| Project/Area Number |
19390398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YAMASHITA Toshihiko Sapporo Medical University, 医学部, 教授 (70244366)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEBAYASHI Tsuneo 札幌医科大学, 医学部, 講師 (30347166)
ISHIAI Sumio 札幌医科大学, 医学部, 教授 (80193241)
TOSE Noritsugu 札幌医科大学, 医学部, 教授 (80192657)
KOKAI Yasuo 札幌医科大学, 医学部, 教授 (20178239)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 運動器 / 慢性疼痛 / 後根神経節 / 交感神経 / グリア細胞 / 神経ペプチド / 脊髄膠様質細胞 / 集学的治療 / 神経根性疼痛 / 神経根絞扼モデル / 脊髄膠様質 / 慢性腰痛 / 集学的アプローチ / パッチクランプ / ノルエピネフリン / マイクログリア / Na+チャネル / 疼痛関連遺伝子 / CGRP / galanin |
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| Research Abstract |
In this study, we investigate the mechanisms and subjective indicators of chronic pain. We also evaluated the treatment of chronic pain patients by a multidisciplinary treatment program. An elctrophysiological study using the patch-clump method revealed increased Na^<2+> current and excitability of the DRG neuron in the root constriction model. The sympathetic nervous system also appeared to contribute to chronic radicular pain. In addition, activation of the glial cells and excitation of the substantia gelatinosa neuron may also contribute to chronic pain in the dorsal horn of spinal cord. Serum concentrations of CGRP and galanin were found to correlate to pain intensity in patients with lumbar disc herniation. Scores for SF-36 and self-efficacy were found to be lower in chronic low-back pain patients, and the multidisciplinary treatment program was effective in improving SF-36 scores in patients with chronic pain.
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