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Tissue engineered allograft tissue to prevent contamination

Research Project

Project/Area Number 19390360
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

MOTOMURA Noboru  The University of Tokyo, 医学部附属病院, 講師 (40332580)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Arata  東京大学, 医学部附属病院 (70190874)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords心臓大血管外科学 / 移植・再生医療 / 細胞・組織 / 微生物 / 放射線 / 外科
Research Abstract

Disinfection of cardiovascular tissues, like cardiac valve or vessels, by using radiation of gamma radiation was tried. Gamma radiation of 2kGy or 4kGy was applied to MRSA suspensions, resulting in no MRSA was detected. Then X-ray was used because X-ray is easier than gamma radiation in the usual hospitals. MRSA could be reduced with 100Gy of X-ray, and MRSA could be reduced in 16% by 400Gy of X-radiation. At 400Gy X-radiation, growth of cultured smooth muscle cells was not deteriorated.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2010 2009 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 16 results) Presentation (7 results)

  • [Journal Article] Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway2009

    • Author(s)
      Narui K, Noguchi N, Saito A, Kakimi K, Motomura N, Kubo K, Takamoto S, Sasatsu M.
    • Journal Title

      Biol Pharm Bull 32

      Pages: 41-44

    • NAID

      110007021739

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward quality improvement of thoracic aortic surgery : estimating volume-outcome effect from national clinical database2009

    • Author(s)
      Miyata H, Motomura N. Ueda Y, Tsukihara H, Tabayashi K, Takamoto S.
    • Journal Title

      Eur J Cardiothorac Surg

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 外科における先進医療と高度医療。3. 同種心臓弁・血管移植と先進医療2009

    • Author(s)
      本村昇
    • Journal Title

      外科 71

      Pages: 594-597

    • Related Report
      2009 Final Research Report
  • [Journal Article] Toward quality improvement of thoracic aortic surgery : estimating volume-outcome effect from national clinical database.2009

    • Author(s)
      Miyata H, Motomura N, et al
    • Journal Title

      Eur J Cardiothorac Surg 36

      Pages: 517-521

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In early-stage diabetic retinopathy, risk of cardiac events after implantation of sirolimus-eluting stent is higher than after coronary artery bypass surgery.2009

    • Author(s)
      Masuzawa A, Motomura N, et al
    • Journal Title

      J Cardiol 53

      Pages: 86-93

    • NAID

      10025182671

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway2009

    • Author(s)
      Narui K, Motomura N, et al
    • Journal Title

      Bio Pharm Bull 32

      Pages: 41-44

    • NAID

      110007021739

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Risk Model of Thoracic Aortic Surgery in 4707 Cases from Single Race Nationwide Population, via Web-based Data Entry System : a First Report of 30-day and Operative Outcome Risk Model on Thoracic Aortic Surgery2008

    • Author(s)
      Motomura N, Takamoto S, Miyata H, Tsukihara H, Okada M, Kiuchi T, Organization J.
    • Journal Title

      Circulation. 118 (Suppl 1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organization JCSD. Japan Adult Cardiovascular Surgery Database : First Report on 30-day and Operative Mortality Rates in Risk Models of Isolated CABG in Japanese2008

    • Author(s)
      Motomura N, Miyata H, Takamoto S, Okada M
    • Journal Title

      Annals Thorac Surg. 86

      Pages: 1866-72

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular Allografts are Resistant to Methicillin-resistant Staphylococcus aureus via Indoleamine 2,3-Dioxygenase in Murine Model2008

    • Author(s)
      Saito A, Motomura N, Kakimi K, Narui K, Noguchi N, Sasatsu M, Kubo K, Koezuka Y, Takai D, Ueha S, Takamoto S.
    • Journal Title

      J Thorac Cardiovasc Surg. 136

      Pages: 159-67

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Procedural Volume on Outcome of CABG Surgery in Japan : Implication toward minimal volume standards and public reporting2008

    • Author(s)
      Miyata H, Motomura N. Ueda Y, Matsuda H, Takamoto S.
    • Journal Title

      J Thorac Cardiovasc Surg. 135

      Pages: 1306-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic Retinopathy and Coronary Artery Disease. From the Cardiac Surgeon's Perspective2008

    • Author(s)
      Ohno T, Takamoto S, Motomura N.
    • Journal Title

      Annals Thorac Surg. 85

      Pages: 681-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward quality improvement of cardiovascular surgery in Japan : An estimation of regionalization effects from a nationwide survey2008

    • Author(s)
      Miyata H, Motomura N. Kondo J, Fushimi K, Ishikawa B, Takamoto S.
    • Journal Title

      Health Policy

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 循環器疾患のリスク管理2008

    • Author(s)
      宮田裕章, 本村昇, 月原弘之, 高本眞一
    • Journal Title

      心臓手術のリスク管理 呼吸と循環 56

      Pages: 137-142

    • Related Report
      2009 Final Research Report
  • [Journal Article] Risk model of thoracic aortic surgery in 4707 cases from a nationwide single-race population through a web-based data entry system2008

    • Author(s)
      N, Motomura, H, Miyata, S. Takamoto, et al
    • Journal Title

      Circulation 118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First report on 30-dayand operative mortality in risk model of isolated coronary artery bypass grafting in Japan2008

    • Author(s)
      N. Motomura, H. Miyatai S. Takamoto, et al
    • Journal Title

      Annals Thorac Surg 86

      Pages: 1866-1872

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic Retinopathy and coronary artery disease from the cardiac surgeon's perspective2008

    • Author(s)
      T.Ohno, S.Takamoto, N.Motomura
    • Journal Title

      The Annals of Thoracic Surgery 85

      Pages: 681-689

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホモグラフトを用いた大動脈基部置換術と体外循環法2007

    • Author(s)
      本村昇, 久保仁
    • Journal Title

      Clinical Engineering 18

      Pages: 989-996

    • Related Report
      2009 Final Research Report
  • [Journal Article] Improving the quality of Healthcare in Japan:A systematic review of procedural volume and outcome literature2007

    • Author(s)
      H.Miyata, N.Motomura, et. al.
    • Journal Title

      BioScience Trends 2

      Pages: 81-89

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心臓手術の実際。ホモグラフトを用いた大動脈基部置換術と体外循環法2007

    • Author(s)
      本村 昇、久保 仁
    • Journal Title

      Clinical Engineering 18

      Pages: 989-996

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Local delivery of antibiotics incorporated in fibrin glue2010

    • Author(s)
      Motomura N, Saito A, Nawata K, Hisagi M, Kyo S, Ono M.
    • Organizer
      59^<Th> Annual Meeting of European Society for Cardiovascular Surgery
    • Place of Presentation
      Izmir, Turkey
    • Year and Date
      2010-04-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Trend in clinical application of cryopreserved heart valve and vascular allografts2009

    • Author(s)
      Motomura N, Saito A, Tamura S, et al.
    • Organizer
      American Association for Tissue Bank
    • Place of Presentation
      Las Vegas
    • Year and Date
      2009-09-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Trend in clinical application of cryopreserved heart valve and vascular allografts.2009

    • Author(s)
      Motomura N, Saito A, et al
    • Organizer
      Annual Meeting of American Association for Tissue Bank
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Risk Model of Cardiac Valve Surgery from a Single Race Nation wide Population, via Web-based Data Entry System: a First Report of 30-day and 30-day Operative Outcome Risk Model on Value Surgery in Japan2008

    • Author(s)
      N. Motomura, H. Miyata, S. Takamoto,et al
    • Organizer
      QCOR2008
    • Place of Presentation
      Baltimore, U. S. A.
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Future of Adult Cardiac Surgery. Contrbution of the Database2008

    • Author(s)
      N. Motomura, S. Takamoto, et. al.
    • Organizer
      16th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Singapore
    • Year and Date
      2008-03-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical results of valve and vascular allograft for cardiovascular diseases in the University of Tokyo2007

    • Author(s)
      Motomura N, Ono M, Yamauchi H, Masuzawa A, Karimov E, Ohtsubo A, Komiyama E, Takamoto S.
    • Organizer
      44^<th> Annual Meeting of the Society for Cryobiology Lake Louise
    • Place of Presentation
      Canada
    • Year and Date
      2007-07-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Clinical results of valve and vascular allograft for cardiovascular diseases in the University of Tokyo2007

    • Author(s)
      Motomura N, Ono M, Saito A, Yamauchi H, Masuzawa A, Karimov E, Ohtsubo A, Komiyama E, Takamoto S.
    • Organizer
      15^<th> Annual Meeting Asian Society for Cardiovascular Surgery
    • Place of Presentation
      Beijing
    • Year and Date
      2007-05-20
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2025-11-18  

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