| Project/Area Number |
19390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUZUKI Michiyasu Yamaguchi University, 大学院・医学系研究科, 教授 (80196873)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
SAITO Takashi 山口大学, 大学院・医学系研究科, 教授 (10162207)
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
ISHIZUKA Satoshi 九州工業大学, 大学院・生命体工学研究科, 准教授 (40124804)
KAJIWARA Koji 山口大学, 大学院・医学系研究科, 准教授 (90253161)
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| Research Collaborator |
MARUTA Yuichi 山口大学, 大学院・医学系研究科, 助教 (30543970)
FUJIOKA Hiroshi 山口大学, 医学部附属病院, 研修医
OKU Takayuki 山口大学, 大学院・医学系研究科・博士課程
UCHIYAMA Jyouji 山口大学, 大学院・医学系研究科・博士課程
TANAKA Nobuhiro 山口大学, 大学院・医学系研究科・博士課程
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 脳冷却 / 生体システム / ペルチエ素子 / 脳機能情報制御 / てんかん / 難治性疼痛ニューロモデュレーション / 局所脳冷却 / てんかん放電 / human / machine hybrid / ニューロモデュレーション / 難治性疼痛 / 凍結損傷 / 脳保護作用 / 脳虚血 / 頭部外傷 |
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| Research Abstract |
The aim of our study is to establish a focal brain cooling as a new treatment of epilepsy, intractable pain or severe neurotrauma. In the field of epilepsy, we demonstrated that focal cooling of the brain to a cortical surface temperature of 15 to 20℃ terminated epileptiform discharges without inducing irreversible neurophysiological dysfunctions or neuronal damage in brain tissue. We also confirmed the significant suppression of nociceptive pain due to the cooling of sensorimotor cortex, with a minimal influence on neurological functions in rats. Our studies suggest the focal cooling of the brain has a neuroprotective effect and has a therapeutic potential for patients who are suffering from severe brain disorders. Because of recent advances in the precision machinery industry, the application of an implantable local cooling system may be expected to become a reality in the near future. Finally, we advocate "thermal neuromodulation" as a new treatment paradigm.
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