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Development of autologous tissue heart valves constructed by in vivo tissue engineering.

Research Project

Project/Area Number 19390368
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KANDA Keiichi  Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60295649)

Co-Investigator(Kenkyū-buntansha) TAKAMIZAWA Keiichi  国立循環器病センター研究所, 生体工学部, 室員 (10163312)
OHBA Keikichi  関西大学, 工学部, 教授 (30029186)
TAJIKAWA Tsutomu  関西大学, 工学部, 講師 (80351500)
WATANABE Taiji  京都府立医科大学, 医学研究科, 助教 (20448723)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo
Research Abstract

We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A tapered silicone mold was covered by a crown-shaped PU sponge scaffold, which was embedded in the subcutaneous space of the Japan white rabbit for 4 weeks. After removal of the silicone mold, tri-leaflet valvular shaped autologous tissues were formed. In the flow circuit, smooth valvular movements were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. The latest model was successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. In vivo tissue engineered "Biovalves" could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (86 results)

All 2010 2009 2008 2007 Other

All Journal Article (28 results) (of which Peer Reviewed: 15 results) Presentation (55 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology: a pilot study in pulmonary valve replacement in a beagle model.2010

    • Author(s)
      Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y.
    • Journal Title

      Circulation (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve).2010

    • Author(s)
      Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Artif Organs (in press)

    • NAID

      10027706030

    • Related Report
      2009 Final Research Report
  • [Journal Article] Autologous small-caliber "biotube" vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits.2010

    • Author(s)
      Watanabe T, Kanda K, Ishibashi-Ueda H, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. 92(1)

      Pages: 236-242

    • Related Report
      2009 Final Research Report
  • [Journal Article] 3-Tesla magnetic resonance angiographic assessment of a tissue-engineered small-caliber vascular graft implanted in a rat.2010

    • Author(s)
      Yamanami M, Yamamoto A, Iida H, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 92(1)

      Pages: 156-160

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology : a pilot study in pulmonary valve replacement in a beagle model.2010

    • Author(s)
      Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
    • Journal Title

      Circulation. Jul ; 86(1)(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve).2010

    • Author(s)
      Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H, Nakavama Y
    • Journal Title

      J Artif Organs Mar6(印刷中)

    • NAID

      10027706030

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous small-caliber "biotube" vascular grafts with argatroban loading : a histomorphological examination after implantation to rabbits.2010

    • Author(s)
      Watanabe T, Kanda K, Ishibashi-Ueda H, Yaku H, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater Jan ; 92(1)

      Pages: 236-242

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3-Tesla magnetic resonance angiographic assessment of a tissue-engineered small-caliber vascular graft implanted in a rat.2010

    • Author(s)
      Yamanami M, Yamamoto A, lida H, Watanabe T, Kanda K, Yaku H, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater Jan ; 92(1)

      Pages: 156-160

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of a completely autologous trileaflet valve-shaped construct by in-body tissue architecture technology.2009

    • Author(s)
      Nakayama Y, Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 91(2)

      Pages: 813-818

    • Related Report
      2009 Final Research Report
  • [Journal Article] In vitro maturation of "biotube" vascular grafts induced by a 2-day pulsatile flow loading.2009

    • Author(s)
      Huang H, Zhou YM, Ishibashi-Ueda H, Takamizawa K, Ando J, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 91(1)

      Pages: 320-328

    • Related Report
      2009 Final Research Report
  • [Journal Article] Local elasticity imaging of vascular tissues using a tactile mapping system.2009

    • Author(s)
      Oie T, Murayama Y, Fukuda T, Nagai C, Omata S, Kanda K, Yaku H, Nakayama Y.
    • Journal Title

      J Artif Organs 12(1)

      Pages: 40-46

    • NAID

      10025350678

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Journal Article] Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold.2009

    • Author(s)
      Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 91(1)

      Pages: 412-420

    • Related Report
      2009 Final Research Report
  • [Journal Article] Preparation of a completely autologous trileaflet valve-shaped construct by in-body tissue architecture technology.2009

    • Author(s)
      Nakayama Y, Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H.
    • Journal Title

      J Biomed Mater Res B Appl Biomater Nov ; 91(2)

      Pages: 813-818

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro maturation of "biotube" vascular grafts induced by a 2-day pulsatile flow loading.2009

    • Author(s)
      Huang H, Zhou YM, Ishibashi-Ueda H, Takamizawa K, Ando J, Kanda K, Yaku H, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater Oct ; 91(1)

      Pages: 320-328

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local elasticity imaging of vascular tissues using a tactile mapping system.2009

    • Author(s)
      Oie T, Murayama Y, Fukuda T, Nagai C, Omata S, Kanda K, Yaku H, Nakayama Y
    • Journal Title

      J Artif Organs 12(1)

      Pages: 40-46

    • NAID

      10025350678

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold.2009

    • Author(s)
      Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater Jul ; 90(1)

      Pages: 412-420

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Faster and stronger vascular “Biotube" graft fabrication in vivo using a novel nicotine-containing mold.2009

    • Author(s)
      Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. 90B

      Pages: 412-420

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit "Biovalve".2008

    • Author(s)
      Hayashida K, Kanda K, Oie T, Okamoto Y, Ishibashi-Ueda H, Onoyama M, Tajikawa T, Ohba K, Yaku H, Nakayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 86(1)

      Pages: 1-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit “Biovalve".2008

    • Author(s)
      Hayashida K. Kanda K, OieT, Okamoto Y, Ishibashi-Ueda H, Onoyama M, Tajikawa T, Ohba K, Yaku H, N akayama Y.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. Jul ; 86(1)

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an in vivo tissue-engineered, autologous heart valve (the biovalve): preparation of a prototype model.2007

    • Author(s)
      K Hayashida, K Kanda, H Yaku, J Ando, Y Nakayama.
    • Journal Title

      J Thorac Cardiovasc Surg 134(1)

      Pages: 152-159

    • NAID

      120000973709

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo.2007

    • Author(s)
      O Sakai, K Kanda, H Ishibashi-Ueda, K Takamizawa, A Ametani, H Yaku, Y Nakayama.
    • Journal Title

      J Biomed Mater Res B Appl Biomater 83(1)

      Pages: 240-247

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of biotube vascular grafts incorporating cuffs for easy implantation.2007

    • Author(s)
      T Watanabe, K Kanda, H Ishibashi-Ueda, H Yaku, Y Nakayama
    • Journal Title

      J Artif Organs 10(1)

      Pages: 10-15

    • NAID

      10018907595

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of an in vivo tissue-engineered, autologous heart valve(the biovalve): preparation of a prototype model.2007

    • Author(s)
      K Hayashida, K Kanda, H Yaku, J Ando, Y Nakayama
    • Journal Title

      J Thorac Cardiovasc Surg. Jul;134(1)

      Pages: 152-9

    • NAID

      120000973709

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "In Vivo Tissue-Engineered" Valved Conduit with Designed Molds and Laser Processed Scaffold2007

    • Author(s)
      K Hayashida, K Kanda, T Oie, Y Okamoto, S Sakai, T Watanebe, H Ishibashi-Ueda, H Yaku, Y Nakayama
    • Journal Title

      J. Cardiovascular Nursing 23(1)

      Pages: 61-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo.2007

    • Author(s)
      O Sakai, K Kanda, H Ishibashi-Ueda, K Takamizawa, A Ametani, H Yaku, Y Nakayama
    • Journal Title

      J Biomed Mater Res B Appl Biomater. Oct;83(1)

      Pages: 240-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of biotube vascular grafts incorporating cuffs for easy implantation. J Artif Organs. 2007;10(1):10-5. Epub 2007 Mar 23.2007

    • Author(s)
      T Watanabe, K Kanda, H Ishibashi-Ueda, H Yaku, Y Nakayama
    • Journal Title

      J Artif Organs. 10(1):

      Pages: 10-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit "Biovalve"2007

    • Author(s)
      K Hayashida, K Kanda, T Oie, Y Okamoto, H shibashi-Ueda, M Onoyama, T Tajikawa, K Ohba, H Yaku, Y Nakayama.
    • Journal Title

      J Biomed Mater Res B Appl Biomater. Dec 12.(電子出版)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "In Vivo Tissue-Engineered" Valved Conduit with Designed Molds and Laser Processed Scaffold.

    • Author(s)
      K Hayashida, K Kanda, T Oie, Y Okamoto, S Sakai, T Watanebe, H Ishibashi-Ueda, H Yaku, Y Nakayama.
    • Journal Title

      J. Cardiovascular Nursing 23(1)

      Pages: 61-66

    • Related Report
      2009 Final Research Report
  • [Presentation] 生体内組織形成技術による小口径代用血管(Biotube)の開発:ラット移植後の早期自己化2010

    • Author(s)
      山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第40回 日本心臓血管外科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Strategy in Tissue Engineered Valve : Development of Autologous Valved-Conduit with the Sinus of Valsalva (BIOVALVEs)2010

    • Author(s)
      山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第74回 日本循環器病学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Do It Yourself Medicine:患者体内で作成するBiotube代用血管2010

    • Author(s)
      神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 兎頸部へ2年以上移植したBiotube人工血管の再生どの評価2010

    • Author(s)
      渡辺太治、山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオチューブ人工血管-大口径動脈への移植-2010

    • Author(s)
      渡辺太治、山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内組織形成技術によるBiovalve心臓代用弁の開発:ビーグル肺動脈弁移植後の早期自己化2010

    • Author(s)
      山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内組織形成技術によるBiotube小口径代用血管の開発:ラット腹部大動脈移植後の組織学的検討2010

    • Author(s)
      山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鮭皮コラーゲンを用いた生体置換型小口径人工血管の開発:ヘパリン架橋による早期血栓閉塞抑制2010

    • Author(s)
      山南将志、神田圭一、夜久均、中山康秀, 他
    • Organizer
      第9回 日本再生医療学会総会
    • Place of Presentation
      広島
    • Related Report
      2009 Annual Research Report
  • [Presentation] MRIを用いた小口径バイオチューブ人工血管のラット移植後の血流評価2009

    • Author(s)
      山南将志、山本明秀、飯田秀博、渡辺太治、神田圭一、夜久均、中山泰秀
    • Organizer
      第37回 日本血管外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銀ナノ粒子コーティング抗菌性人工血管の開発2009

    • Author(s)
      渡辺太治, 神田圭一, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小口径バイオチューブ人工血管のラット腹部大動脈移植実験2009

    • Author(s)
      山南将志, 神田圭一, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオチューブ人工血管の開発 -Yグラフトの作成-2009

    • Author(s)
      渡辺太治, 神田圭一, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 皮下で簡単にできる生体酷似の心臓弁様組織体:Biovalveの完成型2009

    • Author(s)
      山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオバルブ人工弁の力学的性能評価2009

    • Author(s)
      大家智憲, 神田圭一, 山南将志, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] バルサルバ洞付バイオバルブ人工弁の生体外実験における流体力学的機能の評価2009

    • Author(s)
      矢羽田侑希, 神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀, 他
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内で形成され自家組織のみからなる代用血管Biotubeとその他の循環系代用臓器への応用2009

    • Author(s)
      神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
    • Organizer
      第47回 日本人工臓器学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内組織形性術によるValsalva洞付き心臓弁様組織体(Biovalve)の開発:結合組織のみからなるvalved conduitの作製とビーグル犬への同種肺動脈弁移植実験2009

    • Author(s)
      山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀, 他
    • Organizer
      第62回 日本胸部外科学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] IMPROVEMENT OF AUTOLOGOUS TISSUE HEART VALVES "BIOVALVES" CONSTRUCTED BY A SIMPLE AND SAFE I N VIVO TISSUE ENGINEERING2009

    • Author(s)
      K.Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2009
    • Place of Presentation
      コンピエーニュ(フランス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] DEVELOPMENT OF AUTOLOGOUS TISSUE VASCULAR GRA FTS "BIOTUBES"2009

    • Author(s)
      T Watanabe, K Kanda, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2009
    • Place of Presentation
      コンピエーニュ(フランス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Usefulness of magnetic resonance angiography (MRA) for the non-invasive and reliable evaluation of ultra small-caliber vascular grafts after implantation2009

    • Author(s)
      M Yamanami, T Watanabe, K Kanda, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2009
    • Place of Presentation
      コンピエーニュ(フランス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autoimplantation of small-caliber "biotube" vascular grafts to rats2009

    • Author(s)
      M Yamanami T Watanabe, K Kanda, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2009
    • Place of Presentation
      コンピエーニュ(フランス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Completely Autologous Valved-Conduit With the Sinus of Valsalva (BIOVALVEs) Constructed by in vivo-Tissue Engineering : Successful Pulmonary Valve Replacement in Beagle Model2009

    • Author(s)
      M Yamanami, K Kanda, H Yaku, Y Nakayama
    • Organizer
      American Heart Association : Annual Meeting 2009
    • Place of Presentation
      オーランド(アメリカ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管組織のマトリックスレベルでの液中弾性率マッピング2009

    • Author(s)
      鈴木寿人, 大家智憲, 福田達, 村上嘉延, 尾股定夫, 神田圭一, 中山泰秀
    • Organizer
      第8回 日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 裏打ち構造化バイオチューブの一体形成と自家移植2009

    • Author(s)
      山南将志, 神田圭一, 渡辺太治, 夜久 均, 中山泰秀
    • Organizer
      第8回 日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体内で作るバイオチューブ人工血管 : 進歩と可能性2009

    • Author(s)
      中山泰秀, 神田圭一, 渡辺太治, 山南将志, 夜久均
    • Organizer
      第8回 日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recipient体内で形成される自家結合組織代用弁バイオバルブの変遷2009

    • Author(s)
      神田圭一, 矢羽田侑希, 山南将志, 田地川勉, 大場謙吉, 大家智憲, 根本泰, 植田初江, 林田恭子, 渡辺太治, 夜久均, 中山泰秀
    • Organizer
      第8回 日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] バルサルバ洞付自家組織代用心臓弁(バイオバルブ)の生体内作成と生体外実験による流体力学的機能の評価2009

    • Author(s)
      矢羽田侑希, 田地川勉, 大場謙吉, 山南将志神田圭一, 夜久 均, 大家智憲, 根本泰, 中山泰秀
    • Organizer
      第8回 日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体内咀聴き形成技術を応用した自家組織生体心臓弁の開発2008

    • Author(s)
      神田圭一、林田恭子、小埜山昌輝、田地川勉、大場謙吉、大家智憲、岡本吉弘、根本 泰、植田初江、夜久 均、中山泰秀
    • Organizer
      第7回 日本再生医療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] In vivo組織工学を利用した自己組織化ステント(バイオカバードステント)の移植実験2008

    • Author(s)
      中山泰秀、坂井 修、神田圭一、夜久 均
    • Organizer
      第7回 日本再生医療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] RECENT ADVANCES IN AUTOLOGOUS TISSUE HEART VALVES "BIOVALVES": IMPROVED SCAFFOLDS FOR OPTIMAL TISSUE FORMATION AND VALUVULAR FUNCTIONS.2008

    • Author(s)
      K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      14th World Congress on Heart Disease
    • Place of Presentation
      トロント(カナダ)
    • Related Report
      2009 Final Research Report
  • [Presentation] STRUCTURAL IMPROVEMENT IN AUTOLOGOUS TISSUE HEART VALVES (BIOVALVES) CONSTRUCTED BY SYMPLE IN VIVO TISSUE ENGINEERING.2008

    • Author(s)
      K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs: Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2009 Final Research Report
  • [Presentation] Highlights from the Japanese Society for Artificial Organs. New approach in tissue engineering-A Simple, Safe, Practical and Economical Autologous Tissue Regeneration Technique in vivo-2008

    • Author(s)
      K. Kanda, O. Sakai, K. Hayashida, T. Watanabe, M. Yamanami, M. Onoyama, T. Tajikawa, H. Ishida, Y. Yahata, K. Ohba, T. Ooie, Y. Okamoto, Y. Nemoto, H. Ueda, H. Yaku, Y. Nakayama
    • Organizer
      European Society for Artificial Organs: Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2009 Final Research Report
  • [Presentation] 小口径血管内治療を目的とし、自己組織による良好な内皮化能を持つ新しいカバードステント“Biocovered Stent"の開発2008

    • Author(s)
      坂井修, 神田圭一, 林田恭子, 渡辺太治, 中山泰秀, 夜久均
    • Organizer
      第108回 日本外科学会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本発 人工臓器生体内組織形成術による人工臓器開発の現状と将来性2008

    • Author(s)
      中山泰秀, 神田圭一, 夜久均
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] バイオチューブの口径バリエーション2008

    • Author(s)
      渡辺太治, 神田圭一, 山南将志, 夜久均, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 鋳型の工夫によるバイオバルブの完全自家組織化2008

    • Author(s)
      山南将志, 矢羽田侑希, 神田圭一, 田地川勉, 大場謙吉, 渡辺太治, 夜久均, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体組織臓器の微細精密物性評価技術 血管を例としたタクタイルマツピングシステムによる弾性率分布の測定2008

    • Author(s)
      大家智憲, 村山嘉延, 福田達, 永井千晴, 尾股定夫, 光田圭一, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自家組織心臓代用弁(バイオバルブ)の生体外実験による流体力学的機能の評価2008

    • Author(s)
      矢羽田侑希, 田地川勉, 大場謙吉, 山南将志, 神田圭二, 夜久均, 大家智憲, 根本泰, 植田初江, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 補強のためのscaffoldを持たない代用血管は可能か? 自家結合組織のみからなる小口径BIOTUBE代用血管の開発2008

    • Author(s)
      神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 裏打ち構造化によるバイオチューブ人工血管の形成促進と抗血栓性化2008

    • Author(s)
      山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀
    • Organizer
      第46回 日本人工臓器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己組織カバードステント(バイオカバードステント)の開発2008

    • Author(s)
      中山泰秀, 坂井修, 神田圭一, 夜久均
    • Organizer
      第24回 日本脳神経血管内治療学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] RECENT ADVANCES IN AUTOLOGOUS TISSUE HEART VALVES“BIOVALVES" : IMPROVED SCAFFOLDS FOR OPTIMAL TISSUE FORMATION AND VALUVULAR FUNCTIONS2008

    • Author(s)
      K. Kanda. K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      14th World Congress on Heart Disease
    • Place of Presentation
      トロント(カナダ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] STRUCTURAL IMPROVEMENT IN AUTOLOGOUS TISSUE HEART VALVES (BIOVALVES) CONSTRUCTED BY SYMPLE IN VIVO TISSUE ENGINEERING2008

    • Author(s)
      K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2008 Annual Research Report
  • [Presentation] SUCCESSFUL ENDOLUMINAL IMPLANTAION OF SMALL DIAMETER AUTOLOGOUS TISSUE-COVERED STENTS“BIOCOVERED STENTS"TO THE ANIMALS : RAPID TISSUE REGENERATION IN VIVO.2008

    • Author(s)
      K. Kanda, O Sakai, T Watanabe, M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2008 Annual Research Report
  • [Presentation] BIOTUBES DESIGNED FOR LARGE ANIMALS : AUTO-IMPLANTATION TO THE CAROTID ARTERY OF THE BEAGLE DOGS2008

    • Author(s)
      T Watanabe, K. Kanda. M Yamanami, H Yaku, Y Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Highlights from the Japanese Society for Artificial Organs New approach in tissue engineering-A Simple, Safe, Practical and Economical Autologous Tissue Regeneration Technique in vivo-2008

    • Author(s)
      K. Kanda, O. Sakai, K. Hayashida, T. Watanabe, M. Yamanami, M. Onoyama, T. Tajikawa, H. Ishida, Y. Yahata, K. Ohba, T. Ooie, Y. Okamoto, Y. Nemoto, H. Ueda, H. Yaku, Y. Nakayama
    • Organizer
      European Society for Artificial Organs : Annual Meeting 2008
    • Place of Presentation
      ジュネーブ(スイス)
    • Related Report
      2008 Annual Research Report
  • [Presentation] In vitro performance of autologous prosthetic valved conduits fabricated by in vivo tissue engineering.2007

    • Author(s)
      Hayashida K, Kanda K, Oie T, Okamoto Y, Tajikawa T, Oba K, Yaku H, Nakayama Y.
    • Organizer
      The Society for Heart Valve Disease Fourth Biennial Meeting
    • Place of Presentation
      ニューヨーク
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro hydrodynamic functions of "Biovalves"- Mechanical compatibility before implantation.2007

    • Author(s)
      K Kanda, K Hayashida, M Onoyama, T Tajikawa, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, H Yaku
    • Organizer
      ESAO 2007 XXXIV. (European Society for Artificial Organs)
    • Place of Presentation
      クレムス(オーストリア)
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro performance of autologous prosthetic valved conduits fabricated by in vivo tissue engineering.2007

    • Author(s)
      Hayashida K, Kanda K, Oie T, Okamoto Y, Tajikawa T, Oba K, Yaku H, Nakayama Y.
    • Organizer
      The Society for Heart Valve Disease Fourth Biennial Meeting.
    • Place of Presentation
      NY
    • Related Report
      2007 Annual Research Report
  • [Presentation] In vitro hydrodynamic functions of "Biovalves"-Mechanical compatibility before implantation.2007

    • Author(s)
      K Kanda, K Hayashida, M Onoyama, T Tajikawa, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, H Yaku.
    • Organizer
      ESAO 2007 XXXIV.(European Society for Artificial Organs)
    • Place of Presentation
      KREMS, AUSTRIA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of the autologous tissue-covered stent "Biocovered stent"-Pilot animal implantation experiments.2007

    • Author(s)
      T Watanabe, O Sakai, K Kanda, K Hayashida, H Yaku, Y Nakayama.
    • Organizer
      ESAO 2007 XXXIV.(European Society for Artificial Organs)
    • Place of Presentation
      KREMS, AUSTRIA
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自己組織で覆われた新しいステント"Biocovered Stent"の開発2007

    • Author(s)
      坂井 修、神田圭一、林田恭子、渡辺太治、中山泰秀、夜久 均.
    • Organizer
      第35回日本血管外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自己組織で覆われた新しいカバードステント"Biocovered Stent"の開発2007

    • Author(s)
      坂井 修、神田圭一、林田恭子、中山泰秀、夜久 均
    • Organizer
      第60回日本胸部外科学会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] "in body tissue architecture" technologyを用いた体内で作成したコンデュー付自家組織生体弁バイオバルブのin vitroにおける弁機能評価2007

    • Author(s)
      林田恭子、神田圭一、小埜山昌輝、田地川 勉、大場謙吉、大家智憲、岡本吉弘、根本 泰、夜久 均、中山泰秀
    • Organizer
      第60回日本胸部外科学会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 自己組織で覆われた新しいカバードステント"Biocovered Stent"の生体内留置実験2007

    • Author(s)
      坂井 修、神田圭一、林田恭子、渡辺太治、夜久 均、中山泰秀
    • Organizer
      第45回日本人工臓器学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Book] CIRCULATION Up-to-Date2007

    • Author(s)
      林田恭子、神田圭一、大家智憲、岡本吉弘、根本泰、植田初江、小埜山輝昌、田地川勉、大場謙吉、夜久均、中山泰秀
    • Publisher
      メディカ出版
    • Related Report
      2009 Final Research Report
  • [Book] CIRCULATION Up-to-Date(1881-3585)2巻3号2007

    • Author(s)
      林田恭子、神田圭一、大家智憲、岡本吉弘、根本 泰、植田初江、小埜山輝昌、田地川勉、大場謙吉、夜久均、中山泰秀.
    • Publisher
      メディカ出版
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 人工血管及びその製造方法2010

    • Inventor(s)
      中山泰秀・神田圭一
    • Industrial Property Rights Holder
      中山泰秀・新幹工業株式会社
    • Acquisition Date
      2010-04-02
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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