Investigation of the mechanism of age-related macular degeneration in Japanese patients through genomic analysis and stem cell biology

• Project/Area Number: 19390442
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: YOSHIMURA Nagahisa Kyoto University, 医学研究科, 教授 (70211662)
• Co-Investigator(Kenkyū-buntansha): 辻川 明孝 京都大学, 医学研究科, 助教 (40402846) ; 大谷 篤史 京都大学, 医学研究科, 助教 (30314222) ; 田村 寛 京都大学, 医学研究科, 助教 (40418760)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
• Keywords: ゲノム医学 / 加齢黄斑変性 / 骨髄幹細胞 / 疾患感受性遺伝子 / 脈絡膜新生血管 / 骨髄由来末梢血幹細胞 / 強度近視 / 特発性脈絡膜新生血管 / SNP / HTRA1 / COL

Research Abstract

日本人加齢黄斑変性患者の遺伝子解析、末梢血骨髄由来細胞の解析より、欧米との異同、疾患に特徴的な所見、新たな発症・進行に関する知見が得られた。

Research Products

• [Journal Article] Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population (2009)
  • Author(s): Nakanishi H, Yamada R, Gotoh N, Hayashi H, Otani A, Tsujikawa A, Yamashiro K, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. Pages: 544-550
• [Journal Article] Absence of association between COLlA1 polymorphisms and high myopia in the Japanese population. (2009)
  • Author(s): Nakanishi H. Yamado R, Gotoh N, Hayashi H, Otani A, Tsujikawa A, Yamashiro K, Shimada X, Ohno-Matsui K, Mochizuki M, Saito M, Saito, K, Iida T, Matsutia F, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci. 50 Pages: 544-50
  • Peer Reviewed
• [Journal Article] Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration (2008)
  • Author(s): Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Kameda T, Nakamura H, Yoshimura N.
  • Journal Title: Am J Pathol. Pages: 1693-1703
• [Journal Article] Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population (2008)
  • Author(s): Gotoh N, Yamada R, Nakanishi H, Saito M, Iida T, Matsuda F, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol 36 Pages: 437-442
• [Journal Article] Activation of Bone Marrow-Derived Microglia Promotes Photoreceptor Survival in Inherited Retinal Degeneration (2008)
  • Author(s): Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Kameda T, Nakamura H, Yoshimura N.
  • Journal Title: Am J Pathol 172 Pages: 1693-1703
• [Journal Article] Manganese Superoxide dismutase gene(SOD2)polymorphism and exudative age-related macular degeneration in the Japanese population (2008)
  • Author(s): Gotoh N, Yamada R, Matsuda F, Iida T, Yoshimura N.
  • Journal Title: Am J Ophthalmol 146 Pages: 146-147
• [Journal Article] Granulocyte colony stimulating factor protects retinal photoreceptor cells against light-induced damage (2008)
  • Author(s): Oishi A, Otani A, Sasahara M, Kojima H, Nakamura H, Yodoi Y, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci 46 Pages: 5629-5635
• [Journal Article] Correlation between CFH Y402H and HTRA1 rsll200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population. (2008)
  • Author(s): Gotoh N, Yamada R, Nakanishi H, Saito M, Iida T, Matsuda F, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol. 36 Pages: 437-42
  • Peer Reviewed
• [Journal Article] Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. (2008)
  • Author(s): Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Karaeda T, Nakamura H, Yoshimura N.
  • Journal Title: Am J Pathol. 172 Pages: 1693-703
  • Peer Reviewed
• [Journal Article] Retinal nerve fiber layer thickness in patients with retinitis pigmentosa (2008)
  • Author(s): Oishi A, et. al.
  • Journal Title: Eye 14
  • Peer Reviewed
• [Journal Article] Circulating hematopoietic stem cells in patients with neovascular age-related macular degeneration. (2007)
  • Author(s): Yodoi Y, et. al.
  • Journal Title: Invest Ophthalmol Vis Sci. 48 Pages: 5464-72
  • Peer Reviewed
• [Journal Article] Indocyanine green angiography: guided photodynamic therapy for polypoidal choroidal vasculonathy (2007)
  • Author(s): Otani A, et. al.
  • Journal Title: Am J Ophthalmol. 144 Pages: 7-14
  • Peer Reviewed
• [Presentation] 加齢黄斑変性とポリープ状脈絡膜血管症におけるARMS2遺伝子領域の多型 (2008)
  • Author(s): 後藤謙元
  • Organizer: 第47回日本網膜硝子体学会総会・日本眼循環学会 合同学会
  • Place of Presentation: 京都
  • Year and Date: 2008-11-29
• [Presentation] 日本人の病的近視におけるCOL1A1遺伝子多型の関与 (2008)
  • Author(s): 中西秀雄, 後藤謙元、林寿子、大谷篤史、辻川明孝、田村寛、吉村長久、島田典明、大野京子、望月學、斎藤昌晃、斎藤国治、飯田知弘
  • Organizer: 厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 班会議
  • Place of Presentation: 福岡
• [Presentation] 滲出型加齢黄斑変性における遺伝子多型と光線力学療法2年後の成績 (2008)
  • Author(s): 後藤謙元, 辻川明孝、中西秀雄、林寿子、大谷篤史、田村寛、吉村長久、斎藤昌晃、斎藤国治、飯田知弘
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 神奈川
• [Presentation] Circulating Hematopoietic Stem Cells Control The Progression Of Choroidal Neovascularization In Age-related Macular Degeneration (2007)
  • Author(s): Yodoi Y, et. al.
  • Organizer: ARVO
  • Place of Presentation: Ft Lauderdale, FL, USA
  • Year and Date: 2007-05-07
• [Presentation] Lysyl Oxidase-like 1 Polymorphisms and Exfoliation - Syndrome in the Japanese Population
  • Author(s): Hayahshi H, Yoshimura N, et al.
  • Organizer: ARVO 2008
• [Presentation] AssociationBetween LOC387715/HTRA1 and Japanese
  • Author(s): Gotoh N, Yoshimura N.,, et al.
  • Organizer: Exudative Age-Related Macular Degeneration
• [Presentation] Granulocyte Colony Stimulating Factor Protects Retinal
  • Author(s): A. Oishi, A. Otani, M. Sasahara, H. Kojima, Y. Yodoi, N. Yoshimura
  • Organizer: Retinal Photoreceptor Cells Against the Light-Induced Damage
• [Presentation] 加齢黄斑変性とポリープ状脈絡膜血管症におけるARMS2遺伝子領域の多型
  • Author(s): 後藤謙元, 吉村長久, 他
  • Organizer: 第47回日本網膜硝子体学会総会・日本眼循環学会
  • Place of Presentation: 京都
• [Presentation] 血管新生の形態と骨髄細胞の関与
  • Author(s): 大谷篤史, 鄒賀、佐々原学、淀井有子、大石明生、亀田隆範、小嶌洋史、吉村長久
• [Presentation] 骨髄由来細胞と網膜色素変性
  • Author(s): 佐々原学、大谷篤史、大石明生、小蔦洋史、淀井有子、中村元、吉村長久
• [Presentation] G-CSFの網膜光障害における保護効果
  • Author(s): 大石明生、大谷篤史、佐々原学、小蔦洋史、淀井有子、吉村長久
• [Presentation] 日本人におけるLOXL1遺伝子多型と落屑症候群の相関の検討
  • Author(s): 林寿子, 後藤謙元、植田良樹、中西秀雄、板谷正紀、吉村長久
• [Book] 加齢黄斑変性 (2008)
  • Author(s): 吉村長久
  • Total Pages: 264
  • Publisher: 医学書院
• [Book] 加齢黄斑変性
  • Author(s): 吉村長久
  • Publisher: 医学書院
• [Patent(Industrial Property Rights)] 骨髄由来幹細胞、前駆細胞賦活による網膜疾患治療剤 (2008)
  • Inventor(s): 大谷篤史, 佐々原学, 吉村長久
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Number: 2008-033267
  • Filing Date: 2008-02-14
• [Patent(Industrial Property Rights)] 骨髄由来幹細胞、前駆細胞機能賦活による網膜疾患治療