Molecular Target Therapy associated with EGFR mutation Analysis in Non-Small Cell Lung Cancer
Project/Area Number |
19390367
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Nagoya City University |
Principal Investigator |
FUJII Yoshitaka Nagoya City University, 大学院・医学研究科, 教授 (40156831)
|
Co-Investigator(Kenkyū-buntansha) |
SASAKI Hidefumi 名古屋市立大学, 大学院・医学研究科, 講師 (00336695)
YANO Motoki 名古屋市立大学, 大学院・医学研究科, 准教授 (40315883)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
|
Keywords | 呼吸器外科学 / EGFR / 分子標的 / 肺癌 / R497K / エクソン20 / 遺伝子増幅 / ゲフィチニブ |
Research Abstract |
肺癌におけるEGFR遺伝子変異の検索を進め、exon20の挿入変異はgefitinib抵抗例であった。Exon20、およびexon13のpolymorphismと臨床病理学的因子との相関を検討した。EGFR遺伝子増幅の検討はパラフィン切片を用いてFISHによる解析を行った。
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer2008
Author(s)
Sasaki H, Endo K, Okuda K, Kawano O, Kitahara N, Tanaka H, Matsumura A, Iuchi K, Takada M, Kawahara M, Kawaguchi T, Yukiue H, Yokoyama T, Yano M, Fujii Y
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Journal Title
J Cancer Res Clin Oncol 134(5)
Pages: 569-577
Related Report
Peer Reviewed
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[Journal Article] EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer2008
Author(s)
Sasaki H, Okuda K, Shimizu S, Takada M, Kawahara M, Kitahara N, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Kawano O, Yukiue H, Yano M, Fujii Y
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Journal Title
J Cancer Res Clin Oncol 135(2)
Pages: 313-318
Related Report
Peer Reviewed
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[Journal Article] EGFR exon 20 insertion mutation in Japanese lung cancer2007
Author(s)
Sasaki H, Endo K, Takada M, Kawahara M, Kitahara N, Tanaka H, Okumura M, Matsumura A, Iuchi K, Kawaguchi T, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y
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Journal Title
Lung Cancer 58(3)
Pages: 324-328
Related Report
Peer Reviewed
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