Analysis of synovial sarcoma oncogene SYT-SSX for development of new therapy

• Project/Area Number: 19390386
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: TANAKA Shinya Hokkaido University, 大学院・医学研究科, 教授 (70261287)
• Co-Investigator(Kenkyū-buntansha): NISHIHARA Hiroshi 北海道大学, 大学院・医学研究科, 准教授 (50322805) ; MINAMI Akio 北海道大学, 大学院・医学研究科, 教授 (20133738) ; 笹井 研 北海道大学, 大学院・医学研究科, 特任助教 (80435958)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 滑膜肉腫 / SYT-SSX / トランスジェニックマウス / ノックアウトマウス / シグナル伝達 / CRK / knockout mouse / Crk / Gab1 / Knockout mouse / Gabl

Research Abstract

The purpose of this study is to analyze the transforming mechanism of human synovial sarcoma-associated oncogene SYT-SSX and to establish the basic system for the development of new therapy. We originally proved that SYT-SSX is responsible oncogene for human synovial sarcoma, and in this study, we found that signalling adaptor protein Crk is involved in malignant feature of synovial sarcoma and one of the map kinase family protein as p38 plays an important role. Furthermore, SYT-SSX transgenic mice which develop synovial sarcoma and also SYT knockout mice were established in this study. The mice model of human synovial sarcoma should be expected to provide versatile effect for the evaluation of new therapeutic reagents.

Research Products

• [Journal Article] Lab. Invest (2009)
  • Author(s): Kimura, T., Sakai, M., Tabu, K., Wang. L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S., Nakayama, KI
• [Journal Article] Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration (2009)
  • Author(s): Watanabe, T., Tsuda, M., Makino, Y., Konstantinou T., Nishihara, H., Majima, T., Minami, A., Feller, SM., Tanaka, S
  • Journal Title: Cell Res 19 Pages: 638-650
• [Journal Article] Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis (2009)
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  • NAID: 120005367446
• [Journal Article] Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice (2009)
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• [Journal Article] Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice (2009)
  • Author(s): Yokota, T., Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobiri, MA., Ono, T., Suga, T., Kuroda, S., Tanaka, S., Terasaki, F., Okita, K., Tsutsui, H
  • Journal Title: Am J Physiol Heart Circ Physiol 297 Pages: 1069-1077
• [Journal Article] networks for physiological and pathological signaling (2009)
  • Author(s): Birge, RB., Kalodimos, C., Inagaki, F., Tanaka, S. Crk, CrkL adaptor proteins
  • Journal Title: Cell Commun Signal 7 Pages: 13-13
• [Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. (2009)
  • Author(s): Kimura T
  • Journal Title: Lab. Invest 89 Pages: 645-656
  • Peer Reviewed
• [Journal Article] Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. (2009)
  • Author(s): Watanabe T
  • Journal Title: Cell Res 19 Pages: 638-650
  • Peer Reviewed
• [Journal Article] Integral role of transcription factor 8 in the negative regulation of tumor angioge nesis. (2009)
  • Author(s): Inusuka T
  • Journal Title: Cancer Res 69 Pages: 1678-1684
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• [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. (2009)
  • Author(s): Ohnishi N
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 1003-1008
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• [Journal Article] Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. (2009)
  • Author(s): Yokota T
  • Journal Title: Am J Physiol Heart Circ Physiol 297 Pages: 1069-1077
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• [Journal Article] A case of central nervous system lymphomatoid granulomatosis ; characteristics of PET imaging and pathological findings. (2009)
  • Author(s): Nishihara H
  • Journal Title: J Nerooncol 93 Pages: 275-278
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• [Journal Article] Crk and CrkL adaptor proteins : networks for physiological and pathological signaling. (2009)
  • Author(s): Birge RB
  • Journal Title: Cell Commun Singnal 10 Pages: 7-13
  • Peer Reviewed
• [Journal Article] シグナル伝達アダプター分子CRKの生物学的役割 (2009)
  • Author(s): 田中伸哉
  • Journal Title: 生化学 81 Pages: 361-376
  • NAID: 10024916545
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• [Journal Article] 脳腫瘍(グリオーマ)における分子病理診断-分子解析と治療法を示唆するMGMT発現評価法を中心として- (2009)
  • Author(s): 田中伸哉
  • Journal Title: 医学のあゆみ 229 Pages: 981-986
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• [Journal Article] 術中捺印細胞診標本を用いた脳腫瘍のMGMT免疫染色法:退形成性乏突起膠腫による検討 (2009)
  • Author(s): 青柳瑛子
  • Journal Title: 日本臨床細胞学会北海道支部会報 18 Pages: 4-7
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• [Journal Article] Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methy lguanine-DNA methyltransferase status in glioma (2008)
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  • Journal Title: Am. J. Surg. Pathol 32 Pages: 1220-1227
• [Journal Article] Promoter hypomethylation regulates CD133 expression in human gliomas (2008)
  • Author(s): Tabu, K., Sasai, K., Kimura, T., Wang, L., Aoyanagi, E., Kohsaka, S., Tanino, M., Nishihara, H., Tanaka, S
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• [Journal Article] PILRαis a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B (2008)
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  • Journal Title: Cell 132 Pages: 935-944
• [Journal Article] Establishment of a luciferase assay-based screening system: fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT (2008)
  • Author(s): Wang, L., Sasai, K., Akagi, T., Tanaka, S
  • Journal Title: Biochem. Biophys, Res, Commun 373 Pages: 392-396
• [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse (2008)
  • Author(s): Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., Yamada, G., Azuma, T., Hatakeyama, M
  • Journal Title: Proc. Natl. Acad. Sci. U S A 105 Pages: 1003-1008
• [Journal Article] Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/-mice (2008)
  • Author(s): Mishima, T., Iwabuchi, K., Fujii, S., Tanaka, S., Ogura, H., Watano-Miyata, K., Ishimori, N., Andoh, Y. Nakai, Y., Iwabuchi, C., Ato, M., Kitabatake, A., Tsutsui, H., Onoe, K
  • Journal Title: Int., J. Mol. Med 21 Pages: 181-187
• [Journal Article] Harlequin ichthyosis model mouse reveals alveolar aollapse and severe fetal skin barrier defects (2008)
  • Author(s): Yanagi, T., Akiyama, M., Nishihara, H., Sakai, K. Nishie, W., Tanaka, S., Shimizu, H
  • Journal Title: Human Mol. Genetics 17 Pages: 3075-3083
• [Journal Article] Establishment of a luciferase assay-based screening system : fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT (2008)
  • Author(s): Wang, L., et.al.
  • Journal Title: Biochem. Biophys, Res, Commun. 373 Pages: 392-396
  • Peer Reviewed
• [Journal Article] PILRα is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B (2008)
  • Author(s): Satoh, T., et.al.
  • Journal Title: Cell 132 Pages: 935-944
  • Peer Reviewed
• [Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse (2008)
  • Author(s): Ohnishi, N., et.al.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 1003-1008
  • Peer Reviewed
• [Journal Article] Promoter hypomethylation regulates CD133 expression in human gliomas (2008)
  • Author(s): Tabu, K., et.al.
  • Journal Title: Cell Res. 18 Pages: 1037-1046
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-I receptor acts as a growth regulator in synovial sarcoma (2008)
  • Author(s): Friedrichs, N., et.al.
  • Journal Title: J. Pathol. 216 Pages: 428-439
  • Peer Reviewed
• [Journal Article] Harlequin ichthyosis model mouse reveals alveolar aollapse and severe fetal skin barrier defects (2008)
  • Author(s): Yanagi, T., et.al.
  • Journal Title: Human Mol. Genetics 17 Pages: 3075-3083
  • Peer Reviewed
• [Journal Article] Expression of OLIG2 suppresses the motility of human glial tumor cell line via RhoA activation (2008)
  • Author(s): Tabu, K., Ohba, Y., Suzuki, T., Makino, Y., Ohnishi, A., Sakai, M., Watanabe, T., Kimura, T., Tanaka, S., and Sawa, H.
  • Journal Title: Mol. Cancer Res (In press)
  • Peer Reviewed
• [Journal Article] Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK (2007)
  • Author(s): Kobashigawa, Y., Sakai, M., Naito, M., Yokochi, M., Kumeta, H., Makino, Y., Ogura, K., Tanaka, S., Inagaki, F
  • Journal Title: Nature Strct&Mol. Biol 6 Pages: 503-510
  • NAID: 40015830831
• [Journal Article] O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies (2007)
  • Author(s): Sasai, K., Akagi, T., Aoyanagi, E., Tabu, K., Kaneko, S., Tanaka, S
  • Journal Title: Mol. Cancer 6 Pages: 36-36
• [Journal Article] Expression of OLIG2 suppresses the motility of human glial tumor cell line via RhoA activation (2007)
  • Author(s): Tabu, K., Ohba, Y., Suzuki, T., Makino, Y., Ohnish, A., Sakai, M., Watanabe, T., Kimura, T., Tanaka, S., Sawa, H
  • Journal Title: Mol. Cancer Res 5 Pages: 1099-1109
• [Journal Article] Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4 (2007)
  • Author(s): Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H., Tanaka, S
  • Journal Title: Biochem Biophys Res Commun 362 Pages: 976-98
  • NAID: 120000955825
• [Journal Article] Immunohistochemical and Gene Rearrangement Studies of Central Nervous System Lymphomatoid Granulomatosis (2007)
  • Author(s): Nishihara, H., Tateishi, U., Itoh, T., Nagashima, K., Tanaka, S
  • Journal Title: Neuropathology 27 Pages: 413-417
  • NAID: 10021236336
• [Journal Article] Type I interferon prolongs cell cycle progression via p21 WAF1/CIP1 induction in human colon cancer cells (2007)
  • Author(s): Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S
  • Journal Title: Int. J. Oncol 31 Pages: 613-620
• [Journal Article] Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. (2007)
  • Author(s): Kobashigawa, Y., Sakai, M., Naito, M., Yokochi, M., Kumeta, H., Makino, Y., Ogura, K., *Tanaka, S., and *Inagaki, F.(*co-corres ponding author)
  • Journal Title: Nature Strct&Mol. Biol. 6 Pages: 503-510
  • NAID: 40015830831
  • Peer Reviewed
• [Journal Article] O^6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies. (2007)
  • Author(s): Sasai, K., Akagi, T., Aoyanagi, E., Tabu, K., Kaneko, S., and Tanaka, S.
  • Journal Title: Mol. Cancer 6 Pages: 36-36
  • Peer Reviewed
• [Journal Article] Enteritis necroticans ‘pigbel' in a Japanese diabetic adult (2007)
  • Author(s): Matsuda, T., Okada, Y., Inagi, E., Tanabe, Y., Shimizu, Y., Nagashima, K., Sakurai, J., Nagahama, M., and Tanaka, S.
  • Journal Title: Pathol. Inter 57 Pages: 622-626
  • NAID: 10027375194
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• [Journal Article] Primary Gastric Hodgkin's Lymphoma Expressing a B-Cell Profile Including Oct-2 and Bob-1 Proteins. (2007)
  • Author(s): Saito, M., Tanaka, S., Mori, A., Toyoshima, N., Irie, T., Morioka, M.
  • Journal Title: Int J Hematol 85 Pages: 421-425
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• [Journal Article] Type I interferon prolongs cell cycle progression via p21 WAF1/CIP1 induction in human colon cancer cells. (2007)
  • Author(s): Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., and Todo, S.
  • Journal Title: International Journal of oncology 31 Pages: 613-620
  • Peer Reviewed
• [Journal Article] Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4. (2007)
  • Author(s): Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H., Tanaka, S.
  • Journal Title: Biochem Biophys Res Commun 362 Pages: 976-981
  • NAID: 120000955825
  • Peer Reviewed
• [Journal Article] Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis. (2007)
  • Author(s): Nishihara, H, Tateishi, U., Itoh, T., Nagashima, K., and Tanaka, S.
  • Journal Title: Neuropathology 27 Pages: 413-418
  • NAID: 10021236336
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• [Journal Article] Loss of Suppressor-of-Fused function promotes tumorigenesis. (2007)
  • Author(s): Lee, Y., Kawagoe, R., Sasai, K., Li, Y., Russell, HR., Curran, T., McKinnon PJ.
  • Journal Title: Oncogene 26 Pages: 6442-6447
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• [Journal Article] Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a Smoothened inhibitor. (2007)
  • Author(s): Sasai, K., Romer, JT., Kimura, H., Eberhant, DE., Rice, DS., Curran, T.
  • Journal Title: Cancer Res 67 Pages: 3871-3877
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• [Journal Article] The Ras-MARK pathway downregulates Caveolin-1 in rodent fibroblast but not in human fibroblasts: Implications in the resistance to oncogene-mediated transformation. (2007)
  • Author(s): Sasai, K., Kakumoto, K., Hanafusa, H., Akagi, T.
  • Journal Title: Oncogene 26 Pages: 449-455
  • Peer Reviewed
• [Presentation] 個体レベルにおけるHelicobacter pyloci CagA構造多型と病態との関連解析 (2009)
  • Author(s): Nomi Ohnishi
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] 中枢神経発症のリンパ腫様肉芽腫症は、T細胞リンパ腫の初期病変である (2009)
  • Author(s): Hiroshi Nishihara
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] FRETバイオセンターを用いたCML分子標的薬剤の薬効評価系の構築 (2009)
  • Author(s): Tatsuki Mizutani
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] Dock180はホジキン細胞に発現し細胞の形態制御に重要な役割を果たしている (2009)
  • Author(s): 王磊
  • Organizer: 第98回北海道癌談話会例会
  • Place of Presentation: 札幌 札幌医科大学
  • Year and Date: 2009-09-19
• [Presentation] 腫瘍形成におけるoncogene induced senescence回避の解析 (2009)
  • Author(s): 高阪真路
  • Organizer: 第98回北海道癌談話会例会
  • Place of Presentation: 札幌 札幌医科大学
  • Year and Date: 2009-09-19
• [Presentation] 脳腫瘍血管壁の組織病理学的解析;Glomeruloid vesselは肥厚した幼弱なPericyteで構成されている (2009)
  • Author(s): 菅野宏美
  • Organizer: 第42回北海道病理談話会
  • Place of Presentation: 札幌 札幌医科大学
  • Year and Date: 2009-09-12
• [Presentation] 血管内悪性リンパ腫の1剖検例 (2009)
  • Author(s): 古山裕康
  • Organizer: 神経病理学会北海道地方会
  • Place of Presentation: 札幌 北海道大学
  • Year and Date: 2009-09-12
• [Presentation] Dock180はHodgkin細胞に発現し、細胞の形態制御に重要な役割を果たしている (2009)
  • Author(s): 王磊
  • Organizer: 第2回若手研究者交流会
  • Place of Presentation: 札幌 北海道大学学術交流会館
  • Year and Date: 2009-07-17
• [Presentation] 悪性胸膜中皮腫におけるシグナル伝達アダプター分子CRKを介したRac活性の可視化 (2009)
  • Author(s): 谷野美智枝
  • Organizer: 第49回日本呼吸器学会学術講演会
  • Place of Presentation: 東京 東京国際フォーラム
  • Year and Date: 2009-06-12
• [Presentation] 髄膜腫におけるDOCK180の発現の検討 (2009)
  • Author(s): 西原広史
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 香川 サンポート香川、かがわ国際会議場
  • Year and Date: 2009-06-04
• [Presentation] Quantitative Proteome Analysis in Transformed Astrocyte Cells using Spectral Counting and SILAC Methods (2009)
  • Author(s): Kiyonaga Fujii
  • Organizer: Pennsylvanvia Convention Center
  • Place of Presentation: フィラデルフィア Philadelphia、アメリカ
  • Year and Date: 2009-05-31
• [Presentation] GlioblastomaにおけるCD133の発現の免疫組織学的解析 (2009)
  • Author(s): 田中伸哉
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 臨床病理検討会3 (2009)
  • Author(s): 田中伸哉
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 小児脳腫瘍の特性 (2009)
  • Author(s): 田中伸哉
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 悪性グリオーマに対するガンマナイフ治療後の病理像学的検討 (2009)
  • Author(s): 佐藤憲市
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 脳腫瘍血管壁の組織病理学的解析:Glomeruloid vesselは肥厚した幼若なPericyteで構成されている (2009)
  • Author(s): 西原広史
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 北斗病院16年間の脳腫瘍548例の新WHO分類(2007)に基づいた再検討 (2009)
  • Author(s): 吉永智彰
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 第3脳室内に発生し腫瘍出血を伴ったpilocytic astrocytomaの一例 (2009)
  • Author(s): 及川光照
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] 出血を伴った脊髄悪性腫瘍の一例 (2009)
  • Author(s): 尾崎義丸
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡 アクロス福岡
  • Year and Date: 2009-05-08
• [Presentation] Gliomaの腫瘍形成能におけるCHD5の役割の検討 (2009)
  • Author(s): 高阪真路
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] Blastic plasmacytoid dendritic cell neoplasmの2例 (2009)
  • Author(s): ヘールナンデス真子
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] DOCK180はHodgin細胞に発現し、細胞の形態制御に重要な役割を果たしている (2009)
  • Author(s): 王磊
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] グリオーマにおけるOlig2発現制御機構と機能解析 (2009)
  • Author(s): 野田頭未歩
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] N型糖鎖のbisectin GlcNAc構造は膠芽腫においてMIB1インデックスが低い領域に高発現する (2009)
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  • Organizer: 第98回日本病理学会
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• [Presentation] hCG産生大腸癌の分子病理学的検討 (2009)
  • Author(s): 吉永智彰
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] Clostridium属によるガス壊疽により死亡した2剖検例 (2009)
  • Author(s): 石川麻倫
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 転落事故後腹腔内出血にて死亡した一剖検例;Autopsy Imagingの有用性と限界 (2009)
  • Author(s): 川田淑子
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 間質性肺炎の経過中、急性に呼吸不全が悪化し死亡された11剖検例の検討 (2009)
  • Author(s): 谷野美智枝
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] TCF8は血管新生の負の制御因子である (2009)
  • Author(s): 犬塚貴之
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 滑膜肉腫細胞株におけるCD133の機能解析 (2009)
  • Author(s): 木村太一
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 髄膜腫におけるDOCK180の発現の検討 (2009)
  • Author(s): 西原広史、村上普美、木村憲一、佐和弘基、鎌田一、田中伸哉
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
• [Presentation] GlioblastomaにおけるCD133の発現の免疫組織学的解析 (2009)
  • Author(s): 田中伸哉、大森優子、椨康一、野田頭未歩、青柳瑛子、伊藤民雄、中村博彦、西原広史、笹井研
  • Organizer: 第27回日本脳腫瘍病理学会
  • Place of Presentation: 福岡
• [Presentation] OCK180はHodgkin細胞に発現し、細胞の形態制御に重要な役割を果たしている (2009)
  • Author(s): 王磊、西原広史、田中伸哉
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Gliomaの腫瘍形成能におけるCHD5の役割の検討 (2009)
  • Author(s): 高阪真路、笹井研、谷野美智枝、野田頭未歩、田中伸哉
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] 悪性膠腫におけるCD133発現の分子細胞病理学的解析 (2009)
  • Author(s): 椨康一、笹井研、木村太一、谷野美智枝、青柳瑛子、王磊、高阪真路、西原広史、田中伸哉
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] トランスレーショナル・パソロジーを目指して (2008)
  • Author(s): 田中伸哉
  • Organizer: 第88回北海道医学大会病理分科会・第41回北海道病理談話会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-20
• [Presentation] ルシフェラーゼ・アッセイを利用した薬剤スクリーニングシステムの樹立 (2008)
  • Author(s): 王磊, ら
  • Organizer: 第95回北海道癌談話会
  • Place of Presentation: 旭川旭川医科大学
  • Year and Date: 2008-09-06
• [Presentation] ヒト滑膜肉腫関連癌原遺伝子SYTは初期発生に必須であり、細胞運動の制御に重要である (2008)
  • Author(s): 木村太一, ら
  • Organizer: 第95回北海道癌談話会
  • Place of Presentation: 旭川旭川医科大学
  • Year and Date: 2008-09-06
• [Presentation] SYT-SSX1トランスジェニックマウスはp53へテロ環境下で滑膜肉腫様腫瘍を発生する (2008)
  • Author(s): 津田真寿美、渡部琢哉、大場雄介、田中伸哉
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ヒト腫瘍細胞におけるCD133遺伝子の発現メカニズム (2008)
  • Author(s): 木村太一、笹井研、田賀哲也、田中伸哉
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 胸膜中皮腫におけるシグナルアダプター分子CRKの役割の解析 (2008)
  • Author(s): 谷野美智枝、王磊、西原広史、松野吉宏、矢野聖二、曽根三郎、田中伸哉
  • Organizer: 第48回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] MGMT発現評価は病理組織学的に腫瘍と非腫瘍成分を識別することが重要である (2008)
  • Author(s): 田中伸哉、野田頭未歩、青柳瑛子、加藤正仁、村田純一、伊東民雄、尾崎義丸、藤本真、金子貞夫、西原広史、笹井研、長嶋和郎
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京
• [Presentation] 悪性膠腫におけるMGMT発現の解析:免疫染色法とメチル化特異的PCR法の比較. (2008)
  • Author(s): 田中伸哉、野田頭未歩、青柳瑛子、王磊、西原広史、長嶋和郎、笹井研
  • Organizer: 第49回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京
• [Presentation] 悪性膠腫におけるMGMT発現の病理組織学的解析 (2008)
  • Author(s): 野田頭未歩、青柳瑛子、笹井研、王磊、西原広史、長嶋和郎、田中伸哉
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 悪性膠腫におけるMGMT発現の解析 : 免疫染色法とメチル化特異的PCR法の比較 (2008)
  • Author(s): 田中伸哉, ら
  • Organizer: 第49回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京タワーホール船堀
• [Presentation] MGMT発現評価は病理組織学的に腫瘍と非腫瘍成分を識別することが重要である (2008)
  • Author(s): 田中伸哉, ら
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京タワーホール船堀
• [Presentation] 悪性膠種におけるCD133発現の分子細胞病理学的解析 (2008)
  • Author(s): 椨康一, ら
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢石川県立音楽堂