| Project/Area Number |
19390368
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
KANDA Keiichi Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60295649)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAMIZAWA Keiichi 国立循環器病センター研究所, 生体工学部, 室員 (10163312)
OHBA Keikichi 関西大学, 工学部, 教授 (30029186)
TAJIKAWA Tsutomu 関西大学, 工学部, 講師 (80351500)
WATANABE Taiji 京都府立医科大学, 医学研究科, 助教 (20448723)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo |
|---|
| Research Abstract |
We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A tapered silicone mold was covered by a crown-shaped PU sponge scaffold, which was embedded in the subcutaneous space of the Japan white rabbit for 4 weeks. After removal of the silicone mold, tri-leaflet valvular shaped autologous tissues were formed. In the flow circuit, smooth valvular movements were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. The latest model was successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. In vivo tissue engineered "Biovalves" could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.
|
