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The assessment using Positron Emission Tomography in conditionally replicating adenovirus therapy.

Research Project

Project/Area Number 19390420
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionHyogo College of Medicine

Principal Investigator

GOTOH Akinobu  Hyogo College of Medicine, 医学部, 教授 (70283885)

Co-Investigator(Kenkyū-buntansha) TERAO Shuuji  兵庫医科大学, 医学部, 助教 (10457103)
KUBO Shuji  兵庫医科大学, 医学部, 助教 (10441320)
千田 道雄  先端医療振興財団, 先端医療センター, 研究所副所長 (00216558)
富永 英之  先端医療振興財団, 先端医療センター, 研究員 (00393348)
Co-Investigator(Renkei-kenkyūsha) SENDA Michio  先端医療振興財団, 先端医療センター, 研究所副所長 (00216558)
TOMINAGA Hideyuki  先端医療振興財団, 先端医療センター, 研究員 (00393348)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords前立腺癌 / 遺伝子治療 / PET / [^<18>F]FDG / [^<18>F]FHBG
Research Abstract

In this study, we demonstrated the possibility of assessment using Positron Emission Tomography for prostate cancer model received conditionally replicating adenovirus therapy.

Report

(3 results)
  • 2009 Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 11 results) Presentation (15 results) Book (1 results)

  • [Journal Article] Adenovirus vector production using low-multiplicity infection of 293 cells2009

    • Author(s)
      Yamada K, Morishita N, Katsuda T, Kubo S, Gotoh A, Yamaji H
    • Journal Title

      Cytotechnology 59巻

      Pages: 153-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study of quality of life of patients with hormone-refractory prostate cancer after gene therapy2009

    • Author(s)
      Terao S, Gotoh A., et al
    • Journal Title

      Anticancer Res 29巻

      Pages: 1533-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif2009

    • Author(s)
      Terao S, Acharya B, Suzuki T, Aoi T, Naoe M, Hamada K, Mizuguchi H, Gotoh A
    • Journal Title

      Anticancer Res 29巻

      Pages: 2997-3001

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子治療の展望2009

    • Author(s)
      後藤章暢, ほか
    • Journal Title

      Urology View 7

      Pages: 102-8

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Adenovirus vector production using low-multiplicity infection of 293 cells2009

    • Author(s)
      Yamada K., ほか
    • Journal Title

      Cytotechnology 59

      Pages: 153-60

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study of quality of life of patients with hormoner efractory prostate cancer after gene therapy2009

    • Author(s)
      寺尾秀治, ほか
    • Journal Title

      Anticancer Res. 29

      Pages: 1533-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved gene transfer into renal carcinoma cells using adenovirus vector o〓mtaining RGD motif2009

    • Author(s)
      寺尾秀治, ほか
    • Journal Title

      Anticancer Res. 23

      Pages: 2997-3001

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer2009

    • Author(s)
      Nakagawa T., ほか
    • Journal Title

      Arch Otolaryngol Head Neck Surg. 135

      Pages: 282-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells : roles of ERK/MAP kinase2009

    • Author(s)
      Shigemura K., ほか
    • Journal Title

      69

      Pages: 949-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      井村裕夫監修
    • Journal Title

      実践ゲノムの最前線(六然社)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 泌尿器科腫瘍の遺伝子診断と個別化治療を目指した分子標的療法2008

    • Author(s)
      白川利朗, ほか
    • Journal Title

      医薬ジャーナル 44

      Pages: 83-6

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Gene therapy in prostate cancer : past, present and future2008

    • Author(s)
      白川利朗, ほか
    • Journal Title

      Front.Biosci. 13

      Pages: 2115-9

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 内分泌療法抵抗性前立腺癌骨転移〓および局所再発巣に対するAd-OC-TK/VAL遺伝子治癒第I/II相臨床試験2008

    • Author(s)
      寺尾秀治, ほか
    • Journal Title

      泌尿器外科 21

      Pages: 1085-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer2007

    • Author(s)
      Shirakawa, T., Terao, S., Gotoh, A., et al.(18名中18番目)
    • Journal Title

      Hum. Gene Ther 18巻

      Pages: 1225-1232

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌-基礎・臨床研究のアップデート-, 前立腺癌に対する遺伝子治療の現状と展望2007

    • Author(s)
      後藤章暢, 寺尾秀治, 白川利朗
    • Journal Title

      日本臨牀 65巻(増刊10)

      Pages: 517-521

    • Related Report
      2009 Final Research Report
  • [Journal Article] Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer2007

    • Author(s)
      Toshiro Shirakawa
    • Journal Title

      Hum.Gene Ther 第18巻・第2号

      Pages: 1225-1232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌-基礎・臨床研究のアップデートー,前立腺癌に対する遺伝子治療の現状と展望2007

    • Author(s)
      後藤 章暢
    • Journal Title

      日本臨牀 65(増刊10)

      Pages: 517-521

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 前立腺癌-基礎・臨床研究のアップデートー,オステオカルシンプロモーターを用いた遺伝子治療2007

    • Author(s)
      白川 利朗
    • Journal Title

      日本臨牀 65(増刊10)

      Pages: 528-532

    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト膀胱癌細胞株に対するIAI. 3Bプロモーターを組み込んだ制限増殖型アデノウイルスベクターの有用性の検討2009

    • Author(s)
      寺尾秀治, Acharya B, 鈴木透, 濱田雄行, 後藤章暢
    • Organizer
      第59回日本泌尿器科学会中部総
    • Place of Presentation
      金沢
    • Year and Date
      2009-10-30
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト膀胱癌細胞株に対するIAI.3Bプロモーターを組み込んだ制限増殖型アデノウイルスベクターの有用性の検討2009

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      第59回日本泌尿器科学会中部総会
    • Place of Presentation
      金沢
    • Year and Date
      2009-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improved gene transfer into renal carcinoma cells using an adenovirus vector2009

    • Author(s)
      Terao S, Acharya B, Suzuki T, Gotoh A
    • Organizer
      The 19th Annual Meeting of the International Urological Conference of Taiwan
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2009-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Improved gene transfer into renal carcinoma cells using an adenovirus vector2009

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      The 19^<th> Annual Meeting of the International Urological Conference of Taiwan
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2009-08-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intravenous injection of the carrier-cell based oncolytic adenovirus suppresses the growth of multiple lung tumors in mouse squamous cell carcinoma model2009

    • Author(s)
      Shirakawa T., ほか
    • Organizer
      Japan Society of Gene Therapy The 15^<th> Annual Meeting2009
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膀胱癌細胞株に対するアデノウイルスベクターの導入効率向上の試み2009

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎癌細胞株に対するアデノウイルスベクターの遺伝子導入効率向上の試み2009

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      第18回泌尿器科分子・細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-02-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膀胱癌細胞株に対するファイバー改変アデノウイルスベクターを用いた遺伝子導入効率の検討2009

    • Author(s)
      Acharya B., ほか
    • Organizer
      第18回泌尿器科分子・細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-02-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト膀胱癌細胞に対するミドカインプロモーターを組み込んだ増殖制限型アデノウイルスベクター(AD〓E1a)の有用性の検討2008

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells2008

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      2008 International Society for Cell and Gene Therapy of Cancer China Conference
    • Place of Presentation
      Shijiazhuang(中国)
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prostate cancer in a relatively young adult : A case report2008

    • Author(s)
      Suzuki T., ほか
    • Organizer
      The 18^<th> Annual Meeting of the International Urological Conference of Taiwan
    • Place of Presentation
      Taipei
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells2008

    • Author(s)
      Terao, S., Shirakawa, T., Tanaka, K., Takenaka, A., Kamidono, S., Fujisawa, M., Gotoh, A
    • Organizer
      American Urological Association 2008 Annual Meeting (AUA2008)
    • Place of Presentation
      Orlando. U.S. A
    • Year and Date
      2008-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells2008

    • Author(s)
      寺尾秀治, ほか
    • Organizer
      American Urological Association 2008 Annual Meeting(AUA2008)
    • Place of Presentation
      Orlando
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 後藤章暢、内分泌療法抵抗性前立腺癌骨転移巣及び局所再発巣に対するAd-OC-TK/VAL遺伝子治療の第I/II相臨床試験2007

    • Author(s)
      寺尾秀治, 白川利朗, 日向信行, 田中一志, 武中篤, 藤澤正人
    • Organizer
      第23回前立腺シンポジウ
    • Place of Presentation
      東京
    • Year and Date
      2007-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 内分泌療法抵抗性前立腺癌骨転移巣及び局所再発巣に対するAd-OC-TK/VAL遺伝子治療の第I/II相臨床試験2007

    • Author(s)
      寺尾 秀治
    • Organizer
      第23回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-12-09
    • Related Report
      2007 Annual Research Report
  • [Book] 第2部ゲノム医療の実践に向けて第5章遺伝子治療A:(総論)遺伝子治療-歴史と背景-, B:(各論1)前立腺がんの遺伝子治療

    • Author(s)
      後藤章暢
    • Publisher
      六然社
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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