Development of immunotherapy targeting glioma and glioma stem cell antigens
| Project/Area Number |
19390384
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
TODA Masahiro Keio University, 医学部, 講師 (20217508)
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| Co-Investigator(Kenkyū-buntansha) |
河瀬 斌 慶應義塾大学, 医学部, 教授 (40095592)
大多 茂樹 慶應義塾大学, 医学部, 助教 (20365406)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASE Takeshi 慶應義塾大学, 医学部, 教授 (40095592)
OHTA Shigeki 慶應義塾大学, 医学部, 助教 (20365406)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 癌幹細胞 / グリオーマ / 癌抗原 / 免疫療法 / 神経幹細胞 / 脳腫瘍 / 抗原 |
|---|
| Research Abstract |
グリオーマ・脳腫瘍幹細胞(brain cancer stem cell ; BCSC)共通抗原を標的とした免疫療法を開発するため、分離したBCSCの遺伝子解析を行った結果、新規BCSC抗原遺伝子(A)を同定した。また、転写因子SOX6がグリオーマ・BCSC共通抗原であることを明らかにして、SOX6由来のHLA-A02結合性T細胞エピトープペプチドを同定し、BCSC傷害性T細胞の誘導能を証明した。
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Report
(3 results)
Research Products
(55 results)
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[Journal Article] Identification of a neuron-specific human gene,KIAA1110,that is a guanine nucleotide exchange factor for ARF1.2007
Author(s)
Hattori Y, 0hta S, Hamada K, Yamada-Okabe H, kanemura Y, Matsuzaki Y, Okano H, Kawakami Y, Toda M
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Journal Title
Biochem Biophy Res Commun 364(4)
Pages: 737-742
Related Report
Peer Reviewed
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[Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical studies on cell therapy.2007
Author(s)
Ohta S, Ueda Y, Yaguchi M, Matsuzaki Y, Nakamura M, Toyama, Y Tanioka Y, Tamaoki N, Nomura T, Okano H, Kawakami Y, Toda M
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Journal Title
Immunology 123
Pages: 566-574
Related Report
Peer Reviewed
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