| Project/Area Number |
19390440
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MOCHIZUKI Manabu Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (10010464)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Kyouko 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30262174)
SUGITA Sunao 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (10299456)
TANAKA Akiko 東京医科歯科大学, 医学部附属病院, 助教 (60302874)
SUGAMOTO Yoshiharu 東京医科歯科大学, 医学部附属病院, 助教 (20334419)
鴨居 功樹 東京医科歯科大学, 医学部附属病院, 助教 (40451942)
岩永 洋一 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40418661)
佐々木 秀次 東京医科歯科大学, 医学部附属病院, 助教 (80302850)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 自然免疫 / 眼虹彩色素上皮細胞 / 眼網膜色素上皮細胞 / 制御性T細胞 / 免疫調節分子機構 / 眼色素上皮細胞 / 角膜内皮細胞 / 実験的自己免疫性ぶどう膜炎 / マウス / 眼科学 / 虹彩色素上皮 / 角膜内皮 / 活性化T細胞 / ぶどう膜炎 / 網膜色素上皮細胞 / CTLA-2α / 虹彩色素上皮細胞 / 毛様体色素上皮細胞 / 房水 / TGF-β / TSP-1 / 抑制性Tリンパ球 / B7-2 |
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| Research Abstract |
To identify regional immune system in the eye, in vitro studies using ocular pigment epithelial cells (iris, ciliary body, retina) isolated from mouse were carried out. Iris pigment epithelial cells suppressed activated CD4 T cells via cell-to-cell contact through B7-2 on iris pigment epithelial cells, CTLA-4 on activated T cells, and TGF-b and CTLA-2a. In addition, ocular pigment epithelial cells have capacities to promote regulatory T cells and enhance its immune-regulatory activities.
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