| Co-Investigator(Kenkyū-buntansha) |
TSUNEYOSHI Masazumi 九州大学, 大学院・医学研究院, 名誉教授 (20091259)
ODA Yoshinao 九州大学, 大学院・医学研究院, 教授 (70291515)
FUKUSHI Junichi 九州大学, 大学病院, 助教 (40444806)
MATSUMOTO Yoshihiro 九州大学, 大学病院, 助教 (10346794)
SAKAMOTO Akio 九州大学, 大学院・医学研究院, 助教 (40335964)
|
|---|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Research Abstract |
The molecular mechanism of tumor-induced bone destruction was investigated in this study. In tumor-induced bone destruction, tumora-associated macropahges (TAM) play major roles as a cell factor. As soluble factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are found to be critical in the tumor-induced bone destruction. Together, TAM, VEGF, and bFGF would be promising molecular targets for treating the tumor-induced bone destruction.
|
