Development of autologous tissue heart valves constructed by in vivo tissue engineering.

• Project/Area Number: 19390368
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KANDA Keiichi Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60295649)
• Co-Investigator(Kenkyū-buntansha): TAKAMIZAWA Keiichi 国立循環器病センター研究所, 生体工学部, 室員 (10163312) ; OHBA Keikichi 関西大学, 工学部, 教授 (30029186) ; TAJIKAWA Tsutomu 関西大学, 工学部, 講師 (80351500) ; WATANABE Taiji 京都府立医科大学, 医学研究科, 助教 (20448723)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 自家組織 / 心臓生体弁 / 再生医療 / 組織工学 / in vivo

Research Abstract

We have developed the autologous tissue heart valves (Biovalves) constructed by the simple, safe and economical in vivo tissue engineering without any use of specially clean facilities nor complicated procedures. A tapered silicone mold was covered by a crown-shaped PU sponge scaffold, which was embedded in the subcutaneous space of the Japan white rabbit for 4 weeks. After removal of the silicone mold, tri-leaflet valvular shaped autologous tissues were formed. In the flow circuit, smooth valvular movements were observed. Their flow volume pattern was very close to that of native rabbit aortic valves. The latest model was successfully implanted to the pulmonary valves in the allogeneic beagle model as a pilot experiment. In vivo tissue engineered "Biovalves" could be idealistic autologous heart valve prostheses with potentiality replacing the short-coming Homografts.

Research Products

• [Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology: a pilot study in pulmonary valve replacement in a beagle model. (2010)
  • Author(s): Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y.
  • Journal Title: Circulation (in press)
• [Journal Article] Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve). (2010)
  • Author(s): Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H, Nakayama Y.
  • Journal Title: J Artif Organs (in press)
  • NAID: 10027706030
• [Journal Article] Autologous small-caliber "biotube" vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits. (2010)
  • Author(s): Watanabe T, Kanda K, Ishibashi-Ueda H, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater. 92(1) Pages: 236-242
• [Journal Article] 3-Tesla magnetic resonance angiographic assessment of a tissue-engineered small-caliber vascular graft implanted in a rat. (2010)
  • Author(s): Yamanami M, Yamamoto A, Iida H, Watanabe T, Kanda K, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater 92(1) Pages: 156-160
• [Journal Article] Development of a completely autologous valved-conduit with the sinus of valsalva (BIOVALVE) using in-body tissue architecture technology : a pilot study in pulmonary valve replacement in a beagle model. (2010)
  • Author(s): Yamanami M, Yahata Y, Uechi M, Fujiwara M, Ishibashi-Ueda H, Kanda K, Watanabe T, Tajikawa T, Ohba K, Yaku H, Nakayama Y
  • Journal Title: Circulation. Jul ; 86(1)(印刷中)
  • Peer Reviewed
• [Journal Article] Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve). (2010)
  • Author(s): Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H, Nakavama Y
  • Journal Title: J Artif Organs Mar6(印刷中)
  • NAID: 10027706030
  • Peer Reviewed
• [Journal Article] Autologous small-caliber "biotube" vascular grafts with argatroban loading : a histomorphological examination after implantation to rabbits. (2010)
  • Author(s): Watanabe T, Kanda K, Ishibashi-Ueda H, Yaku H, Nakayama Y
  • Journal Title: J Biomed Mater Res B Appl Biomater Jan ; 92(1) Pages: 236-242
  • Peer Reviewed
• [Journal Article] 3-Tesla magnetic resonance angiographic assessment of a tissue-engineered small-caliber vascular graft implanted in a rat. (2010)
  • Author(s): Yamanami M, Yamamoto A, lida H, Watanabe T, Kanda K, Yaku H, Nakayama Y
  • Journal Title: J Biomed Mater Res B Appl Biomater Jan ; 92(1) Pages: 156-160
  • Peer Reviewed
• [Journal Article] Preparation of a completely autologous trileaflet valve-shaped construct by in-body tissue architecture technology. (2009)
  • Author(s): Nakayama Y, Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H.
  • Journal Title: J Biomed Mater Res B Appl Biomater 91(2) Pages: 813-818
• [Journal Article] In vitro maturation of "biotube" vascular grafts induced by a 2-day pulsatile flow loading. (2009)
  • Author(s): Huang H, Zhou YM, Ishibashi-Ueda H, Takamizawa K, Ando J, Kanda K, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater 91(1) Pages: 320-328
• [Journal Article] Local elasticity imaging of vascular tissues using a tactile mapping system. (2009)
  • Author(s): Oie T, Murayama Y, Fukuda T, Nagai C, Omata S, Kanda K, Yaku H, Nakayama Y.
  • Journal Title: J Artif Organs 12(1) Pages: 40-46
  • NAID: 10025350678
• [Journal Article] Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold. (2009)
  • Author(s): Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater 91(1) Pages: 412-420
• [Journal Article] Preparation of a completely autologous trileaflet valve-shaped construct by in-body tissue architecture technology. (2009)
  • Author(s): Nakayama Y, Yamanami M, Yahata Y, Tajikawa T, Ohba K, Watanabe T, Kanda K, Yaku H.
  • Journal Title: J Biomed Mater Res B Appl Biomater Nov ; 91(2) Pages: 813-818
  • Peer Reviewed
• [Journal Article] In vitro maturation of "biotube" vascular grafts induced by a 2-day pulsatile flow loading. (2009)
  • Author(s): Huang H, Zhou YM, Ishibashi-Ueda H, Takamizawa K, Ando J, Kanda K, Yaku H, Nakayama Y
  • Journal Title: J Biomed Mater Res B Appl Biomater Oct ; 91(1) Pages: 320-328
  • Peer Reviewed
• [Journal Article] Local elasticity imaging of vascular tissues using a tactile mapping system. (2009)
  • Author(s): Oie T, Murayama Y, Fukuda T, Nagai C, Omata S, Kanda K, Yaku H, Nakayama Y
  • Journal Title: J Artif Organs 12(1) Pages: 40-46
  • NAID: 10025350678
  • Peer Reviewed
• [Journal Article] Faster and stronger vascular "Biotube" graft fabrication in vivo using a novel nicotine-containing mold. (2009)
  • Author(s): Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y
  • Journal Title: J Biomed Mater Res B Appl Biomater Jul ; 90(1) Pages: 412-420
  • Peer Reviewed
• [Journal Article] Faster and stronger vascular “Biotube" graft fabrication in vivo using a novel nicotine-containing mold. (2009)
  • Author(s): Sakai O, Kanda K, Takamizawa K, Sato T, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater. 90B Pages: 412-420
  • Peer Reviewed
• [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit "Biovalve". (2008)
  • Author(s): Hayashida K, Kanda K, Oie T, Okamoto Y, Ishibashi-Ueda H, Onoyama M, Tajikawa T, Ohba K, Yaku H, Nakayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater 86(1) Pages: 1-8
• [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit “Biovalve". (2008)
  • Author(s): Hayashida K. Kanda K, OieT, Okamoto Y, Ishibashi-Ueda H, Onoyama M, Tajikawa T, Ohba K, Yaku H, N akayama Y.
  • Journal Title: J Biomed Mater Res B Appl Biomater. Jul ; 86(1) Pages: 1-8
  • Peer Reviewed
• [Journal Article] Development of an in vivo tissue-engineered, autologous heart valve (the biovalve): preparation of a prototype model. (2007)
  • Author(s): K Hayashida, K Kanda, H Yaku, J Ando, Y Nakayama.
  • Journal Title: J Thorac Cardiovasc Surg 134(1) Pages: 152-159
  • NAID: 120000973709
• [Journal Article] Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo. (2007)
  • Author(s): O Sakai, K Kanda, H Ishibashi-Ueda, K Takamizawa, A Ametani, H Yaku, Y Nakayama.
  • Journal Title: J Biomed Mater Res B Appl Biomater 83(1) Pages: 240-247
• [Journal Article] Development of biotube vascular grafts incorporating cuffs for easy implantation. (2007)
  • Author(s): T Watanabe, K Kanda, H Ishibashi-Ueda, H Yaku, Y Nakayama
  • Journal Title: J Artif Organs 10(1) Pages: 10-15
  • NAID: 10018907595
• [Journal Article] Development of an in vivo tissue-engineered, autologous heart valve(the biovalve): preparation of a prototype model. (2007)
  • Author(s): K Hayashida, K Kanda, H Yaku, J Ando, Y Nakayama
  • Journal Title: J Thorac Cardiovasc Surg. Jul;134(1) Pages: 152-9
  • NAID: 120000973709
  • Peer Reviewed
• [Journal Article] "In Vivo Tissue-Engineered" Valved Conduit with Designed Molds and Laser Processed Scaffold (2007)
  • Author(s): K Hayashida, K Kanda, T Oie, Y Okamoto, S Sakai, T Watanebe, H Ishibashi-Ueda, H Yaku, Y Nakayama
  • Journal Title: J. Cardiovascular Nursing 23(1) Pages: 61-66
  • Peer Reviewed
• [Journal Article] Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo. (2007)
  • Author(s): O Sakai, K Kanda, H Ishibashi-Ueda, K Takamizawa, A Ametani, H Yaku, Y Nakayama
  • Journal Title: J Biomed Mater Res B Appl Biomater. Oct;83(1) Pages: 240-7
  • Peer Reviewed
• [Journal Article] Development of biotube vascular grafts incorporating cuffs for easy implantation. J Artif Organs. 2007;10(1):10-5. Epub 2007 Mar 23. (2007)
  • Author(s): T Watanabe, K Kanda, H Ishibashi-Ueda, H Yaku, Y Nakayama
  • Journal Title: J Artif Organs. 10(1): Pages: 10-5
  • Peer Reviewed
• [Journal Article] Architecture of an in vivo-tissue engineered autologous conduit "Biovalve" (2007)
  • Author(s): K Hayashida, K Kanda, T Oie, Y Okamoto, H shibashi-Ueda, M Onoyama, T Tajikawa, K Ohba, H Yaku, Y Nakayama.
  • Journal Title: J Biomed Mater Res B Appl Biomater. Dec 12.(電子出版)
  • Peer Reviewed
• [Journal Article] "In Vivo Tissue-Engineered" Valved Conduit with Designed Molds and Laser Processed Scaffold.
  • Author(s): K Hayashida, K Kanda, T Oie, Y Okamoto, S Sakai, T Watanebe, H Ishibashi-Ueda, H Yaku, Y Nakayama.
  • Journal Title: J. Cardiovascular Nursing 23(1) Pages: 61-66
• [Presentation] 生体内組織形成技術による小口径代用血管(Biotube)の開発:ラット移植後の早期自己化 (2010)
  • Author(s): 山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第40回 日本心臓血管外科学会総会
  • Place of Presentation: 神戸
• [Presentation] New Strategy in Tissue Engineered Valve : Development of Autologous Valved-Conduit with the Sinus of Valsalva (BIOVALVEs) (2010)
  • Author(s): 山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第74回 日本循環器病学会
  • Place of Presentation: 京都
• [Presentation] Do It Yourself Medicine:患者体内で作成するBiotube代用血管 (2010)
  • Author(s): 神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 兎頸部へ2年以上移植したBiotube人工血管の再生どの評価 (2010)
  • Author(s): 渡辺太治、山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] バイオチューブ人工血管-大口径動脈への移植- (2010)
  • Author(s): 渡辺太治、山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 生体内組織形成技術によるBiovalve心臓代用弁の開発:ビーグル肺動脈弁移植後の早期自己化 (2010)
  • Author(s): 山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 生体内組織形成技術によるBiotube小口径代用血管の開発:ラット腹部大動脈移植後の組織学的検討 (2010)
  • Author(s): 山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 鮭皮コラーゲンを用いた生体置換型小口径人工血管の開発:ヘパリン架橋による早期血栓閉塞抑制 (2010)
  • Author(s): 山南将志、神田圭一、夜久均、中山康秀, 他
  • Organizer: 第9回 日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] MRIを用いた小口径バイオチューブ人工血管のラット移植後の血流評価 (2009)
  • Author(s): 山南将志、山本明秀、飯田秀博、渡辺太治、神田圭一、夜久均、中山泰秀
  • Organizer: 第37回 日本血管外科学会
  • Place of Presentation: 名古屋
• [Presentation] 銀ナノ粒子コーティング抗菌性人工血管の開発 (2009)
  • Author(s): 渡辺太治, 神田圭一, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] 小口径バイオチューブ人工血管のラット腹部大動脈移植実験 (2009)
  • Author(s): 山南将志, 神田圭一, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] バイオチューブ人工血管の開発 -Yグラフトの作成- (2009)
  • Author(s): 渡辺太治, 神田圭一, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] 皮下で簡単にできる生体酷似の心臓弁様組織体:Biovalveの完成型 (2009)
  • Author(s): 山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] バイオバルブ人工弁の力学的性能評価 (2009)
  • Author(s): 大家智憲, 神田圭一, 山南将志, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] バルサルバ洞付バイオバルブ人工弁の生体外実験における流体力学的機能の評価 (2009)
  • Author(s): 矢羽田侑希, 神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀, 他
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] 生体内で形成され自家組織のみからなる代用血管Biotubeとその他の循環系代用臓器への応用 (2009)
  • Author(s): 神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
  • Organizer: 第47回 日本人工臓器学会
  • Place of Presentation: 新潟
• [Presentation] 生体内組織形性術によるValsalva洞付き心臓弁様組織体(Biovalve)の開発:結合組織のみからなるvalved conduitの作製とビーグル犬への同種肺動脈弁移植実験 (2009)
  • Author(s): 山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀, 他
  • Organizer: 第62回 日本胸部外科学会
  • Place of Presentation: 横浜
• [Presentation] IMPROVEMENT OF AUTOLOGOUS TISSUE HEART VALVES "BIOVALVES" CONSTRUCTED BY A SIMPLE AND SAFE I N VIVO TISSUE ENGINEERING (2009)
  • Author(s): K.Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2009
  • Place of Presentation: コンピエーニュ(フランス)
• [Presentation] DEVELOPMENT OF AUTOLOGOUS TISSUE VASCULAR GRA FTS "BIOTUBES" (2009)
  • Author(s): T Watanabe, K Kanda, M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2009
  • Place of Presentation: コンピエーニュ(フランス)
• [Presentation] Usefulness of magnetic resonance angiography (MRA) for the non-invasive and reliable evaluation of ultra small-caliber vascular grafts after implantation (2009)
  • Author(s): M Yamanami, T Watanabe, K Kanda, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2009
  • Place of Presentation: コンピエーニュ(フランス)
• [Presentation] Autoimplantation of small-caliber "biotube" vascular grafts to rats (2009)
  • Author(s): M Yamanami T Watanabe, K Kanda, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2009
  • Place of Presentation: コンピエーニュ(フランス)
• [Presentation] Completely Autologous Valved-Conduit With the Sinus of Valsalva (BIOVALVEs) Constructed by in vivo-Tissue Engineering : Successful Pulmonary Valve Replacement in Beagle Model (2009)
  • Author(s): M Yamanami, K Kanda, H Yaku, Y Nakayama
  • Organizer: American Heart Association : Annual Meeting 2009
  • Place of Presentation: オーランド(アメリカ)
• [Presentation] 血管組織のマトリックスレベルでの液中弾性率マッピング (2009)
  • Author(s): 鈴木寿人, 大家智憲, 福田達, 村上嘉延, 尾股定夫, 神田圭一, 中山泰秀
  • Organizer: 第8回 日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] 裏打ち構造化バイオチューブの一体形成と自家移植 (2009)
  • Author(s): 山南将志, 神田圭一, 渡辺太治, 夜久 均, 中山泰秀
  • Organizer: 第8回 日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] 体内で作るバイオチューブ人工血管 : 進歩と可能性 (2009)
  • Author(s): 中山泰秀, 神田圭一, 渡辺太治, 山南将志, 夜久均
  • Organizer: 第8回 日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] Recipient体内で形成される自家結合組織代用弁バイオバルブの変遷 (2009)
  • Author(s): 神田圭一, 矢羽田侑希, 山南将志, 田地川勉, 大場謙吉, 大家智憲, 根本泰, 植田初江, 林田恭子, 渡辺太治, 夜久均, 中山泰秀
  • Organizer: 第8回 日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] バルサルバ洞付自家組織代用心臓弁(バイオバルブ)の生体内作成と生体外実験による流体力学的機能の評価 (2009)
  • Author(s): 矢羽田侑希, 田地川勉, 大場謙吉, 山南将志神田圭一, 夜久 均, 大家智憲, 根本泰, 中山泰秀
  • Organizer: 第8回 日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] 生体内咀聴き形成技術を応用した自家組織生体心臓弁の開発 (2008)
  • Author(s): 神田圭一、林田恭子、小埜山昌輝、田地川勉、大場謙吉、大家智憲、岡本吉弘、根本 泰、植田初江、夜久 均、中山泰秀
  • Organizer: 第7回 日本再生医療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] In vivo組織工学を利用した自己組織化ステント(バイオカバードステント)の移植実験 (2008)
  • Author(s): 中山泰秀、坂井 修、神田圭一、夜久 均
  • Organizer: 第7回 日本再生医療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] RECENT ADVANCES IN AUTOLOGOUS TISSUE HEART VALVES "BIOVALVES": IMPROVED SCAFFOLDS FOR OPTIMAL TISSUE FORMATION AND VALUVULAR FUNCTIONS. (2008)
  • Author(s): K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: 14th World Congress on Heart Disease
  • Place of Presentation: トロント(カナダ)
• [Presentation] STRUCTURAL IMPROVEMENT IN AUTOLOGOUS TISSUE HEART VALVES (BIOVALVES) CONSTRUCTED BY SYMPLE IN VIVO TISSUE ENGINEERING. (2008)
  • Author(s): K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs: Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] Highlights from the Japanese Society for Artificial Organs. New approach in tissue engineering-A Simple, Safe, Practical and Economical Autologous Tissue Regeneration Technique in vivo- (2008)
  • Author(s): K. Kanda, O. Sakai, K. Hayashida, T. Watanabe, M. Yamanami, M. Onoyama, T. Tajikawa, H. Ishida, Y. Yahata, K. Ohba, T. Ooie, Y. Okamoto, Y. Nemoto, H. Ueda, H. Yaku, Y. Nakayama
  • Organizer: European Society for Artificial Organs: Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] 小口径血管内治療を目的とし、自己組織による良好な内皮化能を持つ新しいカバードステント“Biocovered Stent"の開発 (2008)
  • Author(s): 坂井修, 神田圭一, 林田恭子, 渡辺太治, 中山泰秀, 夜久均
  • Organizer: 第108回 日本外科学会
  • Place of Presentation: 長崎
• [Presentation] 日本発 人工臓器生体内組織形成術による人工臓器開発の現状と将来性 (2008)
  • Author(s): 中山泰秀, 神田圭一, 夜久均
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] バイオチューブの口径バリエーション (2008)
  • Author(s): 渡辺太治, 神田圭一, 山南将志, 夜久均, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 鋳型の工夫によるバイオバルブの完全自家組織化 (2008)
  • Author(s): 山南将志, 矢羽田侑希, 神田圭一, 田地川勉, 大場謙吉, 渡辺太治, 夜久均, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 生体組織臓器の微細精密物性評価技術 血管を例としたタクタイルマツピングシステムによる弾性率分布の測定 (2008)
  • Author(s): 大家智憲, 村山嘉延, 福田達, 永井千晴, 尾股定夫, 光田圭一, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 自家組織心臓代用弁(バイオバルブ)の生体外実験による流体力学的機能の評価 (2008)
  • Author(s): 矢羽田侑希, 田地川勉, 大場謙吉, 山南将志, 神田圭二, 夜久均, 大家智憲, 根本泰, 植田初江, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 補強のためのscaffoldを持たない代用血管は可能か? 自家結合組織のみからなる小口径BIOTUBE代用血管の開発 (2008)
  • Author(s): 神田圭一, 渡辺太治, 山南将志, 夜久均, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 裏打ち構造化によるバイオチューブ人工血管の形成促進と抗血栓性化 (2008)
  • Author(s): 山南将志, 神田圭一, 渡辺太治, 夜久均, 中山泰秀
  • Organizer: 第46回 日本人工臓器学会
  • Place of Presentation: 東京
• [Presentation] 自己組織カバードステント(バイオカバードステント)の開発 (2008)
  • Author(s): 中山泰秀, 坂井修, 神田圭一, 夜久均
  • Organizer: 第24回 日本脳神経血管内治療学会
  • Place of Presentation: 名古屋
• [Presentation] RECENT ADVANCES IN AUTOLOGOUS TISSUE HEART VALVES“BIOVALVES" : IMPROVED SCAFFOLDS FOR OPTIMAL TISSUE FORMATION AND VALUVULAR FUNCTIONS (2008)
  • Author(s): K. Kanda. K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: 14th World Congress on Heart Disease
  • Place of Presentation: トロント(カナダ)
• [Presentation] STRUCTURAL IMPROVEMENT IN AUTOLOGOUS TISSUE HEART VALVES (BIOVALVES) CONSTRUCTED BY SYMPLE IN VIVO TISSUE ENGINEERING (2008)
  • Author(s): K. Kanda, K Hayashida, M Onoyama, T Tajikawa, H Ishida, Y Yahata, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] SUCCESSFUL ENDOLUMINAL IMPLANTAION OF SMALL DIAMETER AUTOLOGOUS TISSUE-COVERED STENTS“BIOCOVERED STENTS"TO THE ANIMALS : RAPID TISSUE REGENERATION IN VIVO. (2008)
  • Author(s): K. Kanda, O Sakai, T Watanabe, M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] BIOTUBES DESIGNED FOR LARGE ANIMALS : AUTO-IMPLANTATION TO THE CAROTID ARTERY OF THE BEAGLE DOGS (2008)
  • Author(s): T Watanabe, K. Kanda. M Yamanami, H Yaku, Y Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] Highlights from the Japanese Society for Artificial Organs New approach in tissue engineering-A Simple, Safe, Practical and Economical Autologous Tissue Regeneration Technique in vivo- (2008)
  • Author(s): K. Kanda, O. Sakai, K. Hayashida, T. Watanabe, M. Yamanami, M. Onoyama, T. Tajikawa, H. Ishida, Y. Yahata, K. Ohba, T. Ooie, Y. Okamoto, Y. Nemoto, H. Ueda, H. Yaku, Y. Nakayama
  • Organizer: European Society for Artificial Organs : Annual Meeting 2008
  • Place of Presentation: ジュネーブ(スイス)
• [Presentation] In vitro performance of autologous prosthetic valved conduits fabricated by in vivo tissue engineering. (2007)
  • Author(s): Hayashida K, Kanda K, Oie T, Okamoto Y, Tajikawa T, Oba K, Yaku H, Nakayama Y.
  • Organizer: The Society for Heart Valve Disease Fourth Biennial Meeting
  • Place of Presentation: ニューヨーク
• [Presentation] In vitro hydrodynamic functions of "Biovalves"- Mechanical compatibility before implantation. (2007)
  • Author(s): K Kanda, K Hayashida, M Onoyama, T Tajikawa, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, H Yaku
  • Organizer: ESAO 2007 XXXIV. (European Society for Artificial Organs)
  • Place of Presentation: クレムス(オーストリア)
• [Presentation] In vitro performance of autologous prosthetic valved conduits fabricated by in vivo tissue engineering. (2007)
  • Author(s): Hayashida K, Kanda K, Oie T, Okamoto Y, Tajikawa T, Oba K, Yaku H, Nakayama Y.
  • Organizer: The Society for Heart Valve Disease Fourth Biennial Meeting.
  • Place of Presentation: NY
• [Presentation] In vitro hydrodynamic functions of "Biovalves"-Mechanical compatibility before implantation. (2007)
  • Author(s): K Kanda, K Hayashida, M Onoyama, T Tajikawa, K Ooba, T Ooie, Y Okamoto, Y Nemoto, H Ueda, H Yaku.
  • Organizer: ESAO 2007 XXXIV.(European Society for Artificial Organs)
  • Place of Presentation: KREMS, AUSTRIA
• [Presentation] Development of the autologous tissue-covered stent "Biocovered stent"-Pilot animal implantation experiments. (2007)
  • Author(s): T Watanabe, O Sakai, K Kanda, K Hayashida, H Yaku, Y Nakayama.
  • Organizer: ESAO 2007 XXXIV.(European Society for Artificial Organs)
  • Place of Presentation: KREMS, AUSTRIA
• [Presentation] 自己組織で覆われた新しいステント"Biocovered Stent"の開発 (2007)
  • Author(s): 坂井 修、神田圭一、林田恭子、渡辺太治、中山泰秀、夜久 均.
  • Organizer: 第35回日本血管外科学会
  • Place of Presentation: 名古屋
• [Presentation] 自己組織で覆われた新しいカバードステント"Biocovered Stent"の開発 (2007)
  • Author(s): 坂井 修、神田圭一、林田恭子、中山泰秀、夜久 均
  • Organizer: 第60回日本胸部外科学会
  • Place of Presentation: 仙台
• [Presentation] "in body tissue architecture" technologyを用いた体内で作成したコンデュー付自家組織生体弁バイオバルブのin vitroにおける弁機能評価 (2007)
  • Author(s): 林田恭子、神田圭一、小埜山昌輝、田地川 勉、大場謙吉、大家智憲、岡本吉弘、根本 泰、夜久 均、中山泰秀
  • Organizer: 第60回日本胸部外科学会
  • Place of Presentation: 仙台
• [Presentation] 自己組織で覆われた新しいカバードステント"Biocovered Stent"の生体内留置実験 (2007)
  • Author(s): 坂井 修、神田圭一、林田恭子、渡辺太治、夜久 均、中山泰秀
  • Organizer: 第45回日本人工臓器学会
  • Place of Presentation: 大阪
• [Book] CIRCULATION Up-to-Date (2007)
  • Author(s): 林田恭子、神田圭一、大家智憲、岡本吉弘、根本泰、植田初江、小埜山輝昌、田地川勉、大場謙吉、夜久均、中山泰秀
  • Publisher: メディカ出版
• [Book] CIRCULATION Up-to-Date(1881-3585)2巻3号 (2007)
  • Author(s): 林田恭子、神田圭一、大家智憲、岡本吉弘、根本 泰、植田初江、小埜山輝昌、田地川勉、大場謙吉、夜久均、中山泰秀.
  • Publisher: メディカ出版
• [Patent(Industrial Property Rights)] 人工血管及びその製造方法 (2010)
  • Inventor(s): 中山泰秀・神田圭一
  • Industrial Property Rights Holder: 中山泰秀・新幹工業株式会社
  • Acquisition Date: 2010-04-02