| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Research Abstract |
Interstitial cells (ICs) in the urinary tract developed spontaneous Ca^<2+> transients arising from the endoplasmic reticulum Ca^<2+> release in cooperation with the perinuclear mitochondrial Ca^<2+> handling. Spontaneous Ca^<2+> transients in ICs exhibited little temporal relationship with smooth muscle Ca^<2+> signals, and atypical smooth muscle cells play a pacemaker role in the renal pelvis. The number of Kit-positive ICs was increased in the obstructed bladders, while the mice which have a mutation on Kit receptor (W/W^v) or its ligand stem cell factor (Sl/Sl^d) had effects on neither the distribution of ICs nor the smooth muscle contractility.
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