Development of boron neutron capture therapy for the standard treatment of malignant brain tumors

• Project/Area Number: 19390385
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka Medical College
• Principal Investigator: MIYATAKE Shinichi Osaka Medical College, 医学部, 准教授 (90209916)
• Co-Investigator(Kenkyū-buntansha): MATSUI Hideki 岡山大学, 医学部, 教授 (30157234) ; ONO Koji 京都大学, 原子炉実験所, 教授 (90122407) ; KIRIHATA Mitsunori 大阪府立大学, 生命環境科学研究科, 教授 (60128767) ; KASAOKA Satoshi 広島国際大学, 薬学部, 助教 (90338690) ; KUROIWA Toshihiko 大阪医科大学, 医学部, 教授 (30178115) ; KAWABATA Shinji 大阪医科大学, 医学部, 助教 (20340549)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: BNCT / GBM / liposome / 原子炉 / 加速器 / スーパー特区 / lipospme / malignant glioma / malignant meninigioma / Transferin-PEG-Liposome / Protocol

Research Abstract

われわれの施設において硼素中性子捕捉療法により治療した新規診断GBMおよび再発悪性グリオーマの治療成績を検討したところ、後述のように有意な治療効果が確認できた。一方で、硼素化合物のキャリアーとしてはtransferin-liposomeを開発し、これによる治療効果の改善を動物実験モデルを用いて報告した。
2009年度は上記結型サイクロトロ果を基に、多施設共同第二相臨床試験を計画している。加えて、新規中性子源として小ンの開発に成功し、新規硼素化合物と合わせた治験を計画中である。

Research Products

• [Journal Article] Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His (2009)
  • Author(s): Bin Feng, Kazuhito Tomizawa, Hiroyuki Michiue, Shin-ichi Miyatake, Xiao-Jian Han, Atsushi Fujimura, Masaharu Seno, Mitsunori Kirihata, Hideki Matsui
  • Journal Title: Biomaterials 30(9) Pages: 1746-55
  • Peer Reviewed
• [Journal Article] Boron Neutron Capture Therapy for Papillary Cystadenocarcinoma in the Upper Lip : A Case Report (2009)
  • Author(s): Yoshihiro Kimura, Yasunori Ariyoshi, Shin-Ichi Miyatake, Masashi Shimahara, Shinji Kawabata, Koji Ono
  • Journal Title: International Journal of Oral & Maxillofacial Surgery 38(3) Pages: 293-5
  • Peer Reviewed
• [Journal Article] Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas (2009)
  • Author(s): Shin-Ichi Miyatake, Shinji Kawabata, Naosuke Nonoguchi, Kunio Yokoyama, Toshihiko Kuroiwa, Hideki Matsui and Koji Ono
  • Journal Title: Neuro-Onocology
  • Peer Reviewed
• [Journal Article] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas (2009)
  • Author(s): Shin-Ichi Miyatake, Shinji Kawabata, Kunio Yokoyama, Toshihiko Kuroiwa, Hiroyuki Michiue, Yoshinori Sakurai, Hiroaki Kumada, Minoru Suzuki, Akira Maruhashi, Mitsunori Kirihata, Koji Ono
  • Journal Title: J Neuro-Oncol 91 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): Shinji Kawabata, Shin-Ichi Miyatake, Toshihiko Kuroiwa, Kunio Yokoyama, Atsushi Doi, Kyoko Iida, Shiro Miyata, Naosuke Nonoguchi, Hiroyuki Michiue, Masatsugu Takahashi, Taisuke Inomata, Yoshio Imahoti, Mitsunori Kirihata, Yoshinori Sakurai, Akira Maruhashi, Hiroaki Kumada, and Koji Ono
  • Journal Title: J Rad Res 50 Pages: 51-60
  • NAID: 110007042075
  • Peer Reviewed
• [Journal Article] Planned fractionated boron neutron capture therapy using epithermal neutrons for a patient with recurrent squamous cell carcinoma in the temporal bone : a case report (2009)
  • Author(s): Haginomori S, Miyatake-S, et al
  • Journal Title: Head and Neck 31 Pages: 412-418
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): Kawabata S, Miyatake S, et al
  • Journal Title: J Rad Res 50 Pages: 51-60
  • NAID: 110007042075
  • Peer Reviewed
• [Journal Article] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas. (2009)
  • Author(s): Miyatake S, et al
  • Journal Title: J Neuro-Oncol 91 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Boron Neutron Capture Therapy for Papillary Cystadenocarcinoma in the Upper Lip : A Case Report. (2009)
  • Author(s): Kimura Y, Miyatake S, et al
  • Journal Title: International Journal of Oral & Maxillofacial Surgery 38 Pages: 293-295
  • Peer Reviewed
• [Journal Article] Pseudoprogression"と「硼素中性子捕捉療法」 (2009)
  • Author(s): 宮武伸一, 他
  • Journal Title: 脳21 12 Pages: 71-74
• [Journal Article] Delivery of sodium borocaptate to glioma cells using immunoliposomec onjugated with anti-EGFR antibodies by ZZ-His. (2009)
  • Author(s): Feng B, Miyatake S, et al
  • Journal Title: Biomaterials 30 Pages: 1746-1755
  • Peer Reviewed
• [Journal Article] Planned fractionated boron neutron capture therapy using epithermal neutrons for a patient with recurrent squamous cell carcinoma in the temporal bone : a case report (2008)
  • Author(s): Shin-Ichi Haginomori, Shin-Ichi Miyatake, Takaki Inui, Michitosi Araki, Shinji Kawabata, Atsuko Takamaki, Koutetsu Lee, Hiroshi Takenkaka, Toshihiko Kuroiwa, Yasuo Uesugi, Hiroaki, Kumada, Koji Ono
  • Journal Title: Head and Neck 31 Pages: 412-418
  • Peer Reviewed
• [Journal Article] Evaluation of Fluoride-labeled Boronophenylalanine-PET Imaging for the Study of Radiation Effects in Patients with Malignant Gliomas (2008)
  • Author(s): Minoru Miyashita, Shin-Ichi Miyatake, Yoshio Imahori, Kunio Yokoyama, Shinji Kawabata, Yoshinaga Kajimoto, Masa-Aki Shibata, Yoshinori Otsuki, Mitsunori Kirihata, Koji Ono, and Toshihiko Kuroiwa
  • Journal Title: J Neuro-Oncol 89(2) Pages: 239-46
  • Peer Reviewed
• [Journal Article] Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes for boron neutron capture therapy (2008)
  • Author(s): Atsushi Doi, Kyoko Iida, Kunio Yokoyama, Shinji Kawabata, Yoshinaga Kajimoto, Toshihiko Kuroiwa, Takashi Shirakawa, Mitsunori Kirihata, Satoshi Kasaoka, Kazuo Maruyama, Yoshinori Sakurai, Shin-Ichiro Masunaga, Koji Ono and Shin-Ichi Miyatake
  • Journal Title: J Neurooncol 87(3) Pages: 287-94
  • Peer Reviewed
• [Journal Article] Evaluation of Fluoride-labeled Boronophenylalanine-PET Imaging for the Study of Radiation Effects in Patients with Malignant Gliomas (2008)
  • Author(s): Miyashita M, Miyatake S-I, et al.
  • Journal Title: J Neurooncol 89 Pages: 239-46
  • Peer Reviewed
• [Journal Article] Fluorescence of non-neoplastic, MRI-enhancing tissue by 5-aminolevulenic acid : Report of 3 cases (2007)
  • Author(s): Miyatake S, Kuroiwa T, Kajimoto Y, Miyashita M, Tanaka H, Tsuji M
  • Journal Title: Neurosurgery 61
  • Peer Reviewed
• [Journal Article] 放射線治療の新たなパラダイム硼素中性子捕捉療法(細胞選択的放射線治療)の現状と将来 (2007)
  • Author(s): 小野公二、鈴木実、菓子野元郎、木梨友子、増永慎一郎、田中浩樹、丸橋晃、櫻井良憲、宮武伸一、川端信司、平塚純一、粟飯原輝人、加藤逸郎
  • Journal Title: 病院設備 49 Pages: 520-529
• [Journal Article] Boron Neuron Capture Therapy Using Epithermal Neutrons for Recurrent Cancer in the Oral Cavity and Cervical Lymph Node Metastasis (2007)
  • Author(s): Ariyoshi Y, Miyatake S-I, Kimura Y, Shimahara T, Kawabata S, Nagata K, Suzuki M, Maruhashi A, Ono K, Shimahara M
  • Journal Title: Oncol Rep 18(4) Pages: 861-866
  • Peer Reviewed
• [Journal Article] 脳腫瘍に対する新規放射線治療 (2007)
  • Author(s): 宮武伸一
  • Journal Title: CI研究 第29巻 Pages: 1-8
  • NAID: 10019948100
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for malignant tumors related to meninigiomas (2007)
  • Author(s): Shin-Ichi Miyatake, Yoji Tamura, Shinji Kawabata, Toshihiko Kuroiwa, and Koji Ono
  • Journal Title: Neurosurgery 61 Pages: 82-91
  • Peer Reviewed
• [Journal Article] Analysis of boron distribution in vivo for BNCT using two different boron compounds by secondary ion mass spectroscopy (2007)
  • Author(s): Kunio Yokoyama, Shin-Ichi Miyatake, Yoshinaga Kajiomoto, Shinji Kawabata, Atsushi Doi, Toshiko Yoshida, Motonori Okabe, Mitsunori Kirihata, Koji Ono
  • Journal Title: Radiation Research 167 Pages: 102-109
  • Peer Reviewed
• [Journal Article] Analysis of boron distribution in vivo for BNCT using two different boron compounds by secondary ion mass spectroscopy (2007)
  • Author(s): Yokoyama K, Miyatake, S-I., et. al.
  • Journal Title: Radiation Research 167 Pages: 102-109
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for malignant tumors related to meninigiomas (2007)
  • Author(s): Miyatake S-I, et. al.
  • Journal Title: Neurosurgery 61 Pages: 82-91
  • Peer Reviewed
• [Journal Article] 脳腫瘍に対する新規放射線治療 (2007)
  • Author(s): 宮武 伸一
  • Journal Title: CI研究 29 Pages: 1-8
  • NAID: 10019948100
• [Journal Article] Boron Neuron Capture Therapy Using Epithermal Neutrons for Recurrent Cancer in the Oral Cavity and Cervical Lymph Node Metastasis (2007)
  • Author(s): Ariyoshi Y, Miyatake S-I, et. al.
  • Journal Title: Oncol Rep 18 Pages: 861-866
  • Peer Reviewed
• [Journal Article] 放射線治療の新たなパラダイム硼素中性子捕捉療法(細胞選択的放射線治療)の現状と将来 (2007)
  • Author(s): 小野 公二、宮武 伸一, 他
  • Journal Title: 病院設備 49 Pages: 520-529
• [Journal Article] Fluorescence of non-neoplastic,MRI-enhancing tissue by 5-am inolevulenic acid:Report of 3 cases (2007)
  • Author(s): Miyatake S-I, et. al.
  • Journal Title: Neurosurgery 61 Pages: 1101-1104
  • Peer Reviewed
• [Journal Article] Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes for boron neutron capture therapy
  • Author(s): Doi A, Miyatake S-I, et. al.
  • Journal Title: J Neurooncol
  • Peer Reviewed
• [Presentation] BPA-PETによる脳腫瘍の病態解析(放射線壊死の診断と治療) (2009)
  • Author(s): 宮武伸一, 他
  • Organizer: 平成20年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 京都大学原子炉実験所
  • Year and Date: 2009-02-06
• [Presentation] 脳腫瘍の臨床 (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 愛知県松山市大和屋本店
  • Year and Date: 2008-12-01
• [Presentation] グリオーマに対する放射線治療の進歩 (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 愛知県松山市大和屋本店
  • Year and Date: 2008-12-01
• [Presentation] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas (2008)
  • Author(s): Miyatake S-I, et.al.
  • Organizer: 13^<th> ICNCT(International Conference of Neutron Capture Therapy)
  • Place of Presentation: Florence
  • Year and Date: 2008-11-05
• [Presentation] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas (2008)
  • Author(s): Miyatake S-I, et al
  • Organizer: 13^<th> ICNCT (International Conference of Neutron Capture therapy)
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-05
• [Presentation] Biodistribution and Imaging studies on F98 rat glioma by convection enhanced delivery of transferrin targeting PEG liposomes encapsulating both BSH and iodine contrast agent (2008)
  • Author(s): Miyatake S-I, et al
  • Organizer: 13^<th> ICNCT(International Conference of Neutron Capture therapy)
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-11-05
• [Presentation] 悪性脳腫瘍に対する高線量放射線治療の挑戦、腫瘍特異的粒子線治療法硼素中性子捕捉療法(BNCT)を中心として (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第67回日本癌学会学術総会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 悪性脳腫瘍に対する高線量放射線治療の挑戦、腫瘍選択的粒子線治療法素中性子捕捉療法(BNCT)を中心として (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 硼素中性子捕捉療法は再発悪性グリオーマの生命予後改善に貢献しているか? (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 日本脳神経外科学会第67回学術総会
  • Place of Presentation: 盛岡グランドホテル
  • Year and Date: 2008-09-03
• [Presentation] 悪性グリオーマに対する硼素中性子捕捉療法におけるPseudoprogressionその病態の解析 (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 日本脳神経外科学会第67回学術総会
  • Place of Presentation: 盛岡グランドホテル
  • Year and Date: 2008-09-03
• [Presentation] PETに基づいた腫瘍選択的粒子治療borun neutron capture therapy (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: PETサマーセミナー2008in裏磐梯
  • Place of Presentation: 裏磐梯猫魔ホテル
  • Year and Date: 2008-08-23
• [Presentation] 硼素中性子捕捉療法は再発悪性グリオーマの生命予後改善に貢献しているか? (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第5回日本中性子捕捉療法学会
  • Place of Presentation: 倉敷
  • Year and Date: 2008-07-25
• [Presentation] 硼素中性子捕捉療法は再発悪性グリオーマの生命予後改善に貢献しているか? (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第5回日本中性子捕捉療法学会
  • Place of Presentation: 倉敷アイビースクエア
  • Year and Date: 2008-07-25
• [Presentation] Boron neutron capture therapy for newly diagnosed glioblastoma (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第17回国際脳腫瘍治療研究会議
  • Place of Presentation: 函館
  • Year and Date: 2008-06-10
• [Presentation] Boron neutron capture therapy for newly diagnosed gliob lastoma (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第17回国際脳腫瘍治療研究会議
  • Place of Presentation: 大沼プリンスホテル
  • Year and Date: 2008-06-10
• [Presentation] 非腫瘍性病変もPpIXの蛍光を発する (2008)
  • Author(s): 宮武伸一, 他
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2008-05-23
• [Presentation] Can boron neutron capture therapy prolong the survival of recurrent malignant glioma patients? (2008)
  • Author(s): Miyatake S-I, et.al.
  • Organizer: 8^<th> meeting of the European association of Neurooncology
  • Place of Presentation: Barcelona
• [Presentation] Can boron neutron capture therapy prolong the survival of recurrent malignant glioma patients? (2008)
  • Author(s): Miyatake S-I, et al
  • Organizer: 8^<th> MEETING OF THE EUROPEAN ASSOCIATION OF NEUR00NCOLOGY (EANO)
  • Place of Presentation: Spain Barcelona
• [Presentation] F-BPA-PETを用いた悪性脳腫瘍の病態解析 (2007)
  • Author(s): 宮武伸一
  • Organizer: 第66回日本脳神経外科学会総会シンポジウム3A-S21最先端画像診断法の有用性の検討
  • Place of Presentation: 東京
  • Year and Date: 2007-10-05
• [Book] F-BPA-PETによる脳腫瘍の病態解析と細胞選択的粒子線治療への応用デジタルメディスン (2009)
  • Author(s): 宮武伸一
  • Publisher: PET/CT Book
• [Book] 脳21 (2009)
  • Author(s): 宮武伸一、野々口直助、川端信司、黒岩敏彦
  • Publisher: Pseudoprogression"と「硼素中性子捕捉療法」
• [Book] F-BPA-PETによる脳腫瘍の病態解析と細胞選択的粒子線治療への応用 (2009)
  • Author(s): 宮武伸一
  • Total Pages: 175
  • Publisher: デジタルメディスン