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Development of immunotherapy targeting glioma and glioma stem cell antigens

Research Project

Project/Area Number 19390384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKeio University

Principal Investigator

TODA Masahiro  Keio University, 医学部, 講師 (20217508)

Co-Investigator(Kenkyū-buntansha) 河瀬 斌  慶應義塾大学, 医学部, 教授 (40095592)
大多 茂樹  慶應義塾大学, 医学部, 助教 (20365406)
Co-Investigator(Renkei-kenkyūsha) KAWASE Takeshi  慶應義塾大学, 医学部, 教授 (40095592)
OHTA Shigeki  慶應義塾大学, 医学部, 助教 (20365406)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords癌幹細胞 / グリオーマ / 癌抗原 / 免疫療法 / 神経幹細胞 / 脳腫瘍 / 抗原
Research Abstract

グリオーマ・脳腫瘍幹細胞(brain cancer stem cell ; BCSC)共通抗原を標的とした免疫療法を開発するため、分離したBCSCの遺伝子解析を行った結果、新規BCSC抗原遺伝子(A)を同定した。また、転写因子SOX6がグリオーマ・BCSC共通抗原であることを明らかにして、SOX6由来のHLA-A02結合性T細胞エピトープペプチドを同定し、BCSC傷害性T細胞の誘導能を証明した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (55 results)

All 2009 2008 2007

All Journal Article (28 results) (of which Peer Reviewed: 26 results) Presentation (21 results) Book (1 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 3 results)

  • [Journal Article] Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF2009

    • Author(s)
      Hayashi K, Ohta S, Kawakami Y, Toda M
    • Journal Title

      J Neurosci Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical approach for hypoglossal schwannomas to prevent deformity of the atlanto-occipital joint2009

    • Author(s)
      Ichimura S, Yoshida K, Kawase T
    • Journal Title

      Acta Neurochir(Wien)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral tumor with extensive rhabdoid features and a favorable prognosis2009

    • Author(s)
      Ohba S, Yoshida K, Hirose Y, Ikeda E, Nakazato Y, Kawase T.
    • Journal Title

      J Neurosurg

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABC Surgical Risk Scale for skull base meningioma : a new scoring system for predicting the extent of tumor removal and neurological outcome2009

    • Author(s)
      Adachi K, Kawase T, Yoshida K, Yazaki T, Onozuka S.
    • Journal Title

      J Neurosurg

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization of adult infratentorial gliomas2009

    • Author(s)
      Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T
    • Journal Title

      J Neurooncol(Epub 2008 Oct 22) 91(3)

      Pages: 251-255

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer vaccine and immunotherapy for brain tumors.2009

    • Author(s)
      Toda M, Kawakami Y
    • Journal Title

      Curr Pharm Des (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF.2009

    • Author(s)
      Hayashi K, Ohta S, Kawakami Y, Toda M
    • Journal Title

      J Neurosci Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍抗原とマーカー2009

    • Author(s)
      戸田正博
    • Journal Title

      グリオーマ-その最新知見-

      Pages: 32-35

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Intraoperative navigation and fluorescence imagings in malignant glioma surgery2008

    • Author(s)
      Toda M
    • Journal Title

      Keio J Med 57(3)

      Pages: 155-161

    • NAID

      10021988794

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of dendritic cells from common marmosets for the treatment of CNS injury2008

    • Author(s)
      Toda M
    • Journal Title

      Inflammation and Regeneration 28(3)

      Pages: 174-180

    • NAID

      10022602578

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX62008

    • Author(s)
      Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M
    • Journal Title

      Int J Cancer 122(10)

      Pages: 2274-2279

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells following IL-12 administration2008

    • Author(s)
      Yaguchi M, Ohta S, Toyama Y, Kawakami Y, Toda M
    • Journal Title

      J Neurosci Res 86(9)

      Pages: 1972-1980

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmen to ftesticular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data-case report2008

    • Author(s)
      Takahashi S, Yoshida K, Mikami S, Oya M, Kawase T.
    • Journal Title

      Neurol Med Chir(Tokyo) 48(11)

      Pages: 522-525

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined gangliocytoma and prolactinoma of the pituitary gland2008

    • Author(s)
      Mikami S, Kameyama K, Takahashi S, Yoshida K, Kawase T, Sano T, Mukai M.
    • Journal Title

      Endocr Pathol 19(2)

      Pages: 117-121

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posterior inferior cerebellar artery aneurysm associated with persistent primitive hypoglossal artery2008

    • Author(s)
      Kobayashi M, Akaji K, Tanizaki Y, Mihara B, Ohira T, Kawase T
    • Journal Title

      Neurol Med Chir (Tokyo) 48(6)

      Pages: 259-261

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four subtypes of petroclival meningiomas : differences in symptoms and operative findings using the anterior transpetrosal approach2008

    • Author(s)
      Ichimura S, Kawase T, Onozuka S, Yoshida K, Ohira T
    • Journal Title

      Acta Neurochir (Wien)(Epub 2008 Jun 12) 50(7)

      Pages: 637-645

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dumbbell-shaped intradiploic epidermoid cyst involving the dura mater and cerebellum2008

    • Author(s)
      Ichimura S, Hayashi T, Yazaki T, Yoshida K, Kawase T
    • Journal Title

      Neurol Med Chir (Tokyo) 48(2)

      Pages: 83-85

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of dendritic cells from common marmosets for the treatment of CNS injury.2008

    • Author(s)
      Toda M
    • Journal Title

      Inflammation and Regeneration 28(3)

      Pages: 174-180

    • NAID

      10022602578

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6.2008

    • Author(s)
      Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M
    • Journal Title

      Int J Cancer 122(10)

      Pages: 2274-2279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells following IL-12 administration.2008

    • Author(s)
      Yaguchi M, Ohta S, Toyama Y, Kawakami Y, Toda M
    • Journal Title

      J Neurosci Res 86(9)

      Pages: 1972-1980

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative navigation and fluorescence imagings in malignant glioma surgery.2008

    • Author(s)
      Toda M
    • Journal Title

      Keio J Med 57(3)

      Pages: 155-161

    • NAID

      10021988794

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen,SOX6.2008

    • Author(s)
      Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M
    • Journal Title

      Int J Cancer (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells following IL-12 administration.2008

    • Author(s)
      Yaguchi M, Ohta S, Toyama Y, Kawakami Y, Toda M
    • Journal Title

      J Neurosci Res (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative navigation and fluorescence imagines in malignant eliom a surgery2008

    • Author(s)
      Toda M
    • Journal Title

      Keio J Med (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳神経外科学「3.下垂体周辺腫瘍への神経内視鏡手術」2008

    • Author(s)
      戸田 正博
    • Journal Title

      日本医事新報 4375

      Pages: 90-91

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Preferential expression and frequent IgG responses of a tumor antigen,SOX5,in glioma patients.2007

    • Author(s)
      Ueda R, Yoshida K, Kawase T, Kawakami Y, Toda M
    • Journal Title

      lnt J Cancer 120

      Pages: 1704-1711

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a neuron-specific human gene,KIAA1110,that is a guanine nucleotide exchange factor for ARF1.2007

    • Author(s)
      Hattori Y, 0hta S, Hamada K, Yamada-Okabe H, kanemura Y, Matsuzaki Y, Okano H, Kawakami Y, Toda M
    • Journal Title

      Biochem Biophy Res Commun 364(4)

      Pages: 737-742

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical studies on cell therapy.2007

    • Author(s)
      Ohta S, Ueda Y, Yaguchi M, Matsuzaki Y, Nakamura M, Toyama, Y Tanioka Y, Tamaoki N, Nomura T, Okano H, Kawakami Y, Toda M
    • Journal Title

      Immunology 123

      Pages: 566-574

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腫瘍幹細胞はここまで解析されている2009

    • Author(s)
      戸田正博
    • Organizer
      第29回日本脳神経外科コングレス総会
    • Year and Date
      2009-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 再発下垂体腫瘍の画像解析と治療法の検討2009

    • Author(s)
      戸田正博, 高橋里史, 河瀬 斌
    • Organizer
      第19回日本間脳下垂体腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Brain tumor stem cells and immunotherapy2009

    • Author(s)
      Toda M
    • Organizer
      SuZhou and Keio Friendship Joint Conference 2009
    • Place of Presentation
      中国・蘇州
    • Year and Date
      2009-02-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Brain tumor stem cells and immunotherapy.2009

    • Author(s)
      Toda M
    • Organizer
      SuZhou and Keio Friendship Joint Conference 2009
    • Place of Presentation
      中国・蘇州
    • Year and Date
      2009-02-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glioma cancer stem cellをターゲットとした新規治療法の開発2008

    • Author(s)
      深谷雷太、大多茂樹、河上裕、松崎有未、岡野栄之、戸田正博、河瀬斌
    • Organizer
      第26回日本脳腫瘍学会
    • Place of Presentation
      愛媛
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 脳腫瘍幹細胞の新たな分離法の開発2008

    • Author(s)
      戸田正博、大多茂樹、深谷雷太、河瀬斌
    • Organizer
      第26回日本脳腫瘍学会
    • Place of Presentation
      愛媛
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 頭蓋底腫瘍に対する経頭蓋手術と経鼻内視鏡手術併用の有用性2008

    • Author(s)
      戸田正博, 吉田一成, 冨田俊樹, 河瀬斌
    • Organizer
      第15回日本神経内視鏡学会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳腫瘍特異抗原の解析と脳腫瘍幹細胞に対する免疫療法への応用2008

    • Author(s)
      戸田正博
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 下垂体腫瘍の再発予測因子および再発腫瘍に対する治療法の検討2008

    • Author(s)
      戸田正博, 高橋里史, 河瀬斌
    • Organizer
      社団法人日本脳神経外科学会 第67回学術総会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] トルコ鞍下部巨大頭蓋蓋咽頭腫に対する経頭蓋および経鼻複合アプローチによる手術2008

    • Author(s)
      戸田正博
    • Organizer
      第20回日本頭蓋底外科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性脳腫瘍に対する新しい治療戦略2008

    • Author(s)
      戸田正博
    • Organizer
      第12回Water Front Neurosurgical Conference
    • Place of Presentation
      東京
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 前頭蓋底腫瘍に対する経頭蓋・経鼻複合アプローチによる手術2008

    • Author(s)
      戸田正博
    • Organizer
      第23回TKNJ Conference
    • Place of Presentation
      宇都宮
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳腫瘍幹細胞を標的とした新たな治療法の開発2007

    • Author(s)
      戸田 正博、深谷 雷太、田伏 将尚、大多 茂樹、河瀬 斌
    • Organizer
      第25回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] SP分画を用いた神経膠芽腫cell lineからの癌幹細胞様細胞の分離と同定2007

    • Author(s)
      深谷 雷太、大多 茂樹、河上 裕、河瀬 斌、戸田 正博
    • Organizer
      第25回日本脳腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] グリオーマ幹細胞の標的遺伝子の固定と新たな治療法の開発2007

    • Author(s)
      戸田 正博、深谷 雷太、田伏 将尚、大多 茂樹、河瀬 斌
    • Organizer
      第66回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunotherapy for the treatment of glioma & translational research2007

    • Author(s)
      Toda M
    • Organizer
      Samsung International Brain Tumor Symposium
    • Place of Presentation
      韓国・江南
    • Year and Date
      2007-09-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunotherapy targeting brain tumor stem cells2007

    • Author(s)
      Toda M
    • Organizer
      SMC Neuro-Oncology Workshop(Pre-Conference Workshop)
    • Place of Presentation
      韓国・江南
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sox6の神経幹・前駆細胞における発現および機能解析2007

    • Author(s)
      大多 茂樹、岡野 栄之、河瀬 斌、戸田 正博
    • Organizer
      第50回日本神経化学会(横浜)大会 Neuro 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 霊長類モデルを用いた樹状細胞移植による神経損傷治療の解析2007

    • Author(s)
      戸田 正博、矢口 雅江、田伏 将尚、大多 茂樹、塚田 晃三、山根 淳一、中村 雅也、松崎 有未、谷岡 功邦、河瀬 斌、戸山 芳昭、岡野 栄之
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳腫瘍の遺伝子異常-最近の知見と臨床への応用-2007

    • Author(s)
      佐々木 光、矢崎 貴仁、戸田 正博、吉田 一成、河瀬 斌
    • Organizer
      第11回Water Front Neurosurgical Conference
    • Place of Presentation
      横浜
    • Year and Date
      2007-07-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 不活性HSVを用いた悪性神経膠腫に対する免疫療法2007

    • Author(s)
      深谷 雷太、戸田 正博、吉田 一成、河上 裕、河瀬 斌
    • Organizer
      第33回ニューロ・オンコロジィの会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-07
    • Related Report
      2007 Annual Research Report
  • [Book] 腫瘍抗原とマーカーグリオーマ-その最新知見-2009

    • Author(s)
      戸田正博
    • Total Pages
      130
    • Publisher
      メジカルビュー社
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] HSVを用いた抗腫瘍剤2008

    • Inventor(s)
      戸田正博、河上裕、飯塚幸彦、上田陽子、岩堀禎廣
    • Industrial Property Rights Holder
      慶應義塾大学
    • Filing Date
      2008-06-10
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌ワクチン2008

    • Inventor(s)
      戸田正博, 植田良, 塚田晃三
    • Industrial Property Rights Holder
      慶應義塾大学
    • Filing Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 神経幹細胞の分離方法及び増殖促進方法2008

    • Inventor(s)
      戸田 正博、大多 茂樹
    • Industrial Property Rights Holder
      慶鹿義塾
    • Industrial Property Number
      2008-014243
    • Filing Date
      2008-01-24
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌ワクチン2007

    • Inventor(s)
      戸田正博、植田良、塚田晃三
    • Industrial Property Rights Holder
      慶應義塾大学
    • Filing Date
      2007-12-04
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌ワクチン2007

    • Inventor(s)
      戸田 正博、植田 良、塚田 晃三
    • Industrial Property Rights Holder
      慶鹿義塾
    • Industrial Property Number
      2007-313856
    • Filing Date
      2007-12-04
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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