| Project/Area Number |
19390423
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
ARIMA Takahiro Tohoku University, 未来医工学治療開発センター, 准教授 (80253532)
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| Co-Investigator(Kenkyū-buntansha) |
YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
CHISAKA Hirosi 東北大学, 病院, 講師 (40323026)
ABE Keiko 東北大学, 未来医工学治療開発センター, 技術補佐員 (30444003)
高林 俊文 東北大学, 大学院・医学系研究科, 名誉教授 (30124598)
間宮 良子 東北大学, 大学院・医学系研究科, 技術補佐員 (50443990)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 卵巣癌 / エピジェネティックス / 症例対照研究 / ChIP-on-Chip / DNAメチル化 / インプリント遺伝子 / インプリンティング遺伝子 / 抗メチル化シトシン |
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| Research Abstract |
We examined the epigenetic mechanisms (DNA methylation abnormality) in ovarian cancer by the whole-genome tiling array system and analysed the association between the etiology and conditions of a patient (age, staging, histological type). We found early stage variation for some tumor suppressor genes and imprinted genes. From the viewpoint of onset prevention, we examined the environmental factors, such as meals and life-styles. Furthermore, we developed a novel methylation analysis system, PCR-Luminex methods.
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