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Translational Research for Clinical Application of Autologous Bone Marrow Stromal Cell Transplantation for CNS disorders

Research Project

Project/Area Number 19390371
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHokkaido University

Principal Investigator

IWASAKI Yoshinobu  Hokkaido University, 名誉教授 (00113522)

Co-Investigator(Kenkyū-buntansha) KURODA Satoshi  北海道大学, 北海道大学病院, 講師 (10301904)
HIDA Kazutoshi  北海道大学, 大学院・医学研究科, 准教授 (10238305)
SHIGA Tohru  北海道大学, 大学病院, 講師 (80374495)
矢野 俊介  北海道大学, 病院, 助教 (20374481)
小林 浩之  北海道大学, 大学病院, 助教 (70374478)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords神経再生 / 骨髄間質細胞 / 脊髄損傷 / 脳損傷 / 脳梗塞 / 再生医療 / Bone marrow stromal cell / Transplantation / Cerebral infarction / Spinal cord injury / Diffuse axonal injury / Differentiation / Regenerative medicine / Functional restoration
Research Abstract

この3年間に表記の研究課題に関して数多くの知見を得ることができた。すなわち、自己骨髄から分離した骨髄間質細胞(bone marrow stromal cells ; BMSC)の生物学的特性を解明するとともに、MRI、光イメージングなどを多用することで、臨床応用を視野に入れた安全かつ効率的な細胞の培養法、中枢神経への投与法、治療効果判定のための画像診断法を確立するための基礎データを得ることができた。

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (112 results)

All 2010 2009 2008 2007 Other

All Journal Article (52 results) (of which Peer Reviewed: 46 results) Presentation (48 results) Book (12 results)

  • [Journal Article] Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice2010

    • Author(s)
      Hokari M, Kuroda S, Kinugawa S, Ide T, Tsutsui H, Iwasaki Y
    • Journal Title

      Neuropathology (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山拓、伊東雅基、七戸秀夫、黒田敏
    • Journal Title

      再生医療 9

      Pages: 65-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow…2010

    • Author(s)
      Yasuda H, et al.
    • Journal Title

      J Neurosurg 112

      Pages: 336-344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cells using a thermoreversible gelation polymer(TGP)hydrogel…2010

    • Author(s)
      Osanai T, et al.
    • Journal Title

      Neurosurgery (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山, ら
    • Journal Title

      再生医療 (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells-Which are suitable as cell source of transplantation for mice infarct brain?2009

    • Author(s)
      Shichinohe H, Kuroda S, Maruichi K, Osanai T, Sugiyama T, Chiba Y, Yamaguchi A, Iwasaki Y
    • Journal Title

      Neuropathology (Epub ahead of print)

    • NAID

      10029320219

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury model2009

    • Author(s)
      Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neurosurgery 64

      Pages: 991-1000

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration and differentiation of transplanted bone marrow stromal cells in cortical freezing injury model of rats2009

    • Author(s)
      Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y
    • Journal Title

      J Neurosurg (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology (e-pub)

    • NAID

      10028191635

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct2009

    • Author(s)
      Hokari M, Kuroda S, Chiba Y, Maruichi K, Iwasaki Y
    • Journal Title

      Cytokine 46(Epub ahead of print)

      Pages: 260-266

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction-recent advances and perspective2009

    • Author(s)
      Shichinohe H, Kuroda S:
    • Journal Title

      Res Adv in Stroke 1

      Pages: 23-35

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, Fasudil on axon regeneration in rat spinal cord injury2009

    • Author(s)
      Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology (Epub ahead of print)

    • NAID

      10029320824

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats.2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology 29

      Pages: 132-139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology(E-pub) 29

      Pages: 422-432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neurosurgery 64

      Pages: 991-1000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation…2009

    • Author(s)
      Hokari M, et al.
    • Journal Title

      Cytokine 46

      Pages: 260-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells & bone marrow mononuclear cells-Which are suitable as cell source of transplantation…2009

    • Author(s)
      Shichinohe H, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rhokinase(ROCK)inhibitor, Fasudil on axon…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into…2009

    • Author(s)
      Itosaka H, et al.
    • Journal Title

      Neuropathology 29

      Pages: 248-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal iniury in rats2009

    • Author(s)
      Maruichi K, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow2009

    • Author(s)
      Yasuda H, et.al.
    • Journal Title

      J Neurosure (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating fact or on bone marrow stromal cell transplantation2009

    • Author(s)
      Hokari M, et.al.
    • Journal Title

      Cytokine (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell transplantation for cerebral infarction-recent advances and perspective2009

    • Author(s)
      Shichinohe H, et.al.
    • Journal Title

      Res Adv in Stroke 1

      Pages: 23-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生2009

    • Author(s)
      千葉泰弘ら
    • Journal Title

      リハビリテーション医学 45

      Pages: 356-360

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 中枢神経再生におけるバイオマテリアルの役割2009

    • Author(s)
      長内俊也ら
    • Journal Title

      再生医療 7

      Pages: 77-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラボから急性期脳梗塞治療ヘ-ラジカルスカベンジャーと骨髄間質細胞移植2009

    • Author(s)
      黒田敏
    • Journal Title

      脳卒中 30

      Pages: 875-879

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord-A novel material for CNS tissue engineering2008

    • Author(s)
      Itosaka H, Kuroda S, Shichinohe H, Yasuda H, Yano S, Kamei S, Kawamura R, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology (e-pub)

    • NAID

      10026609224

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in mice spinal cord injury model2008

    • Author(s)
      Aoyama T, Hida K, Kuroda S, Seki T, Yano S, Shichinohe H, Iwasaki Y
    • Journal Title

      Neurol Med Chir (Tokyo) 48

      Pages: 539-545

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures: Their role in cell transplantation therapy for spinal cord injury2008

    • Author(s)
      Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Hokari M, Hida K, Kikuchi S, Iwasaki Y
    • Journal Title

      Neurorehabil Neural Repair 22

      Pages: 447-457

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms2008

    • Author(s)
      Hokari M, Kuroda S, Shichinohe H, Yano S, Hida K, Iwasaki Y
    • Journal Title

      J Neurosci Res 86

      Pages: 1024-1035

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生2008

    • Author(s)
      千葉泰弘、黒田敏、穂刈正昭、矢野俊介、飛騨一利、岩崎喜信
    • Journal Title

      リハビリテーション医学 45

      Pages: 356-360

    • NAID

      110006792789

    • Related Report
      2009 Final Research Report
  • [Journal Article] 中枢神経再生におけるバイオマテリアルの役割2008

    • Author(s)
      長内俊也、黒田敏、岩崎喜信
    • Journal Title

      再生医療 7

      Pages: 77-82

    • NAID

      40016387509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ボから急性期脳梗塞の治療へーラジカルスカベンジャーと骨髄細胞移植2008

    • Author(s)
      黒田敏
    • Journal Title

      脳卒中 30

      Pages: 875-879

    • Related Report
      2009 Final Research Report
  • [Journal Article] Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats2008

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathology 29(e-pub)

      Pages: 132-139

    • NAID

      10026608745

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms2008

    • Author(s)
      Hokari M, et.al.
    • Journal Title

      J Neurosci Res 86

      Pages: 1024-1035

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats2008

    • Author(s)
      Maruichi K, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells differentiate into neurons And promote axon elongation in spinal cord slice2008

    • Author(s)
      Shichinohe H, et.al.
    • Journal Title

      Neurorehabil Neural Repair 22

      Pages: 447-457

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into2008

    • Author(s)
      Itosaka H, et.al.
    • Journal Title

      Neuropathology (E-pub)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone (MCI186) scavenges reactive oxygen species and ameliorates tissue damage in mice spinal cord2008

    • Author(s)
      Aoyama T, et.al.
    • Journal Title

      Neurol Med Chir (Tokyo) 48

      Pages: 539-545

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells protect and repair damaged neurons…2008

    • Author(s)
      Hokari, et al
    • Journal Title

      J Neurosci Res 86

      Pages: 1024-1035

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct2007

    • Author(s)
      Shichinohe H, Kuroda S, Yano S, Hida K, Iwasaki Y
    • Journal Title

      Brain Res 1183

      Pages: 138-147

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた脊髄損傷の再生2007

    • Author(s)
      黒田敏、穂刈正昭、千葉泰弘、七戸秀夫、矢野俊介、飛騨一利、岩崎喜信
    • Journal Title

      脊椎脊髄ジャーナル 2

      Pages: 1233-1237

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳損傷の病態と高次脳機能障害-再生治療の展望-2007

    • Author(s)
      丸一勝彦、黒田敏、岩崎喜信
    • Journal Title

      脳外 35

      Pages: 965-969

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of SDF-1/CXCR4 system in survival and migration of…2007

    • Author(s)
      Shichinohe, et al
    • Journal Title

      Brain Res 1183

      Pages: 138-147

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳SPECT/PETによる選択的神経細胞障害のイメージング2007

    • Author(s)
      黒田 敏
    • Journal Title

      分子脳血管病 6

      Pages: 293-299

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 骨髄間質細胞を用いた脊髄損傷の再生2007

    • Author(s)
      黒田 敏
    • Journal Title

      脊椎脊髄ジャーナル 20

      Pages: 1233-1237

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 脳損傷の病態と高次脳機能障害-再生治療の展望-2007

    • Author(s)
      丸一勝彦
    • Journal Title

      脳外 35

      Pages: 965-969

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment with the cyclosporine derivative, NIM811, reduces delayed neuronal death in the hippocampus after transient forebrain ischemia

    • Author(s)
      Hokari M, Kuroda S, Iwasaki Y
    • Journal Title

      J Pharm Pharmacol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cell for ischemic stroke: Preliminary study using a thermoreversible gelation polymer (TGP) hydrogel

    • Author(s)
      Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
    • Journal Title

      Neurosurgery (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat

    • Author(s)
      Chiba Y, et.al.
    • Journal Title

      Neurosurgery (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells differentiate into neurons and promote…

    • Author(s)
      Shichinohe, et al
    • Journal Title

      Neurorehabil Neural Repair (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞を用いた損傷脊髄の再生

    • Author(s)
      千葉泰弘
    • Journal Title

      リハビリテーション医学 (in press)

    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第10回脳血管疾患治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2010

    • Author(s)
      黒田敏
    • Organizer
      第10回脳血管疾患治療研究会
    • Place of Presentation
      東京都、如水会館
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳梗塞の病態と外科治療2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第3回脳卒中撲滅講演会
    • Place of Presentation
      奈良
    • Year and Date
      2010-01-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳梗塞の病態と外科治療2010

    • Author(s)
      黒田敏
    • Organizer
      第3回脳卒中撲滅講演会
    • Place of Presentation
      奈良市、奈良ホテル
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路2010

    • Author(s)
      川堀真人, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討2010

    • Author(s)
      杉山拓, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 慢性脳循環不全+骨髄間質細胞移植モデルにおける記憶学習障害の改善2010

    • Author(s)
      七戸秀夫, ら
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia model2010

    • Author(s)
      Shichinohe H, et al
    • Organizer
      Internatonal Stroke Conference
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路2010

    • Author(s)
      川堀真人, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルへの移植2010

    • Author(s)
      伊東雅基, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討2010

    • Author(s)
      杉山拓, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性脳循環不全・骨髄間質細胞移植モデルにおける記憶学習障害の改善2010

    • Author(s)
      七戸秀夫, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia2010

    • Author(s)
      Shichinohe H, et al
    • Organizer
      International Stroke Conference 2010
    • Place of Presentation
      San Antonio(USA), Convention Center
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏, ら
    • Organizer
      第9回ブレインアタックカンファレンス研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第9回ブレインアタックカンファレンス研究会
    • Place of Presentation
      福岡市、西鉄グランドホテル
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞におる中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏, ら
    • Organizer
      第12回浜松脳神経障害とフリーラジカル研究会
    • Place of Presentation
      浜松
    • Year and Date
      2009-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第12回浜松脳神経障害とフリーラジカル研究会
    • Place of Presentation
      浜松市、オークラアクトシティホテル浜松
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか2009

    • Author(s)
      千葉泰弘, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2009-03-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      松江
    • Related Report
      2009 Final Research Report
  • [Presentation] Bone marrow stromal cell transplantation for central nervous system disorders2009

    • Author(s)
      Kuroda S, et al
    • Organizer
      International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Sapporo
    • Related Report
      2009 Final Research Report
  • [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか?2009

    • Author(s)
      千葉泰弘, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する2009

    • Author(s)
      丸一勝彦, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 長波長蛍光物質で標識した骨髄間質細胞の頭蓋内光イメージング2009

    • Author(s)
      杉山拓, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 自己骨髄細胞による損傷脊髄の再生2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脊髄障害医学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Mitochondrial trans- cription factor Aは虚血による神経細胞障害を軽減する2009

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, et al
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      Chicago
    • Related Report
      2009 Final Research Report
  • [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat spinal cord injury2009

    • Author(s)
      Chiba Y, et al
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      Chicago
    • Related Report
      2009 Final Research Report
  • [Presentation] STA-MCA anastomosis and EDMAPS for moyamoya disease2009

    • Author(s)
      Kuroda S, et al
    • Organizer
      9^<th> International Conference for Cerebrovascular Surgery(ICCVS)
    • Place of Presentation
      名古屋市、ウェスティンナゴヤキャッスル
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性軸策損傷による高次脳機能障害を改善する2009

    • Author(s)
      丸一勝彦, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長波長蛍光物質で標識した骨髄間質細胞の頭蓋内光イメージング2009

    • Author(s)
      杉山拓, ら
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2009

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      島根県民会館、松江市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for central nervous system disorders2009

    • Author(s)
      Kuroda S, et.al.
    • Organizer
      International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido University, Sapporo
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性脳損傷による高次脳機能障害を改善する2008

    • Author(s)
      丸一勝彦, ら
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞の移植は損傷脊髄における皮質脊髄路の再生を促進する2008

    • Author(s)
      千葉泰弘, ら
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 顆粒球コロニー刺激因子は骨髄間質細胞の移植効果を賦活する2008

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 顆粒球コロニー刺激因子は骨髄間質細胞の移植効果を賦活する2008

    • Author(s)
      穂刈正昭
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植は損傷脊髄における皮質脊髄路の再生を促進する2008

    • Author(s)
      千葉泰弘
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性脳損傷による高次脳機能障害を改善する2008

    • Author(s)
      丸一勝彦
    • Organizer
      日本再生治療学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2008-03-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラボから急性期脳梗塞の治療へ:ラジカルスカベンジャーと骨髄細胞移植2008

    • Author(s)
      黒田敏, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat2008

    • Author(s)
      Chiba Y, et.al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      McCormick Place, Chicago
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transplanted bone marrow stromal cells improve cognitive dysfanction due to diffuse axonal iniury in rats2008

    • Author(s)
      Maruichi K, et.al.
    • Organizer
      American Association of Neurological Surgeons
    • Place of Presentation
      McCormick Place, Chicago
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial transcription factor Aは虚血による神経細胞障害を軽減する2008

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      東京ドームホテル、東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己骨髄細胞による損傷脊髄の再生2008

    • Author(s)
      黒田敏
    • Organizer
      日本脊髄障害医学会総会
    • Place of Presentation
      かでる2.7、札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞を用いた損傷脊髄の再生2007

    • Author(s)
      黒田敏, ら
    • Organizer
      日本リハビリテーション医学会
    • Place of Presentation
      神戸
    • Year and Date
      2007-06-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨髄間質細胞を用いた損傷脊髄の再生2007

    • Author(s)
      黒田 敏
    • Organizer
      日本リハビリテーション医学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2007-06-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 障害された神経細胞に対する骨髄間質細胞の神経保護効果-修復メカニズムの解明2007

    • Author(s)
      穂刈正昭, ら
    • Organizer
      日本脳卒中学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Book] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats(Tamaki N and Kuge Y (ed))(Molecular Imaging for Integrated Medical Therapy and Drug Development)2010

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Osanai T, Sugiyama T, Hokari M, Hida K, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Non-invasive optical tracking of bone marrow stromal cells transplanted into rat cerebral infarct2010

    • Author(s)
      Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N and Kuge Y (ed))2010

    • Author(s)
      Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Thermoreversible gelation polymer (TGP) hydrogel as a degradable scaffold for bone marrow stromal cell transplantation2010

    • Author(s)
      Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Kuroda S, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Maruichi K, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Chiba Y, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Osanai T, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Sugiyama T, et al
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] 骨髄間質細胞移植による中枢神経再生-最近の進歩。Annual Review神経2007

    • Author(s)
      黒田敏、岩崎喜信
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report
  • [Book] Annual Review神経2007

    • Author(s)
      黒田 敏
    • Total Pages
      450
    • Publisher
      骨髄間質細胞による中枢神経再生-最近の進歩
    • Related Report
      2007 Annual Research Report
  • [Book] Bone marrow stromal cell transplantation for central nervous system disorders-

    • Author(s)
      Kuroda S, Kuge Y, Tamaki N, Iwasaki Y
    • Total Pages
      2010
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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