| Project/Area Number |
19390388
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORO Toru The University of Tokyo, 医学部附属病院, 特任准教授 (20302698)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Yoshio 東京大学, 医学部附属病院, 特任教授 (40179461)
ISHIHARA Kazuhiko 東京大学, 大学院・工学系研究科, 教授 (90193341)
KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 准教授 (40282660)
SEICHI Atsushi 東京大学, 医学部附属病院, 講師 (70236066)
KARITA Tatsuro 東京大学, 医学部附属病院, 講師 (80359611)
KONNO Tomohiro 東京大学, 大学院・工学系研究科, 特任准教授 (80371706)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 医療・福祉 / 生体材料 / ナノバイオ / バイオテクノロジー / トランスレーショナルリサーチ |
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| Research Abstract |
To evaluate the effect of biocompatible phospholipid polymer on the osteoarthritis progression, we used the ball-on-flat machine, which mimicked a natural joint, and the experimental osteoarthritis model. The friction tests using a ball-on-flat machine revealed that phospholipid polymer extremely improved the friction coefficient as compared to water and hyaluronic acid treatment. In addition, phospholipid polymer prevented the osteoarthritis progression in the experimental osteoarthritis model. From these results of the study, we believe that this new technology will prevent the osteoarthritis progression.
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