Translational Research for Clinical Application of Autologous Bone Marrow Stromal Cell Transplantation for CNS disorders

• Project/Area Number: 19390371
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Hokkaido University
• Principal Investigator: IWASAKI Yoshinobu Hokkaido University, 名誉教授 (00113522)
• Co-Investigator(Kenkyū-buntansha): KURODA Satoshi 北海道大学, 北海道大学病院, 講師 (10301904) ; HIDA Kazutoshi 北海道大学, 大学院・医学研究科, 准教授 (10238305) ; SHIGA Tohru 北海道大学, 大学病院, 講師 (80374495) ; 矢野 俊介 北海道大学, 病院, 助教 (20374481) ; 小林 浩之 北海道大学, 大学病院, 助教 (70374478)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 神経再生 / 骨髄間質細胞 / 脊髄損傷 / 脳損傷 / 脳梗塞 / 再生医療 / Bone marrow stromal cell / Transplantation / Cerebral infarction / Spinal cord injury / Diffuse axonal injury / Differentiation / Regenerative medicine / Functional restoration

Research Abstract

この3年間に表記の研究課題に関して数多くの知見を得ることができた。すなわち、自己骨髄から分離した骨髄間質細胞(bone marrow stromal cells ; BMSC)の生物学的特性を解明するとともに、MRI、光イメージングなどを多用することで、臨床応用を視野に入れた安全かつ効率的な細胞の培養法、中枢神経への投与法、治療効果判定のための画像診断法を確立するための基礎データを得ることができた。

Research Products

• [Journal Article] Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice (2010)
  • Author(s): Hokari M, Kuroda S, Kinugawa S, Ide T, Tsutsui H, Iwasaki Y
  • Journal Title: Neuropathology (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] 中枢神経再生におけるバイオイメージング (2010)
  • Author(s): 杉山拓、伊東雅基、七戸秀夫、黒田敏
  • Journal Title: 再生医療 9 Pages: 65-71
  • Peer Reviewed
• [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow… (2010)
  • Author(s): Yasuda H, et al.
  • Journal Title: J Neurosurg 112 Pages: 336-344
  • Peer Reviewed
• [Journal Article] Non-invasive transplantation of bone marrow stromal cells using a thermoreversible gelation polymer(TGP)hydrogel… (2010)
  • Author(s): Osanai T, et al.
  • Journal Title: Neurosurgery (in press)
  • Peer Reviewed
• [Journal Article] 中枢神経再生におけるバイオイメージング (2010)
  • Author(s): 杉山, ら
  • Journal Title: 再生医療 (in press)
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells-Which are suitable as cell source of transplantation for mice infarct brain? (2009)
  • Author(s): Shichinohe H, Kuroda S, Maruichi K, Osanai T, Sugiyama T, Chiba Y, Yamaguchi A, Iwasaki Y
  • Journal Title: Neuropathology (Epub ahead of print)
  • NAID: 10029320219
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury model (2009)
  • Author(s): Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neurosurgery 64 Pages: 991-1000
  • Peer Reviewed
• [Journal Article] Biodegradable fibrin scaffold enhances survival, migration and differentiation of transplanted bone marrow stromal cells in cortical freezing injury model of rats (2009)
  • Author(s): Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y
  • Journal Title: J Neurosurg (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neuropathology (e-pub)
  • NAID: 10028191635
  • Peer Reviewed
• [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct (2009)
  • Author(s): Hokari M, Kuroda S, Chiba Y, Maruichi K, Iwasaki Y
  • Journal Title: Cytokine 46(Epub ahead of print) Pages: 260-266
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction-recent advances and perspective (2009)
  • Author(s): Shichinohe H, Kuroda S:
  • Journal Title: Res Adv in Stroke 1 Pages: 23-35
  • Peer Reviewed
• [Journal Article] Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, Fasudil on axon regeneration in rat spinal cord injury (2009)
  • Author(s): Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y
  • Journal Title: Neuropathology (Epub ahead of print)
  • NAID: 10029320824
  • Peer Reviewed
• [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats. (2009)
  • Author(s): Maruichi K, et al.
  • Journal Title: Neuropathology 29 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, et al.
  • Journal Title: Neuropathology(E-pub) 29 Pages: 422-432
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat… (2009)
  • Author(s): Chiba Y, et al.
  • Journal Title: Neurosurgery 64 Pages: 991-1000
  • Peer Reviewed
• [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation… (2009)
  • Author(s): Hokari M, et al.
  • Journal Title: Cytokine 46 Pages: 260-266
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells & bone marrow mononuclear cells-Which are suitable as cell source of transplantation… (2009)
  • Author(s): Shichinohe H, et al.
  • Journal Title: Neuropathology(E-pub)
  • Peer Reviewed
• [Journal Article] Synergistic effects of bone marrow stromal cells and a Rhokinase(ROCK)inhibitor, Fasudil on axon… (2009)
  • Author(s): Chiba Y, et al.
  • Journal Title: Neuropathology(E-pub)
  • Peer Reviewed
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into… (2009)
  • Author(s): Itosaka H, et al.
  • Journal Title: Neuropathology 29 Pages: 248-257
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal iniury in rats (2009)
  • Author(s): Maruichi K, et.al.
  • Journal Title: Neuropathology (E-pub)
  • Peer Reviewed
• [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow (2009)
  • Author(s): Yasuda H, et.al.
  • Journal Title: J Neurosure (E-pub)
  • Peer Reviewed
• [Journal Article] Synergistic effects of granulocyte-colony stimulating fact or on bone marrow stromal cell transplantation (2009)
  • Author(s): Hokari M, et.al.
  • Journal Title: Cytokine (E-pub)
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction-recent advances and perspective (2009)
  • Author(s): Shichinohe H, et.al.
  • Journal Title: Res Adv in Stroke 1 Pages: 23-35
  • Peer Reviewed
• [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生 (2009)
  • Author(s): 千葉泰弘ら
  • Journal Title: リハビリテーション医学 45 Pages: 356-360
• [Journal Article] 中枢神経再生におけるバイオマテリアルの役割 (2009)
  • Author(s): 長内俊也ら
  • Journal Title: 再生医療 7 Pages: 77-82
  • Peer Reviewed
• [Journal Article] ラボから急性期脳梗塞治療ヘ-ラジカルスカベンジャーと骨髄間質細胞移植 (2009)
  • Author(s): 黒田敏
  • Journal Title: 脳卒中 30 Pages: 875-879
  • Peer Reviewed
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord-A novel material for CNS tissue engineering (2008)
  • Author(s): Itosaka H, Kuroda S, Shichinohe H, Yasuda H, Yano S, Kamei S, Kawamura R, Hida K, Iwasaki Y
  • Journal Title: Neuropathology (e-pub)
  • NAID: 10026609224
  • Peer Reviewed
• [Journal Article] Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in mice spinal cord injury model (2008)
  • Author(s): Aoyama T, Hida K, Kuroda S, Seki T, Yano S, Shichinohe H, Iwasaki Y
  • Journal Title: Neurol Med Chir (Tokyo) 48 Pages: 539-545
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures: Their role in cell transplantation therapy for spinal cord injury (2008)
  • Author(s): Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Hokari M, Hida K, Kikuchi S, Iwasaki Y
  • Journal Title: Neurorehabil Neural Repair 22 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms (2008)
  • Author(s): Hokari M, Kuroda S, Shichinohe H, Yano S, Hida K, Iwasaki Y
  • Journal Title: J Neurosci Res 86 Pages: 1024-1035
  • Peer Reviewed
• [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生 (2008)
  • Author(s): 千葉泰弘、黒田敏、穂刈正昭、矢野俊介、飛騨一利、岩崎喜信
  • Journal Title: リハビリテーション医学 45 Pages: 356-360
  • NAID: 110006792789
• [Journal Article] 中枢神経再生におけるバイオマテリアルの役割 (2008)
  • Author(s): 長内俊也、黒田敏、岩崎喜信
  • Journal Title: 再生医療 7 Pages: 77-82
  • NAID: 40016387509
  • Peer Reviewed
• [Journal Article] ボから急性期脳梗塞の治療へーラジカルスカベンジャーと骨髄細胞移植 (2008)
  • Author(s): 黒田敏
  • Journal Title: 脳卒中 30 Pages: 875-879
• [Journal Article] Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats (2008)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neuropathology 29(e-pub) Pages: 132-139
  • NAID: 10026608745
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms (2008)
  • Author(s): Hokari M, et.al.
  • Journal Title: J Neurosci Res 86 Pages: 1024-1035
  • Peer Reviewed
• [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats (2008)
  • Author(s): Maruichi K, et.al.
  • Journal Title: Neuropathology (E-pub)
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells differentiate into neurons And promote axon elongation in spinal cord slice (2008)
  • Author(s): Shichinohe H, et.al.
  • Journal Title: Neurorehabil Neural Repair 22 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into (2008)
  • Author(s): Itosaka H, et.al.
  • Journal Title: Neuropathology (E-pub)
  • Peer Reviewed
• [Journal Article] Edaravone (MCI186) scavenges reactive oxygen species and ameliorates tissue damage in mice spinal cord (2008)
  • Author(s): Aoyama T, et.al.
  • Journal Title: Neurol Med Chir (Tokyo) 48 Pages: 539-545
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells protect and repair damaged neurons… (2008)
  • Author(s): Hokari, et al
  • Journal Title: J Neurosci Res 86 Pages: 1024-1035
  • Peer Reviewed
• [Journal Article] Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct (2007)
  • Author(s): Shichinohe H, Kuroda S, Yano S, Hida K, Iwasaki Y
  • Journal Title: Brain Res 1183 Pages: 138-147
  • Peer Reviewed
• [Journal Article] 骨髄間質細胞を用いた脊髄損傷の再生 (2007)
  • Author(s): 黒田敏、穂刈正昭、千葉泰弘、七戸秀夫、矢野俊介、飛騨一利、岩崎喜信
  • Journal Title: 脊椎脊髄ジャーナル 2 Pages: 1233-1237
  • Peer Reviewed
• [Journal Article] 脳損傷の病態と高次脳機能障害-再生治療の展望- (2007)
  • Author(s): 丸一勝彦、黒田敏、岩崎喜信
  • Journal Title: 脳外 35 Pages: 965-969
  • Peer Reviewed
• [Journal Article] Role of SDF-1/CXCR4 system in survival and migration of… (2007)
  • Author(s): Shichinohe, et al
  • Journal Title: Brain Res 1183 Pages: 138-147
  • Peer Reviewed
• [Journal Article] 脳SPECT/PETによる選択的神経細胞障害のイメージング (2007)
  • Author(s): 黒田 敏
  • Journal Title: 分子脳血管病 6 Pages: 293-299
• [Journal Article] 骨髄間質細胞を用いた脊髄損傷の再生 (2007)
  • Author(s): 黒田 敏
  • Journal Title: 脊椎脊髄ジャーナル 20 Pages: 1233-1237
• [Journal Article] 脳損傷の病態と高次脳機能障害-再生治療の展望- (2007)
  • Author(s): 丸一勝彦
  • Journal Title: 脳外 35 Pages: 965-969
  • Peer Reviewed
• [Journal Article] Pretreatment with the cyclosporine derivative, NIM811, reduces delayed neuronal death in the hippocampus after transient forebrain ischemia
  • Author(s): Hokari M, Kuroda S, Iwasaki Y
  • Journal Title: J Pharm Pharmacol (in press)
  • Peer Reviewed
• [Journal Article] Non-invasive transplantation of bone marrow stromal cell for ischemic stroke: Preliminary study using a thermoreversible gelation polymer (TGP) hydrogel
  • Author(s): Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
  • Journal Title: Neurosurgery (in press)
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat
  • Author(s): Chiba Y, et.al.
  • Journal Title: Neurosurgery (In press)
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells differentiate into neurons and promote…
  • Author(s): Shichinohe, et al
  • Journal Title: Neurorehabil Neural Repair (in press)
  • Peer Reviewed
• [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生
  • Author(s): 千葉泰弘
  • Journal Title: リハビリテーション医学 (in press)
• [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略 (2010)
  • Author(s): 黒田敏, ら
  • Organizer: 第10回脳血管疾患治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-27
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2010)
  • Author(s): 黒田敏
  • Organizer: 第10回脳血管疾患治療研究会
  • Place of Presentation: 東京都、如水会館
  • Year and Date: 2010-02-27
• [Presentation] 脳梗塞の病態と外科治療 (2010)
  • Author(s): 黒田敏, ら
  • Organizer: 第3回脳卒中撲滅講演会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-31
• [Presentation] 脳梗塞の病態と外科治療 (2010)
  • Author(s): 黒田敏
  • Organizer: 第3回脳卒中撲滅講演会
  • Place of Presentation: 奈良市、奈良ホテル
  • Year and Date: 2010-01-23
• [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路 (2010)
  • Author(s): 川堀真人, ら
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
• [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討 (2010)
  • Author(s): 杉山拓, ら
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
• [Presentation] 慢性脳循環不全+骨髄間質細胞移植モデルにおける記憶学習障害の改善 (2010)
  • Author(s): 七戸秀夫, ら
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
• [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia model (2010)
  • Author(s): Shichinohe H, et al
  • Organizer: Internatonal Stroke Conference
  • Place of Presentation: San Antonio, USA
• [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路 (2010)
  • Author(s): 川堀真人, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルへの移植 (2010)
  • Author(s): 伊東雅基, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討 (2010)
  • Author(s): 杉山拓, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] 慢性脳循環不全・骨髄間質細胞移植モデルにおける記憶学習障害の改善 (2010)
  • Author(s): 七戸秀夫, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia (2010)
  • Author(s): Shichinohe H, et al
  • Organizer: International Stroke Conference 2010
  • Place of Presentation: San Antonio(USA), Convention Center
• [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏, ら
  • Organizer: 第9回ブレインアタックカンファレンス研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-30
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏
  • Organizer: 第9回ブレインアタックカンファレンス研究会
  • Place of Presentation: 福岡市、西鉄グランドホテル
  • Year and Date: 2009-10-30
• [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏, ら
  • Organizer: 第12回浜松脳神経障害とフリーラジカル研究会
  • Place of Presentation: 浜松
  • Year and Date: 2009-07-08
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏
  • Organizer: 第12回浜松脳神経障害とフリーラジカル研究会
  • Place of Presentation: 浜松市、オークラアクトシティホテル浜松
  • Year and Date: 2009-07-08
• [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか (2009)
  • Author(s): 千葉泰弘, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-03-05
• [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2009)
  • Author(s): 黒田敏, ら
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 松江
• [Presentation] Bone marrow stromal cell transplantation for central nervous system disorders (2009)
  • Author(s): Kuroda S, et al
  • Organizer: International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: Sapporo
• [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか? (2009)
  • Author(s): 千葉泰弘, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京
• [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について (2009)
  • Author(s): 長内俊也, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京
• [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する (2009)
  • Author(s): 丸一勝彦, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京
• [Presentation] 長波長蛍光物質で標識した骨髄間質細胞の頭蓋内光イメージング (2009)
  • Author(s): 杉山拓, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京
• [Presentation] 自己骨髄細胞による損傷脊髄の再生 (2009)
  • Author(s): 黒田敏, ら
  • Organizer: 日本脊髄障害医学会総会
  • Place of Presentation: 札幌
• [Presentation] Mitochondrial trans- cription factor Aは虚血による神経細胞障害を軽減する (2009)
  • Author(s): 穂刈正昭, ら
  • Organizer: 日本脳循環代謝学会
  • Place of Presentation: 東京
• [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, et al
  • Organizer: American Association of Neurological Surgeons
  • Place of Presentation: Chicago
• [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury (2009)
  • Author(s): Chiba Y, et al
  • Organizer: American Association of Neurological Surgeons
  • Place of Presentation: Chicago
• [Presentation] STA-MCA anastomosis and EDMAPS for moyamoya disease (2009)
  • Author(s): Kuroda S, et al
  • Organizer: 9^<th> International Conference for Cerebrovascular Surgery(ICCVS)
  • Place of Presentation: 名古屋市、ウェスティンナゴヤキャッスル
• [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について (2009)
  • Author(s): 長内俊也, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する (2009)
  • Author(s): 丸一勝彦, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] 長波長蛍光物質で標識した骨髄間質細胞の頭蓋内光イメージング (2009)
  • Author(s): 杉山拓, ら
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2009)
  • Author(s): 黒田敏, ら
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 島根県民会館、松江市
• [Presentation] Bone marrow stromal cell transplantation for central nervous system disorders (2009)
  • Author(s): Kuroda S, et.al.
  • Organizer: International Symposium for Future Drug Discovery and Medical Care
  • Place of Presentation: Hokkaido University, Sapporo
• [Presentation] 骨髄間質細胞の移植はびまん性脳損傷による高次脳機能障害を改善する (2008)
  • Author(s): 丸一勝彦, ら
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] 骨髄間質細胞の移植は損傷脊髄における皮質脊髄路の再生を促進する (2008)
  • Author(s): 千葉泰弘, ら
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] 顆粒球コロニー刺激因子は骨髄間質細胞の移植効果を賦活する (2008)
  • Author(s): 穂刈正昭, ら
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-13
• [Presentation] 顆粒球コロニー刺激因子は骨髄間質細胞の移植効果を賦活する (2008)
  • Author(s): 穂刈正昭
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2008-03-13
• [Presentation] 骨髄間質細胞の移植は損傷脊髄における皮質脊髄路の再生を促進する (2008)
  • Author(s): 千葉泰弘
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2008-03-13
• [Presentation] 骨髄間質細胞の移植はびまん性脳損傷による高次脳機能障害を改善する (2008)
  • Author(s): 丸一勝彦
  • Organizer: 日本再生治療学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2008-03-13
• [Presentation] ラボから急性期脳梗塞の治療へ:ラジカルスカベンジャーと骨髄細胞移植 (2008)
  • Author(s): 黒田敏, ら
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 京都
• [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat (2008)
  • Author(s): Chiba Y, et.al.
  • Organizer: American Association of Neurological Surgeons
  • Place of Presentation: McCormick Place, Chicago
• [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfanction due to diffuse axonal iniury in rats (2008)
  • Author(s): Maruichi K, et.al.
  • Organizer: American Association of Neurological Surgeons
  • Place of Presentation: McCormick Place, Chicago
• [Presentation] Mitochondrial transcription factor Aは虚血による神経細胞障害を軽減する (2008)
  • Author(s): 穂刈正昭, ら
  • Organizer: 日本脳循環代謝学会
  • Place of Presentation: 東京ドームホテル、東京
• [Presentation] 自己骨髄細胞による損傷脊髄の再生 (2008)
  • Author(s): 黒田敏
  • Organizer: 日本脊髄障害医学会総会
  • Place of Presentation: かでる2.7、札幌
• [Presentation] 骨髄間質細胞を用いた損傷脊髄の再生 (2007)
  • Author(s): 黒田敏, ら
  • Organizer: 日本リハビリテーション医学会
  • Place of Presentation: 神戸
  • Year and Date: 2007-06-06
• [Presentation] 骨髄間質細胞を用いた損傷脊髄の再生 (2007)
  • Author(s): 黒田 敏
  • Organizer: 日本リハビリテーション医学会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2007-06-06
• [Presentation] 障害された神経細胞に対する骨髄間質細胞の神経保護効果-修復メカニズムの解明 (2007)
  • Author(s): 穂刈正昭, ら
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 福岡
• [Book] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats(Tamaki N and Kuge Y (ed))(Molecular Imaging for Integrated Medical Therapy and Drug Development) (2010)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, Osanai T, Sugiyama T, Hokari M, Hida K, Iwasaki Y
  • Publisher: Springer
• [Book] Non-invasive optical tracking of bone marrow stromal cells transplanted into rat cerebral infarct (2010)
  • Author(s): Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed)) (2010)
  • Author(s): Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
  • Publisher: Springer
• [Book] Thermoreversible gelation polymer (TGP) hydrogel as a degradable scaffold for bone marrow stromal cell transplantation (2010)
  • Author(s): Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Kuroda S, et al
  • Total Pages: 303
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Maruichi K, et al
  • Total Pages: 303
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Chiba Y, et al
  • Total Pages: 303
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Osanai T, et al
  • Total Pages: 303
  • Publisher: Springer
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Sugiyama T, et al
  • Total Pages: 303
  • Publisher: Springer
• [Book] 骨髄間質細胞移植による中枢神経再生-最近の進歩。Annual Review神経 (2007)
  • Author(s): 黒田敏、岩崎喜信
  • Publisher: 中外医学社
• [Book] Annual Review神経 (2007)
  • Author(s): 黒田 敏
  • Total Pages: 450
  • Publisher: 骨髄間質細胞による中枢神経再生-最近の進歩
• [Book] Bone marrow stromal cell transplantation for central nervous system disorders-
  • Author(s): Kuroda S, Kuge Y, Tamaki N, Iwasaki Y
  • Total Pages: 2010
  • Publisher: Springer