| Project/Area Number |
19390390
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
KUSUZAKI Katsuyuki Mie University, 大学院・医学研究科, 教授 (30177993)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Atsumasa 三重大学, 大学院・医学研究科, 教授 (40176681)
MATSUMINE Akihiko 三重大学, 医学部附属病院, 講師 (00335118)
KUMAMOTO Tadashi 三重大学, 大学院・医学研究科, 助教 (50362348)
WAKABAYASHI Hiroki 三重大学, 大学院・医学研究科, 助教 (50362687)
SATONAKA Haruhiko 三重大学, 大学院・医学研究科, 医員 (60515485)
NAKAMURA Tomoki 三重大学, 医学部附属病院, 医員 (50467362)
MATSUBARA Takao 三重大学, 医学部附属病院, 医員 (30422827)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | アクリジンオレンジ / 光線力学的診断 / 光線力学的治療法 / 骨軟部腫瘍 / ストロボ光 / 安全性 / 光線力学的療 |
|---|
| Research Abstract |
To develop photodynamic diagnosis and photodynamic therapy using acridine orange excited by high-power flash light provided from xenon lamp in musculoskeletal sarcomas, we performed this study using mouse osteosarcoma model. Results showed that it was possible to brilliantly detect tumor localization through skin by PDD and to strongly inhibit tumor growth by PDT after intravenous AO injection followed by flash light illumination.
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