Clinical development of early detection method for renal cell carcinoma with serum cancer markers and methylated DNA-fragment cancer markers
Project/Area Number |
19390417
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Kochi University |
Principal Investigator |
SHUIN Taro Kochi University, 教育研究部医療学系, 教授 (80179019)
執印 太郎 (2008) Kochi University, 教育研究部医療学系, 教授 (70128601)
|
Co-Investigator(Kenkyū-buntansha) |
蘆田 真吾 高知大学, 医学部附属病院, 助教 (80380327)
井上 啓史 高知大学, 医学部, 准教授 (00294827)
|
Co-Investigator(Renkei-kenkyūsha) |
ASHIDA Shingo 高知大学, 教育研究部医療学系, 助教 (80380327)
INOUE Keiji 高知大学, 教育研究部医療学系, 准教授 (00294827)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
Keywords | 腎細胞癌 / 腫瘍マーカー / HIG2 / Hoxb13 / メチル化 / HOXB13 / メチル化DNA |
Research Abstract |
ヒト腎の問題点は診断マーカーが存在しないため画像以外には早期診断が難しいこと、また転移の早期発見が難しく転移癌への有効な治療法が存在しないことである。そのためヒトDNAメチル化マーカーと血清マーカーの開発を検討した。その結果血清マーカーHIG2, TMEM22などの有用性を検討し明らかにした。またmethylated DAN marker HOXb13などを中心にメチル化DNAマーカーについても蛋白の発現誘導実験を行い、新しいマーカーの存在を検討した。
|
Report
(3 results)
Research Products
(17 results)
-
[Journal Article] Evidence-based clinical practice guidelines for renal cel carcinoma(Summary-JUA 2007 Edition)2009
Author(s)
Fujioka T, Obara W, Miki Hara I, Hirao Y, Kakehi Y, Kanayama HO, Naito S, Nonomura N, Ogawa Y, Ozono S, Shimazui T, Shinohara N, Shuin T, Takahashi S, Tomita Y, Eto M, Inoue K, Kato T, Kinouchi T, Konda R, Mugiya S, Nagamori S, Nakazawa H, Nishitani MA, Oikawa T, Sugimoto M, Takahashi M, Mizutani Y, Obara W.
-
Journal Title
Int J Urol. 16(4)
Pages: 339-339
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Sarcomatoid acquired cystic disease-associated renal cell carcinoma2008
Author(s)
Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH.
-
Journal Title
HistolHistopathol 23(11)
Pages: 1327-1331
Related Report
Peer Reviewed
-
-
[Journal Article] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cellcarcinoma2008
Author(s)
Obara W, Mizutani Y, Oyama C, Akaza HIshii N, Kohri K, Namiki M, Okuyama A, Shima H, Yokoyama M, Shuin T, Miki T, Watanabe Y Fujioka T.
-
Journal Title
Int J Urol. 15(9)
Pages: 794-799
Related Report
Peer Reviewed
-
-
-
[Journal Article] WT1(Wilms' tumor 1)peptide immunotherapy for renal cell carcinoma2007
Author(s)
Iiyama T, Udaka K, Takeda S, Takeuchi T, Adachi YC, Ohtsuki Y, Tsuboi A, Nakatsuka S, Elisseeva OA, Oji Y, Kawakami M, Nakajima H, Nishida S, Shirakata T, Oka Y, Shuin T, Sugiyama H.
-
Journal Title
Mcrobi Imnol. 51(5)
Pages: 519-30
Related Report
Peer Reviewed
-
-
-
[Journal Article] Renal leiomyoma : an immunohistochemical, ultrastructural and comparative genomic hybridizion study Histol Histopathol2007
Author(s)
Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee GH.
-
Journal Title
Related Report
Peer Reviewed
-
-
-