 16 Pages: 195-206
  • Peer Reviewed
• [Journal Article] A Pilot Study of Human Interferon β Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes (2008)
  • Author(s): Matsumoto K, Kubo H, Murata H, Uhara H, Takata M, Shinichi Shibata S, Yasue S, Sakakibara A, Yasushi TomitaY, Toshiro Kageshita T, Kawakami Y, Mizuno M, Yoshida J and Saida T.
  • Journal Title: Jpn J Clin Oncol 38 Pages: 849-856
  • Peer Reviewed
• [Journal Article] Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope (2008)
  • Author(s): Li Z, Oka Y, Tsuboi A, Fujiki F, Harada Y, Nakajima H, Masuda T, Fukuda Y, Kawakatsu M, Morimoto S, Katagiri T, Tatsumi N, Hosenn N, Shirakata T, Nishida S, Kawakami Y, Udaka K, Kawase I, Oji Y, Sugiyama H.
  • Journal Title: Microbiol Immunol 52 Pages: 551-558
  • Peer Reviewed
• [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6 (2008)
  • Author(s): Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M.
  • Journal Title: Int J Cancer 122 Pages: 2274-2279
  • Peer Reviewed
• [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical studies on cell therapy (2008)
  • Author(s): Ohta S, Ueda Y, Yaguchi M, Matsuzaki Y, Nakamura M, Toyama Y, Tanioka Y, Tamaoki N, Nomura T, Okano H, Kawakami Y, Toda M.
  • Journal Title: Immunol 123 Pages: 566-574
  • Peer Reviewed
• [Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research (2008)
  • Author(s): Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Yaguchi T, Hasegawa G, Hayashi E, Ueda Y, Iwata T, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H.
  • Journal Title: Frontier in Bioscience 13 Pages: 1952-1958
  • Peer Reviewed
• [Journal Article] A Pilot Study of Human Interferon βGene Therapy for Patients with Advanced Melanomaby in vivo Transduction Using Cationic Liposomes. (2008)
  • Author(s): Matsumoto K., et al.
  • Journal Title: Jpn J Clin Oncol. 38 Pages: 849-856
  • Peer Reviewed
• [Journal Article] Improvement of Immunotherapy for Melanoma Based on the Analysis of Antigen Specific T Cells. (2008)
  • Author(s): Kawakami Y., et al.
  • Journal Title: The Proceedings of 5th International Melanoma Research Congress 2008 Pages: 111-115
• [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6. (2008)
  • Author(s): Ueda R., et al.
  • Journal Title: Int J Cancer. 122 Pages: 2274-2279
  • Peer Reviewed
• [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinicalstudies on cell therapy. (2008)
  • Author(s): Ohta S., et al.
  • Journal Title: Immunology 123 Pages: 566-574
  • Peer Reviewed
• [Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research. 13:1952-1958.2008 (2008)
  • Author(s): Kawakami Y., et al.
  • Journal Title: Frontier in Bioscience. 13 Pages: 1952-1958
• [Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research. (2008)
  • Author(s): Kawakami Y, et. al.
  • Journal Title: Frontier in Bioscience 13 Pages: 1952-1958
• [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical studies on cell therapy (2008)
  • Author(s): Ohta S, et. al.
  • Journal Title: Immunol. 123(4) Pages: 566-574
  • Peer Reviewed
• [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen,SOX6. (2008)
  • Author(s): Ueda R, et. al.
  • Journal Title: lnt J Cancer (In press)
  • Peer Reviewed
• [Journal Article] Lentiviral Vector-Mediated RNAi and it's use for Cancer Research (2007)
  • Author(s): Sumimoto H, Kawakami Y.
  • Journal Title: Future Oncology 3 Pages: 655-664
  • Peer Reviewed
• [Journal Article] Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis (2007)
  • Author(s): Hayashi E, Matsuzaki Y, Kurihara S, Hasegawa G, Fujita T, Yaguchi T, Kageshita T, Sano M, Kawakami Y.
  • Journal Title: Clin Cancer Res. 13 Pages: 6267-6274
  • Peer Reviewed
• [Journal Article] Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis (2007)
  • Author(s): Yoshizawa S, Matsuoka K, Inoue N, Takaishi H, Ogata H, Iwao Y, Mukai M, Fujita T, Kawakami Y, Hibi T.
  • Journal Title: Inflamm Bowel Dis.13 Pages: 865-873
  • Peer Reviewed
• [Journal Article] Toda M. Preferential expression and frequent IgG responses of a tumor antigen, SOX5, in glioma patients (2007)
  • Author(s): Ueda R, Yoshida K, Kawase T, Kawakami Y, Toda M.
  • Journal Title: Int J Cancer 120 Pages: 1704-1711
  • Peer Reviewed
• [Journal Article] Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma (2007)
  • Author(s): Inozume T, Mitsui H, Okamoto T, Matsuzaki Y, Kawakami Y, Shibagaki N, Shimada S.
  • Journal Title: J Invest Dermatol 127 Pages: 2818-2822
  • Peer Reviewed
• [Journal Article] Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods (2007)
  • Author(s): Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H, Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, and Kitajima M.
  • Journal Title: Gene Therapy Pages: 240-248
• [Journal Article] Development of individualized immunotherapy based on tha analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods. (2007)
  • Author(s): Kawakami Y, et. al.
  • Journal Title: Gene Therapy Pages: 240-248
• [Journal Article] Preferential expression and frequent IgG responses of a tumor antigen,SOX5,in glioma patients. (2007)
  • Author(s): Ueda R, et. al.
  • Journal Title: lnt J Cancer 120 Pages: 1704-1711
  • Peer Reviewed
• [Journal Article] Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis. (2007)
  • Author(s): Yoshizawa S, et. al.
  • Journal Title: Inflamm Bowel Dis 13 Pages: 865-873
  • Peer Reviewed
• [Journal Article] Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis. (2007)
  • Author(s): Hayashi E, et. al.
  • Journal Title: Clin Cancer Res. 13 Pages: 6267-6274
  • Peer Reviewed
• [Journal Article] Lentiviral Vector-Mediated RNAi and it's use for Cancer Research. (2007)
  • Author(s): Sumimoto H, et. al.
  • Journal Title: Future Oncology 3 Pages: 655-664
  • Peer Reviewed
• [Presentation] 消化器癌に対する樹状細胞を腫瘍内投与による免疫療法の第I相臨床試験 (2008)
  • Author(s): 藤田知信、田邉稔、北川雄光、石田明、桜井敏晴、半田誠、北島政樹、河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明 (2008)
  • Author(s): 谷口智憲、木藤健治、塚本信夫、桜井敏晴、藤田知信、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 消化器癌に対する樹状細胞を腫瘍内投与による免疫療法の第1相臨床試験 (2008)
  • Author(s): 藤田知信, 田邉稔, 北川雄光, 石田明, 桜井敏晴, 半田誠, 北島政樹, 河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-02
• [Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明 (2008)
  • Author(s): 谷口智憲, 木藤健治, 塚本信夫, 桜井敏晴, 藤田知信, 持丸博史, 丸山正太郎, 里見良輔, 井田陽介, 住本秀敏, 河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-02
• [Presentation] 上皮-間葉転換期にある癌細胞から高産生されるIL-13を介した樹状細胞の機能阻害 (2008)
  • Author(s): 工藤千恵、河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 上皮-間葉転換期にある癌細胞から高産生されるIL-13を介した樹状細胞の機能阻害 (2008)
  • Author(s): 工藤千恵, 河上裕
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-01
• [Presentation] Application of tumor cryoablation in the development of cancer immunorherapy (2008)
  • Author(s): Kawakami Y
  • Organizer: 第35回日本低温医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-23
• [Presentation] Application of tumor cryoablation in the development of cancer immunorherapy. (2008)
  • Author(s): Kawakami Y
  • Organizer: 第35回日本低温医学会総会
  • Place of Presentation: Mori Tower 49F
  • Year and Date: 2008-11-23
• [Presentation] Molecular mechanisms for generation of immunosuppressive microenvironment by cancer cells (2008)
  • Author(s): Kawakami Y
  • Organizer: International Society for Biological Therapy of Cancer
  • Place of Presentation: CA(USA)
  • Year and Date: 2008-11-01
• [Presentation] Molecular mechanisms for generation ofo immunosuppressive microenviroment by cancercells (2008)
  • Author(s): Kawakami Y.
  • Organizer: International Society for Biological Therapy of Cancer
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2008-11-01
• [Presentation] 大腸癌新規診断マーカーとしてのKU-CR4の同定 (2008)
  • Author(s): 塚本信夫、寺本華菜、岡田勉、大浪陽子、井田陽介、河上裕
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 上皮-間葉転換期にある癌細胞が転移能獲得と共に誘導する免疫抑制ならびにその制御 (2008)
  • Author(s): 工藤千恵、河上裕
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 癌細胞の転移と抗腫瘍免疫回避に密接に関与する内因性レトロウィルス抗原の発現 (2008)
  • Author(s): 山本隆介、由良昌大、河上裕、工藤千恵
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 培養樹状細胞を用いた免疫療法 (2008)
  • Author(s): 河上裕、住本秀敏、工藤千恵、塚本信夫、藤田知信、桜井敏晴、谷口智憲、岩田知子、川村直
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 大腸癌新規診断マーカーとしてのKU-CR4の同定 (2008)
  • Author(s): 塚本信夫, 寺本華菜, 岡田勉, 大浪陽子, 井田陽介, 河上裕
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 上皮-間葉転換期にある癌細胞が転移能獲得と共に誘導する免疫抑制ならびにその制御 (2008)
  • Author(s): 工藤千恵, 河上裕
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 癌細胞の転移と抗腫瘍免疫回避に密接に関与する内因性レトロウイルス抗原の発現 (2008)
  • Author(s): 山本隆介, 由良昌大, 河上裕, 工藤千恵
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 培養樹状細胞を用いた免疫療法 (2008)
  • Author(s): 河上裕, 住本秀敏, 工藤千恵, 塚本信夫, 藤田知信, 桜井敏晴, 谷口智憲, 岩田知子, 川村直
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] 胃癌細胞株の幹細胞におけるMyeloid cell Leukemia-l(Mcl-l)蛋白阻害によるアポトーシス増強作用の検討 (2008)
  • Author(s): 飯塚秀子, 樋口肇, 住本秀敏, 樺島彩乃, 酒井元, 泉谷幹子, 山岸由幸, 高石官均, 河上裕, 水口裕之, 日比紀之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] Immunotherapy by intratumoral administration of dendritic cells following cryoablative tumor treatment (2008)
  • Author(s): 河上裕
  • Organizer: 第36回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] Immunotherapy by intratumoral administration of BCG-CWS treated DC following cryoablative tumor pretreatment (2008)
  • Author(s): Kawakami Y
  • Organizer: 10^<th> International Symposium on Dendritic Cells
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-03
• [Presentation] Session 4-1 & 4-2 腫瘍における樹状細胞と細胞間相互作用(I & II)Immunotherapy by intratumoral administration of BCG-CWS treated DC following cryoablative tumor pretreatment. (2008)
  • Author(s): Kawakami Y.
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-10-03
• [Presentation] Tumor Immunotherapy (2008)
  • Author(s): Kawakami Y
  • Organizer: 国際シンポジウム生体の「事態」をめぐって「生命の維持、破綻と再生、免疫・移植・癌・感染・幹細胞」
  • Place of Presentation: 東京
  • Year and Date: 2008-09-20
• [Presentation] 生体の「事態」をめぐって。「生命の維持、破綻と再生……免疫・移植・癌・感染・幹細胞」Tumor Immunotherapy (2008)
  • Author(s): 河上裕
  • Organizer: 東京理科大学生命科学研究所設立20周年記念シンポジウム
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-09-20
• [Presentation] Cancer metastasis is accelerated through immunosuppression during epithelialmesenchymal transition of cancer cells (2008)
  • Author(s): 工藤千恵、竹内直志、河上裕
  • Organizer: 第12回基盤的癌免疫研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-07-03
• [Presentation] より有効な細胞障害性T細胞誘導を目指して (2008)
  • Author(s): 河上裕
  • Organizer: 第32回日本リンパ学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-07
• [Presentation] より有効な細胞障害性T細胞誘導を目指して (2008)
  • Author(s): 河上裕
  • Organizer: 第32回日本リンパ学会総会
  • Place of Presentation: 東京サピアタワー
  • Year and Date: 2008-06-07
• [Presentation] Identification of a novel cancer-testis antigen calreticulin2(CRT2)frequently expressed inmelanoma (2008)
  • Author(s): Yaguchi T, Hayashi E, Hasegawa G, Fujita T, Kageshita T, Sano M, Matsuzaki Y, Kawakami Y.
  • Organizer: 20th International Pigment Cell Conference & 5th International Melanoma Research Congress
  • Place of Presentation: Royton Sapporo(Japan)
  • Year and Date: 2008-05-10
• [Presentation] Immunosuppressive mechanisms induced by tumor cells during epithelial-mesenchymal transition leading to tumor metastasis (2008)
  • Author(s): Kudo-Saito C, Shirako H, Kawakami Y
  • Organizer: 99^<th> Annual Meeting of American Association for Cancer Research
  • Place of Presentation: CA(USA)
  • Year and Date: 2008-04-14
• [Presentation] Use of RNA interference for analysis of anti-cancer immune responses and development of immunotherapy (2008)
  • Author(s): Kawakami Y
  • Organizer: The Avison Biomedical Symposium
  • Place of Presentation: Seoul(Korea)
  • Year and Date: 2008-01-17
• [Presentation] Molecular mechanisms for generation of immunosuppressive microenvironment by cancer cells (2007)
  • Author(s): Kawakami Y, Hidetoshi Sumimoto, Chie Kudo, Tomonori Yaguchi
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] ホルマリン加工したHSVアジュバントのミエロイド・サプレッサー細胞の蓄積抑制による抗腫瘍効果 (2007)
  • Author(s): Ohkusu-Tsukada K, Ohta S, Kawakami Y, Masahiro Toda
  • Organizer: 第37回日本免疫学会総
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Induction of FoxP3(+)regulatory T cells by colon cancer cells during epithelial-mesenchymal transition (2007)
  • Author(s): Kudo C, Oike M, Kawakami Y
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Possible mechanism of metastasis enhancement of tumors during epithelial-mesenchymal transition by mediating via immunosuppression involving regulatory T cells (2007)
  • Author(s): Takeuchi T, Kudo C, Kawakami Y
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] 癌細胞におけるimmunoglobulin-like transcript 7 (ILT7) リガンドの発現と免疫抑制 (2007)
  • Author(s): Tsukamoto N, Okada S, Sasaki Y, Kawakami Y
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Molecular mechanisms for generation of immunosuppressive microenvironment by cancer cells. (2007)
  • Author(s): Kawakami Y, et. al.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] Anti-tumor activity through the inhibition of the tumor-associated myeloid suppressor cell-accumulation by formalin-processed. (2007)
  • Author(s): Ohkusu-Tsukada K, et. al.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] Induction of FoxP3(+)regulatory T cells by colon cancer cells during epithelial-mesenchymal transition. (2007)
  • Author(s): Kudo C, et. al.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] Possible immunosuppression by ligands for immunoglobulin-like transcript 7(ILT7) (2007)
  • Author(s): Tsukamoto N, et. al.
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] Possible inhibition of TLR signaling by PI3K through preventing PIP2- associated TIRAP recruitment to plasma cell membrane in human dendritic cells (2007)
  • Author(s): Sumimoto H, Takahashi T, Kawakami Y
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Immunotherapy by Intra-tumoral Administration of Dendritic Cells Following Cryoablative Tumor Treatment (2007)
  • Author(s): Kawakami Y
  • Organizer: 14th World congress of cryosurgery, International society of cryosurgery
  • Place of Presentation: Beijing(China)
  • Year and Date: 2007-11-05
• [Presentation] Immunotherapy by Intra-tumoral Administration of Dendritic Cells Following Cryoablative Tumor Treatment (2007)
  • Author(s): Kawakami Y, et. al.
  • Organizer: 14^<th> World Congress of cryosurgery International society of cryosurgery
  • Place of Presentation: State Guest Hotel Presidential Plaza(Beijing)
  • Year and Date: 2007-11-05
• [Presentation] がん免疫療法の現状と展望 (2007)
  • Author(s): 河上裕
  • Organizer: 第12回北九州がんセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2007-11-02
• [Presentation] がん免疫療法の現状と展望 (2007)
  • Author(s): 河上 裕
  • Organizer: 第12回北九州がんセミナー
  • Place of Presentation: リーガロイヤルホテル小倉
  • Year and Date: 2007-11-02
• [Presentation] がん免疫療法の臨床試験実施における諸問題 (2007)
  • Author(s): 河上裕
  • Organizer: 第45回日本癌治療学会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-24
• [Presentation] Immunotherapy by intratumoral administration of dendritic cells (2007)
  • Author(s): Kawakami Y, Fujita T, Kudo C, Udagawa M, Sakurai T, Ueda Y, Yaguchi T, Sumimoto H
  • Organizer: 第66回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Immunosuppressive mechanisms induced by tumor cells during epithelial-mesenchymal transition (2007)
  • Author(s): Kudo C, Shirako H, Oike M, Tsukamoto N, Kawakami Y
  • Organizer: 第66回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] BORIS is a possible marker for poor prognosis with distant metastasis in patients with colorectal cancer (2007)
  • Author(s): Fujita T, Hirao N, Okada T, Tsukamoto N, Okabayashi K, Kitagawa Y, Kitajima M, Kawakami Y
  • Organizer: 第66回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Immunotherapy by inntratumoral administration of dendritic cells (2007)
  • Author(s): Kawakami Y, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] Immunosuppressive mechanisms induced by tumor cells during epithelial-mesenchymal transition. (2007)
  • Author(s): Kudo C, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] BORIS is a possible marker for poor proenosis with distant metastasis in patients with colorectal cancer (2007)
  • Author(s): Fujita T, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] がんに対する免疫応答と免疫療法 (2007)
  • Author(s): 河上裕
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-03
• [Presentation] 癌シグナル伝達異常による癌免疫逃避機構の解析 (2007)
  • Author(s): 谷口智憲、木藤健治、丸山正太郎、住本秀敏、河上裕
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-03
• [Presentation] Immunoglobulin-like transcript 7(ILT7)リガンドの癌細胞株における発現 (2007)
  • Author(s): 塚本信夫、Okada S、佐々木雄亮、河上裕
  • Organizer: 第11回基盤的癌免疫研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-11
• [Presentation] Clinical significance of serum p53 antibodies in patients with ulcerative colitis (2007)
  • Author(s): Yoshizawa S, Matsuoka K, Inoue N, Takaishi H, Ogata H, Iwao Y, Mukai M, Fujita T, Kawakami Y, Hibi T
  • Organizer: 13^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-07-11
• [Presentation] TGF-beta induces invasion and epithelial to mesenchymal transition in side-population cella from pancreatic cancer (2007)
  • Author(s): Kabashima A, et. al.
  • Organizer: 13^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Annex Tower,Shinagawa Prince Hotel
  • Year and Date: 2007-07-11
• [Presentation] Clinical significance of serum p53 antibodies in patients with ulcerative colitis. (2007)
  • Author(s): Yoshizawa S, et. al.
  • Organizer: 13^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Annex Tbwer,Shinagawa Prince Hotel
  • Year and Date: 2007-07-11
• [Presentation] Enhancement of Human Monocyte-Derived Dendritic Cell Functions by Adenovirus-Mediated RNA Interference of STAT-3 (2007)
  • Author(s): Iwata T, Sumimoto H, Mizuguchi H, Kawakami Y
  • Organizer: 第13回日本遺伝子治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-29
• [Presentation] Enhancement of Human Moncyte-Derived Dendritic Cell Functions by Adenovirus-Mediated RNA Interference of STAT-3 (2007)
  • Author(s): Iwata T, et. al.
  • Organizer: 第13回日本遺伝子治療学会
  • Place of Presentation: 愛知がんセンター
  • Year and Date: 2007-06-29
• [Presentation] Immunotherapy and gene therapy using viral vectors (2007)
  • Author(s): Kawakami Y, Udagawa M , Kido K, Yaguchi T, Toda M, Kudo C, Sumimoto H
  • Organizer: 第13回日本遺伝子治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-28
• [Presentation] テーラーメイド医療と免疫治療 (2007)
  • Author(s): 河上裕
  • Organizer: 第27回日本医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-08
• [Presentation] 癌免疫療法 : 固形癌に対するT細胞・樹状細胞療法 (2007)
  • Author(s): 河上裕
  • Organizer: 第104回日本内科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-05
• [Presentation] Immunoglobulin-like transcript 7 (ILT7)リガンドの癌細胞株における発現 (2007)
  • Author(s): 塚本 信夫, その他
  • Organizer: 第11回基盤的癌免疫研究会
  • Place of Presentation: 東京大学・鉄門講堂
  • Year and Date: 2007-01-11
• [Book] Chapter 13. The RNA silencing technology applied by lentiviral vectors in oncology. Lentivirus Gene Engineering Protocols, the 2^<nd> edition (2009)
  • Author(s): Sumimoto H, Kawakami Y.
  • Publisher: Human Press(in press)
• [Book] The RNA silencing technology applied by lentiviral vectors in oncology, in "Lentivirus Gene Engineering Protocols book the second edition"Humana Press
  • Author(s): Sumimoto H, and Kawakami Y.
  • Publisher: Totowa, NJ.(in press)
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/admedres/index-jp.html
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤千恵、河上裕
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
• [Patent(Industrial Property Rights)] がんの診断方法と治療方法 (2008)
  • Inventor(s): 工藤千恵、河上裕
  • Industrial Property Rights Holder: 慶應義塾
  • Industrial Property Number: 2008-239943
  • Filing Date: 2008-09-18
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
  • Overseas
• [Patent(Industrial Property Rights)] がんの診断方法と治療方法 (2008)
  • Inventor(s): 工藤千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Industrial Property Number: 2008-239943
  • Filing Date: 2008-09-18