New approach for diagnosis and treatment of head and neck cancer by proteomics analysis

• Project/Area Number: 19390432
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: FUKUDA Satoshi Hokkaido University, 大学院・医学研究科, 教授 (20125347)
• Co-Investigator(Kenkyū-buntansha): HOMMA Akihiro 北海道大学, 大学病院, 講師 (30312359) ; HATAKEYAMA Shigetugu 北海道大学, 大学院・医学研究科, 教授 (70294973) ; SHIRATO Hiroki 北海道大学, 大学院・医学研究科, 教授 (20187537)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2007: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 頭頸部癌 / プロテオーム / ユビキチン

Research Abstract

We analyzed the function of Ubiquitin in head and neck cancer. We considered TRIM32 and UBE2Q2 as a important factor to control the treatment of advanced head and neck Cancer.

Research Products

• [Journal Article] Ubiquitin-Conjugating Enzyme UBE2Q2 Suppresses Cell Proliferation and Is Down-Regulated in Recurrent Head and Neck Cancer (2009)
  • Author(s): Maeda H, Miyajima N, Kano S, Tsukiyama T, Okumura F, Fukuda S, Hatakeyama S
  • Journal Title: Mol Cancer Res 7 Pages: 1553-1562
  • Peer Reviewed
• [Journal Article] p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma. (2009)
  • Author(s): Oridate N, Homma A, Higuchi E, Suzuki F, Hatakeyama H, Mizumachi T, Furusawa J, Taki S, Furuta Y, Fukuda S.
  • Journal Title: Auris Nasus Larynx 36 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Ubiquitin-Conjugating Enzyme UBE2Q2 Suppresses Cell Proliferation and Is Down-Regulated in Recurrent Head and Neck Cancer. (2009)
  • Author(s): Maeda H, Miyajima N, Kano S, Tsukiyama T, Okumura F, Fukuda S, Hatakeyama S.
  • Journal Title: Mol Cancer Res 7 Pages: 1553-1562
  • Peer Reviewed
• [Journal Article] Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2 (2008)
  • Author(s): Kano S, Miyajima N, Fukuda S, Hatakeyama S
  • Journal Title: Cancer Res 68 Pages: 5572-5580
  • Peer Reviewed
• [Journal Article] Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells (2008)
  • Author(s): Mizumachi T, Suzuki S, Naito A, Carcel-Trullols J, Evans TT, Spring PM, Oridate N, Furuta Y, Fukuda S
  • Journal Title: Oncogene 27 Pages: 831-838
  • Peer Reviewed
• [Journal Article] Tripartite motif protein 32 facilitates cell growth and migrati on via degradation of Abl-interactor 2 (2008)
  • Author(s): Kano S, Miyajima N, Fukuda S, Hatakeyama S.
  • Journal Title: Cancer Res 68 Pages: 5572-5580
  • Peer Reviewed
• [Journal Article] TRIM68 regulates ligand-dependent transcription of androgen receptorin prostate cancer cells (2008)
  • Author(s): Miyajima N, Maruyama S, Bohgaki M, Kano S, Shigemura M, Shinohara N, Nonomura K, Hatakevama S
  • Journal Title: Cancer Res 68 Pages: 3486-3494
  • Peer Reviewed
• [Journal Article] Increased mitochondrial DNA induces acquired docetaxel resistance in head and neck cancer cells (2008)
  • Author(s): Mizumachi T, Suzuki S, Naito A, Carcel-Trullols J, Evans TT, Spring PM, Oridate N, Furuta Y, Fukuda S.
  • Journal Title: Oncogene 27 Pages: 831-838
  • Peer Reviewed
• [Journal Article] Computer image-guided surgery for total maxillectomy (2008)
  • Author(s): Homma A, Saheki M, Suzuki F, Fukuda S
  • Journal Title: Eur Arch Otorhinolaryngol 265 Pages: 1521-1526
  • Peer Reviewed
• [Journal Article] Clinical Outcomes of Stereotactic Body Radiotherapy for Small Lung Lesions Clinically Diagnosed as Primary Lung Cancer on Radiologic Examination
  • Author(s): Inoue T, Shimizu S, Onimaru R, Takeda A, Onishi H, Nagata Y, Kimuia T, Karasawa K, Arimoto T, Hareyama M, Kikuchi E, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys (In press)
  • Peer Reviewed
• [Presentation] UBE 2 Q 2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer (2009)
  • Author(s): 真栄田裕行, 加納里志, 畠山鎮次, 福田諭
  • Organizer: 第110回日本耳鼻咽喉科学会
  • Place of Presentation: 東京
• [Presentation] UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer. (2009)
  • Author(s): 真栄田裕行, 加納里志, 畠山鎮次, 福田諭
  • Organizer: 第110回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: ザ・プリンスパークタワー東京(東京都)
• [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis (2008)
  • Author(s): Kano S, Hatakevama S. Fukuda S
  • Organizer: The 12th Japan-Korea Joint Meeting of Otorhinolaryngoloe-Head and Neck Surgery
  • Place of Presentation: Nara, JAPAN
  • Year and Date: 2008-04-04
• [Presentation] TRIM32 facilitates cell growth, migration and anti-apoptosis (2008)
  • Author(s): Kano S, Hatakeyama S, Fukuda S
  • Organizer: The 12th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Nara, Japan
• [Presentation] 頭頸部扁平上皮癌におけるユビキチンリガーゼTRIM32の機能解析 (2007)
  • Author(s): 加納里志、真栄田裕行、畠山鎮次、福田 諭
  • Organizer: 第108回日本耳鼻咽喉科学会
  • Place of Presentation: 金沢(石川県立音楽堂)
• [Presentation] ユビキチンリガーゼTripartite motif protein 32(TRIM32)による癌細胞増殖制御 (2007)
  • Author(s): 加納里志、築山忠維、福田 諭、畠山鎮次
  • Organizer: BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
  • Place of Presentation: 横浜(パシフィコ横浜)