| Project/Area Number |
19390430
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
AOKI Daisuke Keio University, 医学部, 教授 (30167788)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUSUMU Nobuyuki 慶應義塾大学, 医学部, 講師 (90206459)
SUZUKI Nao 聖マリアンナ医科大学, 医学部, 講師 (90246356)
SUZUKI Atsushi 慶應義塾大学, 医学部, 助教 (00255514)
BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
HIRASAWA Akira 慶應義塾大学, 医学部, 助教 (90296658)
|
|---|
| Research Collaborator |
OIKAWA Fumiko 慶應義塾大学, 医学部, 研究員
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
|---|
| Keywords | 婦人科癌 / 抗体医薬 / モノクローナル抗体 / 糖鎖抗原 / CD166 / 癌 / 転移 / ヒトモノクローナル抗体 / 糖鎖 |
|---|
| Research Abstract |
We have developed a human monoclonal antibody HMMC-1 specific to gynecological cancers and it showed anti tumor activity for gynecological cancers. Mass spectrometry analysis revealed that HMMC-1 antigen was at least CD166. HMMC-1 intereaction with possibly CD166, may have a direct effect on the growth of cells with high metastatic potential. The chlorate treatment demonstrates that sulfation is necessary for HMMC-1 antigen activity.
|
