Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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Research Abstract |
We employed the computer-assisted microscopy to evaluate microvascular function in the rat brain slices. Electrical stimulation induced constriction of the cerebral parenchymal arteriole, whereas an inhibitor of 20-HETE abolished this response. NMDA, which is one of excitatory amino acids, produced dilation of these arterioles, corresponding with intracellular production of superoxide in addition to nitric oxide in the smooth muscle cells. Propofol within clinically relevant concentrations reduced these vascular responses.
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