Myocardiocyte proliferation by inhibiting p27, a cell-cycle regulator

• Project/Area Number: 19390366
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyushu University
• Principal Investigator: TOMINAGA Ryuji Kyushu University, 医学研究院, 教授 (70136464)
• Co-Investigator(Kenkyū-buntansha): NAKASIMA Atsuhiro 九州大学, 大学病院, 助教 (10260704) ; 江藤 政尚 九州大学, 大学病院, 助教 (20419526) ; 谷口 賢一郎 九州大学, 大学病院, 医員 (60444840)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 心筋細胞増殖 / 再生医療

Research Abstract

臓移植に代わる重症心不全の治療法として、心筋細胞の増殖を起こすことを考えた。通常、成熟した心筋細胞はもはやそれ以上分裂しないことが知られている。今回我々は、細胞分裂の周期をコントロールしているp27 というタンパク質を制御することにより心筋細胞の再分裂、再増殖を促すことを試みた。また、心筋細胞の増殖以外に、心筋細胞内の収縮装置の修復による心機能改善の可能性も見いだした。

Research Products

• [Journal Article] A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation (2008)
  • Author(s): Kobayashi M, Tanoue Y, Eto M, Baba H, Kimura S,Oda S,Taniguchi K,Tominaga R.
  • Journal Title: Jounal of Thorac Cardiovasc Surg. 136(6) Pages: 1586-92
  • Peer Reviewed
• [Journal Article] Role of the cytokine profiles produced by invariant natural killer T cells in the initial phase of cyclophosphamide-induced tolerance (2008)
  • Author(s): Onzuka T, Tomita Y, Shimizu I, Okano S, Yamada H, Yoshikai Y, Tominaga R.
  • Journal Title: Transplantation 86(9) Pages: 1301-10
  • Peer Reviewed
• [Journal Article] Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation (2008)
  • Author(s): Kimura S, Egashira K, Nakano K, Iwata E, Miyagawa M, Tsujimoto H, Hara K, Kawashima Y, Tominaga R, Sunagawa K.
  • Journal Title: Circulation 30 ; 118(14 Suppl)
  • Peer Reviewed
• [Journal Article] Application of cyclophosphamideinduced tolerance in alpha1, 3-galactosyltransferase knockout mice presensitized with Gal alpha 1-3Gal beta-4-GlcNAc antigens (2008)
  • Author(s): Onzuka T, Shimizu I, Tomita Y, Iwai T, Okano S, Tominaga R.
  • Journal Title: Surg Today2008 38(9)
  • Peer Reviewed
• [Journal Article] The immunoregulatory roles of natural killer T cells in cyclophosphamideinduced tolerance (2007)
  • Author(s): Iwai T, Tomita Y, Shimizu I, Kajiwara T, Onzuka T, Okano S, Yasunami Y, Yoshikai Y, Nomoto K, Tominaga R.
  • Journal Title: Transplantation 84(12) Pages: 1686-95
  • Peer Reviewed
• [Journal Article] Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation (2007)
  • Author(s): Tatewaki H, Egashira K, Kimura S, Nishida T, Morita S, Tominaga R.
  • Journal Title: J Vasc Surg. 45(6) Pages: 1236-43
  • Peer Reviewed
• [Journal Article] Effects of cyclosporin A on the activation of natural killer T cells induced by alpha-galactosylceramide (2007)
  • Author(s): Kajiwara T, Tomita Y, Okano S, Iwai T, Yasunami Y, Yoshikai Y, Nomoto K, Yasui H, Tominaga R.
  • Journal Title: Transplantation 83(2) Pages: 184-92
  • Peer Reviewed
• [Journal Article] Efficacy and limitations of natural killer cell depletion in cyclophosphamide-induced tolerance (2007)
  • Author(s): Shimizu I, Tomita Y, Okano S, Iwai T, Kajiwara T, Onzuka T, Tominaga R.
  • Journal Title: SurgToday 37(1)