DVELOPMENT OF HUMAN MONOCLONAL ANTIBODIES WHICH SHOW INHIBITORY EFFECTS TUMOR PROGRESSION.
| Project/Area Number |
19390430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
AOKI Daisuke Keio University, 医学部, 教授 (30167788)
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| Co-Investigator(Kenkyū-buntansha) |
SUSUMU Nobuyuki 慶應義塾大学, 医学部, 講師 (90206459)
SUZUKI Nao 聖マリアンナ医科大学, 医学部, 講師 (90246356)
SUZUKI Atsushi 慶應義塾大学, 医学部, 助教 (00255514)
BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
HIRASAWA Akira 慶應義塾大学, 医学部, 助教 (90296658)
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| Research Collaborator |
OIKAWA Fumiko 慶應義塾大学, 医学部, 研究員
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 婦人科癌 / 抗体医薬 / モノクローナル抗体 / 糖鎖抗原 / CD166 / 癌 / 転移 / ヒトモノクローナル抗体 / 糖鎖 |
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| Research Abstract |
We have developed a human monoclonal antibody HMMC-1 specific to gynecological cancers and it showed anti tumor activity for gynecological cancers. Mass spectrometry analysis revealed that HMMC-1 antigen was at least CD166. HMMC-1 intereaction with possibly CD166, may have a direct effect on the growth of cells with high metastatic potential. The chlorate treatment demonstrates that sulfation is necessary for HMMC-1 antigen activity.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Overexpression of class IIIβ-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma.2009
Author(s)
Aoki D, Oda Y, Hattori S, Taguchi K, Ohishi Y, Basaki Y, Oie S, Suzuki N, Kono S, Tsuneyoshi M, Ono M, Yanagawa T, Kuwano M
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Journal Title
Clin Cancer Res 15(4)
Pages: 1473-1480
Related Report
Peer Reviewed
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[Journal Article] Can ABCF2 protein expression predict the prognosis of urerine cancer?2008
Author(s)
Nishimura S, Tsuda H, Miyagi Y, Hirasawa A, Suzuki A, Kataoka F, Nomura H, Chiyoda T, Banno K, Fujii T, Susumu N, Aoki D
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Journal Title
Br J Cancer 99
Pages: 1651-1655
Related Report
Peer Reviewed
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[Journal Article] Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes.2007
Author(s)
Banno K, Yanokura M, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Tsukazaki K, Aoki D
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Journal Title
nt J Oncol 31(4)
Pages: 713-720
Related Report
Peer Reviewed
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[Presentation] ワークショップ:標準治療を施行した進行上皮性卵巣癌の網羅的探索2008
Author(s)
永英一郎, 荒尾徳三, 津田浩史, 山上亘, 野村弘行, 平沢晃, 鈴木淳, 進伸幸, 西村貞子, 青木大輔, 西尾和人
Organizer
第67回日本癌学会学術総会
Place of Presentation
名古屋
Related Report
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[Presentation] COX-2発現量およびCD8陽性リンパ球数が進行期子宮体癌の予後に与える影響2007
Author(s)
末盛友浩, 進伸幸, 矢野倉恵, 市川義一, 野村弘行, 平沢晃, 玉田裕, 阪埜浩司, 鈴木淳, 塚崎克己, 青木大輔, 吉村泰典
Organizer
第59回日本産科婦人科学会総会・学術講演会
Place of Presentation
京都
Related Report
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