Tissue engineered allograft tissue to prevent contamination
| Project/Area Number |
19390360
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MOTOMURA Noboru The University of Tokyo, 医学部附属病院, 講師 (40332580)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Arata 東京大学, 医学部附属病院 (70190874)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 心臓大血管外科学 / 移植・再生医療 / 細胞・組織 / 微生物 / 放射線 / 外科 |
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| Research Abstract |
Disinfection of cardiovascular tissues, like cardiac valve or vessels, by using radiation of gamma radiation was tried. Gamma radiation of 2kGy or 4kGy was applied to MRSA suspensions, resulting in no MRSA was detected. Then X-ray was used because X-ray is easier than gamma radiation in the usual hospitals. MRSA could be reduced with 100Gy of X-ray, and MRSA could be reduced in 16% by 400Gy of X-radiation. At 400Gy X-radiation, growth of cultured smooth muscle cells was not deteriorated.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Vascular Allografts are Resistant to Methicillin-resistant Staphylococcus aureus via Indoleamine 2,3-Dioxygenase in Murine Model2008
Author(s)
Saito A, Motomura N, Kakimi K, Narui K, Noguchi N, Sasatsu M, Kubo K, Koezuka Y, Takai D, Ueha S, Takamoto S.
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Journal Title
J Thorac Cardiovasc Surg. 136
Pages: 159-67
Related Report
Peer Reviewed
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