Evidence for an epigenetic mechanisms in ovarian cancer by the whole-genome tiling array system.
| Project/Area Number |
19390423
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
ARIMA Takahiro Tohoku University, 未来医工学治療開発センター, 准教授 (80253532)
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| Co-Investigator(Kenkyū-buntansha) |
YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
CHISAKA Hirosi 東北大学, 病院, 講師 (40323026)
ABE Keiko 東北大学, 未来医工学治療開発センター, 技術補佐員 (30444003)
高林 俊文 東北大学, 大学院・医学系研究科, 名誉教授 (30124598)
間宮 良子 東北大学, 大学院・医学系研究科, 技術補佐員 (50443990)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 卵巣癌 / エピジェネティックス / 症例対照研究 / ChIP-on-Chip / DNAメチル化 / インプリント遺伝子 / インプリンティング遺伝子 / 抗メチル化シトシン |
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| Research Abstract |
We examined the epigenetic mechanisms (DNA methylation abnormality) in ovarian cancer by the whole-genome tiling array system and analysed the association between the etiology and conditions of a patient (age, staging, histological type). We found early stage variation for some tumor suppressor genes and imprinted genes. From the viewpoint of onset prevention, we examined the environmental factors, such as meals and life-styles. Furthermore, we developed a novel methylation analysis system, PCR-Luminex methods.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip2010
Author(s)
Hiura H, Sugawara A, Ogawa H, John RM, Miyauchi N, Miyanari Y, Horiike T, Li Y, Yaegashi N, Sasaki H, Kono T, Arima T.
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Journal Title
Nucleic Acids Research (in press)
Related Report
Peer Reviewed
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[Journal Article] A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip2010
Author(s)
Hiura H, Sugawara A, Ogawa H, John RM, Miyauchi N, Miyanari Y, Horiike T, Li Y, Yaegashi N, Sasaki H, Kono T, Arima T.
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Journal Title
Nucleic Acids Research (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Developmental ability of trophoblast stem cells in uniparental mouse embryos2009
Author(s)
Ogawa H, Shindo N, Kumagai T, Usami Y, Shikanai M, Jonwn K, Fukuda A, Kawahara M, Sotomaru Y, Tanaka S, Arima T, Kono T.
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Journal Title
Placenta 30
Pages: 448-456
Related Report
Peer Reviewed
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[Journal Article] DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm2009
Author(s)
Kobayashi H, Hiura H, John R, Sato A, Otsu E, Kobayashi N, Suzuki R, Suzuki F, Hayashi C, Utsunomiya T, Yaegashi N, Arima T.
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Journal Title
Euro J Human Genet 12
Pages: 1582-91
Related Report
Peer Reviewed
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